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Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps.

Abstract：

BACKGROUND:Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation. METHODS:Pharmacological inhibitors were used to block PKC activity in neutrophils harvested from healthy donor blood. RESULTS:Pan PKC inhibition with Ro-31-8220 (p<0.001), conventional PKC inhibition with Go 6976 (p<0.001) and specific PKCβ inhibition with LY333531 (p<0.01) blocked NET formation in response to PMA. Inhibition of novel and atypical PKC had no effect. LY333531 blocked NET induction by the diacylglycerol analogue OAG (conventional PKC activator) (p<0.001). CONCLUSIONS:Conventional PKCs have a prominent role in NET formation. Furthermore PKCβ is the major isoform implicated in NET formation.

journal_name

J Inflamm (Lond)

journal_title

Journal of inflammation (London, England)

authors

Gray RD,Lucas CD,MacKellar A,Li F,Hiersemenzel K,Haslett C,Davidson DJ,Rossi AG

doi

10.1186/1476-9255-10-12

subject

Has Abstract

pub_date

2013-03-21 00:00:00

pages

12

issue

1

issn

1476-9255

pii

1476-9255-10-12

journal_volume

10

pub_type

杂志文章

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