Diagnostic challenges of single plaque-like lesion paucibacillary leprosy.

Abstract:

:The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). Mycobacterium leprae-specific genes were detected using qPCR. The biopsies of 47 out of 57 clinically diagnosed patients who received multidrug therapy were classified as HP/MP, eight of which were qPCR negative. In the LP/OD (n = 19), two out of eight untreated patients showed positive qPCR results. In the absence of typical histopathological features, qPCR may be utilised to aid in final patient diagnosis, thus reducing overtreatment and delay in diagnosis.

journal_name

Mem Inst Oswaldo Cruz

authors

Barbieri RR,Sales AM,Illarramendi X,Moraes MO,Nery JA,Moreira SJ,Sarno EN,Machado Ade M,Bozza FA

doi

10.1590/0074-0276140212

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

944-7

issue

7

eissn

0074-0276

issn

1678-8060

pii

S0074-02762014000700944

journal_volume

109

pub_type

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