Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil.

Abstract:

BACKGROUND:Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. OBJECTIVES:The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. METHODS:A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. FINDINGS:No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). MAIN CONCLUSIONS:This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.

journal_name

Mem Inst Oswaldo Cruz

authors

Ornelas AMM,Xavier-de-Carvalho C,Alvarado-Arnez LE,Ribeiro-Alves M,Rossi ÁD,Tanuri A,de Aguiar RS,Moraes MO,Cardoso CC

doi

10.1590/0074-02760190004

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

e190004

eissn

0074-0276

issn

1678-8060

pii

S0074-02762019000100326

journal_volume

114

pub_type

杂志文章
  • Changing the epidemiology of carbapenem-resistant Pseudomonas aeruginosa in a Brazilian teaching hospital: the replacement of São Paulo metallo-β-lactamase-producing isolates.

    abstract::In Brazil, carbapenem-resistant Pseudomonas aeruginosa isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B me...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762012000300019

    authors: Cavalcanti FL,Almeida AC,Vilela MA,Morais MM,Morais Junior MA

    更新日期:2012-05-01 00:00:00

  • Cotylophoron Travassosi sp. n. (Trematoda--Paramphistomidae) from cattle.

    abstract::A new species of the genus Cotylophoron (Trematoda--Paramphistomidae) --Cotylophoron travassosi sp. n.--is described. The measurements of the worm and its structures are compared with the valid known species. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761992000500013

    authors: Costa HM,Guimaráes MP

    更新日期:1992-01-01 00:00:00

  • The use of polyvinyl alcohol glutaraldehyde as solid-phase in ELISA for plague.

    abstract::Discs of polyvinyl alcohol cross-linked with glutaraldehyde were synthesized under acid catalysis (H2SO4). Then, the antigen F1 purified from Yersinia pestis was covalently linked to this modified polymer. Afterwards, an enzyme-linked immunosorbent assay (ELISA) was established for the diagnosis of plague in rabbit an...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761996000200014

    authors: Araujo AM,Petribú AT,Sales Barbosa GH,Diniz JR,de Almeida AM,Mendes Azevedo W,Malagueño E,Carvalho Júnior LB

    更新日期:1996-03-01 00:00:00

  • Synonymy between Lymnaea bogotensis Pilsbry, 1935 and Lymnaea cousini Jousseaume, 1887 (Gastropoda: Lymnaeidae).

    abstract::The lymneid snail Lymnaea bogotensis Pilsbry 1935 is synonymized with L. cousini Jousseaume 1887, based on morphological comparisons of the reproductive systems. The shell, renal tube, and reproductive system are described and illustrated from specimens collected in the type locality and the municipality of Paipa, Col...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762006000700015

    authors: Velásquez LE

    更新日期:2006-11-01 00:00:00

  • Isotype specific immune responses in murine experimental toxocariasis.

    abstract::In this work, a murine experimental model of toxocariasis has been developed in BALB/c, C57BL/10 and C3H murine strains orally inoculated with 4,000 Toxocara canis embryonated eggs, in order to investigate the isotype-specific immune responses against excretory-secretory antigens from larvae. T. canis specific IgG+M, ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762001000400018

    authors: Cuéllar C,Fenoy S,del Aguila C,Guillén JL

    更新日期:2001-05-01 00:00:00

  • Frequency of human toxocariasis in Jos, Plateau State, Nigeria.

    abstract::The enzyme-linked immunosorbent assay (Elisa) was used to examine sera of 104 children and adults in Jos, Plateau State, Nigeria for anti-toxocaral antibodies, out of which 31 (29.8%) were reactive. The seropositive rates were 30.4% for adults, 29.6% for children, 34% for females and 25.9% for males. However, the diff...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/S0074-02762000000200002

    authors: Ajayi OO,Duhlinska DD,Agwale SM,Njoku M

    更新日期:2000-03-01 00:00:00

  • Immuno-epidemiology of Schistosoma mansoni infections in a recently exposed community in Senegal.

    abstract::Schistosoma mansoni was introduced in the Senegal basin around 1988, due to man-made ecological changes. Since 1991, we investigate a recent but very intense focus, Ndombo, a village near the city of Richard Toll where the outbreak was first described. Four cohorts, each a random sample (+/- 400 subjects each) from th...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761995000200025

    authors: Gryseels B,Stelma F,Talla I,Polman K,Van Dam G,Sow S,Diaw M,Sturrock RF,Decam C,Niang M

    更新日期:1995-03-01 00:00:00

  • Studies on the virulence and attenuation of Trypanosoma cruzi using immunodeficient animals.

    abstract::Tissue invasion and pathology by Trypanosoma cruzi result from an interaction between parasite virulence and host immunity. Successive in vivo generations of the parasite select populations with increasing ability to invade the host. Conversely, prolonged in vitro selection of the parasite produces attenuated sublines...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762000000700029

    authors: Basombrío MA,Segura MA,Gómez L,Padilla M

    更新日期:2000-01-01 00:00:00

  • Domestic and peridomestic transmission of American cutaneous leishmaniasis: changing epidemiological patterns present new control opportunities.

    abstract::Predictions that deforestation would reduce American cutaneous leishmaniasis incidence have proved incorrect. Presentations at a recent international workshop, instead, demonstrated frequent domestication of transmission throughout Latin America. While posing new threats, this process also increases the effectiveness ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762001000200004

    authors: Campbell-Lendrum D,Dujardin JP,Martinez E,Feliciangeli MD,Perez JE,Silans LN,Desjeux P

    更新日期:2001-02-01 00:00:00

  • Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil.

    abstract::Corynebacterium striatum is a potentially pathogenic microorganism with the ability to produce outbreaks of nosocomial infections. Here, we document a nosocomial outbreak caused by multidrug-resistant (MDR) C. striatum in Rio de Janeiro, Brazil. C. striatum identification was confirmed by 16S rRNA and rpoB gene sequen...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762013000100004

    authors: Baio PV,Mota HF,Freitas AD,Gomes DL,Ramos JN,Sant'Anna LO,Souza MC,Camello TC,Hirata Junior R,Vieira VV,Mattos-Guaraldi AL

    更新日期:2013-02-01 00:00:00

  • Laboratory and field evaluation of biodegradable polyesters for sustained release of isometamidium and ethidium.

    abstract::An overview is presented of the results obtained with biodegradable sustained release devices (SRDs) containing a mixture of polymers and either isometamidium (ISMM) or ethidium. Under controlled laboratory conditions (monthly challenge with tsetse flies infected with Trypanosoma congolense) the protection period in S...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章,评审

    doi:10.1590/s0074-02761999000200016

    authors: Geerts S,Brandt J,De Deken R

    更新日期:1999-03-01 00:00:00

  • Application of control measures for infections caused by multi-resistant gram-negative bacteria in intensive care unit patients.

    abstract::Multi-resistant gram-negative rods are important pathogens in intensive care units (ICU), cause high rates of mortality, and need infection control measures to avoid spread to another patients. This study was undertaken prospectively with all of the patients hospitalized at ICU, Anesthesiology of the Hospital São Paul...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762004000300017

    authors: Martins ST,Moreira M,Furtado GH,Marino CG,Machado FR,Wey SB,Medeiros EA

    更新日期:2004-05-01 00:00:00

  • New host and locality records for Tetrameres (Gynaecophila) spirospiculum Pinto & Vicente, 1995 (Nematoda: Tetrameridae), with new morphological data.

    abstract::We report the finding of Tetrameres spirospiculum Pinto & Vicente, 1995 from Theristicus melanopis melanopis (Threskiornithidae) from Patagonia, Argentina. These constitute new host and locality records. We propose the assignation of this species to the subgenus T. (Gynaecophila) Gubanov, 1950, based on the presence o...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762001000300009

    authors: Digiani MC,Cremonte F

    更新日期:2001-04-01 00:00:00

  • [Ecology of Lutzomyia longipalpis (Lutz & Neiva, 1912) and possibilities of the existence of visceral leishmaniasis in Costa Rica].

    abstract::A semiarid area of northwest Costa Rica where Lutzomyia longipalpis is common in corrals around houses is described. Monthly captures of the sandfly during two consecutive years for fixed periods of time indicated that the insect bites avidly cows, horses, pigs, dogs and humans. From a total of 14,215 specimens, 90.5%...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761984000400010

    authors: Zeledón R,Murillo J,Gutierrez H

    更新日期:1984-10-01 00:00:00

  • On the safe use of pesticides in controlling the terrestrial mollusc pests.

    abstract::The preferred food items of the slugs Laevicaulis alte and the snails Achatina fulica were used to prepare 'poison baits' by injecting the pesticides 'Rogor' and 'Nuvan' to kill these mollusc pests. The 'poison baits' prepared with Trichosanthes dioica and Lycopersicum esculentum were accepted by 100% individuals of b...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761993000200019

    authors: Panigrahi A,Raut SK

    更新日期:1993-04-01 00:00:00

  • Concurrent infection with dengue virus type-2 and DENV-3 in a patient from Ceará, Brazil.

    abstract::Dengue outbreaks have occurred in several regions in Brazil and cocirculating dengue virus type 1 (DENV-1), DENV-2, and DENV-3 have been frequently observed. Dual infection by DENV-2 and DENV-3 was identified by type-specific indirect immunofluorescence assay and confirmed by reverse transcription polymerase chain rea...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762006000800017

    authors: Araújo FM,Nogueira RM,de Araújo JM,Ramalho IL,Roriz ML,de Melo ME,Coelho IC

    更新日期:2006-12-01 00:00:00

  • Acquired and congenital ocular toxoplasmosis experimentally induced in Calomys callosus (Rodentia, Cricetidae).

    abstract::An experimental model for acquired and congenital ocular toxoplasmosis as well as a model to induce experimental autoimmune uveitis (EAU) was investigated in Calomys callosus. Toxoplasma gondii, ME-49 strain, was used to infect males and pregnant- and not pregnant-females while S-antigen, a major glycoprotein of the r...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761999000100021

    authors: Pereira Mde F,Silva DA,Ferro EA,Mineo JR

    更新日期:1999-01-01 00:00:00

  • Leishmania (Viannia) naiffi: rare enough to be neglected?

    abstract::In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to the circulation of at least seven Leishmania species. Few reports of Leishmania (Viannia) naiffi infection suggest that its occurrence is uncommon and the reported cases...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760150128

    authors: Fagundes-Silva GA,Romero GA,Cupolillo E,Yamashita EP,Gomes-Silva A,Guerra JA,Da-Cruz AM

    更新日期:2015-09-01 00:00:00

  • Leishmanial infection: analysis of its first steps. A review.

    abstract::The first steps in leishmaniasis are critical in determining the evolution of the disease. Major advances have recently been done in understanding this crucial moment. Fundamental research in parasite-vector interaction, parasite biology, insect saliva, and vertebrate host response have shed new light and uncovered a ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762003000700001

    authors: de Almeida MC,Vilhena V,Barral A,Barral-Netto M

    更新日期:2003-10-01 00:00:00

  • Association of the presence of residual anti-Toxoplasma gondii IgM in pregnant women and their respective family groups in Miracema, Northwest Rio de Janeiro, Brazil.

    abstract::The seroprevalence of toxoplasmosis in 832 pregnant women in Miracema, Rio de Janeiro, was determined and 75.1% (625) and 2.0% (17) were anti-Toxoplasma gondii IgG and IgM positive, respectively. Out of the 17 IgM positive pregnant women, only one had low avidity IgG corresponding to the acute phase of the infection. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762008000600013

    authors: Ribeiro AC,Mutis MS,Fernandes O

    更新日期:2008-09-01 00:00:00

  • Cell populations in lesions of cutaneous leishmaniasis of Leishmania (L.) amazonensis- infected rhesus macaques, Macaca mulatta.

    abstract::The cellular nature of the infiltrate in cutaneous lesion of rhesus monkeys experimentally infected with Leishmania (L.) amazonensis was characterized by immunohistochemistry. Skin biopsies from infected animals with active or healing lesions were compared to non-infected controls (three of each type) to quantitate in...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762000000200012

    authors: Amaral V,Pirmez C,Gonçalves A,Ferreira V,Grimaldi G Jr

    更新日期:2000-03-01 00:00:00

  • Control of Mycobacterium fortuitum and Mycobacterium intracellulare infections with respect to distinct granuloma formations in livers of BALB/c mice.

    abstract::Mycobacterium fortuitum is a rapidly growing nontuberculous Mycobacterium that can cause a range of diseases in humans. Complications from M. fortuitum infection have been associated with numerous surgical procedures. A protective immune response against pathogenic mycobacterial infections is dependent on the granulom...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762010000500007

    authors: Silva TR,Petersen AL,Santos Tde A,Almeida TF,Freitas LA,Veras PS

    更新日期:2010-08-01 00:00:00

  • The London School of Hygiene and Tropical Medicine: a new century of malaria research.

    abstract::The global malaria situation has scarcely improved in the last 100 years, despite major advances in our knowledge of the basic biology, epidemiology and clinical basis of the disease. Effective malaria control, leading to a significant decrease in the morbidity and mortality attributable to malaria, will require a mul...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762000000700004

    authors: Riley EM

    更新日期:2000-01-01 00:00:00

  • Reduced capacity of peritoneal exudate cells for oxidative killing of Schistosoma mansoni schistosomula.

    abstract::Peritoneal exudate cells from mice infected with Schistosoma mansoni (S-PEC) can kill schistosomula in vitro in the presence of immune serum. S-PEC produce a low level of respiratory burst, and schistosomula mortality in their presence is not reduced when exogenous antioxidants are added, suggesting that with S-PEC, o...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761987000800052

    authors: Smith JM,Mikoji GM,Prichard RK

    更新日期:1987-01-01 00:00:00

  • Sequencing and identification of expressed Schistosoma mansoni genes by random selection of cDNA clones from a directional library.

    abstract::We have initiated a gene discovery program in Schistosoma mansoni based on the technique of Expressed Sequence Tags (ESTs), i.e. partial sequences of cDNAs obtained from single passes in automatic DNA sequences. ESTs can be used to identify genes on the basis of their homology with sequences from other species deposit...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761995000200015

    authors: Franco GR,Simpson AJ,Pena SD

    更新日期:1995-03-01 00:00:00

  • Effect of deltamethrin spraying on the sandfly populations in a focus of American cutaneous leishmaniasis.

    abstract::The effect of deltamethrin of the sandfly population in a focus of American Cutaneous Leishmaniasis in Viana, Espírito Santo State is described. The phlebotomine population density was determined inside and outside houses during a one year period in a treated and untreated area. The results showed a significant reduct...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761991000400004

    authors: Falcão AL,Falcão AR,Pinto CT,Gontijo CM,Falqueto A

    更新日期:1991-10-01 00:00:00

  • Characterization of the hemagglutinin receptor specificity and neuraminidase substrate specificity of clinical isolates of human influenza A viruses.

    abstract::Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human erythrocytes enzymatically modified to contain NeuAc alpha 2,6Gal s...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761994000400015

    authors: Couceiro JN,Baum LG

    更新日期:1994-10-01 00:00:00

  • The retained capacity of Lutzomyia longipalpis (Lutz & Neiva) to transmit Leishmania chagasi (Cunha & Chagas) after eight years (64 generations) in a closed laboratory colony.

    abstract::A closed Lutzomyia longipalpis colony, from Ceará has been used to transmit Leishmania chagasi isolated from a fox in Pará state. The last time this colony was successfully used in similar transmission experiments was eight years (64 generations) ago indicating that this colony of Lu. longipalpis has fully maintained ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761985000300010

    authors: Gonçalves MD,Ryan L,Lainson R,Shaw JJ

    更新日期:1985-07-01 00:00:00

  • Commercial enzyme-linked immunosorbent assay versuspolymerase chain reaction for the diagnosis of chronic Chagas disease: a systematic review and meta-analysis.

    abstract::Chronic Chagas disease diagnosis relies on laboratory tests due to its clinical characteristics. The aim of this research was to review commercial enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) diagnostic test performance. Performance of commercial ELISA or PCR for the diagnosis of chron...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,meta分析,评审

    doi:10.1590/0074-02760150296

    authors: Brasil PE,Castro R,Castro Ld

    更新日期:2016-01-01 00:00:00

  • Acanthocefalan eggs in animal coprolites from archaeological sites from Brazil.

    abstract::An important point in paleoparasitology is the correct diagnosis of the origin of coprolites found in archaeological sites. The identification of human and animal coprolites, through the study of the shape, size, characteristics after rehydration, alimentary contents, and the presence of parasites, has proved to be ac...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761989000200007

    authors: Ferreira LF,Araújo A,Confalonieri U,Chame M

    更新日期:1989-04-01 00:00:00