Abstract:
: Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) alkaloids on activity of 12-lipoxygenase (12-LOX), was studied. The reactivity with 1,1-diphenyl-2-picryl-hydrazyl (DPPH), a free stable radical, was evaluated to elucidate the rate of possible lipid-derived radical scavenging in the mechanism of the enzyme inhibition.The results indicate that although the direct radical scavenging mechanism cannot be ruled out in the lipoxygenase inhibition by Mahonia aquifolium and its constituents, other mechanisms based on specific interaction between enzyme and alkaloids could play the critical role in the lipoxygenase inhibition rather than non-specific reactivity with free radicals.
journal_name
J Inflamm (Lond)journal_title
Journal of inflammation (London, England)authors
Rackova L,Oblozinsky M,Kostalova D,Kettmann V,Bezakova Ldoi
10.1186/1476-9255-4-15subject
Has Abstractpub_date
2007-07-16 00:00:00pages
15issn
1476-9255pii
1476-9255-4-15journal_volume
4pub_type
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journal_title:Journal of inflammation (London, England)
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