Human eosinophil-lymphocyte interactions.

Abstract:

:While the eosinophil's effector functions clearly can contribute to the pathogenesis of allergic diseases, the evolutionary benefit to having eosinophils as a distinct class of leukocyte is not clear, especially if one must reconsider the nominally beneficial role of eosinophils in parasite host defense, Eosinophils are equipped to respond to lymphocytes and their cytokines (and not solely the eosinophil growth factor cytokines), but the functional consequences of such eosinophil responses need to be defined. Conversely, eosinophils, as antigen-presenting cells (APCs) or sources of lymphocyte-active cytokines, may stimulate and affect lymphocyte functioning. Eosinophils share with CD4+ lymphocytes expression of a number of receptors, including CD4 and IL-2R, and specific alpha-4 integrins that may help in their common recruitment and activation. Further, elucidation of the interactions between lymphocytes and eosinophils will contribute to a broader understanding of the functioning of eosinophils in "normal" ongoing immune responses and in allergic disorders.

journal_name

Mem Inst Oswaldo Cruz

authors

Weller PF,Lim K

doi

10.1590/s0074-02761997000800023

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

173-82

eissn

0074-0276

issn

1678-8060

pii

S0074-02761997000800023

journal_volume

92 Suppl 2

pub_type

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