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Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway.

Abstract：

:Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups were sacrificed, they were in different weeks of age. If the rats in the control group were compared to the rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups respectively, the results may be biased due to differences in the week age of the rats. We believe that addressing this issue could further increase the value of their study.

journal_name

J Inflamm (Lond)

journal_title

Journal of inflammation (London, England)

authors

Wang L,Feng L,Zhang J

doi

10.1186/s12950-019-0225-z

subject

Has Abstract

pub_date

2019-10-11 00:00:00

pages

21

issn

1476-9255

pii

225

journal_volume

16

pub_type

社论

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