abstract：Background:Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phos...

journal_title：Journal of ginseng research

authors： Xu J,Liu H,Su G,Ding M,Wang W,Lu J,Bi X,Zhao Y

更新日期：2021-01-01 00:00:00

abstract：Background:The circadian rhythm is the internal clock that controls sleep-wake cycles, metabolism, cognition, and several processes in the body, and its disruption has been associated with aging. The differentiated embryo chondrocyte (Dec) gene is related to circadian rhythm. To our knowledge, there are no reports of t...

journal_title：Journal of ginseng research

authors： Nam YH,Jeong SY,Kim YH,Rodriguez I,Nuankaew W,Bhawal UK,Hong BN,Kang TH

更新日期：2021-01-01 00:00:00

abstract：Background:The reports about valuable oligosaccharides in ginseng are quite limited. There is an urgent need to develop a practical procedure to detect and analyze ginseng oligosaccharides. Methods:The oligosaccharide extracts from ginseng were permethylated by solid-phase methylation method and then were analyzed by ...

journal_title：Journal of ginseng research

authors： Li L,Ma L,Guo Y,Liu W,Wang Y,Liu S

更新日期：2020-11-01 00:00:00

abstract：Background:Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarifi...

journal_title：Journal of ginseng research

authors： Xu X,Jin L,Jiang T,Lu Y,Aosai F,Piao HN,Xu GH,Jin CH,Jin XJ,Ma J,Piao LX

更新日期：2020-09-01 00:00:00

abstract：Background:Depression is a common neuropsychiatric disease that shows astrocyte pathology. Ginsenoside Rf (G-Rf) is a saponin found in Panax ginseng which has been used to treat neuropsychiatric diseases. We aimed to investigate antidepressant properties of G-Rf when introduced into the L-alpha-aminoadipic acid (L-AAA)...

journal_title：Journal of ginseng research

authors： Kim Y,Lee HY,Choi YJ,Cho SH

更新日期：2020-07-01 00:00:00

abstract：:Tissue fibrosis is an eventual pathologic change of numerous chronic illnesses, which is characterized by resident fibroblasts differentiation into myofibroblasts during inflammation, coupled with excessive extracellular matrix deposition in tissues, ultimately leading to failure of normal organ function. Now, there a...

journal_title：Journal of ginseng research

authors： Li X,Mo N,Li Z

更新日期：2020-05-01 00:00:00

abstract：Background:Korean Red Ginseng (KRG) has been known to possess many ginsenosides. These ginsenosides are used for curing cardiovascular problems. The present study show the protective potential of KRG against doxorubicin (DOX)-induced myocardial dysfunction, by assessing electrocardiographic, hemodynamic, and biochemica...

journal_title：Journal of ginseng research

authors： Jang YJ,Lee D,Hossain MA,Aravinthan A,Kang CW,Kim NS,Kim JH

更新日期：2020-05-01 00:00:00

abstract：:The detrimental impact of air pollution as a result of frequent exposure to fine particles posed a global public health risk mainly to the pulmonary disorders in pediatric and geriatric population. Here, we reviewed the current literature regarding the role of ginseng and/or its components as antimicrobials, especiall...

journal_title：Journal of ginseng research

authors： Iqbal H,Rhee DK

更新日期：2020-03-01 00:00:00

abstract：Background:Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regul...

journal_title：Journal of ginseng research

authors： Wang CZ,Hou L,Wan JY,Yao H,Yuan J,Zeng J,Park CW,Kim SH,Seo DB,Shin KS,Zhang CF,Chen L,Zhang QH,Liu Z,Sava-Segal C,Yuan CS

更新日期：2020-03-01 00:00:00

abstract：Background:The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition o...

journal_title：Journal of ginseng research

authors： Yi SA,Lee J,Park SK,Kim JY,Park JW,Lee MG,Nam KH,Park JH,Oh H,Kim S,Han J,Kim BK,Jo DG,Han JW

更新日期：2020-01-01 00:00:00

abstract：Background:The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used "Qi-invigorating" herbs, which provides tonic and preventive effects by resisting oxidative...

journal_title：Journal of ginseng research

authors： Huang Y,Kwan KKL,Leung KW,Yao P,Wang H,Dong TT,Tsim KWK

更新日期：2019-10-01 00:00:00

abstract：Background:Cytochrome P450 enzymes catalyze a wide range of reactions in plant metabolism. Besides their physiological functions on primary and secondary metabolites, P450s are also involved in herbicide detoxification via hydroxylation or dealkylation. Ginseng as a perennial plant offers more sustainable solutions to ...

journal_title：Journal of ginseng research

authors： Khanom S,Jang J,Lee OR

更新日期：2019-10-01 00:00:00

abstract：Background:Ginsenoside Rg3, a derivative of steroidal saponins abundant in ginseng, has a range of effects on cancer cells, including anti-cell proliferation and anti-inflammation activity. Here, we investigate two long noncoding RNAs (lncRNAs), STXBP5-AS1 and RFX3-AS1, which are hypomethylated and hypermethylated in t...

journal_title：Journal of ginseng research

authors： Ham J,Jeong D,Park S,Kim HW,Kim H,Kim SJ

更新日期：2019-10-01 00:00:00

abstract：Background:The root and rhizome are historically and officially utilized medicinal parts of Panax notoginseng (PN) (Burk.) F. H. Chen, which in raw and steamed forms are used differently in practice. Methods:To investigate the differences in chemical composition and bioactivities of PN root and rhizome between raw and...

journal_title：Journal of ginseng research

authors： Xiong Y,Chen L,Man J,Hu Y,Cui X

更新日期：2019-07-01 00:00:00

abstract：Background:The mixed-cultivation of different Panax ginseng cultivars can cause adverse effects on stability of yield and quality. K-1 is a superior cultivar with good root shape and stronger disease resistance. DNA markers mined from functional genes are clearly desirable for K-1, as they may associate with major trai...

journal_title：Journal of ginseng research

authors： Wang H,Xu F,Wang X,Kwon WS,Yang DC

更新日期：2019-07-01 00:00:00

abstract：Background:Panax ginseng is regarded as one of the best compounds for promoting health, and it has been used traditionally as a medicinal herb. Recently, Korean Red Ginseng (RG) has been shown to protect skin from aging and wrinkling; it can also relieve atopic dermatitis and allergy symptoms. This study aimed to evalu...

journal_title：Journal of ginseng research

authors： Park KS,Park DH

更新日期：2019-04-01 00:00:00

abstract：Background:Ginsenoside Rf is a ginseng saponin found only in Panax ginseng that affects lipid metabolism. It also has neuroprotective and antiinflammatory properties. We previously showed that Korean Red Ginseng (KRG) inhibited the expression of cyclooxygenase-2 (COX-2) by hypoxia via peroxisome proliferator-activated ...

journal_title：Journal of ginseng research

authors： Song H,Park J,Choi K,Lee J,Chen J,Park HJ,Yu BI,Iida M,Rhyu MR,Lee Y

更新日期：2019-04-01 00:00:00

abstract：Background:Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion...

journal_title：Journal of ginseng research

authors： Jung J,Jang HJ,Eom SJ,Choi NS,Lee NK,Paik HD

更新日期：2019-01-01 00:00:00

abstract：Background:Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The presen...

journal_title：Journal of ginseng research

authors： Yu L,Chen Y,Shi J,Wang R,Yang Y,Yang L,Zhao S,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer's disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression. Recent studies demonstrated that Panax ginseng extract improves AD symptoms in pat...

journal_title：Journal of ginseng research

authors： Kim HJ,Jung SW,Kim SY,Cho IH,Kim HC,Rhim H,Kim M,Nah SY

更新日期：2018-10-01 00:00:00

abstract：Background:Korean ginseng (Panax ginseng) plays an anti-inflammatory role in a variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. g...

journal_title：Journal of ginseng research

authors： Han SY,Kim J,Kim E,Kim SH,Seo DB,Kim JH,Shin SS,Cho JY

更新日期：2018-10-01 00:00:00

abstract：Background:Despite the large number of studies on ginseng, pharmacological activities of ginseng seed oil (GSO) have not been established. GSO is rich in unsaturated fatty acids, mostly oleic and linoleic acids. Unsaturated fatty acids are known to exert a therapeutic effect in nonalcoholic fatty liver disease (NAFLD)....

journal_title：Journal of ginseng research

authors： Kim GW,Jo HK,Chung SH

更新日期：2018-10-01 00:00:00

abstract：Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...

journal_title：Journal of ginseng research

authors： Kim EJ,Kwon KA,Lee YE,Kim JH,Kim SH,Kim JH

更新日期：2018-07-01 00:00:00

abstract：Background:The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-E...

journal_title：Journal of ginseng research

authors： Lee JO,Kim E,Kim JH,Hong YH,Kim HG,Jeong D,Kim J,Kim SH,Park C,Seo DB,Son YJ,Han SY,Cho JY

更新日期：2018-07-01 00:00:00

abstract：Background:Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Me...

journal_title：Journal of ginseng research

authors： Ghaeminia M,Rajkumar R,Koh HL,Dawe GS,Tan CH

更新日期：2018-07-01 00:00:00

abstract：Background:Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the...

journal_title：Journal of ginseng research

authors： Cho SK,Kim D,Yoo D,Jang EJ,Jun JB,Sung YK

更新日期：2018-04-01 00:00:00

abstract：:Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiati...

journal_title：Journal of ginseng research

authors： Choi SY,Kim KJ,Song JH,Lee BY

更新日期：2018-04-01 00:00:00

abstract：Background:Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin e...

journal_title：Journal of ginseng research

authors： Lee BH,Choi SH,Kim HJ,Park SD,Rhim H,Kim HC,Hwang SH,Nah SY

更新日期：2018-01-01 00:00:00

abstract：Background:Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Method...

journal_title：Journal of ginseng research

authors： Lee SY,Go GY,Vuong TA,Kim JW,Lee S,Jo A,An JM,Kim SN,Seo DW,Kim JS,Kim YK,Kang JS,Lee SJ,Bae GU

更新日期：2018-01-01 00:00:00

abstract：:Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effect...

journal_title：Journal of ginseng research

authors： Park TY,Hong M,Sung H,Kim S,Suk KT

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. METHODS:A dammarane-type triterpene saponin was isolated from P. ginseng root throug...

journal_title：Journal of ginseng research

authors： Lee DG,Lee J,Cho IH,Kim HJ,Lee SW,Kim YO,Park CG,Lee S

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Panax ginseng is a traditional herb used for medicinal purposes in eastern Asia. P. ginseng contains various ginsenosides with pharmacological effects. In this study, floralginsenoside A (FGA), ginsenoside Rd (GRD), and ginsenoside Re (GRE) were purified from P. ginseng berry. METHODS:Chemical structures of...

journal_title：Journal of ginseng research

authors： Lee DY,Lee J,Jeong YT,Byun GH,Kim JH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Compound K (CK) is a bioactive derivative of ginsenoside Rb1 in Panax ginseng (Korean ginseng). Its biological and pharmacological activities have been studied in various disease conditions, although its immunomodulatory role in innate immunity mediated by monocytes/macrophages has been poorly understood. In...

journal_title：Journal of ginseng research

authors： Yang WS,Yi YS,Kim D,Kim MH,Park JG,Kim E,Lee SY,Yoon K,Kim JH,Park J,Cho JY

更新日期：2017-07-01 00:00:00

abstract：:Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported....

journal_title：Journal of ginseng research

authors： Liu J,Xu Y,Yang J,Wang W,Zhang J,Zhang R,Meng Q

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Radiotherapy is one of the most important modalities in cancer treatment; however, normal tissue damage is a serious concern. Drug development for the protection or reduction of normal tissue damage is therefore a clinical issue. Herein, we evaluated the protective properties of Panax ginseng Meyer and its c...

journal_title：Journal of ginseng research

authors： Kim HG,Jang SS,Lee JS,Kim HS,Son CG

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion...

journal_title：Journal of ginseng research

authors： Park SE,Na CS,Yoo SA,Seo SH,Son HS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:We evaluated the drug interaction profile of Red Ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers. METHODS:This article describes an open-label, crossover study. CYP probe cocktail drugs, caffeine, ...

journal_title：Journal of ginseng research

authors： Kim DS,Kim Y,Jeon JY,Kim MG

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. METHODS:Medium-pressure liquid chromatography and semiprep...

journal_title：Journal of ginseng research

authors： Wang YS,Jin YP,Gao W,Xiao SY,Zhang YW,Zheng PH,Wang J,Liu JX,Sun CH,Wang YP

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. In this work, enzymatic hydrolysis of ginsenoside Rb1 was studied using enzyme preparations from cultured ...

journal_title：Journal of ginseng research

authors： Upadhyaya J,Kim MJ,Kim YH,Ko SR,Park HW,Kim MK

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:To investigate the effect of pectinase-treated Panax ginseng (GINST) in cellular and male subfertility animal models. METHODS:Hydrogen peroxide (H2O2)-induced mouse spermatocyte GC-2spd cells were used as an in vitro model. Cell viability was measured using MTT assay. For the in vivo study, GINST (200 mg/kg...

journal_title：Journal of ginseng research

authors： Kopalli SR,Cha KM,Jeong MS,Lee SH,Sung JH,Seo SK,Kim SK

更新日期：2016-04-01 00:00:00