Mast cell changes in experimental diabetes: focus on attenuation of allergic events.


:The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective treatment of one disease exacerbates the other. This review gives an update of the state-of-the-art concerning the intercurrence of allergy and diabetes, particularly focusing on the consequences to the allergen-evoked vascular and cellular changes. It is proposed that the reduction in mast cell numbers and reactivity may be a pivotal mechanism behind the mutual exclusion phenomenon.


Mem Inst Oswaldo Cruz


Carvalho VF,Barreto EO,Cordeiro RS,Lagente V,Martins MA,e Silva PM




Has Abstract


2005-03-01 00:00:00










100 Suppl 1


  • Malpighian tubule polytene chromosomes of Culex quinquefasciatus (Diptera, Culicinae).

    abstract::Dipteran polytene chromosomes provide an excellent model for understanding in species complexes, as well as for structural and functional cytogenetics. The status of species in the Culex pipiens complex is controversial and the use of polytene chromosomes for cytogenetic analysis in the subfamily Culicinae has been di...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Campos J,Andrade CF,Recco-Pimentel SM

    更新日期:2003-04-01 00:00:00

  • Aspects of classification of Hemiptera hemocytes from six triatomine species.

    abstract::The objective of this work was to characterize, and compare different morphological types of hemocytes of Rhodnius prolixus, Rhodnius robustus, Rhodnius neglectus, Triatoma infestans, Panstrongylus megistus, and Dipetalogaster maximus. This information provides the basis for studying the cellular immune systems of the...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: de Azambuja P,Garcia ES,Ratcliffe NA

    更新日期:1991-01-01 00:00:00

  • Achievement of constitutive fluorescent pLEXSY-egfp Leishmania braziliensis and its application as an alternative method for drug screening in vitro.

    abstract:BACKGROUND:Gene reporter-fluorescent cells have emerged as alternative method for drug screening. OBJECTIVE:Achievement of constitutive expression of fluorescent protein GFP by Leishmania braziliensis as alternative method for drug screening. METHODS:L. braziliensis-GFP was generated using Leishmania tarentolae pLEXS...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Bastos MS,Souza LÂ,Onofre TS,Silva A Júnior,Almeida MR,Bressan GC,Fietto JL

    更新日期:2017-02-01 00:00:00

  • Comparative chromatin analysis of Trypanosoma congolense.

    abstract::The chromatin of Trypanosoma congolense was analyzed by electron microscopy. The chromatin is organized as nucleosome filaments but does not form a 30 nm fiber. There are five groups of histones, including a histone H1-like protein, which as a molecular weight within the range of the core histones, and is extremely hy...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Schlimme W,Burri M,Betschart B,Hecker H

    更新日期:1994-04-01 00:00:00

  • A checklist of arthropods associated with pig carrion and human corpses in southeastern brazil.

    abstract::Necrophagous insects, mainly Diptera and Coleoptera, are attracted to specific stages of carcass decomposition, in a process of faunistic succession. They are very important in estimating the postmortem interval, the time interval between the death and the discovery of the body. In studies done with pig carcasses expo...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Carvalho LM,Thyssen PJ,Linhares AX,Palhares FA

    更新日期:2000-01-01 00:00:00

  • Ecology of sandflies (Diptera:Psychodidae) in a restricted focus of cutaneous leishmaniasis in northern Venezuela. II. Species composition in relation to habitat, catching method and hour of catching.

    abstract::The ecology of phlebotomine sandflies in an endemic focus of cutaneous leishmaniasis in Northern Venezuela (San Esteban, Carabobo State) was investigated through a year-term study. Three different habitats: viz. a house, a peridomestic area and a sylvatic area, were covered and the species composition, the abundance a...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Feliciangeli MD

    更新日期:1987-01-01 00:00:00

  • Genotyping of gastroenteric viruses in hospitalised children: first report of norovirus GII.21 in Brazil.

    abstract::This retrospective study (April-September 2003) was designed to investigate the roles of the main viruses responsible for cases of acute infantile gastroenteritis in hospitalised children up to two years of age. The viruses were identified in 64.7% (88/136) of the cases and the detection rates of rotavirus A (RVA), no...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Ferreira MS,Cubel Garcia Rde C,Xavier Mda P,Ribeiro RL,Assis RM,Mota Mdo C,Leite JP,Miagostovich MP,de Oliveira SA

    更新日期:2012-12-01 00:00:00

  • Chromatin regulation in schistosomes and histone modifying enzymes as drug targets.

    abstract::Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objective we have chosen to target the enzymes modifying histones and in part...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Pierce RJ,Dubois-Abdesselem F,Caby S,Trolet J,Lancelot J,Oger F,Bertheaume N,Roger E

    更新日期:2011-11-01 00:00:00

  • Diversity of Campylobacter isolates from three activated sludge systems.

    abstract::Thermophilic campylobacters were isolated from three sewage plants in Rio de Janeiro, RJ, Brazil and identified. Laboratory analysis of 390 sewage samples showed the presence of 169 thermophilic strains. The results demonstrated that human and animal pathogenic biotypes could be isolated from activated sludge during t...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Lauria-Filgueiras AL,Hofer E

    更新日期:1998-05-01 00:00:00

  • Hepatitis B infection among patients attending a sexually transmitted diseases clinic in Rio de Janeiro, Brazil.

    abstract::Hepatitis B virus (HBV) has a low endemicity in Rio de Janeiro, Brazil. Sexual transmission must play an important role in this virus, but the prevalence and risk factors have never been properly investigated. The aim of this paper is to determine the prevalence and risk factors for HBV infection in patients attending...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Oliveira LH,Silva IR,Xavier BL,Cavalcanti SM

    更新日期:2001-07-01 00:00:00

  • Assessment of immunological changes in Epstein-Barr virus co-infection in Egyptian chronic HCV patients.

    abstract::Epstein-Barr virus (EBV) plays a major role in liver pathology. Similar to other members of the herpesvirus family, EBV establishes a persistent infection in more than 90% of adults. The aim of this study was to evaluate the impact of EBV and chronic hepatitis C co-infection (HCV) on biochemical and immunological resp...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Shoman S,Nabil M,Tabl A,Ghanem H,Kafrawy SE

    更新日期:2014-09-01 00:00:00

  • Crossing experiments detect genetic incompatibility among populations of Triatoma brasiliensis Neiva, 1911 (Heteroptera, Reduviidae, Triatominae).

    abstract::Triatoma brasiliensis is composed of at least four geographic populations (brasiliensis, melanica, macromelasoma, and juazeiro) that have distinct chromatic, morphologic, biologic and ecologic patterns, and genetic composition. Reciprocal crosses between all pairwise combinations were carried out in order to evaluate ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Costa J,Almeida CE,Dujardin JP,Beard CB

    更新日期:2003-07-01 00:00:00

  • Effect of angiotensin II and losartan on the phagocytic activity of peritoneal macrophages from Balb/C mice.

    abstract::Angiotensin II (AII), a product of rennin-angiotensin system, exerts an important role on the function of immune system cells. In this study, the effect of AII on the phagocytic activity of mouse peritoneal macrophages was assessed. Mice peritoneal macrophages were cultured for 48 h and the influence of different conc...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Belline P,da Melo PS,Haun M,Palhares FB,Boer PA,Gontijo JA,Figueiredo JF

    更新日期:2004-03-01 00:00:00

  • Chagas disease: national survey of seroprevalence in children under five years of age conducted in 2008.

    abstract:BACKGROUND:Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector contr...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Russomando G,Cousiño B,Sanchez Z,Franco LX,Nara EM,Chena L,Martínez M,Galeano ME,Benitez L

    更新日期:2017-05-01 00:00:00

  • Leishmanial infection: analysis of its first steps. A review.

    abstract::The first steps in leishmaniasis are critical in determining the evolution of the disease. Major advances have recently been done in understanding this crucial moment. Fundamental research in parasite-vector interaction, parasite biology, insect saliva, and vertebrate host response have shed new light and uncovered a ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: de Almeida MC,Vilhena V,Barral A,Barral-Netto M

    更新日期:2003-10-01 00:00:00

  • A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information.

    abstract::The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Alves-Ferreira M,Guimarães AC,Capriles PV,Dardenne LE,Degrave WM

    更新日期:2009-12-01 00:00:00

  • Comparative descriptions of eggs from three species of Rhodnius (Hemiptera: Reduviidae: Triatominae).

    abstract::The authors describe and compare the morphological and ultrastructural characteristics of eggs from the three most recent described species of the genus Rhodnius Stål, 1859, which have not previously been studied. These species are Rhodnius colombiensis (Mejia, Galvão & Jurberg 1999), Rhodnius milesi (Carcavallo, Roch...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Santos CM,Jurberg J,Galvão C,Rosa JA,Júnior WC,Barata JM,Obara MT

    更新日期:2009-11-01 00:00:00

  • The use of polyvinyl alcohol glutaraldehyde as solid-phase in ELISA for plague.

    abstract::Discs of polyvinyl alcohol cross-linked with glutaraldehyde were synthesized under acid catalysis (H2SO4). Then, the antigen F1 purified from Yersinia pestis was covalently linked to this modified polymer. Afterwards, an enzyme-linked immunosorbent assay (ELISA) was established for the diagnosis of plague in rabbit an...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Araujo AM,Petribú AT,Sales Barbosa GH,Diniz JR,de Almeida AM,Mendes Azevedo W,Malagueño E,Carvalho Júnior LB

    更新日期:1996-03-01 00:00:00

  • The control of schistosomiasis: epidemiological aspects of reinfection.

    abstract::Current strategies for schistosomiasis control rely heavily on drug treatment intended to reduce morbidity and disease to an insignificant level of public health importance. This approach reduces but rarely, if ever, eliminates transmission. Indeed, snail infection rates may be little altered by such chemotherapy. Rei...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Sturrock RF

    更新日期:1989-10-01 00:00:00

  • Diphtheria-neutralizing antibody levels in healthy adults from Rio de Janeiro, Brazil.

    abstract::In Brazil, until 2004, the immunization policy against diphtheria involved childhood vaccination with no official routine booster dose administered after 15 years of age. This study assessed functional antibody levels against diphtheria among blood donors. A total of 140 blood samples were collected, and diphtheria an...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Pimenta FP,Damasco PV,Cerbino Neto J,Lopes GS,Hirata R Jr,Milagres LG,Mattos-Guaraldi AL

    更新日期:2006-06-01 00:00:00

  • Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses.

    abstract:BACKGROUND:Dengue virus (DENV) has circulated in Brazil for over 30 years. During this time, one serotype has cyclically replaced the other, until recently, when all four distinct serotypes began to circulate together. Persistent circulation of DENV for long time periods makes sequential infections throughout a person'...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Oliveira RA,de Oliveira-Filho EF,Fernandes AI,Brito CA,Marques ET,Tenório MC,Gil LH

    更新日期:2019-01-01 00:00:00

  • The impact of Chagas disease control in Latin America: a review.

    abstract::Discovered in 1909, Chagas disease was progressively shown to be widespread throughout Latin America, affecting millions of rural people with a high impact on morbidity and mortality. With no vaccine or specific treatment available for large-scale public health interventions, the main control strategy relies on preven...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Dias JC,Silveira AC,Schofield CJ

    更新日期:2002-07-01 00:00:00

  • Cell populations in lesions of cutaneous leishmaniasis of Leishmania (L.) amazonensis- infected rhesus macaques, Macaca mulatta.

    abstract::The cellular nature of the infiltrate in cutaneous lesion of rhesus monkeys experimentally infected with Leishmania (L.) amazonensis was characterized by immunohistochemistry. Skin biopsies from infected animals with active or healing lesions were compared to non-infected controls (three of each type) to quantitate in...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Amaral V,Pirmez C,Gonçalves A,Ferreira V,Grimaldi G Jr

    更新日期:2000-03-01 00:00:00

  • COVID-19: molecular targets, drug repurposing and new avenues for drug discovery.

    abstract::Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Senger MR,Evangelista TCS,Dantas RF,Santana MVDS,Gonçalves LCS,de Souza Neto LR,Ferreira SB,Silva-Junior FP

    更新日期:2020-10-02 00:00:00

  • Evolution and pathology in chagas disease--a review.

    abstract::Trypanosoma cruzi acute infections often go unperceived, but one third of chronically infected individuals die of Chagas disease, showing diverse manifestations affecting the heart, intestines, and nervous systems. A common denominator of pathology in Chagas disease is the minimal rejection unit, whereby parasite-free...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Teixeira AR,Nascimento RJ,Sturm NR

    更新日期:2006-08-01 00:00:00

  • Gastropods as intermediate hosts of Angiostrongylus spp. in the Americas: bioecological characteristics and geographical distribution.

    abstract:BACKGROUND:Intermediate hosts are key organisms in maintaining parasite life cycles, because they can act as amplifiers in the transmission from natural reservoirs to humans. One of the most important groups of intermediate hosts for zoonotic nematode infections are gastropods,slugs and snails. These are essential orga...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Valente R,Robles MDR,Diaz JI

    更新日期:2020-11-27 00:00:00

  • More productive in vitro culture of Cryptosporidium parvum for better study of the intra- and extracellular phases.

    abstract::The great difficulties in treating people and animals suffering from cryptosporidiosis have prompted the development of in vitro experimental models. Due to the models of in vitro culture, new extracellular stages of Cryptosporidium have been demonstrated. The development of these extracellular phases depends on the t...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Perez Cordón G,Marin C,Romero D,Rosales C,Sánchez Moreno M,Rosales MJ

    更新日期:2007-08-01 00:00:00

  • Clinical spectrum of uncomplicated malaria in semi-immune Amazonians: beyond the " symptomatic " vs " asymptomatic " dichotomy.

    abstract::We analyzed prospectively 326 laboratory-confirmed, uncomplicated malarial infections (46.3% due to Plasmodium vivax, 35.3% due to P. falciparum, and 18.4% mixed-species infections) diagnosed in 162 rural Amazonians aged 5-73 years. Thirteen symptoms (fever, chills, sweating, headache, myalgia, arthralgia, abdominal p...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: da Silva-Nunes M,Ferreira MU

    更新日期:2007-06-01 00:00:00

  • DNA evidence of Trypanosoma cruzi in the Chilean wild vector Mepraia spinolai (Hemiptera: Reduviidae).

    abstract::Molecular evidence showed 46.2% of Trypanosoma cruzi infection in Mepraia spinolai insects from North-Central Chile, which is significantly higher than previous reports of up to 26% by microscopic observation. Our results show similar infection levels among nymphal stages, ranging from 38.3 to 54.1%, indicating that y...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Botto-Mahan C,Ortiz S,Rozas M,Cattan PE,Solari A

    更新日期:2005-05-01 00:00:00

  • Borrelia-like spirochetes recovered from ticks and small mammals collected in the Atlantic Forest Reserve, Cotia county, State of São Paulo, Brazil.

    abstract::Forty-four marsupials, 77 rodents and 161 ticks were captured in an Atlantic Forest Reserve in Cotia county, State of São Paulo, where human cases of Lyme disease (LD) simile were reported. Twenty-one borrelia-like spirochete isolates were recovered from the mammals' blood and rodent livers or spleens, and triturated ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Abel IS,Marzagão G,Yoshinari NH,Schumaker TT

    更新日期:2000-09-01 00:00:00