当前位置： SCI文献检索 > Journal of Inflammation-London期刊下所有文献 > The effect of two iso-caloric meals containing equal amounts of fats with a different fat composition on the inflammatory and metabolic markers in apparently healthy volunteers.

The effect of two iso-caloric meals containing equal amounts of fats with a different fat composition on the inflammatory and metabolic markers in apparently healthy volunteers.

Abstract：

BACKGROUND:Little is known about the time-course of the postprandial appearance of macronutrient-induced inflammatory response. Our aim was to investigate the postprandial inflammatory and metabolic response following high fat, high caloric popular meals in apparently healthy participants. METHODS:Fifty four apparently healthy normal weight volunteers (BMI of 25.9±0.9) were given two iso-caloric meals with similar amounts but different composition of fats: a meal high in monounsaturated fats (MUFA), and a meal high in saturated fat (SFA). Three main effects and the interactions between them were analyzed: the time (before and 2 and 4 hours following the meals), the meal (MUFA or SFA) and the gender. RESULTS:The effect of time from the meal on hs-CRP level was highly significant (p=0.004). The highest responses were observed 2 hours after the meal (p=0.002). A statistically significant interaction was found between the time and the meal (p≤0.0001), which reflects the higher increase in hs-CRP values 2 hours after the SFA meal, with no effect by the MUFA meal. The white blood cell counts were affected significantly by the time (p≤0.0001) however, other inflammatory markers (fibrinogen, IL-6, TNFα, ICAM and VICAM) were not. All the metabolic markers (insulin, glucose, HOMA-R, QUICKI and triglycerides) were affected by the time (p≤0.0001), with no interactions observed. CONCLUSIONS:Metabolic and modest inflammatory changes occur within a few hours after the ingestion of a high SFA meal in apparently healthy adults.

journal_name

J Inflamm (Lond)

journal_title

Journal of inflammation (London, England)

authors

Raz O,Steinvil A,Berliner S,Rosenzweig T,Justo D,Shapira I

doi

10.1186/1476-9255-10-3

subject

Has Abstract

pub_date

2013-01-31 00:00:00

pages

3

issue

1

issn

1476-9255

pii

1476-9255-10-3

journal_volume

10

pub_type

杂志文章

相关文献

Journal of Inflammation-London文献大全
  • Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function.

    abstract：BACKGROUND:The key co-repressor complex components HDAC-2, Mi-2alpha/beta and mSin3a are all critical to the regulation of gene transcription. HDAC-2 function is impaired by oxidative stress in a PI3Kdelta dependant manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lungs of COPD...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-33

    authors： Marwick JA,Stevenson CS,Chung KF,Adcock IM,Kirkham PA

    更新日期：2010-07-16 00:00:00

  • Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway.

    abstract：:Qihong Que and colleagues found that liraglutide exhibited anti-inflammatory activity through the activation of the PKA/CREB pathway in an OA rat model. We believe there was a flaw in this research. In their first experiment, the sacrifice time of the 10 rats in the control group has not been stated. And when the rats...

    journal_title：Journal of inflammation (London, England)

    pub_type： 社论

    doi：10.1186/s12950-019-0225-z

    authors： Wang L,Feng L,Zhang J

    更新日期：2019-10-11 00:00:00

  • Dimethylfumarate protects against TNF-α-induced secretion of inflammatory cytokines in human endothelial cells.

    abstract：BACKGROUND:Inflammation, angiogenesis and oxidative stress have been implicated in the pathogenesis of various vascular diseases. Recent evidence suggests that dimethylfumarate (DMF), an antiposriatic and anti-multiple sclerosis agent, possesses anti-inflammatory, anti-oxidative and anti-angiogenic properties. Here, we...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-015-0094-z

    authors： Gerhardt S,König V,Doll M,Hailemariam-Jahn T,Hrgovic I,Zöller N,Kaufmann R,Kippenberger S,Meissner M

    更新日期：2015-08-06 00:00:00

  • Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.

    abstract：BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-017-0162-7

    authors： Yin H,Song S,Pan X

    更新日期：2017-08-09 00:00:00

  • Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production.

    abstract：BACKGROUND:Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects. OBJECTIVE:A study was conducted to establish ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-6

    authors： Dixit VD,Yang H,Sayeed KS,Stote KS,Rumpler WV,Baer DJ,Longo DL,Mattson MP,Taub DD

    更新日期：2011-03-07 00:00:00

  • Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations.

    abstract：BACKGROUND:Heat shock protein 90 (Hsp90), a chaperone that regulates activity of many client proteins responsible for cellular growth, differentiation, and apoptosis, has been proposed as an important clinical and preclinical therapeutic target in a number of malignancies and autoimmune diseases, respectively. In this ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-10

    authors： Tukaj S,Zillikens D,Kasperkiewicz M

    更新日期：2014-04-02 00:00:00

  • Portrait of inflammatory response to ionizing radiation treatment.

    abstract：:Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular radiation-dependent re...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-015-0058-3

    authors： Di Maggio FM,Minafra L,Forte GI,Cammarata FP,Lio D,Messa C,Gilardi MC,Bravatà V

    更新日期：2015-02-18 00:00:00

  • Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages.

    abstract：BACKGROUND:Nuclear factor kappa B (NF-kappaB) has been shown to play an important role in regulating the expression of many genes involved in cell survival, immunity and in the inflammatory processes. NF-kappaB activation upregulates inducible nitric oxide synthase leading to enhanced nitric oxide production during an ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-23

    authors： Jones E,Adcock IM,Ahmed BY,Punchard NA

    更新日期：2007-11-24 00:00:00

  • Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonar...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-34

    authors： Arunachalam G,Sundar IK,Hwang JW,Yao H,Rahman I

    更新日期：2010-07-22 00:00:00

  • Cancer, inflammation and the AT1 and AT2 receptors.

    abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-1-3

    authors： Smith GR,Missailidis S

    更新日期：2004-09-30 00:00:00

  • WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells.

    abstract：BACKGROUND:Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained unclear. Recently, we showed that Wnt5A affects barrier function in ...

    journal_title：Journal of inflammation (London, England)

    pub_type：

    doi：10.1186/s12950-017-0157-4

    authors： Skaria T,Bachli E,Schoedon G

    更新日期：2017-05-19 00:00:00

  • Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70.

    abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has been attributed to abnormal apoptosis. While not comprehensively investigated, perturbations in peripheral blood lymphocyte (PBL) apoptosis may also be...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-30

    authors： Moodley D,Mody GM,Chuturgoon AA

    更新日期：2011-11-03 00:00:00

  • Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis.

    abstract：BACKGROUND:Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs have the potential to undergo chondrogenesis, but for yet...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0120-9

    authors： Fichadiya A,Bertram KL,Ren G,Yates RM,Krawetz RJ

    更新日期：2016-04-06 00:00:00

  • JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin.

    abstract：BACKGROUND:Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee venom) have anti-inflammatory effect by reacting with the sulfhydryl group of p50 of nuclear factor-ka...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-5-7

    authors： Park HJ,Lee HJ,Choi MS,Son DJ,Song HS,Song MJ,Lee JM,Han SB,Kim Y,Hong JT

    更新日期：2008-05-29 00:00:00

  • Targeting CD226/DNAX accessory molecule-1 (DNAM-1) in collagen-induced arthritis mouse models.

    abstract：BACKGROUND:Genetic studies have pointed out that CD226 variants, encoding DNAM-1, could be associated with susceptibility to rheumatoid arthritis. Therefore, we aimed to determine the influence of DNAM-1 on the development of arthritis using the collagen-induced arthritis (CIA) mouse model. METHODS:CIA was induced in ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-015-0056-5

    authors： Elhai M,Chiocchia G,Marchiol C,Lager F,Renault G,Colonna M,Bernhardt G,Allanore Y,Avouac J

    更新日期：2015-02-08 00:00:00

  • Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns.

    abstract：BACKGROUND:Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial c...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-20

    authors： Mai K,Chui JJ,Di Girolamo N,McCluskey PJ,Wakefield D

    更新日期：2014-07-16 00:00:00

  • Post heat shock tolerance: a neuroimmunological anti-inflammatory phenomenon.

    abstract：: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-7

    authors： Shahabi S,Hassan ZM,Jazani NH

    更新日期：2009-03-27 00:00:00

  • Accelerated wound healing phenotype in Interleukin 12/23 deficient mice.

    abstract：BACKGROUND:The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present study explored the effect of abrogation of the p40 subunit, which...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-39

    authors： Matias MA,Saunus JM,Ivanovski S,Walsh LJ,Farah CS

    更新日期：2011-12-20 00:00:00

  • Chondroprotective effect of high-molecular-weight hyaluronic acid on osteoarthritic chondrocytes in a co-cultivation inflammation model with M1 macrophages.

    abstract：BACKGROUND:Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0139-y

    authors： Bauer C,Niculescu-Morzsa E,Jeyakumar V,Kern D,Späth SS,Nehrer S

    更新日期：2016-09-13 00:00:00

  • Waist circumference as the predominant contributor to the micro-inflammatory response in the metabolic syndrome: a cross sectional study.

    abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-35

    authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

    更新日期：2010-07-26 00:00:00

  • Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK.

    abstract：BACKGROUND:Homocysteine (Hcy) and inflammatory cytokines have been linked to adverse outcomes in persons with cardiovascular and kidney diseases and recent reports suggest that cytokine-mediated inflammatory infiltrates may be an important contributor to the pathogenesis the aforementioned diseases. Although some repor...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-27

    authors： Shastry S,James LR

    更新日期：2009-09-26 00:00:00

  • Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.

    abstract：:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-4

    authors： Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

    更新日期：2013-01-31 00:00:00

  • TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice.

    abstract：BACKGROUND:Airway inflammation and asthma have been linked to oxidative stress and the melastatin-related transient receptor potential cation channel, member 2 (TRPM2), which can be activated by reactive oxygen species (ROS), has emerged as a potential therapeutic target for inflammatory diseases. OBJECTIVE:Using TRPM...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-19

    authors： Sumoza-Toledo A,Fleig A,Penner R

    更新日期：2013-05-01 00:00:00

  • PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population.

    abstract：BACKGROUND:Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic components triggered by pediatric obesity is a common but scarcely understood aspect of the disease. Per...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-020-00264-2

    authors： Vargas-Sánchez K,Vargas L,Urrutia Y,Beltrán I,Rossi AB,Lozano HY,Guarín J,Losada-Barragán M

    更新日期：2020-10-31 00:00:00

  • Regulation of IkappaBalpha expression involves both NF-kappaB and the MAP kinase signaling pathways.

    abstract：:IkappaBalpha is an inhibitor of the nuclear transcription factor NF-kappaB. Binding of IkappaBalpha to NF-kappaB inactivates the transcriptional activity of NF-kappaB. Expression of IkappaBalpha itself is regulated by NF-kappaB, which provides auto-regulation of this signaling pathway. Here we present a mouse model fo...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-2-10

    authors： Zhang N,Ahsan MH,Zhu L,Sambucetti LC,Purchio AF,West DB

    更新日期：2005-10-05 00:00:00

  • Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity.

    abstract：BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-020-00265-1

    authors： Cui F,Guo J,Hu HF,Zhang Y,Shi M

    更新日期：2020-11-07 00:00:00

  • Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB.

    abstract：BACKGROUND:Milk-derived bioactive peptides retain many biological properties and have therapeutic effects in cardiovascular disorders such as atherosclerosis. Under inflammatory conditions the expression of endothelial cells adhesion molecules is induced, increasing monocyte adhesion to human vessel wall, a critical st...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-014-0044-1

    authors： Marcone S,Haughton K,Simpson PJ,Belton O,Fitzgerald DJ

    更新日期：2015-01-20 00:00:00

  • Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol).

    abstract：:French maritime pine bark extract (Pycnogenol) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven heal...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-3-1

    authors： Grimm T,Chovanová Z,Muchová J,Sumegová K,Liptáková A,Duracková Z,Högger P

    更新日期：2006-01-27 00:00:00

  • Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome.

    abstract：Background:The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was to investigate the corpus cavernosum smooth muscle cell function and phenotype transformation in Ex...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-019-0233-z

    authors： Wang GC,Huang TR,Hu YY,Wang KY,Shi H,Yin L,Peng B

    更新日期：2020-01-06 00:00:00

  • Role of autophagy in atherosclerosis: foe or friend?

    abstract：:Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detec...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/s12950-019-0212-4

    authors： Hassanpour M,Rahbarghazi R,Nouri M,Aghamohammadzadeh N,Safaei N,Ahmadi M

    更新日期：2019-05-02 00:00:00