Abstract:
:Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.
journal_name
J Ginseng Resjournal_title
Journal of ginseng researchauthors
Choi SY,Kim KJ,Song JH,Lee BYdoi
10.1016/j.jgr.2017.02.002subject
Has Abstractpub_date
2018-04-01 00:00:00pages
225-228issue
2eissn
1226-8453issn
2093-4947pii
S1226-8453(17)30026-Xjournal_volume
42pub_type
杂志文章abstract:BACKGROUND:This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. METHODS:Samples of powdered Vietnamese ginseng were steamed at 120°C for various times and their extracts were subjecte...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2013.11.015
更新日期:2014-04-01 00:00:00
abstract:Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.03.008
更新日期:2018-07-01 00:00:00
abstract:Background:Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin e...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2016.12.007
更新日期:2018-01-01 00:00:00
abstract::The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. Th...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2013.11.008
更新日期:2014-01-01 00:00:00
abstract:Background:Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarifi...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.06.002
更新日期:2020-09-01 00:00:00
abstract:Background:Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The presen...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.09.005
更新日期:2019-01-01 00:00:00
abstract::This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.1.102
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. METHODS:Medium-pressure liquid chromatography and semiprep...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.08.003
更新日期:2016-07-01 00:00:00
abstract:Background:The root and rhizome are historically and officially utilized medicinal parts of Panax notoginseng (PN) (Burk.) F. H. Chen, which in raw and steamed forms are used differently in practice. Methods:To investigate the differences in chemical composition and bioactivities of PN root and rhizome between raw and...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.11.004
更新日期:2019-07-01 00:00:00
abstract:Background:The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-E...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.02.007
更新日期:2018-07-01 00:00:00
abstract::Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effect...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2016.11.004
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Although the aerial parts of hydroponic Panax ginseng are reported to contain higher contents of total ginsenosides than those of roots, the isolation and identification of active metabolites from the aerial parts of hydroponic P. ginseng have not been carried out so far. METHODS:The aerial parts of hydropo...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2014.10.005
更新日期:2015-04-01 00:00:00
abstract:Background:Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phos...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.11.002
更新日期:2021-01-01 00:00:00
abstract:Background:The circadian rhythm is the internal clock that controls sleep-wake cycles, metabolism, cognition, and several processes in the body, and its disruption has been associated with aging. The differentiated embryo chondrocyte (Dec) gene is related to circadian rhythm. To our knowledge, there are no reports of t...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2020.09.003
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Identifying suitable site for growing mountain-cultivated ginseng is a concern for ginseng producers. This study was conducted to evaluate the soil properties of cultivation sites for mountain-cultivated ginseng in Hamyang-gun, which is one of the most well-known areas for mountain-cultivated ginseng in Kore...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2014.06.004
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts antidiabetic effects. We tested whether the insulin-sensitizing and antidiabetic effects of G-Rb1 results from a reduction in ectopic fat accumulation, mediated by inhibition of lipolysis in adipocytes. ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2014.11.004
更新日期:2015-07-01 00:00:00
abstract:Background:The mixed-cultivation of different Panax ginseng cultivars can cause adverse effects on stability of yield and quality. K-1 is a superior cultivar with good root shape and stronger disease resistance. DNA markers mined from functional genes are clearly desirable for K-1, as they may associate with major trai...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.07.001
更新日期:2019-07-01 00:00:00
abstract::Tissue fibrosis is an eventual pathologic change of numerous chronic illnesses, which is characterized by resident fibroblasts differentiation into myofibroblasts during inflammation, coupled with excessive extracellular matrix deposition in tissues, ultimately leading to failure of normal organ function. Now, there a...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2019.12.003
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:To investigate the effect of pectinase-treated Panax ginseng (GINST) in cellular and male subfertility animal models. METHODS:Hydrogen peroxide (H2O2)-induced mouse spermatocyte GC-2spd cells were used as an in vitro model. Cell viability was measured using MTT assay. For the in vivo study, GINST (200 mg/kg...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.08.005
更新日期:2016-04-01 00:00:00
abstract::Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L.) are the two most recognized ginseng botanicals. It is believed that the ginseng saponins called ginsenosides are the major active constituents in both ginsengs. Although American ginseng is not as extensively studied as Asian ginseng, it is on...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2010.34.3.160
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Blind and excessive application of fertilizers was found during the cultivation of Panax notoginseng in fields, as well as increase in root rot disease incidence. METHODS:Both "3414" application and orthogonal test designs were performed at Shilin county, Yunnan province, China, for NPK (nitrogen, phosphoru...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.04.003
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.12.008
更新日期:2017-01-01 00:00:00
abstract::There seems to be some controversy about the effect of total ginseng saponin (TGS) on the secretion of catecholamines (CA) from the adrenal gland. Therefore, the present study aimed to determine whether TGS can affect the CA release in the perfused model of the adrenal medulla isolated from spontaneously hypertensive ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2011.35.2.176
更新日期:2011-06-01 00:00:00
abstract:Background:Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.01.006
更新日期:2018-04-01 00:00:00
abstract::We previously reported that in vitro anti-platelet activity of tissue-cultured mountain ginseng (TCMG) ethanol extracts show improved efficacy when compared with commercial ginseng products such as Korean red ginseng and Panax ginseng. However, information on the anti-platelet activity of the ethyl acetate fraction fr...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2011.35.4.442
更新日期:2011-11-01 00:00:00
abstract::The ginseng plant (Panax ginseng Meyer) has a large number of active ingredients including steroidal saponins with a dammarane skeleton as well as protopanaxadiol and protopanaxatriol, commonly known as ginsenosides, which have antioxidant, anticancer, antidiabetic, anti-adipocyte, and sexual enhancing effects. Though...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.5142/jgr.2013.37.261
更新日期:2013-07-01 00:00:00
abstract::Korean red ginseng (KRG) is used worldwide as a popular traditional herbal medicine. KRG has shown beneficial effects on cardiovascular diseases, such as atherosclerosis, diabetes, and hypertension. Up-regulation of a cytoprotective protein, heme oxygenase (HO)-1, is considered to augment the cellular defense against ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2011.35.3.352
更新日期:2011-09-01 00:00:00
abstract::Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported....
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2017.01.001
更新日期:2017-07-01 00:00:00
abstract:Background:Cytochrome P450 enzymes catalyze a wide range of reactions in plant metabolism. Besides their physiological functions on primary and secondary metabolites, P450s are also involved in herbicide detoxification via hydroxylation or dealkylation. Ginseng as a perennial plant offers more sustainable solutions to ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.04.005
更新日期:2019-10-01 00:00:00
abstract::Ginsenoside (ginseng saponin), the principal component of ginseng, is responsible for the pharmacological and biological activities of ginseng. We isolated lactic acid bacteria from Kimchi using esculin agar, to produce β-glucosidase. We focused on the bio-transformation of ginsenoside. Phylogenetic analysis was perfo...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.3.291
更新日期:2012-07-01 00:00:00