听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览ANNALS OF NEUROLOGY期刊下所有文献
  • Socioeconomic Status Mediates Racial Differences Seen Using the AT(N) Framework.

    abstract:OBJECTIVES:African Americans are at greater risk for developing Alzheimer's disease (AD) dementia than non-Hispanic whites. In addition to biological considerations (eg, genetic influences and comorbid disorders), social and environmental factors may increase the risk of AD dementia. This paper (1) assesses neuroimagin...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25948

    authors: Meeker KL,Wisch JK,Hudson D,Coble D,Xiong C,Babulal GM,Gordon BA,Schindler SE,Cruchaga C,Flores S,Dincer A,Benzinger TL,Morris JC,Ances BM

    更新日期:2021-02-01 00:00:00

  • Perfusion-Dependent Cerebral Autoregulation Impairment in Hemispheric Stroke.

    abstract:OBJECTIVE:Loss of cerebral autoregulation (CA) plays a key role in secondary neurologic injury. However, the regional distribution of CA impairment after acute cerebral injury remains unclear because, in clinical practice, CA is only assessed within a limited compartment. Here, we performed large-scale regional mapping...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25963

    authors: Hecht N,Schrammel M,Neumann K,Müller MM,Dreier JP,Vajkoczy P,Woitzik J

    更新日期:2021-02-01 00:00:00

  • Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy.

    abstract:OBJECTIVE:The objective of this study was to evaluate patients with ganglionic acetylcholine receptor antibody (gAChR-Ab) positive autoimmune autonomic ganglionopathy using a multimodal testing protocol to characterize their full clinical phenotype and explore biomarkers to quantify immunotherapy response. METHODS:We ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.26018

    authors: Koay S,Vichayanrat E,Bremner F,Panicker JN,Lang B,Lunn MP,Watson L,Ingle GT,Hagen EM,McNamara P,Jacobson L,Provitera V,Nolano M,Vincent A,Mathias CJ,Iodice V

    更新日期:2021-01-13 00:00:00

  • Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter.

    abstract:OBJECTIVE:Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease of unknown etiology. Although the prevalent view regards a CD4+ -lymphocyte autoimmune reaction against myelin at the root of the disease, recent studies propose autoimmunity as a secondary reaction to idiopathic brain damage...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.26014

    authors: Luchicchi A,Hart B,Frigerio I,van Dam AM,Perna L,Offerhaus HL,Stys PK,Schenk GJ,Geurts JJG

    更新日期:2021-01-06 00:00:00

  • Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi-Omics.

    abstract:OBJECTIVE:Gut microbiome alterations in Parkinson disease (PD) have been reported repeatedly, but their functional relevance remains unclear. Fecal metabolomics, which provide a functional readout of microbial activity, have scarcely been investigated. We investigated fecal microbiome and metabolome alterations in PD, ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25982

    authors: Tan AH,Chong CW,Lim SY,Yap IKS,Teh CSJ,Loke MF,Song SL,Tan JY,Ang BH,Tan YQ,Kho MT,Bowman J,Mahadeva S,Yong HS,Lang AE

    更新日期:2020-12-03 00:00:00

  • Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis.

    abstract:OBJECTIVE:Recent studies carried out on amyotrophic lateral sclerosis patients suggest that the disease might initiate in the motor cortex and spread to its targets along the corticofugal tracts. In this study, we aimed to test the corticofugal hypothesis of amyotrophic lateral sclerosis experimentally. METHODS:Sod1G8...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25833

    authors: Burg T,Bichara C,Scekic-Zahirovic J,Fischer M,Stuart-Lopez G,Brunet A,Lefebvre F,Cordero-Erausquin M,Rouaux C

    更新日期:2020-10-01 00:00:00

  • Haploinsufficiency of Cyfip2 Causes Lithium-Responsive Prefrontal Dysfunction.

    abstract:OBJECTIVE:Genetic variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) encoding an actin-regulatory protein are associated with brain disorders, including intellectual disability and epilepsy. However, specific in vivo neuronal defects and potential treatments for CYFIP2-associated brain disorders remain lar...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25827

    authors: Lee SH,Zhang Y,Park J,Kim B,Kim Y,Lee SH,Kim GH,Huh YH,Lee B,Kim Y,Lee Y,Kim JY,Kang H,Choi SY,Jang S,Li Y,Kim S,Jin C,Pang K,Kim E,Lee Y,Kim H,Kim E,Choi JH,Kim J,Lee KJ,Choi SY,Han K

    更新日期:2020-09-01 00:00:00

  • Development and Validation of Forecasting Next Reported Seizure Using e-Diaries.

    abstract:OBJECTIVE:There are no validated methods for predicting the timing of seizures. Using machine learning, we sought to forecast 24-hour risk of self-reported seizure from e-diaries. METHODS:Data from 5,419 patients on SeizureTracker.com (including seizure count, type, and duration) were split into training (3,806 patien...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25812

    authors: Goldenholz DM,Goldenholz SR,Romero J,Moss R,Sun H,Westover B

    更新日期:2020-09-01 00:00:00

  • NMDAR Antibodies Alter Dopamine Receptors and Cause Psychotic Behavior in Mice.

    abstract:OBJECTIVE:The aim was to demonstrate that antibodies from patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis alter the levels of dopamine 1 receptor (D1R) and dopamine 2 receptor (D2R) and cause psychotic-like features in mice. METHODS:Cultured rat hippocampal neurons were treated with cerebrospinal...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25829

    authors: Carceles-Cordon M,Mannara F,Aguilar E,Castellanos A,Planagumà J,Dalmau J

    更新日期:2020-09-01 00:00:00

  • Gut Microbiome Signatures of Risk and Prodromal Markers of Parkinson Disease.

    abstract:OBJECTIVE:Alterations of the gut microbiome in Parkinson disease (PD) have been repeatedly demonstrated. However, little is known about whether such alterations precede disease onset and how they relate to risk and prodromal markers of PD. We investigated associations of these features with gut microbiome composition. ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25788

    authors: Heinzel S,Aho VTE,Suenkel U,von Thaler AK,Schulte C,Deuschle C,Paulin L,Hantunen S,Brockmann K,Eschweiler GW,Maetzler W,Berg D,Auvinen P,Scheperjans F

    更新日期:2020-08-01 00:00:00

  • Pediatric Leigh Syndrome: Neuroimaging Features and Genetic Correlations.

    abstract::The neurodiagnostic criteria of Leigh syndrome have not yet been clearly redefined based on the expanding of molecular etiologies. We aimed to analyze 20 years of clinical, genetic, and magnetic resonance studies from our Leigh syndrome cohort to provide a detailed description of central nervous system lesions in Leig...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25789

    authors: Alves CAPF,Teixeira SR,Martin-Saavedra JS,Guimarães Gonçalves F,Lo Russo F,Muraresku C,McCormick EM,Falk MJ,Zolkipli-Cunningham Z,Ganetzky R,Vossough A,Goldstein A,Zuccoli G

    更新日期:2020-08-01 00:00:00

  • Quantitative Separation of Tremor and Ataxia in Essential Tremor.

    abstract:OBJECTIVE:This study addresses an important problem in neurology, distinguishing tremor and ataxia using quantitative methods. Specifically, we aimed to quantitatively separate dysmetria, a cardinal sign of ataxia, from tremor in essential tremor (ET). METHODS:In Experiment 1, we compared 19 participants diagnosed wit...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25781

    authors: Casamento-Moran A,Yacoubi B,Wilkes BJ,Hess CW,Foote KD,Okun MS,Wagle Shukla A,Vaillancourt DE,Christou EA

    更新日期:2020-08-01 00:00:00

  • Post-Traumatic Stress Disorder is Associated with further Increased Parkinson's Disease Risk in Veterans with Traumatic Brain Injury.

    abstract:OBJECTIVE:Determining if traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are risk factors for Parkinson's disease (PD). This constitutes a research priority for the Veterans Administration (VA) with implications for screening policy and prevention. METHODS:Population-based, matched case-control ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25726

    authors: White DL,Kunik ME,Yu H,Lin HL,Richardson PA,Moore S,Sarwar AI,Marsh L,Jorge RE

    更新日期:2020-07-01 00:00:00

  • Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers.

    abstract:OBJECTIVE:C9orf72 expansion is the most common genetic cause of frontotemporal dementia (FTD). We examined aging trajectories of cortical thickness (CTh) and surface area in C9orf72 expansion adult carriers compared to healthy controls to characterize preclinical cerebral changes leading to symptoms. METHODS:Data were...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25748

    authors: Le Blanc G,Jetté Pomerleau V,McCarthy J,Borroni B,van Swieten J,Galimberti D,Sanchez-Valle R,LaForce R Jr,Moreno F,Synofzik M,Graff C,Masellis M,Tartaglia MC,Rowe JB,Vandenberghe R,Finger E,Tagliavini F,de Mendonça A,

    更新日期:2020-07-01 00:00:00

  • Natural History of Adult Patients with GM2 Gangliosidosis.

    abstract:OBJECTIVE:GM2 gangliosidoses are lysosomal diseases due to biallelic mutations in the HEXA (Tay-Sachs disease [TS]) or HEXB (Sandhoff disease [SD]) genes, with subsequent low hexosaminidase(s) activity. Most patients have childhood onset, but some experience the first symptoms during adolescence/adulthood. This study a...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25689

    authors: Masingue M,Dufour L,Lenglet T,Saleille L,Goizet C,Ayrignac X,Ory-Magne F,Barth M,Lamari F,Mandia D,Caillaud C,Nadjar Y

    更新日期:2020-04-01 00:00:00

  • Optimizing Patient Selection for Endovascular Treatment in Acute Ischemic Stroke (SELECT): A Prospective, Multicenter Cohort Study of Imaging Selection.

    abstract:OBJECTIVE:The primary imaging modalities used to select patients for endovascular thrombectomy (EVT) are noncontrast computed tomography (CT) and CT perfusion (CTP). However, their relative utility is uncertain. We prospectively assessed CT and CTP concordance/discordance and correlated the imaging profiles on both wit...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ana.25669

    authors: Sarraj A,Hassan AE,Grotta J,Sitton C,Cutter G,Cai C,Chen PR,Imam B,Pujara D,Arora A,Reddy S,Parsha K,Riascos RF,Vora N,Abraham M,Edgell R,Hellinger F,Haussen DC,Blackburn S,Kamal H,Barreto AD,Martin-Schild S,L

    更新日期:2020-03-01 00:00:00

  • A 30-Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes.

    abstract:OBJECTIVE:Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long-term clinical outcomes in MS, and to identify early prognostic features of these outcomes. METHODS:One hundred thirty-two people presenting with a clinically isolated syndrome were prospectively recruited between 1...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25637

    authors: Chung KK,Altmann D,Barkhof F,Miszkiel K,Brex PA,O'Riordan J,Ebner M,Prados F,Cardoso MJ,Vercauteren T,Ourselin S,Thompson A,Ciccarelli O,Chard DT

    更新日期:2020-01-01 00:00:00

  • Strategic Considerations for Applying the Flipped Classroom to Neurology Education.

    abstract::Nowadays, the "flipped classroom" approach is taking the center stage within medical education. However, very few reports on the implementation of the flipped classroom in neurology have been published to date, and this educational model still represents a challenge for students and educators alike. In this article, n...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25609

    authors: Sandrone S,Berthaud JV,Carlson C,Cios J,Dixit N,Farheen A,Kraker J,Owens JWM,Patino G,Sarva H,Weber D,Schneider LD

    更新日期:2020-01-01 00:00:00

  • Therapeutic Drug Monitoring of Newer Antiepileptic Drugs: A Randomized Trial for Dosage Adjustment.

    abstract:OBJECTIVE:Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is widely established for older generation AEDs, whereas there is limited evidence about newer AEDs. Our aim is to assess the benefit of TDM of newer generation AEDs in epilepsy. METHODS:We performed a randomized, controlled trial comparing syst...

    journal_title:Annals of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ana.25641

    authors: Aícua-Rapún I,André P,Rossetti AO,Ryvlin P,Hottinger AF,Decosterd LA,Buclin T,Novy J

    更新日期:2020-01-01 00:00:00

  • Intravenous thrombolysis for suspected ischemic stroke with seizure at onset.

    abstract:OBJECTIVE:Seizure at onset (SaO) has been considered a relative contraindication for intravenous thrombolysis (IVT) in patients with acute ischemic stroke, although this appraisal is not evidence based. Here, we investigated the prognostic significance of SaO in patients treated with IVT for suspected ischemic stroke. ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ana.25582

    authors: Polymeris AA,Curtze S,Erdur H,Hametner C,Heldner MR,Groot AE,Zini A,Béjot Y,Dietrich A,Martinez-Majander N,von Rennenberg R,Gumbinger C,Schaedelin S,De Marchis GM,Thilemann S,Traenka C,Lyrer PA,Bonati LH,Wegener S,R

    更新日期:2019-11-01 00:00:00

  • Associations between cerebrovascular risk factors and parkinson disease.

    abstract:OBJECTIVE:To determine whether cerebrovascular risk factors are associated with subsequent diagnoses of Parkinson disease, and whether these associations are similar in magnitude to those with subsequent diagnoses of Alzheimer disease. METHODS:This was a retrospective cohort study using claims data from a 5% random sa...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25564

    authors: Kummer BR,Diaz I,Wu X,Aaroe AE,Chen ML,Iadecola C,Kamel H,Navi BB

    更新日期:2019-10-01 00:00:00

  • A Trial of Sertraline or Cognitive Behavior Therapy for Depression in Epilepsy.

    abstract:OBJECTIVE:Limited evidence is available to guide treatment of depression for persons with epilepsy. We evaluated the comparative effectiveness of sertraline and cognitive behavior therapy (CBT) for depression, quality of life, seizures, and adverse treatment effects. METHODS:We randomly assigned 140 adult outpatients ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ana.25561

    authors: Gilliam FG,Black KJ,Carter J,Freedland KE,Sheline YI,Tsai WY,Lustman PJ

    更新日期:2019-10-01 00:00:00

  • Interleukin 9 alterations linked to alzheimer disease in african americans.

    abstract:OBJECTIVE:Compared to older Caucasians, older African Americans have higher risks of developing Alzheimer disease (AD) and lower cerebrospinal fluid (CSF) tau biomarker levels. It is not known whether tau-related differences begin earlier in life or whether race modifies other AD-related biomarkers such as inflammatory...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25543

    authors: Wharton W,Kollhoff AL,Gangishetti U,Verble DD,Upadhya S,Zetterberg H,Kumar V,Watts KD,Kippels AJ,Gearing M,Howell JC,Parker MW,Hu WT

    更新日期:2019-09-01 00:00:00

  • Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition.

    abstract:OBJECTIVE:Alzheimer disease (AD) is the most common form of dementia and is responsible for a huge and growing health care burden in the developed and developing world. The polygenic risk score (PRS) approach has shown 75 to 84% prediction accuracy of identifying individuals with AD risk. METHODS:In this study, we tes...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25530

    authors: Leonenko G,Shoai M,Bellou E,Sims R,Williams J,Hardy J,Escott-Price V,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2019-09-01 00:00:00

  • Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage.

    abstract:OBJECTIVE:To investigate whether soluble growth stimulation expressed gene 2 (sST2), a prognostic marker in cardiovascular and inflammatory disorders, is associated with neurological injury after aneurysmal subarachnoid hemorrhage (SAH). METHODS:We studied SAH patients from 2 independent cohorts. Outcome assessments i...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ana.25545

    authors: Bevers MB,Wolcott Z,Bache S,Hansen C,Sastre C,Mylvaganam R,Koch MJ,Patel AB,Møller K,Kimberly WT

    更新日期:2019-09-01 00:00:00

  • Deoxynucleoside Therapy for Thymidine Kinase 2-Deficient Myopathy.

    abstract:OBJECTIVE:Thymidine kinase 2, encoded by the nuclear gene TK2, is required for mitochondrial DNA maintenance. Autosomal recessive TK2 mutations cause depletion and multiple deletions of mtDNA that manifest predominantly as a myopathy usually beginning in childhood and progressing relentlessly. We investigated the safet...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ana.25506

    authors: Domínguez-González C,Madruga-Garrido M,Mavillard F,Garone C,Aguirre-Rodríguez FJ,Donati MA,Kleinsteuber K,Martí I,Martín-Hernández E,Morealejo-Aycinena JP,Munell F,Nascimento A,Kalko SG,Sardina MD,Álvarez Del Vayo C,Serrano

    更新日期:2019-08-01 00:00:00

  • Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation.

    abstract:OBJECTIVE:We compared outcomes after treatment with direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with atrial fibrillation (AF) and a recent cerebral ischemia. METHODS:We conducted an individual patient data analysis of seven prospective cohort studies. We included patients with AF an...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25489

    authors: Seiffge DJ,Paciaroni M,Wilson D,Koga M,Macha K,Cappellari M,Schaedelin S,Shakeshaft C,Takagi M,Tsivgoulis G,Bonetti B,Kallmünzer B,Arihiro S,Alberti A,Polymeris AA,Ambler G,Yoshimura S,Venti M,Bonati LH,Muir KW,Ya

    更新日期:2019-06-01 00:00:00

  • Penumbra detection in acute stroke with perfusion magnetic resonance imaging: Validation with 15 O-positron emission tomography.

    abstract:OBJECTIVE:Accurate identification of the ischemic penumbra, the therapeutic target in acute clinical stroke, is of critical importance to identify patients who might benefit from reperfusion therapies beyond the established time windows. Therefore, we aimed to validate magnetic resonance imaging (MRI) mismatch-based pe...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25479

    authors: Zaro-Weber O,Fleischer H,Reiblich L,Schuster A,Moeller-Hartmann W,Heiss WD

    更新日期:2019-06-01 00:00:00

  • Skin nerve pathology: Biomarkers of premanifest and manifest amyloid neuropathy.

    abstract:OBJECTIVE:Small-fiber sensory and autonomic symptoms are early presentations of familial amyloid polyneuropathy (FAP) with transthyretin (TTR) mutations. This study aimed to explore the potential of skin nerve pathologies as early and disease-progression biomarkers and their relationship with skin amyloid deposits. ME...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25433

    authors: Chao CC,Hsueh HW,Kan HW,Liao CH,Jiang HH,Chiang H,Lin WM,Yeh TY,Lin YH,Cheng YY,Hsieh ST

    更新日期:2019-04-01 00:00:00

  • A surface-in gradient of thalamic damage evolves in pediatric multiple sclerosis.

    abstract:OBJECTIVE:Central nervous system pathology in multiple sclerosis includes both focal inflammatory perivascular injury and injury to superficial structures, including the subpial region of the cortex, which reportedly exhibits a gradient of damage from the surface inward. We assessed how early in the multiple sclerosis ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25429

    authors: Fadda G,Brown RA,Magliozzi R,Aubert-Broche B,O'Mahony J,Shinohara RT,Banwell B,Marrie RA,Yeh EA,Collins DL,Arnold DL,Bar-Or A,Canadian Pediatric Demyelinating Disease Network.

    更新日期:2019-03-01 00:00:00

  • Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease.

    abstract:OBJECTIVE:Newer magnetic resonance imaging (MRI) techniques have shown promise in capturing early Parkinson disease (PD)-related changes in the substantia nigra pars compacta (SNc), the key pathological loci. Their translational value, however, is hindered by technical complexity and inconsistent results. METHODS:A no...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ana.25376

    authors: Du G,Lewis MM,Sica C,Kong L,Huang X

    更新日期:2019-01-01 00:00:00

  • Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia.

    abstract:OBJECTIVE:Friedreich ataxia (FRDA), an autosomal recessive neurodegenerative disease caused by mutations in the gene encoding for the mitochondrial protein frataxin, is characterized by ataxia and gait instability, immobility, and eventual death. We evaluated corneal confocal microscopy (CCM) quantification of corneal ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25355

    authors: Pagovich OE,Vo ML,Zhao ZZ,Petropoulos IN,Yuan M,Lertsuwanroj B,Ciralsky J,Lai E,Kiss S,D'Amico DJ,Mezey JG,Malik RA,Crystal RG

    更新日期:2018-12-01 00:00:00

  • Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage.

    abstract:OBJECTIVE:Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. METHODS:We performed a systematic review and individual patient data meta-analysis of cohort studie...

    journal_title:Annals of neurology

    pub_type: 杂志文章,meta分析

    doi:10.1002/ana.25342

    authors: Tsivgoulis G,Wilson D,Katsanos AH,Sargento-Freitas J,Marques-Matos C,Azevedo E,Adachi T,von der Brelie C,Aizawa Y,Abe H,Tomita H,Okumura K,Hagii J,Seiffge DJ,Lioutas VA,Traenka C,Varelas P,Basir G,Krogias C,Purrucke

    更新日期:2018-11-01 00:00:00

  • In vivo characterization of white matter pathology in premanifest huntington's disease.

    abstract:OBJECTIVE:Huntington's disease (HD) is a monogenic, fully penetrant neurodegenerative disorder, providing an ideal model for understanding brain changes occurring in the years prior to disease onset. Diffusion tensor imaging (DTI) studies show widespread white matter disorganization in the early premanifest stages (pre...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ana.25309

    authors: Zhang J,Gregory S,Scahill RI,Durr A,Thomas DL,Lehericy S,Rees G,Tabrizi SJ,Zhang H,TrackOn-HD investigators.

    更新日期:2018-10-01 00:00:00

  • Expanded disability status scale progression assessment heterogeneity in multiple sclerosis according to geographical areas.

    abstract::Using placebo data from 3 randomized multiple sclerosis (MS) trials with uniform inclusion criteria, we investigated heterogeneity of Expanded Disability Status Scale (EDSS) progression by geographical areas. Our analysis revealed a significantly lower EDSS progression in Eastern European countries (10.8%) compared wi...

    journal_title:Annals of neurology

    pub_type: 杂志文章,meta分析

    doi:10.1002/ana.25323

    authors: Bovis F,Signori A,Carmisciano L,Maietta I,Steinerman JR,Li T,Tansy AP,Sormani MP

    更新日期:2018-10-01 00:00:00

  • Hypoperfusion ratio predicts infarct growth during transfer for thrombectomy.

    abstract::We hypothesized that automated assessment of collaterals on computed tomography perfusion can predict the rate of infarct growth during transfer from a primary to a comprehensive stroke center for endovascular stroke treatment. We identified consecutive patients (N = 28) and assessed their collaterals based on the hyp...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25320

    authors: Guenego A,Mlynash M,Christensen S,Kemp S,Heit JJ,Lansberg MG,Albers GW

    更新日期:2018-10-01 00:00:00

  • Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis.

    abstract:OBJECTIVE:Cortical spreading depolarizations (CSDs) are intense and ubiquitous depolarization waves relevant for the pathophysiology of migraine and brain injury. CSDs disrupt the blood-brain barrier (BBB), but the mechanisms are unknown. METHODS:A total of six CSDs were evoked over 1 hour by topical application of 30...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25298

    authors: Sadeghian H,Lacoste B,Qin T,Toussay X,Rosa R,Oka F,Chung DY,Takizawa T,Gu C,Ayata C

    更新日期:2018-09-01 00:00:00

  • Remodeled cortical inhibition prevents motor seizures in generalized epilepsy.

    abstract:OBJECTIVE:Deletions of CACNA1A, encoding the α1 subunit of CaV 2.1 channels, cause epilepsy with ataxia in humans. Whereas the deletion of Cacna1a in γ-aminobutyric acidergic (GABAergic) interneurons (INs) derived from the medial ganglionic eminence (MGE) impairs cortical inhibition and causes generalized seizures in N...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25301

    authors: Jiang X,Lupien-Meilleur A,Tazerart S,Lachance M,Samarova E,Araya R,Lacaille JC,Rossignol E

    更新日期:2018-09-01 00:00:00

  • A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.

    abstract:OBJECTIVE:To identify novel autoantibodies for neuropathic pain (NeP). METHODS:We screened autoantibodies that selectively bind to mouse unmyelinated C-fiber type dorsal root ganglion (DRG) neurons using tissue-based indirect immunofluorescence assays (IFA) with sera from 110 NeP patients with various inflammatory and...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25279

    authors: Fujii T,Yamasaki R,Iinuma K,Tsuchimoto D,Hayashi Y,Saitoh BY,Matsushita T,Kido MA,Aishima S,Nakanishi H,Nakabeppu Y,Kira JI

    更新日期:2018-08-01 00:00:00

  • Continuous electroencephalography predicts delayed cerebral ischemia after subarachnoid hemorrhage: A prospective study of diagnostic accuracy.

    abstract:OBJECTIVE:Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI is a key focus of neurocritical care, but interventions carry risk and cannot be applied indiscriminately. Although retrospective studies have identified continuous electroencephalographic (cEE...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25232

    authors: Rosenthal ES,Biswal S,Zafar SF,O'Connor KL,Bechek S,Shenoy AV,Boyle EJ,Shafi MM,Gilmore EJ,Foreman BP,Gaspard N,Leslie-Mazwi TM,Rosand J,Hoch DB,Ayata C,Cash SS,Cole AJ,Patel AB,Westover MB

    更新日期:2018-05-01 00:00:00

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