Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver.

abstract：:Male Siberian hamsters undergo physiological weight change in changing photoperiod. Weight loss was induced by food restriction in long days to mimic short-day weight loss, or by food restriction superimposed on short-day weight loss, to test the hypothesis that the hypothalamus differentiates between weight change in...

journal_title：Endocrinology

authors： Mercer JG,Moar KM,Logie TJ,Findlay PA,Adam CL,Morgan PJ

更新日期：2001-10-01 00:00:00

abstract：:To examine further the relationship between developmental changes in LH release and the onset of puberty, effects of posterior hypothalamic lesions were tested in ovariectomized (OVX), sexually immature female monkeys. In OVX females (n = 3) with sham hypothalamic lesions basal LH levels were suppressed during the pre...

journal_title：Endocrinology

authors： Schultz NJ,Terasawa E

更新日期：1988-07-01 00:00:00

abstract：:The present study examined the effects of FSH and insulin (IN) on 17 beta-estradiol (E2) secretion and granulosa cell proliferation. For these studies, immature rat ovaries were maintained in perifusion culture and continuously exposed to FSH (0-800 ng RP-1 eq/ml) and /or IN (0.2 U/ml). At specific times, the ovaries ...

journal_title：Endocrinology

authors： Peluso JJ,Delidow BC,Lynch J,White BA

更新日期：1991-01-01 00:00:00

abstract：:Two experiments tested whether serotonergic neurons participate in the acute feedback effects of estradiol on LH and PRL secretion. In the first study, ovariectomized female rats received oil vehicle or estradiol benzoate and were killed 3 h later. The turnover of serotonin [5-hydroxytryptamine (5-HT)] in microdissect...

journal_title：Endocrinology

authors： Johnson MD,Crowley WR

更新日期：1983-12-01 00:00:00

abstract：:A mitochondrial fraction prepared from homogenates of rat hypothalamic tissue was found by means of electron microscopy to be enriched with synaptosomes. The release of luteinizing hormone releasing hormone (LHRH) and thyrotropin releasing hormone (TRH) from this preparation was investigated. After incubation, the syn...

journal_title：Endocrinology

authors： Warberg J,Eskay RL,Barnea A,Reynolds RC,Porter JC

更新日期：1977-03-01 00:00:00

abstract：:The purpose of this study was to determine whether normal morphological development occurs in pituitary corticotrophs deprived of products of the hypothalamic paraventricular nucleus (PVN), e.g. corticotropin releasing hormone and arginine vasopressin (AVP), after PVN lesions. In addition, we have attempted to ascerta...

journal_title：Endocrinology

authors： McDonald TJ,Hoffman GE,Nathanielsz PW

更新日期：1992-09-01 00:00:00

abstract：:We investigated, in five cell strains per experiment, whether several cytokines known or believed to have effects on bone resorption were produced by nearly homogeneous strains of cultured normal human osteoblast-like (hOB) cells that display virtually the complete phenotype of the mature osteoblast. In unstimulated h...

journal_title：Endocrinology

authors： Chaudhary LR,Spelsberg TC,Riggs BL

更新日期：1992-05-01 00:00:00

abstract：:The ability of the adult pancreas to generate new insulin (beta) cells has been controversial because of difficulties in unequivocally identifying the precursor population. We recently determined that beta cells were generated during development from precursors that expressed the homeodomain-containing transcription f...

journal_title：Endocrinology

authors： Fernandes A,King LC,Guz Y,Stein R,Wright CV,Teitelman G

更新日期：1997-04-01 00:00:00

abstract：:The effects of endothelin-1 (ET) on several tissues are mediated by prostaglandins. In this study, we investigated the actions of ET on bone and determined whether they are mediated through prostaglandin-dependent pathways. Bone resorption, collagen, and non-collagen protein synthesis and inositol phosphate (IP) produ...

journal_title：Endocrinology

authors： Tatrai A,Foster S,Lakatos P,Shankar G,Stern PH

更新日期：1992-08-01 00:00:00

abstract：:The expression of cholesterol side-chain cleavage cytochrome P450 (P450scc), 17 alpha-hydroxylase cytochrome P450 (P45017 alpha), and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) was studied in bovine placenta and fetal adrenal glands throughout gestation. The levels of expression of these enzymes were much lower ...

journal_title：Endocrinology

authors： Conley AJ,Head JR,Stirling DT,Mason JI

更新日期：1992-05-01 00:00:00

abstract：:The action of sex steroids on the growth and differentiation of target tissues requires the presence of specific intracellular receptors. We compared the distribution of cells containing estrogen receptor (ER) and/or progesterone receptor (PR) in rabbit uterus by immunohistochemistry using monoclonal antibodies direct...

journal_title：Endocrinology

authors： Zaino RJ,Clarke CL,Feil PD,Satyaswaroop PG

更新日期：1989-11-01 00:00:00

abstract：:Brown adipose tissue (BAT) is a major site of nonshivering thermogenesis in mammals. Rodent studies indicated that BAT thermogenic activity may protect against obesity. Recent findings using novel radiodiagnosis procedures revealed unanticipated high activity of BAT in adult humans. Moreover, complex processes of cell...

journal_title：Endocrinology

authors： Giralt M,Villarroya F

更新日期：2013-09-01 00:00:00

abstract：:Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...

journal_title：Endocrinology

authors： Naulé L,Maione L,Kaiser UB

更新日期：2021-01-01 00:00:00

abstract：:In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexame...

journal_title：Endocrinology

authors： Naylor PH,Gilani SS,Milholland RJ,Rosen F

更新日期：1980-07-01 00:00:00

abstract：:Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity, one modeling hypothalamic obesity with a combined me...

journal_title：Endocrinology

authors： Elfers CT,Roth CL

更新日期：2017-01-01 00:00:00

abstract：:The time sequence of the metabolism of [4-14C] pregnenolone to testosterone in homogenates of human and rat testis was studied with special emphasis on the chain of events in the early 15 min of incubation. The incubations were performed at 32 C in the presence of NAD and a NADPH-generating system. The various interme...

journal_title：Endocrinology

authors： Weusten JJ,Smals AG,Hofman JA,Kloppenborg PW,Benraad TJ

更新日期：1987-05-01 00:00:00

abstract：:3-Iodothyronamine (3-T 1 AM) and thyronamine (T AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T(3)) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less ...

journal_title：Endocrinology

authors： Piehl S,Heberer T,Balizs G,Scanlan TS,Smits R,Koksch B,Köhrle J

更新日期：2008-06-01 00:00:00

abstract：:Both peroxisome proliferator-activated receptor-alpha (PPARalpha) and pancreatic/duodenal homeobox-1 (PDX-1) have been reported to be associated with glucose-stimulated insulin secretion (GSIS), but the relationship between PPARalpha and PDX-1 is not yet fully understood. In the present study, we tested the hypothesis...

journal_title：Endocrinology

authors： Sun Y,Zhang L,Gu HF,Han W,Ren M,Wang F,Gong B,Wang L,Guo H,Xin W,Zhao J,Gao L

更新日期：2008-02-01 00:00:00

abstract：:Free radical production and lipid peroxidation are potentially important mediators in testicular physiology and toxicology. The cytochrome P450 enzymes of the steroidogenic pathway are known to produce free radicals. The present study was conducted to elucidate in vivo the gonadotropin regulation of free radical-media...

journal_title：Endocrinology

authors： Peltola V,Huhtaniemi I,Metsa-Ketela T,Ahotupa M

更新日期：1996-01-01 00:00:00

abstract：:Ovarian angiotensin I (Ang I)-converting enzyme (ACE), estimated by the specific binding of the ACE inhibitor [125I]iodo-MK-351A, is localized on multiple ovarian structures, including follicular granulosa cells, corpora lutea, terminal epithelium, and ovarian blood vessels, but total ovarian ACE does not display a cy...

journal_title：Endocrinology

authors： Daud AI,Bumpus FM,Husain A

更新日期：1990-06-01 00:00:00

abstract：:T(4) activation into T(3) is catalyzed by type 2 deiodinase (D2) in the brain. The rapid induction of D2 in astrocytes by transient brain ischemia has prompted us to explore the effects of hypoxia on D2 in cultures of astrocytes. Hypoxia (2.5% O(2)) of cultured astrocytes increased D2 activity, alone or in association...

journal_title：Endocrinology

authors： Lamirand A,Mercier G,Ramaugé M,Pierre M,Courtin F

更新日期：2007-10-01 00:00:00

abstract：:A transient increase in serum progesterone concentrations (to 1 ng/ml for 1-2 days) is observed in the majority of ewes before the first estrous cycle of the breeding season. To determine whether such a brief antecedent rise in progesterone ensures initiation of a full-length cycle by the next LH surge, synthetic GnRH...

journal_title：Endocrinology

authors： Legan SJ,I'Anson H,Fitzgerald BP,Akaydin MS Jr

更新日期：1985-10-01 00:00:00

abstract：:Prenatal stress is associated with altered behavior and hypothalamic-pituitary-adrenal (HPA) axis function postnatally. Recent studies suggest that these outcomes are dependent on the timing of the prenatal stress. The majority of these studies have been carried out in male offspring. We hypothesized that a short peri...

journal_title：Endocrinology

authors： Kapoor A,Matthews SG

更新日期：2008-12-01 00:00:00

abstract：:Proglucagon, synthesized in the pancreatic islets and the intestinal L-cells, contains in its precursor structure glucagon, glicentin, and two glucagon-like peptides (GLP-I and GLP-II) separated by an intervening peptide (IP-II). We have cloned a stable rat islet cell line expressing the glucagon gene at high levels, ...

journal_title：Endocrinology

authors： Philippe J,Mojsov S,Drucker DJ,Habener JF

更新日期：1986-12-01 00:00:00

abstract：:The rate of internalization and degradation of radioiodinated hCG and ovine LH (oLH) as well as homologous and heterologous recombinants of their subunits was studied in suspensions of ovine luteal cells. Hormone bound to the plasma membrane was quantified by treating the cells with acidic buffer (pH 3.0) and quantifi...

journal_title：Endocrinology

authors： Mock EJ,Papkoff H,Niswender GD

更新日期：1983-07-01 00:00:00

abstract：:An estrogen-regulated arginine esteropeptidase is present in the immature rat uterus. The enzymatic complex consists of a membrane-bound activator and a soluble proenzyme. The activator is under strong estrogen control; its activity increases 10-fold 3 h after a single dose of 17 beta-estradiol. The subcellular locali...

journal_title：Endocrinology

authors： Jazín EE,Dickerman HW,Henrikson KP

更新日期：1988-02-01 00:00:00

abstract：:Preincubation of rat pituitary cells in primary culture with rat GH-releasing factor (rGRF) resulted in substantial desensitization to subsequent GRF stimulation. rGRF-directed GH release and intracellular cAMP accumulation decreased in the desensitized cells. Whereas prior treatment of rat pituitary cells caused part...

journal_title：Endocrinology

authors： Ceda GP,Hoffman AR

更新日期：1985-04-01 00:00:00

abstract：:The long-acting synthetic enkephalin FK 33-824 (FK) potently inhibits LH secretion in gonadectomized prepubertal male and female rats. The effect is reversible by coinjection of naloxone. We have observed an age-related decrease in the ability of FK to reduce LH secretion in the 48 h post-gonadectomized rat. Thus, the...

journal_title：Endocrinology

authors： Wilkinson M,Bhanot R

更新日期：1982-03-01 00:00:00

abstract：:Cultured astroglial cells were found to contain a type II 5'-deiodinase (5'D) activity which was increased by 10(-3) M (Bu)2cAMP but not by 2 X 10(-3) M n-butyrate. 8-Bromo-cAMP (8-Br-cAMP) (10(-3) M) also increased this enzyme activity. Cycloheximide (2 micrograms/ml) inhibited the 8-Br-cAMP effect on 5'D activity. F...

journal_title：Endocrinology

authors： Courtin F,Chantoux F,Pierre M,Francon J

更新日期：1988-09-01 00:00:00

abstract：:We have previously documented that raloxifene enhances the mechanical properties of dog vertebrae independent of changes in bone mass, suggesting a positive effect of raloxifene on material-level mechanical properties. The goal of this study was to determine the separate effects of raloxifene on the material-level mec...

journal_title：Endocrinology

authors： Allen MR,Hogan HA,Hobbs WA,Koivuniemi AS,Koivuniemi MC,Burr DB

更新日期：2007-08-01 00:00:00