当前位置： SCI文献检索 > Journal of Inflammation-London期刊下所有文献 > Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation.

Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation.

Abstract：

BACKGROUND:PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T cells derived from PTPH1-KO mice. The aim of the present study is to characterize PTPH1 phenotype in two in vivo inflammatory models and to give insights in possible PTPH1 functions in cytokine release. METHODS:We challenged PTPH1-KO mice with two potent immunomodulatory molecules, carrageenan and LPS, in order to determine PTPH1 possible role in inflammatory response in vivo. Cytokine release, inflammatory pain and gene expression were investigated in challenged PTPH1-WT and KO mice. RESULTS:The present study shows that carrageenan induces a trend of slightly increased spontaneous pain sensitivity in PTPH1-KO mice compared to WT (wild-type) littermates, but no differences in cytokine release, induced pain perception and cellular infiltration have been detected between the two genotypes in this mouse model. On the other hand, LPS-induced TNFalpha, MCP-1 and IL10 release was significantly reduced in PTPH1-KO plasma compared to WTs 30 and 60 minutes post challenge. No cytokine release modulation was detectable 180 minutes post LPS challenge. CONCLUSION:In conclusion, the present study points out a slight potential role for PTPH1 in spontaneous pain sensitivity and it indicates that this phosphatase might play a role in the positive regulation of the LPS-induced cytokines release in vivo, in contrast to previous reports indicating PTPH1 as potential negative regulator of immune response.

journal_name

J Inflamm (Lond)

journal_title

Journal of inflammation (London, England)

authors

Patrignani C,Lafont DT,Muzio V,Gréco B,Hooft van Huijsduijnen R,Zaratin PF

doi

10.1186/1476-9255-7-16

subject

Has Abstract

pub_date

2010-03-30 00:00:00

pages

16

issn

1476-9255

pii

1476-9255-7-16

journal_volume

7

pub_type

杂志文章

相关文献

Journal of Inflammation-London文献大全
  • Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations.

    abstract：BACKGROUND:Heat shock protein 90 (Hsp90), a chaperone that regulates activity of many client proteins responsible for cellular growth, differentiation, and apoptosis, has been proposed as an important clinical and preclinical therapeutic target in a number of malignancies and autoimmune diseases, respectively. In this ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-10

    authors： Tukaj S,Zillikens D,Kasperkiewicz M

    更新日期：2014-04-02 00:00:00

  • MicroRNAs differentially expressed in Behçet disease are involved in interleukin-6 production.

    abstract：BACKGROUND:Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNA...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0130-7

    authors： Woo MY,Yun SJ,Cho O,Kim K,Lee ES,Park S

    更新日期：2016-07-19 00:00:00

  • Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells.

    abstract：BACKGROUND:NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regene...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-020-00267-z

    authors： Kohno K,Koya-Miyata S,Harashima A,Tsukuda T,Katakami M,Ariyasu T,Ushio S,Iwaki K

    更新日期：2021-01-07 00:00:00

  • Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages.

    abstract：BACKGROUND:Nuclear factor kappa B (NF-kappaB) has been shown to play an important role in regulating the expression of many genes involved in cell survival, immunity and in the inflammatory processes. NF-kappaB activation upregulates inducible nitric oxide synthase leading to enhanced nitric oxide production during an ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-23

    authors： Jones E,Adcock IM,Ahmed BY,Punchard NA

    更新日期：2007-11-24 00:00:00

  • Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women.

    abstract：BACKGROUND:Circulating 25 hydroxyvitamin D (25 (OH)D), an accurate measure of vitamin D status, is markedly greater in individuals with increased exposure to ultraviolet B (UVB) light via sunlight or the use of artificial UV light. Aside from the known relationship between vitamin D and bone, vitamin D has also been im...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-5-10

    authors： Peterson CA,Heffernan ME

    更新日期：2008-07-24 00:00:00

  • CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients.

    abstract：Background:Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clin...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-018-0186-7

    authors： Patry C,Stamm D,Betzen C,Tönshoff B,Yard BA,Beck GC,Rafat N

    更新日期：2018-05-16 00:00:00

  • Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.

    abstract：BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-017-0162-7

    authors： Yin H,Song S,Pan X

    更新日期：2017-08-09 00:00:00

  • Cancer, inflammation and the AT1 and AT2 receptors.

    abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-1-3

    authors： Smith GR,Missailidis S

    更新日期：2004-09-30 00:00:00

  • Simvastatin protects bladder and renal functions following spinal cord injury in rats.

    abstract：BACKGROUND:Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury (SCI) in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore, in experimental models the effects of SCI therapy on bladder and ren...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-17

    authors： Shunmugavel A,Khan M,Te Chou PC,Dhindsa RK,Martin MM,Copay AG,Subach BR,Schuler TC,Bilgen M,Orak JK,Singh I

    更新日期：2010-04-19 00:00:00

  • Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB.

    abstract：BACKGROUND:Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril is able to attenuate the cardiac inflammatory process associated with arterial hypertension. METHODS:Left ventricle mR...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-21

    authors： Miguel-Carrasco JL,Zambrano S,Blanca AJ,Mate A,Vázquez CM

    更新日期：2010-05-12 00:00:00

  • A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage.

    abstract：BACKGROUND:Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery. CPB is however associated with a strong induction of systemic inflammatory response syndrome (SIRS) which in conjunction with ischemia and reperfusion may lead to multiple organ failure. The aim of the study was to establish and ch...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-014-0026-3

    authors： Engels M,Bilgic E,Pinto A,Vasquez E,Wollschläger L,Steinbrenner H,Kellermann K,Akhyari P,Lichtenberg A,Boeken U

    更新日期：2014-08-12 00:00:00

  • WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells.

    abstract：BACKGROUND:Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained unclear. Recently, we showed that Wnt5A affects barrier function in ...

    journal_title：Journal of inflammation (London, England)

    pub_type：

    doi：10.1186/s12950-017-0157-4

    authors： Skaria T,Bachli E,Schoedon G

    更新日期：2017-05-19 00:00:00

  • The inflammatory cytokine tumor necrosis factor modulates the expression of Salmonella typhimurium effector proteins.

    abstract：: Tumor necrosis factor alpha (TNF-alpha)is a host inflammatory factor. Bacteria increase TNF-alpha expression in a variety of human diseases including infectious diseases, inflammatory bowel diseases, and cancer. It is unknown, however, how TNF-alpha directly modulates bacterial protein expression during intestinal in...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-42

    authors： Ma J,Zhang YG,Xia Y,Sun J

    更新日期：2010-08-12 00:00:00

  • A dynamic model of gene expression in monocytes reveals differences in immediate/early response genes between adult and neonatal cells.

    abstract：:Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a well-established microarray to analyze differences between LPS-stimulated human cord blood and adult monocytes...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-4

    authors： Lawrence S,Tang Y,Frank MB,Dozmorov I,Jiang K,Chen Y,Cadwell C,Turner S,Centola M,Jarvis JN

    更新日期：2007-02-16 00:00:00

  • Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model.

    abstract：Background:Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for its strong immunoregulatory and anti-inflammatory abilities. However, whether and how IL-10 protects...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-018-0180-0

    authors： Lin R,Chen F,Wen S,Teng T,Pan Y,Huang H

    更新日期：2018-02-27 00:00:00

  • Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome.

    abstract：Background:The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was to investigate the corpus cavernosum smooth muscle cell function and phenotype transformation in Ex...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-019-0233-z

    authors： Wang GC,Huang TR,Hu YY,Wang KY,Shi H,Yin L,Peng B

    更新日期：2020-01-06 00:00:00

  • Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns.

    abstract：BACKGROUND:Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial c...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-20

    authors： Mai K,Chui JJ,Di Girolamo N,McCluskey PJ,Wakefield D

    更新日期：2014-07-16 00:00:00

  • Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.

    abstract：:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-4

    authors： Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

    更新日期：2013-01-31 00:00:00

  • Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity.

    abstract：BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-020-00265-1

    authors： Cui F,Guo J,Hu HF,Zhang Y,Shi M

    更新日期：2020-11-07 00:00:00

  • Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production.

    abstract：BACKGROUND:Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects. OBJECTIVE:A study was conducted to establish ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-6

    authors： Dixit VD,Yang H,Sayeed KS,Stote KS,Rumpler WV,Baer DJ,Longo DL,Mattson MP,Taub DD

    更新日期：2011-03-07 00:00:00

  • Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin.

    abstract：:Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells. It was tested whether PR-39 affects human neutrophil m...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-3-14

    authors： Djanani A,Mosheimer B,Kaneider NC,Ross CR,Ricevuti G,Patsch JR,Wiedermann CJ

    更新日期：2006-11-02 00:00:00

  • Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway.

    abstract：:Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats...

    journal_title：Journal of inflammation (London, England)

    pub_type： 社论

    doi：10.1186/s12950-019-0225-z

    authors： Wang L,Feng L,Zhang J

    更新日期：2019-10-11 00:00:00

  • Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis.

    abstract：BACKGROUND:Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs have the potential to undergo chondrogenesis, but for yet...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0120-9

    authors： Fichadiya A,Bertram KL,Ren G,Yates RM,Krawetz RJ

    更新日期：2016-04-06 00:00:00

  • Accelerated wound healing phenotype in Interleukin 12/23 deficient mice.

    abstract：BACKGROUND:The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present study explored the effect of abrogation of the p40 subunit, which...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-39

    authors： Matias MA,Saunus JM,Ivanovski S,Walsh LJ,Farah CS

    更新日期：2011-12-20 00:00:00

  • Regulation of IkappaBalpha expression involves both NF-kappaB and the MAP kinase signaling pathways.

    abstract：:IkappaBalpha is an inhibitor of the nuclear transcription factor NF-kappaB. Binding of IkappaBalpha to NF-kappaB inactivates the transcriptional activity of NF-kappaB. Expression of IkappaBalpha itself is regulated by NF-kappaB, which provides auto-regulation of this signaling pathway. Here we present a mouse model fo...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-2-10

    authors： Zhang N,Ahsan MH,Zhu L,Sambucetti LC,Purchio AF,West DB

    更新日期：2005-10-05 00:00:00

  • Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70.

    abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has been attributed to abnormal apoptosis. While not comprehensively investigated, perturbations in peripheral blood lymphocyte (PBL) apoptosis may also be...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-30

    authors： Moodley D,Mody GM,Chuturgoon AA

    更新日期：2011-11-03 00:00:00

  • Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factor.

    abstract：BACKGROUND:The pleiotropic protein MIF, (macrophage migration inhibitory factor), has been demonstrated to modulate several key proteins governing cell cycle control and is considered to contribute to cell growth and differentiation. In this study we investigated the effect of MIF on the expression and cellular distrib...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-24

    authors： Taranto E,Xue JR,Morand EF,Leech M

    更新日期：2009-08-24 00:00:00

  • Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment.

    abstract：BACKGROUND:Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid abnormal cannabidiol (Abn-CBD) on wound healing, inflammatory cell recruitment and colitis in mice....

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0129-0

    authors： Krohn RM,Parsons SA,Fichna J,Patel KD,Yates RM,Sharkey KA,Storr MA

    更新日期：2016-07-14 00:00:00

  • JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin.

    abstract：BACKGROUND:Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee venom) have anti-inflammatory effect by reacting with the sulfhydryl group of p50 of nuclear factor-ka...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-5-7

    authors： Park HJ,Lee HJ,Choi MS,Son DJ,Song HS,Song MJ,Lee JM,Han SB,Kim Y,Hong JT

    更新日期：2008-05-29 00:00:00

  • Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function.

    abstract：BACKGROUND:The key co-repressor complex components HDAC-2, Mi-2alpha/beta and mSin3a are all critical to the regulation of gene transcription. HDAC-2 function is impaired by oxidative stress in a PI3Kdelta dependant manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lungs of COPD...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-33

    authors： Marwick JA,Stevenson CS,Chung KF,Adcock IM,Kirkham PA

    更新日期：2010-07-16 00:00:00