听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览ENDOCRINOLOGY期刊下所有文献
  • CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.

    abstract::COP9 signalosome subunit 5 (CSN5) plays a key role in carcinogenesis of multiple cancers and contributes to the stabilization of target proteins through deubiquitylation. However, the underlying role of CSN5 in thyroid carcinoma has not been reported. In this research, our data showed that CSN5 was overexpressed in th...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa206

    authors: Xie P,Wang H,Fang J,Du D,Tian Z,Zhen J,Liu Y,Ding Y,Fu B,Liu F,Huang D,Yu J

    更新日期:2021-03-01 00:00:00

  • Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.

    abstract::The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) d...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa245

    authors: Allensworth-James M,Banik J,Odle A,Hardy L,Lagasse A,Moreira ARS,Bird J,Thomas CL,Avaritt N,Kharas MG,Lengner CJ,Byrum SD,MacNicol MC,Childs GV,MacNicol AM

    更新日期:2021-03-01 00:00:00

  • The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity.

    abstract::Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity that disrupts gene expression programs essential for cell function and i...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa213

    authors: Davidson RK,Kanojia S,Spaeth JM

    更新日期:2021-02-01 00:00:00

  • Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues.

    abstract::LA-PTH is a long-acting parathyroid hormone (PTH) peptide analogue in preclinical development for hypoparathyroidism (HP). Like native PTH, LA-PTH contains a methionine at position 8 (Met8) that is predicted to be critical for function. We assessed the impact of Met oxidation on the functional properties of LA-PTH and...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa216

    authors: Daley EJ,Khatri A,Dean T,Vilardaga JP,Zaidi SA,Katritch V,Gardella TJ

    更新日期:2021-02-01 00:00:00

  • The Importance of Leptin to Reproduction.

    abstract::A healthy nutritional state is required for all aspects of reproduction and is signaled by the adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little will compromise fertility. The leptin signal timing is important to prepubertal development in both sexes. In the brain, leptin...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa204

    authors: Childs GV,Odle AK,MacNicol MC,MacNicol AM

    更新日期:2021-02-01 00:00:00

  • Genome-Wide Estrogen Receptor Activity in Breast Cancer.

    abstract::The largest subtype of breast cancer is characterized by the expression and activity of the estrogen receptor alpha (ERalpha/ER). Although several effective therapies have significantly improved survival, the adaptability of cancer cells means that patients frequently stop responding or develop resistance to endocrine...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa224

    authors: Farcas AM,Nagarajan S,Cosulich S,Carroll JS

    更新日期:2021-02-01 00:00:00

  • Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ.

    abstract::Previous studies showed that noncalcemic 20(OH)D3, a product of CYP11A1 action on vitamin D3, has antifibrotic activity in human dermal fibroblasts and in a bleomycin mouse model of scleroderma. In this study, we tested the role of retinoic acid-related orphan receptor γ (RORγ), which is expressed in skin, in the acti...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa198

    authors: Janjetovic Z,Postlethwaite A,Kang HS,Kim TK,Tuckey RC,Crossman DK,Qayyum S,Jetten AM,Slominski AT

    更新日期:2021-01-01 00:00:00

  • Prostate-Specific Deletion of Cdh1 Induces Murine Prostatic Inflammation and Bladder Overactivity.

    abstract::Benign prostatic hyperplasia (BPH) is an age-related debilitating prostatic disease that is frequently associated with prostatic inflammation and bothersome lower urinary tract symptoms (LUTS). Animal models have shown that formalin- and bacterial-induced prostatic inflammation can induce bladder dysfunction; however,...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa212

    authors: Pascal LE,Mizoguchi S,Chen W,Rigatti LH,Igarashi T,Dhir R,Tyagi P,Wu Z,Yang Z,de Groat WC,DeFranco DB,Yoshimura N,Wang Z

    更新日期:2021-01-01 00:00:00

  • Puberty, A Sensitive Window of Hypothalamic Development and Plasticity.

    abstract::Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa209

    authors: Naulé L,Maione L,Kaiser UB

    更新日期:2021-01-01 00:00:00

  • Puberty, A Sensitive Window of Hypothalamic Development and Plasticity.

    abstract::Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa209

    authors: Naulé L,Maione L,Kaiser UB

    更新日期:2021-01-01 00:00:00

  • Loss of Inhibin Advances Follicle Activation and Female Puberty Onset but Blocks Oocyte Maturation in Zebrafish.

    abstract::Inhibin was first characterized in mammals as a gonadal dimeric protein that inhibited pituitary follicle-stimulating hormone (FSH) secretion. As in mammals, the inhibin-specific α subunit (INHA/Inha/inha) has also been characterized in teleosts; however, its functions and physiological importance in fish reproduction...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa184

    authors: Lu H,Zhao C,Zhu B,Zhang Z,Ge W

    更新日期:2020-12-01 00:00:00

  • Corticosterone Is Essential for Survival Through Frog Metamorphosis.

    abstract::Thyroid hormone (TH) is required for frog metamorphosis, and corticosterone (CORT) increases TH signaling to accelerate metamorphic progression. However, a requirement for CORT in metamorphosis has been difficult to assess prior to the recent development of gene-editing technologies. We addressed this long-standing qu...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa193

    authors: Shewade LH,Schoephoerster JA,Patmann MD,Kulkarni SS,Buchholz DR

    更新日期:2020-12-01 00:00:00

  • A CRH Receptor Type 1 Agonist Increases GABA Transmission to GnRH Neurons in a Circulating-Estradiol-Dependent Manner.

    abstract::GnRH neurons are central regulators of reproduction and respond to factors affecting fertility, such as stress. Corticotropin-releasing hormone (CRH) is released during stress response. In brain slices from unstressed controls, CRH has opposite, estradiol-dependent effects on GnRH neuron firing depending on the CRH re...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa140

    authors: Phumsatitpong C,De Guzman RM,Zuloaga DG,Moenter SM

    更新日期:2020-11-01 00:00:00

  • Mechanisms by Which Membrane and Nuclear ER Alpha Inhibit Adipogenesis in Cells Isolated From Female Mice.

    abstract::Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alph...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa175

    authors: Ahluwalia A,Hoa N,Ge L,Blumberg B,Levin ER

    更新日期:2020-11-01 00:00:00

  • High-Fat Diet Alters LH Secretion and Pulse Frequency in Female Mice in an Estrous Cycle-Dependent Manner.

    abstract::Reproductive fitness in females is susceptible to obesogenic diets. Energy balance and reproduction are tightly regulated, in part, by hypothalamic neurons in the arcuate nucleus (ARC), and high-fat diet (HFD) can steadily increase estradiol levels in rodents. Estradiol regulates the reproductive axis via negative fee...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa146

    authors: Negrón AL,Radovick S

    更新日期:2020-10-01 00:00:00

  • Bone Regulation of Insulin Secretion and Glucose Homeostasis.

    abstract::For centuries our image of the skeleton has been one of an inert structure playing a supporting role for muscles and a protective role for inner organs like the brain. Cell biology and physiology modified this view in the 20st century by defining the constant interplay between bone-forming and bone resorbing cells tha...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa149

    authors: Ducy P

    更新日期:2020-10-01 00:00:00

  • Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan.

    abstract::Ovarian hormones, including 17β-estradiol, are implicated in numerous physiological processes, including sleep. Beginning at puberty, girls report more sleep complaints than boys, which is maintained throughout the reproductive life stage. Sleep problems are exacerbated during the menopausal transition, evidenced by g...

    journal_title:Endocrinology

    pub_type: 杂志文章,评审

    doi:10.1210/endocr/bqaa128

    authors: Brown AMC,Gervais NJ

    更新日期:2020-09-01 00:00:00

  • Sex Differences in Long-term Metabolic Effects of Maternal Resveratrol Intake in Adult Rat Offspring.

    abstract::Maternal nutrition can affect the susceptibility of the offspring to metabolic disease later in life, suggesting that this period is a window of opportunity for intervention to reduce the risk of metabolic disease. Resveratrol, a natural polyphenol, has a wide range of beneficial properties including anti-obesogenic, ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa090

    authors: Ros P,Díaz F,Freire-Regatillo A,Argente-Arizón P,Barrios V,Argente J,Chowen JA

    更新日期:2020-08-01 00:00:00

  • Dapagliflozin Does Not Directly Affect Human α or β Cells.

    abstract::Selective inhibitors of sodium glucose cotransporter-2 (SGLT2) are widely used for the treatment of type 2 diabetes and act primarily to lower blood glucose by preventing glucose reabsorption in the kidney. However, it is controversial whether these agents also act on the pancreatic islet, specifically the α cell, to ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa080

    authors: Dai C,Walker JT,Shostak A,Bouchi Y,Poffenberger G,Hart NJ,Jacobson DA,Calcutt MW,Bottino R,Greiner DL,Shultz LD,McGuinness OP,Dean ED,Powers AC

    更新日期:2020-08-01 00:00:00

  • The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?

    abstract::A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this isoform in vivo, observing that GHv treatment in male high-fat fed rats had several GH-like activities, but unlike GH lacked diabetogenic and lactogenic activities and failed to increase...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa097

    authors: List EO,Berryman DE,Basu R,Buchman M,Funk K,Kulkarni P,Duran-Ortiz S,Qian Y,Jensen EA,Young JA,Yildirim G,Yakar S,Kopchick JJ

    更新日期:2020-08-01 00:00:00

  • Corticosterone, Adrenal, and the Pituitary-Gonadal Axis in Neonatal Rats: Effect of Maternal Separation and Hypoxia.

    abstract::Hypoxia, a common stressor in prematurity, leads to sexually dimorphic, short- and long-term effects on the adult hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. We hypothesized that these effects are due to stress-induced increases in testosterone during early postnatal life. We ev...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa085

    authors: Gehrand AL,Phillips J,Malott K,Raff H

    更新日期:2020-07-01 00:00:00

  • The Complex Signaling Pathways of the Ghrelin Receptor.

    abstract::The ghrelin receptor (GhrR) is known for its strong orexigenic effects in pharmacological doses and has long been considered as a promising target for the treatment of obesity. Several antagonists have been developed to decrease the orexigenic signaling, but none of these have been approved for the treatment of obesit...

    journal_title:Endocrinology

    pub_type: 杂志文章,评审

    doi:10.1210/endocr/bqaa020

    authors: Hedegaard MA,Holst B

    更新日期:2020-04-01 00:00:00

  • Roles of Endogenous IL-10 and IL-10-Competent and CD5+ B Cells in Autoimmune Thyroiditis in NOD.H-2h4 Mice.

    abstract::Interleukin (IL)-10 is a highly important anti-inflammatory cytokine in the immune system. CD1dhi and CD5+ B cells are both traditionally defined IL-10-secreting B cells. In recent years, a B cell group with combined markers of CD1dhi and CD5+ has been widely studied as it has been reported to suppress autoimmunity in...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa033

    authors: Qin J,Zhao N,Wang S,Liu S,Liu Y,Cui X,Wang S,Xiang Y,Fan C,Li Y,Shan Z,Teng W

    更新日期:2020-04-01 00:00:00

  • Impact of Exogenous Testosterone on Reproduction in Transgender Men.

    abstract::Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovaria...

    journal_title:Endocrinology

    pub_type: 杂志文章,评审

    doi:10.1210/endocr/bqaa014

    authors: Moravek MB,Kinnear HM,George J,Batchelor J,Shikanov A,Padmanabhan V,Randolph JF

    更新日期:2020-03-01 00:00:00

  • Extension of Survival in Bilaterally Adrenalectomized Mice by Implantation of SF-1/Ad4BP-Induced Steroidogenic Cells.

    abstract::Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqaa007

    authors: Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

    更新日期:2020-03-01 00:00:00

  • FGF21 and the Physiological Regulation of Macronutrient Preference.

    abstract::The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of water, sodium, or energy intake triggers adaptive responses that conser...

    journal_title:Endocrinology

    pub_type: 杂志文章,评审

    doi:10.1210/endocr/bqaa019

    authors: Hill CM,Qualls-Creekmore E,Berthoud HR,Soto P,Yu S,McDougal DH,Münzberg H,Morrison CD

    更新日期:2020-03-01 00:00:00

  • Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus.

    abstract::Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqz033

    authors: Herrera GGB,Lierz SL,Harris EA,Donoghue LJ,Hewitt SC,Rodriguez KF,Jefferson WN,Lydon JP,DeMayo FJ,Williams CJ,Korach KS,Winuthayanon W

    更新日期:2020-02-01 00:00:00

  • Leptin Controls Glutamatergic Synaptogenesis and NMDA-Receptor Trafficking via Fyn Kinase Regulation of NR2B.

    abstract::Activation of the leptin receptor, LepRb, by the adipocytokine/neurotrophic factor leptin in the central nervous system has procognitive and antidepressive effects. Leptin has been shown to increase glutamatergic synaptogenesis in multiple brain regions. In contrast, mice that have a mutation in the LepRb gene show ab...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqz030

    authors: Bland T,Zhu M,Dillon C,Sahin GS,Rodriguez-Llamas JL,Appleyard SM,Wayman GA

    更新日期:2020-02-01 00:00:00

  • The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.

    abstract::The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the secretory pathway and is the site where protein folding and quality control are initiated. The storage and release of Ca2+ are critical physiological functions of the ER. Disrupted ER homeostasis activates the unfolded protein respo...

    journal_title:Endocrinology

    pub_type: 杂志文章,评审

    doi:10.1210/endocr/bqz028

    authors: Zhang IX,Raghavan M,Satin LS

    更新日期:2020-02-01 00:00:00

  • Insulin Signaling Via Progesterone-Regulated Insulin Receptor Substrate 2 is Critical for Human Uterine Decidualization.

    abstract::Decidualization, the process by which fibroblastic human endometrial stromal cells (HESC) differentiate into secretory decidual cells, is a critical event during the establishment of pregnancy. It is dependent on the steroid hormone progesterone acting through the nuclear progesterone receptor (PR). Previously, we ide...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endocr/bqz021

    authors: Neff AM,Yu J,Taylor RN,Bagchi IC,Bagchi MK

    更新日期:2020-01-01 00:00:00

  • Spermatogonial Type 3 Deiodinase Regulates Thyroid Hormone Target Genes in Developing Testicular Somatic Cells.

    abstract::Premature overexposure to thyroid hormone causes profound effects on testis growth, spermatogenesis, and male fertility. We used genetic mouse models of type 3 deiodinase (DIO3) deficiency to determine the genetic programs affected by premature thyroid hormone action and to define the role of DIO3 in regulating thyroi...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00259

    authors: Martinez ME,Lary CW,Karaczyn AA,Griswold MD,Hernandez A

    更新日期:2019-12-01 00:00:00

  • Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models.

    abstract::Isolated growth hormone deficiency type II (IGHD2) is mainly caused by heterozygous splice-site mutations in intron 3 of the GH1 gene. A dominant-negative effect of the mutant GH lacking exon 3 on wild-type GH secretion has been proposed; however, the molecular mechanisms involved are elusive. To uncover the molecular...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00306

    authors: Ariyasu D,Kubo E,Higa D,Shibata S,Takaoka Y,Sugimoto M,Imaizumi K,Hasegawa T,Araki K

    更新日期:2019-11-01 00:00:00

  • Ferredoxin 1b Deficiency Leads to Testis Disorganization, Impaired Spermatogenesis, and Feminization in Zebrafish.

    abstract::The roles of steroids in zebrafish sex differentiation, gonadal development, and function of the adult gonad are poorly understood. Herein, we used ferredoxin 1b (fdx1b) mutant zebrafish to explore such processes. Fdx1b is an essential electron-providing cofactor to mitochondrial steroidogenic enzymes, which are cruci...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00068

    authors: Oakes JA,Li N,Wistow BRC,Griffin A,Barnard L,Storbeck KH,Cunliffe VT,Krone NP

    更新日期:2019-10-01 00:00:00

  • Ancestral Fluoxetine Exposure Sensitizes Zebrafish to Venlafaxine-Induced Reductions in Cortisol and Spawning.

    abstract::Owing to the prevalence of depression during childbearing, mothers can be prescribed multiple antidepressants; however, little is known about the risk and consequences to the offspring or subsequent generations. Fluoxetine (FLX) is usually the first-line of pharmacological treatment for affective disorders in pregnant...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00281

    authors: Vera-Chang MN,Moon TW,Trudeau VL

    更新日期:2019-09-01 00:00:00

  • Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice.

    abstract::Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. Developmental exposure produces changes in behavior and gene expression in the brain. Here, we examined social recognition behaviors in mice from the third familial generation (F3) after exposure to gestational BPA. Second-generation mice were bred in on...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00196

    authors: Wolstenholme JT,Drobná Z,Henriksen AD,Goldsby JA,Stevenson R,Irvin JW,Flaws JA,Rissman EF

    更新日期:2019-08-01 00:00:00

  • Extracellular Matrix-Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival.

    abstract::This review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing β-cell is key for maintaining glucose homeostasis. The islet microenvironment greatl...

    journal_title:Endocrinology

    pub_type: 杂志文章,评审

    doi:10.1210/en.2019-00206

    authors: Townsend SE,Gannon M

    更新日期:2019-08-01 00:00:00

  • Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice.

    abstract::Developmental exposures to phthalates are suspected to contribute to risk of metabolic syndrome. However, findings from human studies are inconsistent, and long-term metabolic impacts of early-life phthalate and phthalate mixture exposures are not fully understood. Furthermore, most animal studies investigating metabo...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00287

    authors: Neier K,Cheatham D,Bedrosian LD,Gregg BE,Song PXK,Dolinoy DC

    更新日期:2019-07-01 00:00:00

  • Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling.

    abstract::Excess of glucocorticoids (GCs) is a leading cause of bone fragility, and therapeutic targets are sorely needed. We report that genetic deletion or pharmacological inhibition of proline-rich tyrosine kinase 2 (Pyk2) prevents GC-induced bone loss by overriding GC effects of detachment-induced bone cell apoptosis (anoik...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00237

    authors: Sato AY,Cregor M,McAndrews K,Li T,Condon KW,Plotkin LI,Bellido T

    更新日期:2019-07-01 00:00:00

  • Growth Hormone Induces Colon DNA Damage Independent of IGF-1.

    abstract::DNA damage occurs as a result of environmental insults and aging and, if unrepaired, may lead to chromosomal instability and tumorigenesis. Because GH suppresses ataxia-telangiectasia mutated kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH effects on DNA da...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2019-00132

    authors: Chesnokova V,Zonis S,Barrett RJ,Gleeson JP,Melmed S

    更新日期:2019-06-01 00:00:00

  • Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver.

    abstract::Sex differences in liver gene expression are determined by pituitary growth hormone secretion patterns, which regulate sex-dependent liver transcription factors and establish sex-specific chromatin states. Hypophysectomy (hypox) identifies two major classes of liver sex-biased genes, defined by their sex-dependent pos...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2018-00949

    authors: Melia T,Waxman DJ

    更新日期:2019-05-01 00:00:00

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