Mast cell changes in experimental diabetes: focus on attenuation of allergic events.

Abstract:

:The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective treatment of one disease exacerbates the other. This review gives an update of the state-of-the-art concerning the intercurrence of allergy and diabetes, particularly focusing on the consequences to the allergen-evoked vascular and cellular changes. It is proposed that the reduction in mast cell numbers and reactivity may be a pivotal mechanism behind the mutual exclusion phenomenon.

journal_name

Mem Inst Oswaldo Cruz

authors

Carvalho VF,Barreto EO,Cordeiro RS,Lagente V,Martins MA,e Silva PM

doi

10.1590/s0074-02762005000900021

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

121-5

eissn

0074-0276

issn

1678-8060

pii

S0074-02762005000900021

journal_volume

100 Suppl 1

pub_type

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