Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model.

abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

journal_title：Journal of inflammation (London, England)

authors： Smith GR,Missailidis S

更新日期：2004-09-30 00:00:00

abstract：BACKGROUND:Circulating 25 hydroxyvitamin D (25 (OH)D), an accurate measure of vitamin D status, is markedly greater in individuals with increased exposure to ultraviolet B (UVB) light via sunlight or the use of artificial UV light. Aside from the known relationship between vitamin D and bone, vitamin D has also been im...

journal_title：Journal of inflammation (London, England)

authors： Peterson CA,Heffernan ME

更新日期：2008-07-24 00:00:00

abstract：:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

journal_title：Journal of inflammation (London, England)

authors： Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNA...

journal_title：Journal of inflammation (London, England)

authors： Woo MY,Yun SJ,Cho O,Kim K,Lee ES,Park S

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Salivary histatins are bioactive peptides related to the innate immune system associated with antimicrobial activities. However, very little is known about the physiological and biological functions of histatins against host cells or their role in oral cell inflammation. Histatin 3 binds to heat shock cognat...

journal_title：Journal of inflammation (London, England)

authors： Imamura Y,Wang PL

更新日期：2014-02-04 00:00:00

abstract：:Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular radiation-dependent re...

journal_title：Journal of inflammation (London, England)

authors： Di Maggio FM,Minafra L,Forte GI,Cammarata FP,Lio D,Messa C,Gilardi MC,Bravatà V

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...

journal_title：Journal of inflammation (London, England)

authors： Van Welden S,Laukens D,Ferdinande L,De Vos M,Hindryckx P

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Milk-derived bioactive peptides retain many biological properties and have therapeutic effects in cardiovascular disorders such as atherosclerosis. Under inflammatory conditions the expression of endothelial cells adhesion molecules is induced, increasing monocyte adhesion to human vessel wall, a critical st...

journal_title：Journal of inflammation (London, England)

authors： Marcone S,Haughton K,Simpson PJ,Belton O,Fitzgerald DJ

更新日期：2015-01-20 00:00:00

abstract：: Allogeneic human mesenchymal stem cells (hMSCs) can suppress graft versus host disease (GvHD) and have profound anti-inflammatory and regenerative capacity in stroke, infarct, spinal cord injury, meniscus regeneration, tendinitis, acute renal failure, and heart disease in human and animal models of disease. There is ...

journal_title：Journal of inflammation (London, England)

authors： Bonfield TL,Nolan Koloze MT,Lennon DP,Caplan AI

更新日期：2010-10-25 00:00:00

abstract：BACKGROUND:Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic components triggered by pediatric obesity is a common but scarcely understood aspect of the disease. Per...

journal_title：Journal of inflammation (London, England)

authors： Vargas-Sánchez K,Vargas L,Urrutia Y,Beltrán I,Rossi AB,Lozano HY,Guarín J,Losada-Barragán M

更新日期：2020-10-31 00:00:00

abstract：BACKGROUND:Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved. METHODS:Patients aged 18 years or more with documented first time sepsis events were included ...

journal_title：Journal of inflammation (London, England)

authors： Jacobsson S,Larsson P,Johansson G,Norberg M,Wadell G,Hallmans G,Winsö O,Söderberg S

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation. METHODS:Pharmacological inhibitors were used to block PKC activity in neutrophils harvested f...

journal_title：Journal of inflammation (London, England)

authors： Gray RD,Lucas CD,MacKellar A,Li F,Hiersemenzel K,Haslett C,Davidson DJ,Rossi AG

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

journal_title：Journal of inflammation (London, England)

authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

更新日期：2010-07-26 00:00:00

abstract：BACKGROUND:Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial c...

journal_title：Journal of inflammation (London, England)

authors： Mai K,Chui JJ,Di Girolamo N,McCluskey PJ,Wakefield D

更新日期：2014-07-16 00:00:00

abstract：: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...

journal_title：Journal of inflammation (London, England)

authors： Shahabi S,Hassan ZM,Jazani NH

更新日期：2009-03-27 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the ...

journal_title：Journal of inflammation (London, England)

authors： Bauer C,Niculescu-Morzsa E,Jeyakumar V,Kern D,Späth SS,Nehrer S

更新日期：2016-09-13 00:00:00

abstract：BACKGROUND:Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple sclerosis agent, possesses anti-inflammatory, anti-oxidative and anti-angiogenic properties. Here, we...

journal_title：Journal of inflammation (London, England)

authors： Gerhardt S,König V,Doll M,Hailemariam-Jahn T,Hrgovic I,Zöller N,Kaufmann R,Kippenberger S,Meissner M

更新日期：2015-08-06 00:00:00

abstract：Background:Chronic kidney disease (CKD) is associated with endothelial dysfunctions thus prompting links between microcirculation (MC), inflammation and major cardiovascular risk factors. Purpose of the study:We have previously reported that siRNA-silencing of CD40 (siCD40) reduced atherosclerosis (ATH) progression. H...

journal_title：Journal of inflammation (London, England)

authors： Hueso M,Casas A,Mallén A,de Ramón L,Bolaños N,Varela C,Cruzado JM,Torras J,Navarro E

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. METHODS:German landrace pigs under...

journal_title：Journal of inflammation (London, England)

authors： Abdel-Rahman U,Margraf S,Aybek T,Lögters T,Bitu-Moreno J,Francischetti I,Kranert T,Grünwald F,Windolf J,Moritz A,Scholz M

更新日期：2007-10-10 00:00:00

abstract：BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...

journal_title：Journal of inflammation (London, England)

authors： Cui F,Guo J,Hu HF,Zhang Y,Shi M

更新日期：2020-11-07 00:00:00

abstract：BACKGROUND:124 triazolo [4, 3-a]18naphthyridine derivatives (including NF161 and NF177) were tested for anti-inflammatory, analgesic and antipyretic properties and for their effects on spontaneous locomotor activity in mice and acute gastrolesivity in rats. Both NF161 and NF177 appeared to be anti-inflammatory and anal...

journal_title：Journal of inflammation (London, England)

authors： Dianzani C,Collino M,Gallicchio M,Di Braccio M,Roma G,Fantozzi R

更新日期：2006-03-28 00:00:00

abstract：BACKGROUND:Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac surgery. CPB is however associated with a strong induction of systemic inflammatory response syndrome (SIRS) which in conjunction with ischemia and reperfusion may lead to multiple organ failure. The aim of the study was to establish and ch...

journal_title：Journal of inflammation (London, England)

authors： Engels M,Bilgic E,Pinto A,Vasquez E,Wollschläger L,Steinbrenner H,Kellermann K,Akhyari P,Lichtenberg A,Boeken U

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid abnormal cannabidiol (Abn-CBD) on wound healing, inflammatory cell recruitment and colitis in mice....

journal_title：Journal of inflammation (London, England)

authors： Krohn RM,Parsons SA,Fichna J,Patel KD,Yates RM,Sharkey KA,Storr MA

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders....

journal_title：Journal of inflammation (London, England)

authors： Grzanka A,Machura E,Mazur B,Misiolek M,Jochem J,Kasperski J,Kasperska-Zajac A

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:Little is known about the time-course of the postprandial appearance of macronutrient-induced inflammatory response. Our aim was to investigate the postprandial inflammatory and metabolic response following high fat, high caloric popular meals in apparently healthy participants. METHODS:Fifty four apparentl...

journal_title：Journal of inflammation (London, England)

authors： Raz O,Steinvil A,Berliner S,Rosenzweig T,Justo D,Shapira I

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:BMP4, a member of the transforming growth factor-beta superfamily, is upregulated in the aortas of diabetic db/db mice. However, little is known about its role in diabetic atherosclerosis. Therefore, we examined the roles of BMP4 in the formation of diabetic atherosclerosis in apolipoprotein E knockout (ApoE...

journal_title：Journal of inflammation (London, England)

authors： Koga M,Yamauchi A,Kanaoka Y,Jige R,Tsukamoto A,Teshima N,Nishioku T,Kataoka Y

更新日期：2013-10-09 00:00:00

abstract：:Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities...

journal_title：Journal of inflammation (London, England)

authors： Shih KC,Lun CN,Jhanji V,Thong BY,Tong L

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury (SCI) in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore, in experimental models the effects of SCI therapy on bladder and ren...

journal_title：Journal of inflammation (London, England)

authors： Shunmugavel A,Khan M,Te Chou PC,Dhindsa RK,Martin MM,Copay AG,Subach BR,Schuler TC,Bilgen M,Orak JK,Singh I

更新日期：2010-04-19 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functionality of TLRs in human corneal epithelial cells (HCE) and in conjunctival fibroblasts (HCF). METHO...

journal_title：Journal of inflammation (London, England)

authors： Erdinest N,Aviel G,Moallem E,Anteby I,Yahalom C,Mechoulam H,Ovadia H,Solomon A

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development ...

journal_title：Journal of inflammation (London, England)

authors： Schneider S,Hoppmann P,Koch W,Kemmner S,Schmaderer C,Renders L,Kastrati A,Laugwitz KL,Heemann U,Baumann M

更新日期：2015-10-01 00:00:00