Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects.

Abstract:

:BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.

journal_name

Mem Inst Oswaldo Cruz

authors

Lima LRP,Araújo NA,Guterres A,Pilotto JH,Niel C,Paula VS

doi

10.1590/0074-02760180328

subject

Has Abstract

pub_date

2018-12-03 00:00:00

pages

e180328

issue

12

eissn

0074-0276

issn

1678-8060

pii

S0074-02762018001200402

journal_volume

113

pub_type

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