当前位置： SCI文献检索 > Journal of Inflammation-London期刊下所有文献 > Defining human mesenchymal stem cell efficacy in vivo.

Defining human mesenchymal stem cell efficacy in vivo.

Abstract：

: Allogeneic human mesenchymal stem cells (hMSCs) can suppress graft versus host disease (GvHD) and have profound anti-inflammatory and regenerative capacity in stroke, infarct, spinal cord injury, meniscus regeneration, tendinitis, acute renal failure, and heart disease in human and animal models of disease. There is significant clinical hMSC variability in efficacy and the ultimate response in vivo. The challenge in hMSC based therapy is defining the efficacy of hMSC in vivo. Models which may provide insight into hMSC bioactivity in vivo would provide a means to distinguish hMSCs for clinical utility. hMSC function has been described as both regenerative and trophic through the production of bioactive factors. The regenerative component involves the multi-potentiality of hMSC progenitor differentiation. The secreted factors generated by the hMSCs are milieu and injury specific providing unique niches for responses in vivo. These bioactive factors are anti-scarring, angiogenic, anti-apoptotic as well as regenerative. Further, from an immunological standpoint, hMSC's can avoid host immune response, providing xenographic applications. To study the in vivo immuno-regulatory effectiveness of hMSCs, we used the ovalbumin challenge model of acute asthma. This is a quick 3 week in vivo pulmonary inflammation model with readily accessible ways of measuring effectiveness of hMSCs. Our data show that there is a direct correlation between the traditional ceramic cube score to hMSCs attenuation of cellular recruitment due to ovalbumin challenge. The results from these studies verify the in vivo immuno-modulator effectiveness of hMSCs and support the potential use of the ovalbumin model as an in vivo model of hMSC potency and efficacy. Our data also support future directions toward exploring hMSCs as an alternative therapeutic for the treatment of airway inflammation associated with asthma.

journal_name

J Inflamm (Lond)

journal_title

Journal of inflammation (London, England)

authors

Bonfield TL,Nolan Koloze MT,Lennon DP,Caplan AI

doi

10.1186/1476-9255-7-51

subject

Has Abstract

pub_date

2010-10-25 00:00:00

pages

51

issn

1476-9255

pii

1476-9255-7-51

journal_volume

7

pub_type

杂志文章

相关文献

Journal of Inflammation-London文献大全
  • Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids.

    abstract：: Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) a...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-15

    authors： Rackova L,Oblozinsky M,Kostalova D,Kettmann V,Bezakova L

    更新日期：2007-07-16 00:00:00

  • Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway.

    abstract：:Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats...

    journal_title：Journal of inflammation (London, England)

    pub_type： 社论

    doi：10.1186/s12950-019-0225-z

    authors： Wang L,Feng L,Zhang J

    更新日期：2019-10-11 00:00:00

  • Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis.

    abstract：BACKGROUND:Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs have the potential to undergo chondrogenesis, but for yet...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0120-9

    authors： Fichadiya A,Bertram KL,Ren G,Yates RM,Krawetz RJ

    更新日期：2016-04-06 00:00:00

  • Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome.

    abstract：:Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/s12950-017-0174-3

    authors： Shih KC,Lun CN,Jhanji V,Thong BY,Tong L

    更新日期：2017-11-21 00:00:00

  • Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factor.

    abstract：BACKGROUND:The pleiotropic protein MIF, (macrophage migration inhibitory factor), has been demonstrated to modulate several key proteins governing cell cycle control and is considered to contribute to cell growth and differentiation. In this study we investigated the effect of MIF on the expression and cellular distrib...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-24

    authors： Taranto E,Xue JR,Morand EF,Leech M

    更新日期：2009-08-24 00:00:00

  • Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages.

    abstract：BACKGROUND:Nuclear factor kappa B (NF-kappaB) has been shown to play an important role in regulating the expression of many genes involved in cell survival, immunity and in the inflammatory processes. NF-kappaB activation upregulates inducible nitric oxide synthase leading to enhanced nitric oxide production during an ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-23

    authors： Jones E,Adcock IM,Ahmed BY,Punchard NA

    更新日期：2007-11-24 00:00:00

  • Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK.

    abstract：BACKGROUND:Homocysteine (Hcy) and inflammatory cytokines have been linked to adverse outcomes in persons with cardiovascular and kidney diseases and recent reports suggest that cytokine-mediated inflammatory infiltrates may be an important contributor to the pathogenesis the aforementioned diseases. Although some repor...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-27

    authors： Shastry S,James LR

    更新日期：2009-09-26 00:00:00

  • Simvastatin protects bladder and renal functions following spinal cord injury in rats.

    abstract：BACKGROUND:Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury (SCI) in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore, in experimental models the effects of SCI therapy on bladder and ren...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-17

    authors： Shunmugavel A,Khan M,Te Chou PC,Dhindsa RK,Martin MM,Copay AG,Subach BR,Schuler TC,Bilgen M,Orak JK,Singh I

    更新日期：2010-04-19 00:00:00

  • WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells.

    abstract：BACKGROUND:Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained unclear. Recently, we showed that Wnt5A affects barrier function in ...

    journal_title：Journal of inflammation (London, England)

    pub_type：

    doi：10.1186/s12950-017-0157-4

    authors： Skaria T,Bachli E,Schoedon G

    更新日期：2017-05-19 00:00:00

  • Chondroprotective effect of high-molecular-weight hyaluronic acid on osteoarthritic chondrocytes in a co-cultivation inflammation model with M1 macrophages.

    abstract：BACKGROUND:Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0139-y

    authors： Bauer C,Niculescu-Morzsa E,Jeyakumar V,Kern D,Späth SS,Nehrer S

    更新日期：2016-09-13 00:00:00

  • Portrait of inflammatory response to ionizing radiation treatment.

    abstract：:Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular radiation-dependent re...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-015-0058-3

    authors： Di Maggio FM,Minafra L,Forte GI,Cammarata FP,Lio D,Messa C,Gilardi MC,Bravatà V

    更新日期：2015-02-18 00:00:00

  • Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.

    abstract：BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-017-0162-7

    authors： Yin H,Song S,Pan X

    更新日期：2017-08-09 00:00:00

  • CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients.

    abstract：Background:Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clin...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-018-0186-7

    authors： Patry C,Stamm D,Betzen C,Tönshoff B,Yard BA,Beck GC,Rafat N

    更新日期：2018-05-16 00:00:00

  • Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin.

    abstract：:Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells. It was tested whether PR-39 affects human neutrophil m...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-3-14

    authors： Djanani A,Mosheimer B,Kaneider NC,Ross CR,Ricevuti G,Patsch JR,Wiedermann CJ

    更新日期：2006-11-02 00:00:00

  • Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells.

    abstract：BACKGROUND:NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regene...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-020-00267-z

    authors： Kohno K,Koya-Miyata S,Harashima A,Tsukuda T,Katakami M,Ariyasu T,Ushio S,Iwaki K

    更新日期：2021-01-07 00:00:00

  • Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.

    abstract：:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-4

    authors： Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

    更新日期：2013-01-31 00:00:00

  • Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation.

    abstract：BACKGROUND:PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T cells derived from PTPH1-...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-16

    authors： Patrignani C,Lafont DT,Muzio V,Gréco B,Hooft van Huijsduijnen R,Zaratin PF

    更新日期：2010-03-30 00:00:00

  • Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity.

    abstract：BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-020-00265-1

    authors： Cui F,Guo J,Hu HF,Zhang Y,Shi M

    更新日期：2020-11-07 00:00:00

  • Cancer, inflammation and the AT1 and AT2 receptors.

    abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-1-3

    authors： Smith GR,Missailidis S

    更新日期：2004-09-30 00:00:00

  • Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers.

    abstract：BACKGROUND:Monocytes and neutrophils are examples of phagocytic leukocytes, with neutrophils being considered as the 'chief' phagocytic leukocyte. Both monocytes and neutrophils have been implicated to play a key role in the development of ischaemia-reperfusion injury, where they are intrinsically involved in leukocyte...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-12

    authors： Hughes SF,Hendricks BD,Edwards DR,Bastawrous SS,Roberts GE,Middleton JF

    更新日期：2007-05-30 00:00:00

  • Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function.

    abstract：BACKGROUND:The key co-repressor complex components HDAC-2, Mi-2alpha/beta and mSin3a are all critical to the regulation of gene transcription. HDAC-2 function is impaired by oxidative stress in a PI3Kdelta dependant manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lungs of COPD...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-33

    authors： Marwick JA,Stevenson CS,Chung KF,Adcock IM,Kirkham PA

    更新日期：2010-07-16 00:00:00

  • Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation.

    abstract：UNLABELLED: BACKGROUND:Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation of inflammatory activity and associated impaired pro...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-9-48

    authors： Ahmad R,Al-Mass A,Atizado V,Al-Hubail A,Al-Ghimlas F,Al-Arouj M,Bennakhi A,Dermime S,Behbehani K

    更新日期：2012-11-28 00:00:00

  • CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis.

    abstract：BACKGROUND:CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease. METHODS:Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharmacodynamic consequence...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-32

    authors： Wang Y,Cui L,Gonsiorek W,Min SH,Anilkumar G,Rosenblum S,Kozlowski J,Lundell D,Fine JS,Grant EP

    更新日期：2009-11-11 00:00:00

  • Post heat shock tolerance: a neuroimmunological anti-inflammatory phenomenon.

    abstract：: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-7

    authors： Shahabi S,Hassan ZM,Jazani NH

    更新日期：2009-03-27 00:00:00

  • Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol).

    abstract：:French maritime pine bark extract (Pycnogenol) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven heal...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-3-1

    authors： Grimm T,Chovanová Z,Muchová J,Sumegová K,Liptáková A,Duracková Z,Högger P

    更新日期：2006-01-27 00:00:00

  • Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.

    abstract：BACKGROUND:The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evalu...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-16

    authors： Miller MJ,Bobrowski P,Shukla M,Gupta K,Haqqi TM

    更新日期：2007-08-14 00:00:00

  • TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice.

    abstract：BACKGROUND:Airway inflammation and asthma have been linked to oxidative stress and the melastatin-related transient receptor potential cation channel, member 2 (TRPM2), which can be activated by reactive oxygen species (ROS), has emerged as a potential therapeutic target for inflammatory diseases. OBJECTIVE:Using TRPM...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-19

    authors： Sumoza-Toledo A,Fleig A,Penner R

    更新日期：2013-05-01 00:00:00

  • Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts.

    abstract：BACKGROUND:Salivary histatins are bioactive peptides related to the innate immune system associated with antimicrobial activities. However, very little is known about the physiological and biological functions of histatins against host cells or their role in oral cell inflammation. Histatin 3 binds to heat shock cognat...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-4

    authors： Imamura Y,Wang PL

    更新日期：2014-02-04 00:00:00

  • Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women.

    abstract：BACKGROUND:Circulating 25 hydroxyvitamin D (25 (OH)D), an accurate measure of vitamin D status, is markedly greater in individuals with increased exposure to ultraviolet B (UVB) light via sunlight or the use of artificial UV light. Aside from the known relationship between vitamin D and bone, vitamin D has also been im...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-5-10

    authors： Peterson CA,Heffernan ME

    更新日期：2008-07-24 00:00:00

  • Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis.

    abstract：: Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-10

    authors： Liang B,Song Z,Wu B,Gardner D,Shealy D,Song XY,Wooley PH

    更新日期：2009-04-15 00:00:00