Spermatogonial Type 3 Deiodinase Regulates Thyroid Hormone Target Genes in Developing Testicular Somatic Cells.

abstract：:IGF-II has been reported to decrease neonatal islet cell apoptosis and in vitro adult islet cell necrosis and apoptosis, but the usefulness of IGF-II in a transplantation setting is unknown. We evaluated the effect of in vitro IGF-II incubations on microencapsulated rat islet survival both in vitro and in minimal mass...

journal_title：Endocrinology

authors： Robitaille R,Dusseault J,Henley N,Rosenberg L,Hallé JP

更新日期：2003-07-01 00:00:00

abstract：:An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl coenzyme A (CoA) to the regulation of energy balance. Thus, factors that activate AMPK and decrease the concentration of malonyl CoA in peripheral tissues, such as exercise, decrease triglyceride accumulation in the adipocyte and...

journal_title：Endocrinology

authors： Ruderman NB,Saha AK,Kraegen EW

更新日期：2003-12-01 00:00:00

abstract：:Sorbin is a 153-amino acid peptide that was initially discovered in the porcine duodenum. We have reported previously that this peptide regulates intestinal electrolyte transport and have described accumulation sites in the rat digestive tract. In the present study, we investigated the anatomical distribution and the ...

journal_title：Endocrinology

authors： El Fadil FA,Nicol P,Leduque P,Berger F,Descroix-Vagne M,Pansu D

更新日期：1997-11-01 00:00:00

abstract：:Corticostatic peptides are a family of arginine-rich cysteine-rich peptides that inhibit ACTH-stimulated corticosterone (B) production in rat adrenal cell suspensions. In this communication we describe a new method for the facile isolation and purification of these basic peptides from rabbit adult lung. We then descri...

journal_title：Endocrinology

authors： Zhu Q,Solomon S

更新日期：1992-03-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is produced in multiple tissues and is believed to exert its action in a paracrine or autocrine fashion. We have investigated the GH dependency of tissue IGF-I gene expression in rats harboring implanted somatomammotropic tumors. Circulating GH and radioimmunoassayable IGF-I levels...

journal_title：Endocrinology

authors： Fagin JA,Brown A,Melmed S

更新日期：1988-05-01 00:00:00

abstract：:Spermatogenesis is sustained by a heterogeneous population of spermatogonia that includes the spermatogonial stem cells. However, the mechanisms underlying their establishment from gonocyte embryonic precursors and their maintenance thereafter remain largely unknown. In this study, we report that inactivation of the u...

journal_title：Endocrinology

authors： Fok KL,Bose R,Sheng K,Chang CW,Katz-Egorov M,Culty M,Su S,Yang M,Ruan YC,Chan HC,Iavarone A,Lasorella A,Cencic R,Pelletier J,Nagano M,Xu W,Wing SS

更新日期：2017-11-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase 2 (11 beta-HSD2) protects mineralocorticoid receptors from high circulating levels of glucocorticoids and cDNAs for 11 beta-HSD2 from human and sheep have been recently cloned. We have isolated the gene for mouse 11 beta-HSD2, which spans 7 kilobases and is composed of 5 exons. In ...

journal_title：Endocrinology

authors： Cole TJ

更新日期：1995-10-01 00:00:00

abstract：:Insulin and insulin-like growth factors (IGFs) stimulate responses in skeletal muscle that include effects on carbohydrate and fat metabolism, protein turnover, growth, and differentiation. To gain insight into the relative importance of insulin and IGFs at different stages of development, the expression of their spec...

journal_title：Endocrinology

authors： Alexandrides T,Moses AC,Smith RJ

更新日期：1989-02-01 00:00:00

abstract：:The activity of hepatic NADPH cytochrome c reductase, an enzyme important in drug and steroid metabolism, increases rapidly during the perinatal period in rats. However, the regulation of this increase is not well understood. To investigate the role of hormones in the development of NADPH cytochrome c reductase activi...

journal_title：Endocrinology

authors： Kriz BM,Gates JA,Read FE,Fong BB

更新日期：1982-06-01 00:00:00

abstract：:Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises dramatically as women approach parturition. To determine whether the rodent is a suitable animal model for ...

journal_title：Endocrinology

authors： Draper LB,Chong H,Wang E,Woodruff TK

更新日期：1997-07-01 00:00:00

abstract：:In an attempt to further define the optimum experimental conditions for the in vitro study of PRL endocrinology, the effect of extracellular leucine concentration on PRL secretion was assessed. Rat pituitary cells, maintained in short term monolayer culture, were washed free of serum and placed in Minimum Essential Me...

journal_title：Endocrinology

authors： Cross M,Walker AM

更新日期：1984-01-01 00:00:00

abstract：:GH is known to increase the formation of bone and hard tissues of the tooth (dentine, cementum, and enamel), as do bone morphogenetic proteins. GH receptors are expressed in these tissues and could mediate local growth responses. Here we report that both GH and insulin-like growth factor I (IGF-I) are able to increase...

journal_title：Endocrinology

authors： Li H,Bartold PM,Zhang CZ,Clarkson RW,Young WG,Waters MJ

更新日期：1998-09-01 00:00:00

abstract：:A clonal cell line (44-2C) which synthesizes and secretes somatostatin, neurotensin, calcitonin (CT), and CT gene-related peptide and transiently expresses c-fos was used to characterize the mechanism of action of basic fibroblast growth factor (bFGF). bFGF had two modes of action: 1) short term incubation of 44-2C ce...

journal_title：Endocrinology

authors： Zeytin FN,Rusk SF,Raymond V,Mandell AJ

更新日期：1988-03-01 00:00:00

abstract：:Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, because the developing brain is highly sensitive to estrogens. In the present study, we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes irreversible suppres...

journal_title：Endocrinology

authors： Minabe S,Ieda N,Watanabe Y,Inoue N,Uenoyama Y,Maeda KI,Tsukamura H

更新日期：2017-09-01 00:00:00

abstract：:Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysacc...

journal_title：Endocrinology

authors： Coste SC,Heldwein KA,Stevens SL,Tobar-Dupres E,Stenzel-Poore MP

更新日期：2001-08-01 00:00:00

abstract：:The levels of the GnRH receptor (GnRHR) and its messenger RNA depend on the pattern of administration of GnRH. In this study, internal deletion mutants in a luciferase reporter gene vector (GnRHR-pXP2) containing a 1226-bp promoter fragment of mouse GnRHR gene were used to examine the regulation of GnRHR gene transcri...

journal_title：Endocrinology

authors： Maya-Núñez G,Conn PM

更新日期：1999-08-01 00:00:00

abstract：:Experiments were carried out in castrate adult male rats to further examine whether endogenous opioids are involved in CRF-induced suppression of LH secretion. Serum LH levels in rats castrated 5 days earlier were significantly reduced by intracerebroventricular administration of homologous (rat) CRF (0.02-2 nmol) wit...

journal_title：Endocrinology

authors： Almeida OF,Nikolarakis KE,Herz A

更新日期：1988-03-01 00:00:00

abstract：:The plasma osteocalcin (OC) concentration correlates with histological parameters of bone formation and has been used as an index of osteoblast activity. Although the rate of OC synthesis is likely to be a major determinant of the plasma OC level, the contribution of other processes, for example, OC plasma clearance, ...

journal_title：Endocrinology

authors： Fortune CL,Farrugia W,Tresham J,Scoggins BA,Wark JD

更新日期：1989-06-01 00:00:00

abstract：:The electrical responses of rat islet cells maintained in culture with varying levels of glucose were determined. After culture with 2.8 or 4.2 mM glucose, the beta-cells did not respond electrically to 27.8 mM glucose. However, after culture in 5.6 mM glucose, the cells responded to 27.8 mM glucose in short term expe...

journal_title：Endocrinology

authors： Pace CS,Conant S,Lacy PE

更新日期：1978-05-01 00:00:00

abstract：:It is still controversial whether the bone-derived hormone fibroblast growth factor-23 (FGF23) has additional physiological functions apart from its well-known suppressive actions on renal phosphate reabsorption and vitamin D hormone synthesis. Here we analyzed premature aging, mineral homeostasis, carbohydrate metabo...

journal_title：Endocrinology

authors： Streicher C,Zeitz U,Andrukhova O,Rupprecht A,Pohl E,Larsson TE,Windisch W,Lanske B,Erben RG

更新日期：2012-04-01 00:00:00

abstract：:In the rat a GH-binding protein (GHBP) exists that is derived from the GH receptor gene by an alternative messenger RNA splicing mechanism such that the transmembrane and intracellular domains of the GH receptor are replaced by a hydrophilic carboxy terminus. Previous immunohistochemical studies detailing the localiza...

journal_title：Endocrinology

authors： Lobie PE,García-Aragón J,Wang BS,Baumbach WR,Waters MJ

更新日期：1992-05-01 00:00:00

abstract：:In the murine Ob 17 preadipocyte cell line, the thyroid hormone T3 is an adipogenic factor necessary at an early stage for differentiation into adipocyte. We demonstrate here that this T3 dependence may involve a transient expression (at both the messenger RNA and the protein levels) of c-ErbA beta-type receptors (T3R...

journal_title：Endocrinology

authors： Dace A,Sarkissian G,Schneider L,Martin-El Yazidi C,Bonne J,Margotat A,Planells R,Torresani J

更新日期：1999-07-01 00:00:00

abstract：:TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies ind...

journal_title：Endocrinology

authors： Vo BT,Morton D Jr,Komaragiri S,Millena AC,Leath C,Khan SA

更新日期：2013-05-01 00:00:00

abstract：:A central step in the development and sexual differentiation of the brain is the intraneuronal conversion of testosterone to estrogen. This conversion is catalyzed by an enzyme complex comprised of cytochrome P450 aromatase and the ubiquitous NADPH-dependent cytochrome P450 reductase. Brain aromatase activity is devel...

journal_title：Endocrinology

authors： Lauber ME,Lichtensteiger W

更新日期：1994-10-01 00:00:00

abstract：:Bone marrow-derived cells are major cellular components of human decidua, with macrophages comprising about 30% of the cells in term tissue. Because cytokines released by bone marrow-derived cells are known to affect hormone release in many tissues, we examined whether cytokines affect the release of PRL from human de...

journal_title：Endocrinology

authors： Jikihara H,Handwerger S

更新日期：1994-01-01 00:00:00

abstract：:In male hamsters, light deprivation was reported to reduce both testis weight and prolactin (PRL) levels. Therefore, we decided to examine the effects of PRL on testicular function in hamsters exposed to short day-length. Adult hamsters were exposed to 5 h of light per day to induce gonadal atrophy, and, starting two ...

journal_title：Endocrinology

authors： Bartke A,Croft BT,Dalterio S

更新日期：1975-12-01 00:00:00

abstract：:It has previously been established that neuropeptide-Y (NPY) is a potent inhibitor of alpha MSH release from the pars intermedia of the amphibian Xenopus laevis. The location of binding sites for NPY in the pars intermedia of the pituitary has now been studied with light microscopic autoradiography, using a dispersed ...

journal_title：Endocrinology

authors： De Rijk EP,Cruijsen PM,Jenks BG,Roubos EW

更新日期：1991-02-01 00:00:00

abstract：:We have examined the regulation of an insulin-like growth factor-binding protein-3 (IGFBP-3) protease secreted by MCF-7 human breast cancer cells using a ligand-binding assay that relies on the decrease in affinity for des(1-3)IGF-I that occurs when IGFBP-3 becomes proteolyzed. IGFBP-3 protease activity was not altere...

journal_title：Endocrinology

authors： Salahifar H,Baxter RC,Martin JL

更新日期：2000-09-01 00:00:00

abstract：:Estradiol-17beta (E2) is suspected to exert a role in the regulation of testicular activity. Using a nonmammalian vertebrate model (the frog, Rana esculenta), we have investigated whether c-fos activity is detectable in the testis during the annual sexual cycle and whether E2 exerts a regulatory role on spermatogenesi...

journal_title：Endocrinology

authors： Cobellis G,Pierantoni R,Minucci S,Pernas-Alonso R,Meccariello R,Fasano S

更新日期：1999-07-01 00:00:00

abstract：:We have previously demonstrated that CGP 42112 (AT(2) agonist > or =1 nM) markedly reduces catecholamine biosynthesis through AT(2), which is the major angiotensin II (AngII) receptor subtype in cultured porcine chromaffin cells. Also, we have shown that CGP 42112 (> or =1 nM) induces a reduction in cGMP production in...

journal_title：Endocrinology

authors： Takekoshi K,Ishii K,Kawakami Y,Isobe K,Nakai T

更新日期：2001-07-01 00:00:00