Abstract:
: The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate commensal bacteria and food antigens. Intestinal pathogens have developed strategies to regulate intestinal immunity and inflammation in order to establish or prolong infection. The organisms that employ a type III secretion system use a molecular syringe to deliver effector proteins into the cytoplasm of host cells. These effectors target the host cell cytoskeleton, cell organelles and signaling pathways. This review addresses the multiple mechanisms by which the type III secretion system targets the intestinal immune response, with a special focus on pathogenic E. coli.
journal_name
J Inflamm (Lond)journal_title
Journal of inflammation (London, England)authors
Vossenkämper A,Macdonald TT,Marchès Odoi
10.1186/1476-9255-8-11subject
Has Abstractpub_date
2011-05-03 00:00:00pages
11issn
1476-9255pii
1476-9255-8-11journal_volume
8pub_type
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