abstract：:Red blood cell (RBC) alloimmunization is a serious complication of blood transfusions, challenging selection of compatible units for future transfusions. Genetic characteristics may be associated with the risk of RBC alloimmunization and may therefore serve to identify high-risk patients. The aim of this systematic re...

journal_title：Blood reviews

authors： Gerritsma JJ,Oomen I,Meinderts S,van der Schoot CE,Biemond BJ,van der Bom JG,Fijnvandraat K,SCORE consortium.

更新日期：2021-01-05 00:00:00

abstract：:Most leukemia patients experience little benefit from immunotherapy, in part due to the immunosuppressive bone marrow microenvironment. Various metabolic mechanisms orchestrate the behaviors of immune cells and leukemia cells in the bone marrow microenvironment. Furthermore, leukemia cells regulate the bone marrow mic...

journal_title：Blood reviews

authors： Xu B,Hu R,Liang Z,Chen T,Chen J,Hu Y,Jiang Y,Li Y

更新日期：2020-12-09 00:00:00

abstract：:Venous thromboembolism (VTE) is a common condition with high associated morbidity and mortality. Athletes have unique VTE risk factors compared with the general population, and may have a higher than anticipated risk of thrombosis. Anticoagulant treatment poses additional challenges in athletes, as these individuals u...

journal_title：Blood reviews

authors： Swan D,Carter-Brzezinski L,Thachil J

更新日期：2020-11-15 00:00:00

abstract：:The clinical relevance of flow cytometry (FC)-based bone marrow involvement (BMI) in B cell non-Hodgkin lymphoma (B-NHL) is not well established. We conducted a systematic review of MEDLINE regarding the use of FC to establish BMI in B-NHL to determine the prevalence of BMI by FC, to understand the interrelation betwe...

journal_title：Blood reviews

authors： Sorigue M,Cañamero E,Miljkovic MD

更新日期：2020-11-08 00:00:00

abstract：:Myeloid neoplasms like acute myeloid leukemia (AML) originate from genomic disruption, usually in a multi-step fashion. Hematopoietic stem/progenitor cell acquisition of abnormalities in vital cellular processes, when coupled with intrinsic factors such as germline predisposition or extrinsic factors such as the marro...

journal_title：Blood reviews

authors： Shallis RM,Weiss JJ,Deziel NC,Gore SD

更新日期：2020-09-22 00:00:00

abstract：:The myeloproliferative neoplasms (MPNs) encompass a heterogenous set of diseases that have variable survival, but in the setting of treatment refractory and progressive disease, prognosis has been characteristically poor. JAK inhibition with ruxolitinib or fedratinib therapy has become the first line treatment for sym...

journal_title：Blood reviews

authors： Scherber RM,Mesa RA

更新日期：2020-07-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICI) have yielded mixed but largely underwhelming results in clinical trials in patients with acute myeloid leukemia and myelodysplastic syndromes to date. However, increasing understanding of the immunologic landscape, potential biomarkers for benefits, and mechanisms of resistance, as w...

journal_title：Blood reviews

authors： Bewersdorf JP,Shallis RM,Zeidan AM

更新日期：2020-05-23 00:00:00

abstract：:For many years red blood cells have been described as inert bystanders rather than participants in intercellular signalling, immune function, and inflammatory processes. However, studies are now reporting that red blood cells from healthy individuals regulate immune cell activity and maturation, and red blood cells fr...

journal_title：Blood reviews

authors： Karsten E,Herbert BR

更新日期：2020-05-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid disorders characterized by cytopenias and increased risk of acute leukemia transformation. Prognosis of MDS patients can be assessed by various scoring systems, the most common being the International Prognostic Scoring System (IPSS) now refined by t...

journal_title：Blood reviews

authors： Scalzulli E,Pepe S,Colafigli G,Breccia M

更新日期：2020-03-31 00:00:00

abstract：:Most acute myeloid leukemia (AML) patients will be aged more than 65 years. Chronological aging is accompanied by decreasing stem cell and solid organ reserve as well as an increased incidence of medical comorbidity. For the older patient with AML, these patient-specific factors are compounded by an association with c...

journal_title：Blood reviews

authors： Shallis RM,Boddu PC,Bewersdorf JP,Zeidan AM

更新日期：2020-03-01 00:00:00

abstract：:Platelets play a major role in primary hemostasis and thrombus formation. After vascular injury, platelets adhere to injured site and rapidly change their shape that switches the resting platelets to active state. Activated platelets aggregate and secrete biologically active intermediate substances that further potent...

journal_title：Blood reviews

authors： Kannan M,Ahmad F,Saxena R

更新日期：2019-09-01 00:00:00

abstract：:Extramedullary disease of multiple myeloma (EM) remains a treatment challenge even in the era of new drugs. While many reports analyzing various aspects of EM have been published, mechanism of EM development has not been clarified yet. This review summarizes current knowledge about this clinical entity, including its ...

journal_title：Blood reviews

authors： Sevcikova S,Minarik J,Stork M,Jelinek T,Pour L,Hajek R

更新日期：2019-07-01 00:00:00

abstract：:Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently above 85% due to huge improvements in treatment. However, 15-20% of children still experience relapses. Relapses can either occur in the bone marrow or at extramedullary sites, such as gonads or the central nervous system (CNS), for...

journal_title：Blood reviews

authors： Gaudichon J,Jakobczyk H,Debaize L,Cousin E,Galibert MD,Troadec MB,Gandemer V

更新日期：2019-07-01 00:00:00

abstract：:The improvement in supportive care and the introduction of new therapeutic agents, including lenalidomide and hypomethylating agents, in myelodysplastic syndromes have improved patients' outcomes; however, at the same time, the frequency and epidemiology of infections have changed. Therefore, the great strides in the ...

journal_title：Blood reviews

authors： Girmenia C,Candoni A,Delia M,Latagliata R,Molteni A,Oliva EN,Palumbo GA,Poloni A,Salutari P,Santini V,Voso MT,Musto P

更新日期：2019-03-01 00:00:00

abstract：:In patients with hemophilia, osteoporosis is frequently observed for which the etiology remains unclear. The aim of this paper is to review the available experimental evidence indicating the presence of this disorder in patients with hemophilia, explore the potential mechanisms which may lead to reduced bone mineral d...

journal_title：Blood reviews

authors： Rodriguez-Merchan EC,Valentino LA

更新日期：2019-01-01 00:00:00

abstract：:Venous thromboembolism (VTE) remains a major cause of morbidity and mortality in patients with cancer. Although some very well validated scores delineate the risk of VTE by cancer subtype and other risk factors, hematologic malignancies are underrepresented in these models. This subgroup represents a unique entity tha...

journal_title：Blood reviews

authors： Kekre N,Connors JM

更新日期：2019-01-01 00:00:00

abstract：:Lymphomas cause significant morbidity and mortality worldwide. A substantial number of patients ultimately relapse after standard treatment. However, the efficacy of these therapies can be counteracted by the patients' immune system, more specifically by myeloid-derived suppressor cells (MDSC). MDSC are a heterogeneou...

journal_title：Blood reviews

authors： Betsch A,Rutgeerts O,Fevery S,Sprangers B,Verhoef G,Dierickx D,Beckers M

更新日期：2018-11-01 00:00:00

abstract：:Excess iron can be extremely toxic for the body and may cause organ damage in the absence of iron chelation therapy. Preclinical studies on the role of free iron on bone marrow function have shown that iron toxicity leads to the accumulation of reactive oxygen species, affects the expression of genes coding for protei...

journal_title：Blood reviews

authors： Isidori A,Borin L,Elli E,Latagliata R,Martino B,Palumbo G,Pilo F,Loscocco F,Visani G,Cianciulli P

更新日期：2018-11-01 00:00:00

abstract：:Musculo-skeletal pain treatment is inadequate in many haemophilic patients. Analgesics are used only by 36% of adult patients. FVIII/FIX intravenous infusion is mainly used to lessen pain, followed in frequency by usage of NSAIDS (primarily COX-2 inhibitors). In about 30% of patients, pain continues after infusion of ...

journal_title：Blood reviews

authors： Rodriguez-Merchan EC

更新日期：2018-03-01 00:00:00

abstract：:Erythropoiesis is a dynamic process regulated at multiple levels to balance proliferation, differentiation and survival of erythroid progenitors. Ineffective erythropoiesis is a key feature of various diseases, including β-thalassemia. The pathogenic mechanisms leading to ineffective erythropoiesis are complex and sti...

journal_title：Blood reviews

authors： Oikonomidou PR,Rivella S

更新日期：2018-03-01 00:00:00

abstract：:Four decades ago, two staging systems were developed to help stratify CLL into different prognostic categories. These systems, the Rai and the Binet staging, depended entirely on abnormal exam findings and evidence of anemia and thrombocytopenia. Better understanding of biologic, genetic, and molecular characteristics...

journal_title：Blood reviews

authors： Mina A,Sandoval Sus J,Sleiman E,Pinilla-Ibarz J,Awan FT,Kharfan-Dabaja MA

更新日期：2018-03-01 00:00:00

abstract：:Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells...

journal_title：Blood reviews

authors： Grosso R,Fader CM,Colombo MI

更新日期：2017-09-01 00:00:00

abstract：:Fanconi anemia (FA) is a rare autosomal and X-linked genetic disease characterized by congenital abnormalities, progressive bone marrow failure (BMF), and increased cancer risk during early adulthood. The median lifespan for FA patients is approximately 33years. The proteins encoded by the FA genes function together i...

journal_title：Blood reviews

authors： Mamrak NE,Shimamura A,Howlett NG

更新日期：2017-05-01 00:00:00

abstract：:The majority of aggressive lymphomas is characterized by an up regulated glycolytic activity, which enables the visualization by F-18 FDG-PET/CT. One-stop hybrid FDG-PET/CT combines the functional and morphologic information, outperforming both, CT and FDG-PET as separate imaging modalities. This has resulted in sever...

journal_title：Blood reviews

authors： Valls L,Badve C,Avril S,Herrmann K,Faulhaber P,O'Donnell J,Avril N

更新日期：2016-07-01 00:00:00

abstract：:Parenteral arsenic trioxide (ATO) has been firmly established as a standard therapy for acute promyelocytic leukemia (APL). Despite widespread use of oral arsenicals in medicine historically, they had disappeared from modern pharmacopeia until oral ATO was redeveloped in Hong Kong in 2000. Since then, over 200 patient...

journal_title：Blood reviews

authors： Torka P,Al Ustwani O,Wetzler M,Wang ES,Griffiths EA

更新日期：2016-05-01 00:00:00

abstract：:Current genomic technologies have immensely improved disease classification and prognostication of major subtypes of B-cell lymphomas. This novel genetic information has not only aided in diagnosis, but has also revealed a landscape of critical molecular events that determine the biological and clinical behavior of a ...

journal_title：Blood reviews

authors： Iqbal J,Naushad H,Bi C,Yu J,Bouska A,Rohr J,Chao W,Fu K,Chan WC,Vose JM

更新日期：2016-03-01 00:00:00

abstract：:Anemia is present in over two-thirds of patients with malignant hematological disorders. The etiology of anemia predominates from ineffective erythropoiesis from marrow infiltration, cytokine related suppression, erythropoietin suppression, and vitamin deficiency; ineffective erythropoiesis is further exacerbated by a...

journal_title：Blood reviews

authors： Shah N,Andrews J,Goodnough LT

更新日期：2015-09-01 00:00:00

abstract：:Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. α-Granules contain multiple cytokines, mitogens, pro- and anti-i...

journal_title：Blood reviews

authors： Golebiewska EM,Poole AW

更新日期：2015-05-01 00:00:00

abstract：:Cerebral venous thrombosis (CVT) is a condition that can affect all age groups and can often be difficult to diagnose and treat. The difficulties in diagnosis are mainly due to the non-specific presenting features of CVT, which can range from isolated headache and visual or auditory problems, to serious symptoms such ...

journal_title：Blood reviews

authors： Thorell SE,Parry-Jones AR,Punter M,Hurford R,Thachil J

更新日期：2015-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome and not an independent disease. HLH represents the extreme end of a severe uncontrolled hyperinflammatory reaction that can occur in many underlying conditions. Genetic forms of HLHs are due to defects in transport, processing an...

journal_title：Blood reviews

authors： Janka GE,Lehmberg K

更新日期：2014-07-01 00:00:00

abstract：:Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (AVP) V2-receptors in endothelial cells and possible in platelets increases the circulating levels of coagulation factor VIII (FVIII), von Willebrand factor (VWF) and tissue plasminogen activator (t-PA). The purpose of th...

journal_title：Blood reviews

authors： Svensson PJ,Bergqvist PB,Juul KV,Berntorp E

更新日期：2014-05-01 00:00:00

abstract：:In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis studies, reflects the platelet responses in human haemostasis and thrombosis. Following this concept, we give an up-to-date overview of the main platelet receptors and sign...

journal_title：Blood reviews

authors： Swieringa F,Kuijpers MJ,Heemskerk JW,van der Meijden PE

更新日期：2014-01-01 00:00:00

abstract：:Notch signaling can regulate both hematopoietic progenitors and alloimmune T cells in the setting of allogeneic bone marrow or hematopoietic cell transplantation (allo-HCT). Ex vivo culture of multipotent blood progenitors with immobilized Delta-like ligands induces supraphysiological Notch signals and can markedly en...

journal_title：Blood reviews

authors： Ebens CL,Maillard I

更新日期：2013-11-01 00:00:00

abstract：:Hemophilia A is an X-linked hereditary bleeding disorder due to the deficiency of coagulation factor VIII (FVIII). According to the degree of FVIII deficiency, mild, moderate or severe forms are recognized. Although patients with mild hemophilia A usually bleed excessively only after trauma or surgery, those with seve...

journal_title：Blood reviews

authors： Franchini M,Mannucci PM

更新日期：2013-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) have become one of the hottest topics in biology over recent years, but remarkably have only been formally recognized for just over 10 years. These endogenously produced short (19-24 nt) non-coding RNAs have introduced an entirely new paradigm in our understanding of gene control and it is now evide...

journal_title：Blood reviews

authors： Lawrie CH

更新日期：2013-05-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor (TF)-mediated coagulation. In atherosclerotic plaques TFPI co-localizes with TF, where it is believed to play an important role in attenuating TF activity. Findings in animal models such as TFPI knockout models and gene transfer models are c...

journal_title：Blood reviews

authors： Winckers K,ten Cate H,Hackeng TM

更新日期：2013-05-01 00:00:00

abstract：:von Willebrand disease (VWD) affects approximately 1% of the population. Joint bleeds are not a predominant symptom of VWD, however they do occur. Especially in patients with severe VWD, joint bleeds have been described in up to 45% of the patients. Recurrent hemarthroses can lead to joint destruction which is the mai...

journal_title：Blood reviews

authors： van Galen KP,Mauser-Bunschoten EP,Leebeek FW

更新日期：2012-11-01 00:00:00

abstract：:The innate immune system orchestrated by leukocytes primarily neutrophils, serves to remove dead and dying host cells and to provide protection against invasion by pathogens. Failure of this system results in the onset of sepsis leading to grave consequences for the host. Together with mechanical methods to physically...

journal_title：Blood reviews

authors： Gardiner EE,Andrews RK

更新日期：2012-11-01 00:00:00

abstract：:Uncontrolled bleeding is the most common preventable cause of death for patients with severe injury. Coagulopathy inevitably accompanies severe bleeding, exacerbated by the ongoing blood loss and the treatments administered. There is debate about the underlying pathophysiological mechanisms of early traumatic coagulop...

journal_title：Blood reviews

authors： Curry NS,Davenport RA,Hunt BJ,Stanworth SJ

更新日期：2012-09-01 00:00:00

abstract：:ABVD continues to be the standard of care for patients with advanced stage Hodgkin Lymphoma (HL) although escalated BEACOPP has improved survival in one randomized controlled trial (RCT). More intensive regimens have higher rates of acute and late toxicities and this poses significant issues for patients. Consolidatio...

journal_title：Blood reviews

authors： Uhm J,Kuruvilla J

更新日期：2012-07-01 00:00:00