Abstract：
:Uncontrolled bleeding is the most common preventable cause of death for patients with severe injury. Coagulopathy inevitably accompanies severe bleeding, exacerbated by the ongoing blood loss and the treatments administered. There is debate about the underlying pathophysiological mechanisms of early traumatic coagulopathy and uncertainty about whether injury induces a unique coagulopathy when compared to other forms of major haemorrhage. This review describes current understanding of the coagulopathy of major blood loss and focuses on the early coagulation changes that occur following severe injury. It then reports on the contemporary management of coagulopathic bleeding using new transfusion strategies. Finally this review presents some practical points to the delivery of transfusion for major blood loss in the modern hospital setting.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Curry NS,Davenport RA,Hunt BJ,Stanworth SJdoi
10.1016/j.blre.2012.06.004subject
Has Abstractpub_date
2012-09-01 00:00:00pages
223-32issue
5eissn
0268-960Xissn
1532-1681pii
S0268-960X(12)00048-3journal_volume
26pub_type
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