Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.

abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

journal_title：Journal of inflammation (London, England)

authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

更新日期：2010-07-26 00:00:00

abstract：BACKGROUND:Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders....

journal_title：Journal of inflammation (London, England)

authors： Grzanka A,Machura E,Mazur B,Misiolek M,Jochem J,Kasperski J,Kasperska-Zajac A

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:The effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro. METHODS:In vivo studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs. Exudate volu...

journal_title：Journal of inflammation (London, England)

authors： Garbacki N,Kinet M,Nusgens B,Desmecht D,Damas J

更新日期：2005-08-09 00:00:00

abstract：Background:Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clin...

journal_title：Journal of inflammation (London, England)

authors： Patry C,Stamm D,Betzen C,Tönshoff B,Yard BA,Beck GC,Rafat N

更新日期：2018-05-16 00:00:00

abstract：:Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells. It was tested whether PR-39 affects human neutrophil m...

journal_title：Journal of inflammation (London, England)

authors： Djanani A,Mosheimer B,Kaneider NC,Ross CR,Ricevuti G,Patsch JR,Wiedermann CJ

更新日期：2006-11-02 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonar...

journal_title：Journal of inflammation (London, England)

authors： Arunachalam G,Sundar IK,Hwang JW,Yao H,Rahman I

更新日期：2010-07-22 00:00:00

abstract：BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...

journal_title：Journal of inflammation (London, England)

authors： Yin H,Song S,Pan X

更新日期：2017-08-09 00:00:00

abstract：:Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detec...

journal_title：Journal of inflammation (London, England)

authors： Hassanpour M,Rahbarghazi R,Nouri M,Aghamohammadzadeh N,Safaei N,Ahmadi M

更新日期：2019-05-02 00:00:00

abstract：BACKGROUND:PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T cells derived from PTPH1-...

journal_title：Journal of inflammation (London, England)

authors： Patrignani C,Lafont DT,Muzio V,Gréco B,Hooft van Huijsduijnen R,Zaratin PF

更新日期：2010-03-30 00:00:00

abstract：Background:Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. Purpose of the study:We have previously reported that siRNA-silencing of CD40 (siCD40) reduced atherosclerosis (ATH) progression. H...

journal_title：Journal of inflammation (London, England)

authors： Hueso M,Casas A,Mallén A,de Ramón L,Bolaños N,Varela C,Cruzado JM,Torras J,Navarro E

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evalu...

journal_title：Journal of inflammation (London, England)

authors： Miller MJ,Bobrowski P,Shukla M,Gupta K,Haqqi TM

更新日期：2007-08-14 00:00:00

abstract：BACKGROUND:This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms. METHODS:Rats were exposed to 50 mg/kg PQ by oral gavage, and treated with thalidomide through oral administration at 60 mg/kg once a day, ...

journal_title：Journal of inflammation (London, England)

authors： Li D,Zhang XW,Jiang XQ,Yin YJ,Fan Z,Sun CB,Chen XH,Li YH,Liu KX

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial c...

journal_title：Journal of inflammation (London, England)

authors： Mai K,Chui JJ,Di Girolamo N,McCluskey PJ,Wakefield D

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease. METHODS:Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharmacodynamic consequence...

journal_title：Journal of inflammation (London, England)

authors： Wang Y,Cui L,Gonsiorek W,Min SH,Anilkumar G,Rosenblum S,Kozlowski J,Lundell D,Fine JS,Grant EP

更新日期：2009-11-11 00:00:00

abstract：: Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-...

journal_title：Journal of inflammation (London, England)

authors： Liang B,Song Z,Wu B,Gardner D,Shealy D,Song XY,Wooley PH

更新日期：2009-04-15 00:00:00

abstract：: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...

journal_title：Journal of inflammation (London, England)

authors： Shahabi S,Hassan ZM,Jazani NH

更新日期：2009-03-27 00:00:00

abstract：:Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a well-established microarray to analyze differences between LPS-stimulated human cord blood and adult monocytes...

journal_title：Journal of inflammation (London, England)

authors： Lawrence S,Tang Y,Frank MB,Dozmorov I,Jiang K,Chen Y,Cadwell C,Turner S,Centola M,Jarvis JN

更新日期：2007-02-16 00:00:00

abstract：: Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) a...

journal_title：Journal of inflammation (London, England)

authors： Rackova L,Oblozinsky M,Kostalova D,Kettmann V,Bezakova L

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. METHODS:German landrace pigs under...

journal_title：Journal of inflammation (London, England)

authors： Abdel-Rahman U,Margraf S,Aybek T,Lögters T,Bitu-Moreno J,Francischetti I,Kranert T,Grünwald F,Windolf J,Moritz A,Scholz M

更新日期：2007-10-10 00:00:00

abstract：BACKGROUND:Airway inflammation and asthma have been linked to oxidative stress and the melastatin-related transient receptor potential cation channel, member 2 (TRPM2), which can be activated by reactive oxygen species (ROS), has emerged as a potential therapeutic target for inflammatory diseases. OBJECTIVE:Using TRPM...

journal_title：Journal of inflammation (London, England)

authors： Sumoza-Toledo A,Fleig A,Penner R

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) and inflammatory cytokines have been linked to adverse outcomes in persons with cardiovascular and kidney diseases and recent reports suggest that cytokine-mediated inflammatory infiltrates may be an important contributor to the pathogenesis the aforementioned diseases. Although some repor...

journal_title：Journal of inflammation (London, England)

authors： Shastry S,James LR

更新日期：2009-09-26 00:00:00

abstract：BACKGROUND:Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury (SCI) in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore, in experimental models the effects of SCI therapy on bladder and ren...

journal_title：Journal of inflammation (London, England)

authors： Shunmugavel A,Khan M,Te Chou PC,Dhindsa RK,Martin MM,Copay AG,Subach BR,Schuler TC,Bilgen M,Orak JK,Singh I

更新日期：2010-04-19 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functionality of TLRs in human corneal epithelial cells (HCE) and in conjunctival fibroblasts (HCF). METHO...

journal_title：Journal of inflammation (London, England)

authors： Erdinest N,Aviel G,Moallem E,Anteby I,Yahalom C,Mechoulam H,Ovadia H,Solomon A

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee venom) have anti-inflammatory effect by reacting with the sulfhydryl group of p50 of nuclear factor-ka...

journal_title：Journal of inflammation (London, England)

authors： Park HJ,Lee HJ,Choi MS,Son DJ,Song HS,Song MJ,Lee JM,Han SB,Kim Y,Hong JT

更新日期：2008-05-29 00:00:00

abstract：BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...

journal_title：Journal of inflammation (London, England)

authors： Van Welden S,Laukens D,Ferdinande L,De Vos M,Hindryckx P

更新日期：2013-11-20 00:00:00

abstract：Background:The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was to investigate the corpus cavernosum smooth muscle cell function and phenotype transformation in Ex...

journal_title：Journal of inflammation (London, England)

authors： Wang GC,Huang TR,Hu YY,Wang KY,Shi H,Yin L,Peng B

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Salivary histatins are bioactive peptides related to the innate immune system associated with antimicrobial activities. However, very little is known about the physiological and biological functions of histatins against host cells or their role in oral cell inflammation. Histatin 3 binds to heat shock cognat...

journal_title：Journal of inflammation (London, England)

authors： Imamura Y,Wang PL

更新日期：2014-02-04 00:00:00

abstract：:Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular radiation-dependent re...

journal_title：Journal of inflammation (London, England)

authors： Di Maggio FM,Minafra L,Forte GI,Cammarata FP,Lio D,Messa C,Gilardi MC,Bravatà V

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regene...

journal_title：Journal of inflammation (London, England)

authors： Kohno K,Koya-Miyata S,Harashima A,Tsukuda T,Katakami M,Ariyasu T,Ushio S,Iwaki K

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development ...

journal_title：Journal of inflammation (London, England)

authors： Schneider S,Hoppmann P,Koch W,Kemmner S,Schmaderer C,Renders L,Kastrati A,Laugwitz KL,Heemann U,Baumann M

更新日期：2015-10-01 00:00:00