Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart.

Abstract:

:Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a large proportion of dogs (11 out of 56) examined in an endemic area of leishmaniasis presented induration at the site of injection of a diluent containing thimerosal alone. This clearly demonstrates that thimerosal leads to a high number of false positive skin reactions in dogs and that its use in Montenegro's skin test antigenic preparations should be avoided.

journal_name

Mem Inst Oswaldo Cruz

authors

Paranhos-Silva M,Pontes-de-Carvalho LC,de Sá Oliveira GG,Nascimento EG,dos-Santos WL

doi

10.1590/s0074-02762001000500017

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

679-81

issue

5

eissn

0074-0276

issn

1678-8060

pii

S0074-02762001000500017

journal_volume

96

pub_type

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