Abstract:
:Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in the pathophysiology of envenomation, being responsible for local and systemic hemorrhage frequently observed in the victims. Snake venom metalloproteinases (SVMP) are zinc-dependent enzymes of varying molecular weights having multidomain organization. Some SVMP comprise only the proteinase domain, whereas others also contain a disintegrin-like domain, cysteine-rich, and lectin domains. They have strong structural similarities with both mammalian matrix metalloproteinases (MMP) and members of ADAMs (a disintegrin and metalloproteinase) group. Besides hemorrhage, snake venom metalloproteinase induce local myonecrosis, skin damage, and inflammatory reaction in experimental models. Local inflammation is an important characteristic of snakebite envenomations inflicted by viperine and crotaline snake species. Thus, in the recent years there is a growing effort to understand the mechanisms responsible for SVMP-induced inflammatory reaction and the structural determinants of this effect. This short review focuses the inflammatory effects evoked by SVMP.
journal_name
Mem Inst Oswaldo Cruzjournal_title
Memorias do Instituto Oswaldo Cruzauthors
Teixeira Cde F,Fernandes CM,Zuliani JP,Zamuner SFdoi
10.1590/s0074-02762005000900031subject
Has Abstractpub_date
2005-03-01 00:00:00pages
181-4eissn
0074-0276issn
1678-8060pii
S0074-02762005000900031journal_volume
100 Suppl 1pub_type
杂志文章,评审abstract::Toxocara cati is a common feline parasite transmitted by the ingestion of embryonated eggs, by the transmammary route or by predation of paratenic hosts harbouring third-stage larvae in their bodies. In the present study, the larval distribution of T. cati in tissues and organs of Rattus norvegicus experimentally infe...
journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
doi:10.1590/s0074-02761996000600020
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章,评审
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abstract::To study the action of molluscicide nine ponds were selected: 3 of them lying in Maruim municipality, 29 km far from north Aracaju, the State capital, and 6 ponds in Itabaianinha municipality, 118 km far from south Aracaju. This study was carried out for 16 months. Environmental parameters observed were those thought ...
journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 历史文章,杂志文章
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章,评审
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journal_title:Memorias do Instituto Oswaldo Cruz
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
doi:10.1590/S0074-02762000000100003
更新日期:2000-01-01 00:00:00
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 临床试验,杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
doi:10.1590/s0074-02762001000500027
更新日期:2001-07-01 00:00:00
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journal_title:Memorias do Instituto Oswaldo Cruz
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00