当前位置： SCI文献检索 > Journal of Inflammation-London期刊下所有文献 > Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1.

Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1.

Abstract：

BACKGROUND:The effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro. METHODS:In vivo studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs. Exudate volume and PMNs accumulation were measured. Leukocyte cell adhesion molecules (LFA-1, Mac-1 and VLA-4) mobilization in circulating granulocytes were analysed by flow cytometry and endothelial cell adhesion molecules (ICAM-1 and VCAM-1) were detected by immunohistochemistry on lung sections. In vitro studies were conducted on endothelial LT2 cells, stimulated with TNF-alpha, to evaluate ICAM-1, IL-8 and VEGF mRNA expression upon PACs treatment. Data sets were examined by one-way analysis of variance (ANOVA) followed by a Scheffe post-hoc test. RESULTS:Pretreatment of the animals with PACs (10, 30 and 60 mg/kg) inhibited dose-dependently carrageenin-induced pleurisy in rats by reducing pleural exudate formation and PMNs infliltration. Leukocyte cell adhesion molecules mobilization was not down-regulated on granulocytes by PACs. Immunohistochemistry on lung sections showed a decreased production of endothelial cell adhesion molecules. In vitro experiments demonstrated that PACs were able to significantly inhibit ICAM-1 but not IL-8 and VEGF165 mRNA expression. Moreover, VEGF121 mRNA expression was dose-dependently enhanced. CONCLUSION:This study provides evidence to support the anti-inflammatory activity of proanthocyanidins is related to an inhibition of leukocyte infiltration which can be explained at least in part by a down-regulation of endothelial adhesion molecules, ICAM-1 and VCAM-1 and that these compounds are capable of modulating TNF-alpha-induced VEGF transcription.

journal_name

J Inflamm (Lond)

journal_title

Journal of inflammation (London, England)

authors

Garbacki N,Kinet M,Nusgens B,Desmecht D,Damas J

doi

10.1186/1476-9255-2-9

keywords:

subject

Has Abstract

pub_date

2005-08-09 00:00:00

pages

9

issn

1476-9255

pii

1476-9255-2-9

journal_volume

2

pub_type

杂志文章

相关文献

Journal of Inflammation-London文献大全
  • Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation.

    abstract：UNLABELLED: BACKGROUND:Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation of inflammatory activity and associated impaired pro...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-9-48

    authors： Ahmad R,Al-Mass A,Atizado V,Al-Hubail A,Al-Ghimlas F,Al-Arouj M,Bennakhi A,Dermime S,Behbehani K

    更新日期：2012-11-28 00:00:00

  • Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis.

    abstract：: Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-6-10

    authors： Liang B,Song Z,Wu B,Gardner D,Shealy D,Song XY,Wooley PH

    更新日期：2009-04-15 00:00:00

  • The effect of two iso-caloric meals containing equal amounts of fats with a different fat composition on the inflammatory and metabolic markers in apparently healthy volunteers.

    abstract：BACKGROUND:Little is known about the time-course of the postprandial appearance of macronutrient-induced inflammatory response. Our aim was to investigate the postprandial inflammatory and metabolic response following high fat, high caloric popular meals in apparently healthy participants. METHODS:Fifty four apparentl...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-3

    authors： Raz O,Steinvil A,Berliner S,Rosenzweig T,Justo D,Shapira I

    更新日期：2013-01-31 00:00:00

  • Waist circumference as the predominant contributor to the micro-inflammatory response in the metabolic syndrome: a cross sectional study.

    abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-35

    authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

    更新日期：2010-07-26 00:00:00

  • Accelerated wound healing phenotype in Interleukin 12/23 deficient mice.

    abstract：BACKGROUND:The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present study explored the effect of abrogation of the p40 subunit, which...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-39

    authors： Matias MA,Saunus JM,Ivanovski S,Walsh LJ,Farah CS

    更新日期：2011-12-20 00:00:00

  • CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients.

    abstract：Background:Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clin...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-018-0186-7

    authors： Patry C,Stamm D,Betzen C,Tönshoff B,Yard BA,Beck GC,Rafat N

    更新日期：2018-05-16 00:00:00

  • Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70.

    abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease, which causes synovial damage. Persistence of lymphocyte infiltrates in the rheumatoid synovium has been attributed to abnormal apoptosis. While not comprehensively investigated, perturbations in peripheral blood lymphocyte (PBL) apoptosis may also be...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-30

    authors： Moodley D,Mody GM,Chuturgoon AA

    更新日期：2011-11-03 00:00:00

  • The inflammatory cytokine tumor necrosis factor modulates the expression of Salmonella typhimurium effector proteins.

    abstract：: Tumor necrosis factor alpha (TNF-alpha)is a host inflammatory factor. Bacteria increase TNF-alpha expression in a variety of human diseases including infectious diseases, inflammatory bowel diseases, and cancer. It is unknown, however, how TNF-alpha directly modulates bacterial protein expression during intestinal in...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-42

    authors： Ma J,Zhang YG,Xia Y,Sun J

    更新日期：2010-08-12 00:00:00

  • Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB.

    abstract：BACKGROUND:Milk-derived bioactive peptides retain many biological properties and have therapeutic effects in cardiovascular disorders such as atherosclerosis. Under inflammatory conditions the expression of endothelial cells adhesion molecules is induced, increasing monocyte adhesion to human vessel wall, a critical st...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-014-0044-1

    authors： Marcone S,Haughton K,Simpson PJ,Belton O,Fitzgerald DJ

    更新日期：2015-01-20 00:00:00

  • Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome.

    abstract：Background:The relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) has been shown in many studies. However, the specific mechanism remains unclear. This study was to investigate the corpus cavernosum smooth muscle cell function and phenotype transformation in Ex...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-019-0233-z

    authors： Wang GC,Huang TR,Hu YY,Wang KY,Shi H,Yin L,Peng B

    更新日期：2020-01-06 00:00:00

  • BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages.

    abstract：BACKGROUND:BMP4, a member of the transforming growth factor-beta superfamily, is upregulated in the aortas of diabetic db/db mice. However, little is known about its role in diabetic atherosclerosis. Therefore, we examined the roles of BMP4 in the formation of diabetic atherosclerosis in apolipoprotein E knockout (ApoE...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-32

    authors： Koga M,Yamauchi A,Kanaoka Y,Jige R,Tsukamoto A,Teshima N,Nishioku T,Kataoka Y

    更新日期：2013-10-09 00:00:00

  • Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.

    abstract：:Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neo...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-4

    authors： Davoine F,Sim A,Tang C,Fisher S,Ethier C,Puttagunta L,Wu Y,McGaw WT,Yu D,Cameron L,Adamko DJ,Moqbel R

    更新日期：2013-01-31 00:00:00

  • Portrait of inflammatory response to ionizing radiation treatment.

    abstract：:Ionizing radiation (IR) activates both pro-and anti-proliferative signal pathways producing an imbalance in cell fate decision. IR is able to regulate several genes and factors involved in cell-cycle progression, survival and/or cell death, DNA repair and inflammation modulating an intracellular radiation-dependent re...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-015-0058-3

    authors： Di Maggio FM,Minafra L,Forte GI,Cammarata FP,Lio D,Messa C,Gilardi MC,Bravatà V

    更新日期：2015-02-18 00:00:00

  • Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity.

    abstract：BACKGROUND:Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved effects on cardiovascular, nervous, metabolic and immune systems. We hypothesized that CIHH may amelio...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-020-00265-1

    authors： Cui F,Guo J,Hu HF,Zhang Y,Shi M

    更新日期：2020-11-07 00:00:00

  • Anti-inflammatory effects of resolvin-D1 on human corneal epithelial cells: in vitro study.

    abstract：BACKGROUND:This study evaluated the anti-inflammatory effects of Resolvin-D1 (RV-D1) and its mechanism of action in human corneal epithelial (HCE) cells. METHODS:HCE cells were incubated with different concentrations of RV-D1 for different time periods. Oleic acid (OA) and Dexamethasone (DM) served as negative and pos...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-6

    authors： Erdinest N,Ovadia H,Kormas R,Solomon A

    更新日期：2014-03-02 00:00:00

  • Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls.

    abstract：BACKGROUND:Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a promising alternative treatment for inflammatory bowel disease (IBD). In this study, we explored the co...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-10-36

    authors： Van Welden S,Laukens D,Ferdinande L,De Vos M,Hindryckx P

    更新日期：2013-11-20 00:00:00

  • Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids.

    abstract：: Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) a...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-15

    authors： Rackova L,Oblozinsky M,Kostalova D,Kettmann V,Bezakova L

    更新日期：2007-07-16 00:00:00

  • Detection of cytokine protein expression in mouse lung homogenates using suspension bead array.

    abstract：BACKGROUND:The objective for this present study was to determine whether or not suspension bead array is a feasible method to detect changes in cytokine protein expression in mouse lung tissue homogenates. Here, we report on suspension bead array as a feasible method for detection of lipopolysaccharide (LPS)-evoked cha...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-3-15

    authors： McDuffie E,Obert L,Chupka J,Sigler R

    更新日期：2006-11-29 00:00:00

  • Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts.

    abstract：BACKGROUND:Toll-like receptors (TLRs) are recognized as important contributors to the initiation and modulation of the inflammatory response in the eye. This study investigated the precise expression patterns and functionality of TLRs in human corneal epithelial cells (HCE) and in conjunctival fibroblasts (HCF). METHO...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-3

    authors： Erdinest N,Aviel G,Moallem E,Anteby I,Yahalom C,Mechoulam H,Ovadia H,Solomon A

    更新日期：2014-02-04 00:00:00

  • Cancer, inflammation and the AT1 and AT2 receptors.

    abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-1-3

    authors： Smith GR,Missailidis S

    更新日期：2004-09-30 00:00:00

  • Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study.

    abstract：BACKGROUND:124 triazolo [4, 3-a]18naphthyridine derivatives (including NF161 and NF177) were tested for anti-inflammatory, analgesic and antipyretic properties and for their effects on spontaneous locomotor activity in mice and acute gastrolesivity in rats. Both NF161 and NF177 appeared to be anti-inflammatory and anal...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-3-4

    authors： Dianzani C,Collino M,Gallicchio M,Di Braccio M,Roma G,Fantozzi R

    更新日期：2006-03-28 00:00:00

  • Role of autophagy in atherosclerosis: foe or friend?

    abstract：:Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the engaging different cells from the vascular wall and circulatory cells. Attempts are currently focused on the detec...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/s12950-019-0212-4

    authors： Hassanpour M,Rahbarghazi R,Nouri M,Aghamohammadzadeh N,Safaei N,Ahmadi M

    更新日期：2019-05-02 00:00:00

  • Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production.

    abstract：BACKGROUND:Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects. OBJECTIVE:A study was conducted to establish ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-8-6

    authors： Dixit VD,Yang H,Sayeed KS,Stote KS,Rumpler WV,Baer DJ,Longo DL,Mattson MP,Taub DD

    更新日期：2011-03-07 00:00:00

  • Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns.

    abstract：BACKGROUND:Toll-like receptor (TLR) activation is hypothesized to contribute to inflammatory eye disease including uveitis, yet the distribution pattern of TLRs in human uveal tissues remains poorly described. The purpose of this study was to investigate the expression profile of TLRs in human iris pigment epithelial c...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-11-20

    authors： Mai K,Chui JJ,Di Girolamo N,McCluskey PJ,Wakefield D

    更新日期：2014-07-16 00:00:00

  • Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonar...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-34

    authors： Arunachalam G,Sundar IK,Hwang JW,Yao H,Rahman I

    更新日期：2010-07-22 00:00:00

  • Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation.

    abstract：BACKGROUND:PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T cells derived from PTPH1-...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-7-16

    authors： Patrignani C,Lafont DT,Muzio V,Gréco B,Hooft van Huijsduijnen R,Zaratin PF

    更新日期：2010-03-30 00:00:00

  • Protective effects of thalidomide on pulmonary injuries in a rat model of paraquat intoxication.

    abstract：BACKGROUND:This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms. METHODS:Rats were exposed to 50 mg/kg PQ by oral gavage, and treated with thalidomide through oral administration at 60 mg/kg once a day, ...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-015-0093-0

    authors： Li D,Zhang XW,Jiang XQ,Yin YJ,Fan Z,Sun CB,Chen XH,Li YH,Liu KX

    更新日期：2015-07-28 00:00:00

  • MicroRNAs differentially expressed in Behçet disease are involved in interleukin-6 production.

    abstract：BACKGROUND:Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNA...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-016-0130-7

    authors： Woo MY,Yun SJ,Cho O,Kim K,Lee ES,Park S

    更新日期：2016-07-19 00:00:00

  • Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.

    abstract：BACKGROUND:The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evalu...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/1476-9255-4-16

    authors： Miller MJ,Bobrowski P,Shukla M,Gupta K,Haqqi TM

    更新日期：2007-08-14 00:00:00

  • Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.

    abstract：BACKGROUND:Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of mi...

    journal_title：Journal of inflammation (London, England)

    pub_type： 杂志文章

    doi：10.1186/s12950-017-0162-7

    authors： Yin H,Song S,Pan X

    更新日期：2017-08-09 00:00:00