听力与言语-语言病理学

行为科学

医学伦理学

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  • Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells.

    abstract:BACKGROUND:NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regene...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-020-00267-z

    authors: Kohno K,Koya-Miyata S,Harashima A,Tsukuda T,Katakami M,Ariyasu T,Ushio S,Iwaki K

    更新日期:2021-01-07 00:00:00

  • Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity.

    abstract:BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-020-00265-1

    authors: Cui F,Guo J,Hu HF,Zhang Y,Shi M

    更新日期:2020-11-07 00:00:00

  • PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population.

    abstract:BACKGROUND:Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic components triggered by pediatric obesity is a common but scarcely understood aspect of the disease. Per...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-020-00264-2

    authors: Vargas-Sánchez K,Vargas L,Urrutia Y,Beltrán I,Rossi AB,Lozano HY,Guarín J,Losada-Barragán M

    更新日期:2020-10-31 00:00:00

  • Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome.

    abstract:Background:The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was to investigate the corpus cavernosum smooth muscle cell function and phenotype transformation in Ex...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-019-0233-z

    authors: Wang GC,Huang TR,Hu YY,Wang KY,Shi H,Yin L,Peng B

    更新日期:2020-01-06 00:00:00

  • The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE -/- mice.

    abstract:Background:Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. Purpose of the study:We have previously reported that siRNA-silencing of CD40 (siCD40) reduced atherosclerosis (ATH) progression. H...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-019-0228-9

    authors: Hueso M,Casas A,Mallén A,de Ramón L,Bolaños N,Varela C,Cruzado JM,Torras J,Navarro E

    更新日期:2019-12-16 00:00:00

  • Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway.

    abstract::Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats...

    journal_title:Journal of inflammation (London, England)

    pub_type: 社论

    doi:10.1186/s12950-019-0225-z

    authors: Wang L,Feng L,Zhang J

    更新日期:2019-10-11 00:00:00

  • Role of autophagy in atherosclerosis: foe or friend?

    abstract::Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detec...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s12950-019-0212-4

    authors: Hassanpour M,Rahbarghazi R,Nouri M,Aghamohammadzadeh N,Safaei N,Ahmadi M

    更新日期:2019-05-02 00:00:00

  • CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients.

    abstract:Background:Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clin...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-018-0186-7

    authors: Patry C,Stamm D,Betzen C,Tönshoff B,Yard BA,Beck GC,Rafat N

    更新日期:2018-05-16 00:00:00

  • Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model.

    abstract:Background:Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for its strong immunoregulatory and anti-inflammatory abilities. However, whether and how IL-10 protects...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-018-0180-0

    authors: Lin R,Chen F,Wen S,Teng T,Pan Y,Huang H

    更新日期:2018-02-27 00:00:00

  • Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome.

    abstract::Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s12950-017-0174-3

    authors: Shih KC,Lun CN,Jhanji V,Thong BY,Tong L

    更新日期:2017-11-21 00:00:00

  • Leptin independently predicts development of sepsis and its outcome.

    abstract:BACKGROUND:Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved. METHODS:Patients aged 18 years or more with documented first time sepsis events were included ...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-017-0167-2

    authors: Jacobsson S,Larsson P,Johansson G,Norberg M,Wadell G,Hallmans G,Winsö O,Söderberg S

    更新日期:2017-09-11 00:00:00

  • Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.

    abstract:BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-017-0162-7

    authors: Yin H,Song S,Pan X

    更新日期:2017-08-09 00:00:00

  • WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells.

    abstract:BACKGROUND:Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained unclear. Recently, we showed that Wnt5A affects barrier function in ...

    journal_title:Journal of inflammation (London, England)

    pub_type:

    doi:10.1186/s12950-017-0157-4

    authors: Skaria T,Bachli E,Schoedon G

    更新日期:2017-05-19 00:00:00

  • Chondroprotective effect of high-molecular-weight hyaluronic acid on osteoarthritic chondrocytes in a co-cultivation inflammation model with M1 macrophages.

    abstract:BACKGROUND:Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the ...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-016-0139-y

    authors: Bauer C,Niculescu-Morzsa E,Jeyakumar V,Kern D,Späth SS,Nehrer S

    更新日期:2016-09-13 00:00:00

  • MicroRNAs differentially expressed in Behçet disease are involved in interleukin-6 production.

    abstract:BACKGROUND:Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNA...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-016-0130-7

    authors: Woo MY,Yun SJ,Cho O,Kim K,Lee ES,Park S

    更新日期:2016-07-19 00:00:00

  • Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.

    abstract:BACKGROUND:Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid abnormal cannabidiol (Abn-CBD) on wound healing, inflammatory cell recruitment and colitis in mice....

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-016-0129-0

    authors: Krohn RM,Parsons SA,Fichna J,Patel KD,Yates RM,Sharkey KA,Storr MA

    更新日期:2016-07-14 00:00:00

  • Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis.

    abstract:BACKGROUND:Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs have the potential to undergo chondrogenesis, but for yet...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-016-0120-9

    authors: Fichadiya A,Bertram KL,Ren G,Yates RM,Krawetz RJ

    更新日期:2016-04-06 00:00:00

  • Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790.

    abstract:BACKGROUND:Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development ...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-015-0100-5

    authors: Schneider S,Hoppmann P,Koch W,Kemmner S,Schmaderer C,Renders L,Kastrati A,Laugwitz KL,Heemann U,Baumann M

    更新日期:2015-10-01 00:00:00

  • Dimethylfumarate protects against TNF-α-induced secretion of inflammatory cytokines in human endothelial cells.

    abstract:BACKGROUND:Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple sclerosis agent, possesses anti-inflammatory, anti-oxidative and anti-angiogenic properties. Here, we...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-015-0094-z

    authors: Gerhardt S,König V,Doll M,Hailemariam-Jahn T,Hrgovic I,Zöller N,Kaufmann R,Kippenberger S,Meissner M

    更新日期:2015-08-06 00:00:00

  • Protective effects of thalidomide on pulmonary injuries in a rat model of paraquat intoxication.

    abstract:BACKGROUND:This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms. METHODS:Rats were exposed to 50 mg/kg PQ by oral gavage, and treated with thalidomide through oral administration at 60 mg/kg once a day, ...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-015-0093-0

    authors: Li D,Zhang XW,Jiang XQ,Yin YJ,Fan Z,Sun CB,Chen XH,Li YH,Liu KX

    更新日期:2015-07-28 00:00:00

  • Portrait of inflammatory response to ionizing radiation treatment.

    abstract::Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular radiation-dependent re...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-015-0058-3

    authors: Di Maggio FM,Minafra L,Forte GI,Cammarata FP,Lio D,Messa C,Gilardi MC,Bravatà V

    更新日期:2015-02-18 00:00:00

  • Targeting CD226/DNAX accessory molecule-1 (DNAM-1) in collagen-induced arthritis mouse models.

    abstract:BACKGROUND:Genetic studies have pointed out that CD226 variants, encoding DNAM-1, could be associated with susceptibility to rheumatoid arthritis. Therefore, we aimed to determine the influence of DNAM-1 on the development of arthritis using the collagen-induced arthritis (CIA) mouse model. METHODS:CIA was induced in ...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-015-0056-5

    authors: Elhai M,Chiocchia G,Marchiol C,Lager F,Renault G,Colonna M,Bernhardt G,Allanore Y,Avouac J

    更新日期:2015-02-08 00:00:00

  • Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB.

    abstract:BACKGROUND:Milk-derived bioactive peptides retain many biological properties and have therapeutic effects in cardiovascular disorders such as atherosclerosis. Under inflammatory conditions the expression of endothelial cells adhesion molecules is induced, increasing monocyte adhesion to human vessel wall, a critical st...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-014-0044-1

    authors: Marcone S,Haughton K,Simpson PJ,Belton O,Fitzgerald DJ

    更新日期:2015-01-20 00:00:00

  • A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage.

    abstract:BACKGROUND:Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery. CPB is however associated with a strong induction of systemic inflammatory response syndrome (SIRS) which in conjunction with ischemia and reperfusion may lead to multiple organ failure. The aim of the study was to establish and ch...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/s12950-014-0026-3

    authors: Engels M,Bilgic E,Pinto A,Vasquez E,Wollschläger L,Steinbrenner H,Kellermann K,Akhyari P,Lichtenberg A,Boeken U

    更新日期:2014-08-12 00:00:00

  • Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns.

    abstract:BACKGROUND:Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial c...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-11-20

    authors: Mai K,Chui JJ,Di Girolamo N,McCluskey PJ,Wakefield D

    更新日期:2014-07-16 00:00:00

  • Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations.

    abstract:BACKGROUND:Heat shock protein 90 (Hsp90), a chaperone that regulates activity of many client proteins responsible for cellular growth, differentiation, and apoptosis, has been proposed as an important clinical and preclinical therapeutic target in a number of malignancies and autoimmune diseases, respectively. In this ...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-11-10

    authors: Tukaj S,Zillikens D,Kasperkiewicz M

    更新日期:2014-04-02 00:00:00

  • Anti-inflammatory effects of resolvin-D1 on human corneal epithelial cells: in vitro study.

    abstract:BACKGROUND:This study evaluated the anti-inflammatory effects of Resolvin-D1 (RV-D1) and its mechanism of action in human corneal epithelial (HCE) cells. METHODS:HCE cells were incubated with different concentrations of RV-D1 for different time periods. Oleic acid (OA) and Dexamethasone (DM) served as negative and pos...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-11-6

    authors: Erdinest N,Ovadia H,Kormas R,Solomon A

    更新日期:2014-03-02 00:00:00

  • Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts.

    abstract:BACKGROUND:Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functionality of TLRs in human corneal epithelial cells (HCE) and in conjunctival fibroblasts (HCF). METHO...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-11-3

    authors: Erdinest N,Aviel G,Moallem E,Anteby I,Yahalom C,Mechoulam H,Ovadia H,Solomon A

    更新日期:2014-02-04 00:00:00

  • Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts.

    abstract:BACKGROUND:Salivary histatins are bioactive peptides related to the innate immune system associated with antimicrobial activities. However, very little is known about the physiological and biological functions of histatins against host cells or their role in oral cell inflammation. Histatin 3 binds to heat shock cognat...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-11-4

    authors: Imamura Y,Wang PL

    更新日期:2014-02-04 00:00:00

  • Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria.

    abstract:BACKGROUND:Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders....

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-11-2

    authors: Grzanka A,Machura E,Mazur B,Misiolek M,Jochem J,Kasperski J,Kasperska-Zajac A

    更新日期:2014-02-03 00:00:00

  • Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls.

    abstract:BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-10-36

    authors: Van Welden S,Laukens D,Ferdinande L,De Vos M,Hindryckx P

    更新日期:2013-11-20 00:00:00

  • BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages.

    abstract:BACKGROUND:BMP4, a member of the transforming growth factor-beta superfamily, is upregulated in the aortas of diabetic db/db mice. However, little is known about its role in diabetic atherosclerosis. Therefore, we examined the roles of BMP4 in the formation of diabetic atherosclerosis in apolipoprotein E knockout (ApoE...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-10-32

    authors: Koga M,Yamauchi A,Kanaoka Y,Jige R,Tsukamoto A,Teshima N,Nishioku T,Kataoka Y

    更新日期:2013-10-09 00:00:00

  • TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice.

    abstract:BACKGROUND:Airway inflammation and asthma have been linked to oxidative stress and the melastatin-related transient receptor potential cation channel, member 2 (TRPM2), which can be activated by reactive oxygen species (ROS), has emerged as a potential therapeutic target for inflammatory diseases. OBJECTIVE:Using TRPM...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-10-19

    authors: Sumoza-Toledo A,Fleig A,Penner R

    更新日期:2013-05-01 00:00:00

  • Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps.

    abstract:BACKGROUND:Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation. METHODS:Pharmacological inhibitors were used to block PKC activity in neutrophils harvested f...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-10-12

    authors: Gray RD,Lucas CD,MacKellar A,Li F,Hiersemenzel K,Haslett C,Davidson DJ,Rossi AG

    更新日期:2013-03-21 00:00:00

  • The effect of two iso-caloric meals containing equal amounts of fats with a different fat composition on the inflammatory and metabolic markers in apparently healthy volunteers.

    abstract:BACKGROUND:Little is known about the time-course of the postprandial appearance of macronutrient-induced inflammatory response. Our aim was to investigate the postprandial inflammatory and metabolic response following high fat, high caloric popular meals in apparently healthy participants. METHODS:Fifty four apparentl...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-10-3

    authors: Raz O,Steinvil A,Berliner S,Rosenzweig T,Justo D,Shapira I

    更新日期:2013-01-31 00:00:00

  • Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.

    abstract::Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-10-4

    authors: Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

    更新日期:2013-01-31 00:00:00

  • Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation.

    abstract:UNLABELLED: BACKGROUND:Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation of inflammatory activity and associated impaired pro...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-9-48

    authors: Ahmad R,Al-Mass A,Atizado V,Al-Hubail A,Al-Ghimlas F,Al-Arouj M,Bennakhi A,Dermime S,Behbehani K

    更新日期:2012-11-28 00:00:00

  • Accelerated wound healing phenotype in Interleukin 12/23 deficient mice.

    abstract:BACKGROUND:The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present study explored the effect of abrogation of the p40 subunit, which...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-8-39

    authors: Matias MA,Saunus JM,Ivanovski S,Walsh LJ,Farah CS

    更新日期:2011-12-20 00:00:00

  • Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70.

    abstract:BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has been attributed to abnormal apoptosis. While not comprehensively investigated, perturbations in peripheral blood lymphocyte (PBL) apoptosis may also be...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-8-30

    authors: Moodley D,Mody GM,Chuturgoon AA

    更新日期:2011-11-03 00:00:00

  • Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system.

    abstract:: The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate commensal bacteria and food antigens. Intestinal pathogens have ...

    journal_title:Journal of inflammation (London, England)

    pub_type: 杂志文章

    doi:10.1186/1476-9255-8-11

    authors: Vossenkämper A,Macdonald TT,Marchès O

    更新日期:2011-05-03 00:00:00

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