Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns.

abstract：BACKGROUND:Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved. METHODS:Patients aged 18 years or more with documented first time sepsis events were included ...

journal_title：Journal of inflammation (London, England)

authors： Jacobsson S,Larsson P,Johansson G,Norberg M,Wadell G,Hallmans G,Winsö O,Söderberg S

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the ...

journal_title：Journal of inflammation (London, England)

authors： Bauer C,Niculescu-Morzsa E,Jeyakumar V,Kern D,Späth SS,Nehrer S

更新日期：2016-09-13 00:00:00

abstract：:Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells. It was tested whether PR-39 affects human neutrophil m...

journal_title：Journal of inflammation (London, England)

authors： Djanani A,Mosheimer B,Kaneider NC,Ross CR,Ricevuti G,Patsch JR,Wiedermann CJ

更新日期：2006-11-02 00:00:00

abstract：BACKGROUND:The objective for this present study was to determine whether or not suspension bead array is a feasible method to detect changes in cytokine protein expression in mouse lung tissue homogenates. Here, we report on suspension bead array as a feasible method for detection of lipopolysaccharide (LPS)-evoked cha...

journal_title：Journal of inflammation (London, England)

authors： McDuffie E,Obert L,Chupka J,Sigler R

更新日期：2006-11-29 00:00:00

abstract：:Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a well-established microarray to analyze differences between LPS-stimulated human cord blood and adult monocytes...

journal_title：Journal of inflammation (London, England)

authors： Lawrence S,Tang Y,Frank MB,Dozmorov I,Jiang K,Chen Y,Cadwell C,Turner S,Centola M,Jarvis JN

更新日期：2007-02-16 00:00:00

abstract：:Adult bone marrow derived mesenchymal stem cells offer the potential to open a new frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of conditions associated with damaged cartilage, bone, muscle, tendon and ligament. However the normal process of immune rejection of mismatched a...

journal_title：Journal of inflammation (London, England)

authors： Ryan JM,Barry FP,Murphy JM,Mahon BP

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present study explored the effect of abrogation of the p40 subunit, which...

journal_title：Journal of inflammation (London, England)

authors： Matias MA,Saunus JM,Ivanovski S,Walsh LJ,Farah CS

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNA...

journal_title：Journal of inflammation (London, England)

authors： Woo MY,Yun SJ,Cho O,Kim K,Lee ES,Park S

更新日期：2016-07-19 00:00:00

abstract：:Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities...

journal_title：Journal of inflammation (London, England)

authors： Shih KC,Lun CN,Jhanji V,Thong BY,Tong L

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury (SCI) in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore, in experimental models the effects of SCI therapy on bladder and ren...

journal_title：Journal of inflammation (London, England)

authors： Shunmugavel A,Khan M,Te Chou PC,Dhindsa RK,Martin MM,Copay AG,Subach BR,Schuler TC,Bilgen M,Orak JK,Singh I

更新日期：2010-04-19 00:00:00

abstract：BACKGROUND:The effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro. METHODS:In vivo studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs. Exudate volu...

journal_title：Journal of inflammation (London, England)

authors： Garbacki N,Kinet M,Nusgens B,Desmecht D,Damas J

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple sclerosis agent, possesses anti-inflammatory, anti-oxidative and anti-angiogenic properties. Here, we...

journal_title：Journal of inflammation (London, England)

authors： Gerhardt S,König V,Doll M,Hailemariam-Jahn T,Hrgovic I,Zöller N,Kaufmann R,Kippenberger S,Meissner M

更新日期：2015-08-06 00:00:00

abstract：BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...

journal_title：Journal of inflammation (London, England)

authors： Van Welden S,Laukens D,Ferdinande L,De Vos M,Hindryckx P

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has been attributed to abnormal apoptosis. While not comprehensively investigated, perturbations in peripheral blood lymphocyte (PBL) apoptosis may also be...

journal_title：Journal of inflammation (London, England)

authors： Moodley D,Mody GM,Chuturgoon AA

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:Monocytes and neutrophils are examples of phagocytic leukocytes, with neutrophils being considered as the 'chief' phagocytic leukocyte. Both monocytes and neutrophils have been implicated to play a key role in the development of ischaemia-reperfusion injury, where they are intrinsically involved in leukocyte...

journal_title：Journal of inflammation (London, England)

authors： Hughes SF,Hendricks BD,Edwards DR,Bastawrous SS,Roberts GE,Middleton JF

更新日期：2007-05-30 00:00:00

abstract：BACKGROUND:Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development ...

journal_title：Journal of inflammation (London, England)

authors： Schneider S,Hoppmann P,Koch W,Kemmner S,Schmaderer C,Renders L,Kastrati A,Laugwitz KL,Heemann U,Baumann M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic components triggered by pediatric obesity is a common but scarcely understood aspect of the disease. Per...

journal_title：Journal of inflammation (London, England)

authors： Vargas-Sánchez K,Vargas L,Urrutia Y,Beltrán I,Rossi AB,Lozano HY,Guarín J,Losada-Barragán M

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND:Nuclear factor kappa B (NF-kappaB) has been shown to play an important role in regulating the expression of many genes involved in cell survival, immunity and in the inflammatory processes. NF-kappaB activation upregulates inducible nitric oxide synthase leading to enhanced nitric oxide production during an ...

journal_title：Journal of inflammation (London, England)

authors： Jones E,Adcock IM,Ahmed BY,Punchard NA

更新日期：2007-11-24 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) and inflammatory cytokines have been linked to adverse outcomes in persons with cardiovascular and kidney diseases and recent reports suggest that cytokine-mediated inflammatory infiltrates may be an important contributor to the pathogenesis the aforementioned diseases. Although some repor...

journal_title：Journal of inflammation (London, England)

authors： Shastry S,James LR

更新日期：2009-09-26 00:00:00

abstract：BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...

journal_title：Journal of inflammation (London, England)

authors： Cui F,Guo J,Hu HF,Zhang Y,Shi M

更新日期：2020-11-07 00:00:00

abstract：: The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate commensal bacteria and food antigens. Intestinal pathogens have ...

journal_title：Journal of inflammation (London, England)

authors： Vossenkämper A,Macdonald TT,Marchès O

更新日期：2011-05-03 00:00:00

abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

journal_title：Journal of inflammation (London, England)

authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

更新日期：2010-07-26 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functionality of TLRs in human corneal epithelial cells (HCE) and in conjunctival fibroblasts (HCF). METHO...

journal_title：Journal of inflammation (London, England)

authors： Erdinest N,Aviel G,Moallem E,Anteby I,Yahalom C,Mechoulam H,Ovadia H,Solomon A

更新日期：2014-02-04 00:00:00

abstract：:French maritime pine bark extract (Pycnogenol) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven heal...

journal_title：Journal of inflammation (London, England)

authors： Grimm T,Chovanová Z,Muchová J,Sumegová K,Liptáková A,Duracková Z,Högger P

更新日期：2006-01-27 00:00:00

abstract：BACKGROUND:This study evaluated the anti-inflammatory effects of Resolvin-D1 (RV-D1) and its mechanism of action in human corneal epithelial (HCE) cells. METHODS:HCE cells were incubated with different concentrations of RV-D1 for different time periods. Oleic acid (OA) and Dexamethasone (DM) served as negative and pos...

journal_title：Journal of inflammation (London, England)

authors： Erdinest N,Ovadia H,Kormas R,Solomon A

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evalu...

journal_title：Journal of inflammation (London, England)

authors： Miller MJ,Bobrowski P,Shukla M,Gupta K,Haqqi TM

更新日期：2007-08-14 00:00:00

abstract：:IkappaBalpha is an inhibitor of the nuclear transcription factor NF-kappaB. Binding of IkappaBalpha to NF-kappaB inactivates the transcriptional activity of NF-kappaB. Expression of IkappaBalpha itself is regulated by NF-kappaB, which provides auto-regulation of this signaling pathway. Here we present a mouse model fo...

journal_title：Journal of inflammation (London, England)

authors： Zhang N,Ahsan MH,Zhu L,Sambucetti LC,Purchio AF,West DB

更新日期：2005-10-05 00:00:00

abstract：Background:Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for its strong immunoregulatory and anti-inflammatory abilities. However, whether and how IL-10 protects...

journal_title：Journal of inflammation (London, England)

authors： Lin R,Chen F,Wen S,Teng T,Pan Y,Huang H

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...

journal_title：Journal of inflammation (London, England)

authors： Yin H,Song S,Pan X

更新日期：2017-08-09 00:00:00

abstract：BACKGROUND:Heat shock protein 90 (Hsp90), a chaperone that regulates activity of many client proteins responsible for cellular growth, differentiation, and apoptosis, has been proposed as an important clinical and preclinical therapeutic target in a number of malignancies and autoimmune diseases, respectively. In this ...

journal_title：Journal of inflammation (London, England)

authors： Tukaj S,Zillikens D,Kasperkiewicz M

更新日期：2014-04-02 00:00:00