Simvastatin protects bladder and renal functions following spinal cord injury in rats.

abstract：BACKGROUND:Little is known about the time-course of the postprandial appearance of macronutrient-induced inflammatory response. Our aim was to investigate the postprandial inflammatory and metabolic response following high fat, high caloric popular meals in apparently healthy participants. METHODS:Fifty four apparentl...

journal_title：Journal of inflammation (London, England)

authors： Raz O,Steinvil A,Berliner S,Rosenzweig T,Justo D,Shapira I

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

journal_title：Journal of inflammation (London, England)

authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

更新日期：2010-07-26 00:00:00

abstract：BACKGROUND:Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid abnormal cannabidiol (Abn-CBD) on wound healing, inflammatory cell recruitment and colitis in mice....

journal_title：Journal of inflammation (London, England)

authors： Krohn RM,Parsons SA,Fichna J,Patel KD,Yates RM,Sharkey KA,Storr MA

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved. METHODS:Patients aged 18 years or more with documented first time sepsis events were included ...

journal_title：Journal of inflammation (London, England)

authors： Jacobsson S,Larsson P,Johansson G,Norberg M,Wadell G,Hallmans G,Winsö O,Söderberg S

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease. METHODS:Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharmacodynamic consequence...

journal_title：Journal of inflammation (London, England)

authors： Wang Y,Cui L,Gonsiorek W,Min SH,Anilkumar G,Rosenblum S,Kozlowski J,Lundell D,Fine JS,Grant EP

更新日期：2009-11-11 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functionality of TLRs in human corneal epithelial cells (HCE) and in conjunctival fibroblasts (HCF). METHO...

journal_title：Journal of inflammation (London, England)

authors： Erdinest N,Aviel G,Moallem E,Anteby I,Yahalom C,Mechoulam H,Ovadia H,Solomon A

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNA...

journal_title：Journal of inflammation (London, England)

authors： Woo MY,Yun SJ,Cho O,Kim K,Lee ES,Park S

更新日期：2016-07-19 00:00:00

abstract：:Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detec...

journal_title：Journal of inflammation (London, England)

authors： Hassanpour M,Rahbarghazi R,Nouri M,Aghamohammadzadeh N,Safaei N,Ahmadi M

更新日期：2019-05-02 00:00:00

abstract：:Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities...

journal_title：Journal of inflammation (London, England)

authors： Shih KC,Lun CN,Jhanji V,Thong BY,Tong L

更新日期：2017-11-21 00:00:00

abstract：:Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats...

journal_title：Journal of inflammation (London, England)

authors： Wang L,Feng L,Zhang J

更新日期：2019-10-11 00:00:00

abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

journal_title：Journal of inflammation (London, England)

authors： Smith GR,Missailidis S

更新日期：2004-09-30 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonar...

journal_title：Journal of inflammation (London, England)

authors： Arunachalam G,Sundar IK,Hwang JW,Yao H,Rahman I

更新日期：2010-07-22 00:00:00

abstract：: Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) a...

journal_title：Journal of inflammation (London, England)

authors： Rackova L,Oblozinsky M,Kostalova D,Kettmann V,Bezakova L

更新日期：2007-07-16 00:00:00

abstract：:Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a well-established microarray to analyze differences between LPS-stimulated human cord blood and adult monocytes...

journal_title：Journal of inflammation (London, England)

authors： Lawrence S,Tang Y,Frank MB,Dozmorov I,Jiang K,Chen Y,Cadwell C,Turner S,Centola M,Jarvis JN

更新日期：2007-02-16 00:00:00

abstract：BACKGROUND:PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T cells derived from PTPH1-...

journal_title：Journal of inflammation (London, England)

authors： Patrignani C,Lafont DT,Muzio V,Gréco B,Hooft van Huijsduijnen R,Zaratin PF

更新日期：2010-03-30 00:00:00

abstract：UNLABELLED: BACKGROUND:Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation of inflammatory activity and associated impaired pro...

journal_title：Journal of inflammation (London, England)

authors： Ahmad R,Al-Mass A,Atizado V,Al-Hubail A,Al-Ghimlas F,Al-Arouj M,Bennakhi A,Dermime S,Behbehani K

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects. OBJECTIVE:A study was conducted to establish ...

journal_title：Journal of inflammation (London, England)

authors： Dixit VD,Yang H,Sayeed KS,Stote KS,Rumpler WV,Baer DJ,Longo DL,Mattson MP,Taub DD

更新日期：2011-03-07 00:00:00

abstract：BACKGROUND:Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development ...

journal_title：Journal of inflammation (London, England)

authors： Schneider S,Hoppmann P,Koch W,Kemmner S,Schmaderer C,Renders L,Kastrati A,Laugwitz KL,Heemann U,Baumann M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders....

journal_title：Journal of inflammation (London, England)

authors： Grzanka A,Machura E,Mazur B,Misiolek M,Jochem J,Kasperski J,Kasperska-Zajac A

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Milk-derived bioactive peptides retain many biological properties and have therapeutic effects in cardiovascular disorders such as atherosclerosis. Under inflammatory conditions the expression of endothelial cells adhesion molecules is induced, increasing monocyte adhesion to human vessel wall, a critical st...

journal_title：Journal of inflammation (London, England)

authors： Marcone S,Haughton K,Simpson PJ,Belton O,Fitzgerald DJ

更新日期：2015-01-20 00:00:00

abstract：BACKGROUND:The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evalu...

journal_title：Journal of inflammation (London, England)

authors： Miller MJ,Bobrowski P,Shukla M,Gupta K,Haqqi TM

更新日期：2007-08-14 00:00:00

abstract：BACKGROUND:Nuclear factor kappa B (NF-kappaB) has been shown to play an important role in regulating the expression of many genes involved in cell survival, immunity and in the inflammatory processes. NF-kappaB activation upregulates inducible nitric oxide synthase leading to enhanced nitric oxide production during an ...

journal_title：Journal of inflammation (London, England)

authors： Jones E,Adcock IM,Ahmed BY,Punchard NA

更新日期：2007-11-24 00:00:00

abstract：BACKGROUND:Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple sclerosis agent, possesses anti-inflammatory, anti-oxidative and anti-angiogenic properties. Here, we...

journal_title：Journal of inflammation (London, England)

authors： Gerhardt S,König V,Doll M,Hailemariam-Jahn T,Hrgovic I,Zöller N,Kaufmann R,Kippenberger S,Meissner M

更新日期：2015-08-06 00:00:00

abstract：:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

journal_title：Journal of inflammation (London, England)

authors： Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs have the potential to undergo chondrogenesis, but for yet...

journal_title：Journal of inflammation (London, England)

authors： Fichadiya A,Bertram KL,Ren G,Yates RM,Krawetz RJ

更新日期：2016-04-06 00:00:00

abstract：BACKGROUND:The effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro. METHODS:In vivo studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs. Exudate volu...

journal_title：Journal of inflammation (London, England)

authors： Garbacki N,Kinet M,Nusgens B,Desmecht D,Damas J

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) and inflammatory cytokines have been linked to adverse outcomes in persons with cardiovascular and kidney diseases and recent reports suggest that cytokine-mediated inflammatory infiltrates may be an important contributor to the pathogenesis the aforementioned diseases. Although some repor...

journal_title：Journal of inflammation (London, England)

authors： Shastry S,James LR

更新日期：2009-09-26 00:00:00

abstract：: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...

journal_title：Journal of inflammation (London, England)

authors： Shahabi S,Hassan ZM,Jazani NH

更新日期：2009-03-27 00:00:00

abstract：BACKGROUND:Airway inflammation and asthma have been linked to oxidative stress and the melastatin-related transient receptor potential cation channel, member 2 (TRPM2), which can be activated by reactive oxygen species (ROS), has emerged as a potential therapeutic target for inflammatory diseases. OBJECTIVE:Using TRPM...

journal_title：Journal of inflammation (London, England)

authors： Sumoza-Toledo A,Fleig A,Penner R

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...

journal_title：Journal of inflammation (London, England)

authors： Van Welden S,Laukens D,Ferdinande L,De Vos M,Hindryckx P

更新日期：2013-11-20 00:00:00