Abstract:
:Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities of treatment. Fluoromethalone eye drops over 8 weeks were more effective than topical cyclosporine in the treatment of dry eye symptoms and signs; similarly, indomethacin eye drops over 1 month were more efficacious than diclofenac eye drops. Oral pilocarpine 5 mg twice daily over 3 months was superior to use of lubricants or punctal plugs for treating dry eye, but 5% of participants had gastrointestinal adverse effects from pilocarpine, though none discontinued treatment. In contrast, etanercept, a TNF-alpha blocking antibody, administered as subcutaneous injections twice weekly, did not improve dry eye significantly compared to placebo injections. In conclusion, topical corticosteroids have been shown to be effective in dry eye associated with Sjögren's syndrome. As some topical non-steroidal anti-inflammatory drugs may be more effective than others, these should be further evaluated. Systemic secretagogues like pilocarpine have a role in Sjögren's syndrome but the adverse effects may limit their clinical use. It is disappointing that systemic cytokine therapy did not produce encouraging ocular outcomes but participants should have assessment of cytokine levels in such trials, as those with higher baseline cytokine levels may respond better. (229 words).
journal_name
J Inflamm (Lond)journal_title
Journal of inflammation (London, England)authors
Shih KC,Lun CN,Jhanji V,Thong BY,Tong Ldoi
10.1186/s12950-017-0174-3subject
Has Abstractpub_date
2017-11-21 00:00:00pages
26issn
1476-9255pii
174journal_volume
14pub_type
杂志文章,评审abstract:BACKGROUND:Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonar...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-7-34
更新日期:2010-07-22 00:00:00
abstract:BACKGROUND:NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regene...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-020-00267-z
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-10-36
更新日期:2013-11-20 00:00:00
abstract:BACKGROUND:124 triazolo [4, 3-a]18naphthyridine derivatives (including NF161 and NF177) were tested for anti-inflammatory, analgesic and antipyretic properties and for their effects on spontaneous locomotor activity in mice and acute gastrolesivity in rats. Both NF161 and NF177 appeared to be anti-inflammatory and anal...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-3-4
更新日期:2006-03-28 00:00:00
abstract:BACKGROUND:Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial c...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-11-20
更新日期:2014-07-16 00:00:00
abstract:BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-020-00265-1
更新日期:2020-11-07 00:00:00
abstract:BACKGROUND:The objective for this present study was to determine whether or not suspension bead array is a feasible method to detect changes in cytokine protein expression in mouse lung tissue homogenates. Here, we report on suspension bead array as a feasible method for detection of lipopolysaccharide (LPS)-evoked cha...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-3-15
更新日期:2006-11-29 00:00:00
abstract:BACKGROUND:Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury (SCI) in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore, in experimental models the effects of SCI therapy on bladder and ren...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-7-17
更新日期:2010-04-19 00:00:00
abstract:BACKGROUND:The key co-repressor complex components HDAC-2, Mi-2alpha/beta and mSin3a are all critical to the regulation of gene transcription. HDAC-2 function is impaired by oxidative stress in a PI3Kdelta dependant manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lungs of COPD...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-7-33
更新日期:2010-07-16 00:00:00
abstract::The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-1-3
更新日期:2004-09-30 00:00:00
abstract:BACKGROUND:Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid abnormal cannabidiol (Abn-CBD) on wound healing, inflammatory cell recruitment and colitis in mice....
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-016-0129-0
更新日期:2016-07-14 00:00:00
abstract:BACKGROUND:Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation. METHODS:Pharmacological inhibitors were used to block PKC activity in neutrophils harvested f...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-10-12
更新日期:2013-03-21 00:00:00
abstract:BACKGROUND:Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs have the potential to undergo chondrogenesis, but for yet...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-016-0120-9
更新日期:2016-04-06 00:00:00
abstract::French maritime pine bark extract (Pycnogenol) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven heal...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-3-1
更新日期:2006-01-27 00:00:00
abstract:BACKGROUND:Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects. OBJECTIVE:A study was conducted to establish ...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-8-6
更新日期:2011-03-07 00:00:00
abstract:BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-017-0162-7
更新日期:2017-08-09 00:00:00
abstract:: The limitations of steroidal and non steroidal anti-inflammatory drugs have prompted investigation into other biologically based therapeutics, and identification of immune selective anti-inflammatory agents of salivary origin. The traditional view of salivary glands as accessory digestive structures is changing as th...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-7-49
更新日期:2010-09-28 00:00:00
abstract:BACKGROUND:Genetic studies have pointed out that CD226 variants, encoding DNAM-1, could be associated with susceptibility to rheumatoid arthritis. Therefore, we aimed to determine the influence of DNAM-1 on the development of arthritis using the collagen-induced arthritis (CIA) mouse model. METHODS:CIA was induced in ...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-015-0056-5
更新日期:2015-02-08 00:00:00
abstract:Background:Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. Purpose of the study:We have previously reported that siRNA-silencing of CD40 (siCD40) reduced atherosclerosis (ATH) progression. H...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-019-0228-9
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms. METHODS:Rats were exposed to 50 mg/kg PQ by oral gavage, and treated with thalidomide through oral administration at 60 mg/kg once a day, ...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-015-0093-0
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple sclerosis agent, possesses anti-inflammatory, anti-oxidative and anti-angiogenic properties. Here, we...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-015-0094-z
更新日期:2015-08-06 00:00:00
abstract:: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-6-7
更新日期:2009-03-27 00:00:00
abstract:UNLABELLED: BACKGROUND:Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation of inflammatory activity and associated impaired pro...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-9-48
更新日期:2012-11-28 00:00:00
abstract::Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular radiation-dependent re...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-015-0058-3
更新日期:2015-02-18 00:00:00
abstract::Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a well-established microarray to analyze differences between LPS-stimulated human cord blood and adult monocytes...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-4-4
更新日期:2007-02-16 00:00:00
abstract:: Tumor necrosis factor alpha (TNF-alpha)is a host inflammatory factor. Bacteria increase TNF-alpha expression in a variety of human diseases including infectious diseases, inflammatory bowel diseases, and cancer. It is unknown, however, how TNF-alpha directly modulates bacterial protein expression during intestinal in...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-7-42
更新日期:2010-08-12 00:00:00
abstract:BACKGROUND:BMP4, a member of the transforming growth factor-beta superfamily, is upregulated in the aortas of diabetic db/db mice. However, little is known about its role in diabetic atherosclerosis. Therefore, we examined the roles of BMP4 in the formation of diabetic atherosclerosis in apolipoprotein E knockout (ApoE...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-10-32
更新日期:2013-10-09 00:00:00
abstract::Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats...
journal_title:Journal of inflammation (London, England)
pub_type: 社论
doi:10.1186/s12950-019-0225-z
更新日期:2019-10-11 00:00:00
abstract:BACKGROUND:Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the ...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/s12950-016-0139-y
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril is able to attenuate the cardiac inflammatory process associated with arterial hypertension. METHODS:Left ventricle mR...
journal_title:Journal of inflammation (London, England)
pub_type: 杂志文章
doi:10.1186/1476-9255-7-21
更新日期:2010-05-12 00:00:00