The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms.

Abstract:

:Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).

journal_name

Mem Inst Oswaldo Cruz

authors

Sales Júnior PA,Rezende Júnior CO,Le Hyaric M,Almeida MV,Romanha AJ

doi

10.1590/0074-0276130496

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

362-4

issue

3

eissn

0074-0276

issn

1678-8060

pii

S0074-02762014005030496

journal_volume

109

pub_type

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