Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model.

abstract：BACKGROUND:Salivary histatins are bioactive peptides related to the innate immune system associated with antimicrobial activities. However, very little is known about the physiological and biological functions of histatins against host cells or their role in oral cell inflammation. Histatin 3 binds to heat shock cognat...

journal_title：Journal of inflammation (London, England)

authors： Imamura Y,Wang PL

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

journal_title：Journal of inflammation (London, England)

authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

更新日期：2010-07-26 00:00:00

abstract：BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...

journal_title：Journal of inflammation (London, England)

authors： Van Welden S,Laukens D,Ferdinande L,De Vos M,Hindryckx P

更新日期：2013-11-20 00:00:00

abstract：Background:Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clin...

journal_title：Journal of inflammation (London, England)

authors： Patry C,Stamm D,Betzen C,Tönshoff B,Yard BA,Beck GC,Rafat N

更新日期：2018-05-16 00:00:00

abstract：BACKGROUND:Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs have the potential to undergo chondrogenesis, but for yet...

journal_title：Journal of inflammation (London, England)

authors： Fichadiya A,Bertram KL,Ren G,Yates RM,Krawetz RJ

更新日期：2016-04-06 00:00:00

abstract：:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

journal_title：Journal of inflammation (London, England)

authors： Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

更新日期：2013-01-31 00:00:00

abstract：:Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells. It was tested whether PR-39 affects human neutrophil m...

journal_title：Journal of inflammation (London, England)

authors： Djanani A,Mosheimer B,Kaneider NC,Ross CR,Ricevuti G,Patsch JR,Wiedermann CJ

更新日期：2006-11-02 00:00:00

abstract：BACKGROUND:The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evalu...

journal_title：Journal of inflammation (London, England)

authors： Miller MJ,Bobrowski P,Shukla M,Gupta K,Haqqi TM

更新日期：2007-08-14 00:00:00

abstract：:Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats...

journal_title：Journal of inflammation (London, England)

authors： Wang L,Feng L,Zhang J

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:The pleiotropic protein MIF, (macrophage migration inhibitory factor), has been demonstrated to modulate several key proteins governing cell cycle control and is considered to contribute to cell growth and differentiation. In this study we investigated the effect of MIF on the expression and cellular distrib...

journal_title：Journal of inflammation (London, England)

authors： Taranto E,Xue JR,Morand EF,Leech M

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Circulating 25 hydroxyvitamin D (25 (OH)D), an accurate measure of vitamin D status, is markedly greater in individuals with increased exposure to ultraviolet B (UVB) light via sunlight or the use of artificial UV light. Aside from the known relationship between vitamin D and bone, vitamin D has also been im...

journal_title：Journal of inflammation (London, England)

authors： Peterson CA,Heffernan ME

更新日期：2008-07-24 00:00:00

abstract：BACKGROUND:Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved. METHODS:Patients aged 18 years or more with documented first time sepsis events were included ...

journal_title：Journal of inflammation (London, England)

authors： Jacobsson S,Larsson P,Johansson G,Norberg M,Wadell G,Hallmans G,Winsö O,Söderberg S

更新日期：2017-09-11 00:00:00

abstract：:IkappaBalpha is an inhibitor of the nuclear transcription factor NF-kappaB. Binding of IkappaBalpha to NF-kappaB inactivates the transcriptional activity of NF-kappaB. Expression of IkappaBalpha itself is regulated by NF-kappaB, which provides auto-regulation of this signaling pathway. Here we present a mouse model fo...

journal_title：Journal of inflammation (London, England)

authors： Zhang N,Ahsan MH,Zhu L,Sambucetti LC,Purchio AF,West DB

更新日期：2005-10-05 00:00:00

abstract：BACKGROUND:The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. METHODS:German landrace pigs under...

journal_title：Journal of inflammation (London, England)

authors： Abdel-Rahman U,Margraf S,Aybek T,Lögters T,Bitu-Moreno J,Francischetti I,Kranert T,Grünwald F,Windolf J,Moritz A,Scholz M

更新日期：2007-10-10 00:00:00

abstract：BACKGROUND:NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regene...

journal_title：Journal of inflammation (London, England)

authors： Kohno K,Koya-Miyata S,Harashima A,Tsukuda T,Katakami M,Ariyasu T,Ushio S,Iwaki K

更新日期：2021-01-07 00:00:00

abstract：:French maritime pine bark extract (Pycnogenol) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven heal...

journal_title：Journal of inflammation (London, England)

authors： Grimm T,Chovanová Z,Muchová J,Sumegová K,Liptáková A,Duracková Z,Högger P

更新日期：2006-01-27 00:00:00

abstract：:Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detec...

journal_title：Journal of inflammation (London, England)

authors： Hassanpour M,Rahbarghazi R,Nouri M,Aghamohammadzadeh N,Safaei N,Ahmadi M

更新日期：2019-05-02 00:00:00

abstract：BACKGROUND:This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms. METHODS:Rats were exposed to 50 mg/kg PQ by oral gavage, and treated with thalidomide through oral administration at 60 mg/kg once a day, ...

journal_title：Journal of inflammation (London, England)

authors： Li D,Zhang XW,Jiang XQ,Yin YJ,Fan Z,Sun CB,Chen XH,Li YH,Liu KX

更新日期：2015-07-28 00:00:00

abstract：:Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities...

journal_title：Journal of inflammation (London, England)

authors： Shih KC,Lun CN,Jhanji V,Thong BY,Tong L

更新日期：2017-11-21 00:00:00

abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

journal_title：Journal of inflammation (London, England)

authors： Smith GR,Missailidis S

更新日期：2004-09-30 00:00:00

abstract：BACKGROUND:Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril is able to attenuate the cardiac inflammatory process associated with arterial hypertension. METHODS:Left ventricle mR...

journal_title：Journal of inflammation (London, England)

authors： Miguel-Carrasco JL,Zambrano S,Blanca AJ,Mate A,Vázquez CM

更新日期：2010-05-12 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonar...

journal_title：Journal of inflammation (London, England)

authors： Arunachalam G,Sundar IK,Hwang JW,Yao H,Rahman I

更新日期：2010-07-22 00:00:00

abstract：BACKGROUND:Monocytes and neutrophils are examples of phagocytic leukocytes, with neutrophils being considered as the 'chief' phagocytic leukocyte. Both monocytes and neutrophils have been implicated to play a key role in the development of ischaemia-reperfusion injury, where they are intrinsically involved in leukocyte...

journal_title：Journal of inflammation (London, England)

authors： Hughes SF,Hendricks BD,Edwards DR,Bastawrous SS,Roberts GE,Middleton JF

更新日期：2007-05-30 00:00:00

abstract：BACKGROUND:Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee venom) have anti-inflammatory effect by reacting with the sulfhydryl group of p50 of nuclear factor-ka...

journal_title：Journal of inflammation (London, England)

authors： Park HJ,Lee HJ,Choi MS,Son DJ,Song HS,Song MJ,Lee JM,Han SB,Kim Y,Hong JT

更新日期：2008-05-29 00:00:00

abstract：: Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) a...

journal_title：Journal of inflammation (London, England)

authors： Rackova L,Oblozinsky M,Kostalova D,Kettmann V,Bezakova L

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the ...

journal_title：Journal of inflammation (London, England)

authors： Bauer C,Niculescu-Morzsa E,Jeyakumar V,Kern D,Späth SS,Nehrer S

更新日期：2016-09-13 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functionality of TLRs in human corneal epithelial cells (HCE) and in conjunctival fibroblasts (HCF). METHO...

journal_title：Journal of inflammation (London, England)

authors： Erdinest N,Aviel G,Moallem E,Anteby I,Yahalom C,Mechoulam H,Ovadia H,Solomon A

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple sclerosis agent, possesses anti-inflammatory, anti-oxidative and anti-angiogenic properties. Here, we...

journal_title：Journal of inflammation (London, England)

authors： Gerhardt S,König V,Doll M,Hailemariam-Jahn T,Hrgovic I,Zöller N,Kaufmann R,Kippenberger S,Meissner M

更新日期：2015-08-06 00:00:00

abstract：: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...

journal_title：Journal of inflammation (London, England)

authors： Shahabi S,Hassan ZM,Jazani NH

更新日期：2009-03-27 00:00:00

abstract：BACKGROUND:Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNA...

journal_title：Journal of inflammation (London, England)

authors： Woo MY,Yun SJ,Cho O,Kim K,Lee ES,Park S

更新日期：2016-07-19 00:00:00