Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages.

Abstract:

:A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages.

journal_name

Mem Inst Oswaldo Cruz

authors

Martins PR,Gameiro MC,Castoldi L,Romagnoli GG,Lopes FC,Pinto AV,Loyola W,Kaneno R

doi

10.1590/s0074-02762008005000011

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

244-50

issue

3

eissn

0074-0276

issn

1678-8060

pii

S0074-02762008005000011

journal_volume

103

pub_type

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