Abstract:
:Non-bilayer phospholipid arrangements are three-dimensional structures that form when anionic phospholipids with an intermediate structure of the tubular hexagonal phase II are present in a bilayer of lipids. Antibodies that recognise these arrangements have been described in patients with antiphospholipid syndrome and/or systemic lupus erythematosus and in those with preeclampsia; these antibodies have also been documented in an experimental murine model of lupus, in which they are associated with immunopathology. Here, we demonstrate the presence of antibodies against non-bilayer phospholipid arrangements containing mycolic acids in the sera of lepromatous leprosy (LL) patients, but not those of healthy volunteers. The presence of antibodies that recognise these non-bilayer lipid arrangements may contribute to the hypergammaglobulinaemia observed in LL patients. We also found IgM and IgG anti-cardiolipin antibodies in 77% of the patients. This positive correlation between the anti-mycolic-non-bilayer arrangements and anti-cardiolipin antibodies suggests that both types of antibodies are produced by a common mechanism, as was demonstrated in the experimental murine model of lupus, in which there was a correlation between the anti-non-bilayer phospholipid arrangements and anti-cardiolipin antibodies. Antibodies to non-bilayer lipid arrangements may represent a previously unrecognised pathogenic mechanism in LL and the detection of these antibodies may be a tool for the early diagnosis of LL patients.
journal_name
Mem Inst Oswaldo Cruzjournal_title
Memorias do Instituto Oswaldo Cruzauthors
Baeza I,Wong-Baeza C,Valerdi E,Serafin-Lopez J,Ibáñez M,Estrada-Parra S,Wong C,Estrada-Garcia Idoi
10.1590/s0074-02762012000900016subject
Has Abstractpub_date
2012-12-01 00:00:00pages
95-103eissn
0074-0276issn
1678-8060pii
S0074-02762012000900016journal_volume
107 Suppl 1pub_type
杂志文章abstract::Coagulase-negative staphylococci (CNS) have been identified as the etiological agent in various infections and are currently the microorganisms most frequently isolated in nosocomial infections. However, little is known about the virulence factors produced by CNS that contribute to the pathogenesis of infections cause...
journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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