Differential regulation of granuloma size and hepatic fibrosis in schistosome infections.

Abstract:

:Granuloma size is the variable most frequently used to evaluate the immunopathogenesis of schistosome infections. However, hepatic fibrosis is at the least an equally relevant variable. Hepatic fibrosis and the size of circumoval granulomas are frequently dissociated in experimental murine Schistosoma mansoni and S. japonicum infections. Virtually nothing is known of the immunoregulation of schistosomal hepatic fibrosis. This review notes many of the studies which have found discrepancies in granuloma volume and hepatic fibrosis, attempts to put them in perspective and to evaluate different methods of calculating changes in collagen synthesis or content.

journal_name

Mem Inst Oswaldo Cruz

authors

Cheever AW

doi

10.1590/s0074-02761997000500024

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

689-92

issue

5

eissn

0074-0276

issn

1678-8060

pii

S0074-02761997000500024

journal_volume

92

pub_type

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