Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area.

Abstract:

:The antibody response to Plasmodium falciparum parasites of naturally infected population is critical to elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96 individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2 region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore, its importance on malaria vaccine efficacy.

journal_name

Mem Inst Oswaldo Cruz

authors

Sallenave-Sales S,Faria CP,Zalis MG,Daniel-Ribeiro CT,Ferreira-da-Cruz Mde F

doi

10.1590/s0074-02762007005000048

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

421-4

issue

3

eissn

0074-0276

issn

1678-8060

pii

S0074-02762007000300024

journal_volume

102

pub_type

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