Effect of angiotensin II and losartan on the phagocytic activity of peritoneal macrophages from Balb/C mice.

Abstract:

:Angiotensin II (AII), a product of rennin-angiotensin system, exerts an important role on the function of immune system cells. In this study, the effect of AII on the phagocytic activity of mouse peritoneal macrophages was assessed. Mice peritoneal macrophages were cultured for 48 h and the influence of different concentrations of AII (10(-14) to 10(-7) M) and/or losartan, 10(-16) to 10(-6) M), an AT1 angiotensin receptor antagonist, on phagocytic activity and superoxide anion production was determined. Dimethylthiazoldiphenyltetrazolium bromide reduction and the nucleic acid content were used to assess the cvtotoxicity of losartan. A stimulatory effect on phagocytic activity (P < 0.05) was observed with 10(-13) M and 10(-12 M) AII concentrations. The addition of losartan (up to10(-14) M) to the cell cultures blocked (P < 0.001) the phagocytosis indicating the involvement of AT1 receptors. In contrast, superoxide anion production was not affected by AII or losartan. The existence of AT1 and AT2 receptors in peritoneal macrophages was demonstrated by immunofluorescence microscopy. These results support the hypothesis that AII receptors can modulate murine macrophage activity and phagocytosis, and suggest that AII may have a therapeutic role as an immunomodulatory agent in modifying the host resistance to infection.

journal_name

Mem Inst Oswaldo Cruz

authors

Belline P,da Melo PS,Haun M,Palhares FB,Boer PA,Gontijo JA,Figueiredo JF

doi

10.1590/s0074-02762004000200009

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

167-72

issue

2

eissn

0074-0276

issn

1678-8060

journal_volume

99

pub_type

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