Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells.

Abstract:

:Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.

journal_name

J Ginseng Res

authors

Choi SY,Kim KJ,Song JH,Lee BY

doi

10.1016/j.jgr.2017.02.002

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

225-228

issue

2

eissn

1226-8453

issn

2093-4947

pii

S1226-8453(17)30026-X

journal_volume

42

pub_type

杂志文章
  • Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity.

    abstract:BACKGROUND:This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. METHODS:Samples of powdered Vietnamese ginseng were steamed at 120°C for various times and their extracts were subjecte...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2013.11.015

    authors: Le TH,Lee SY,Kim TR,Kim JY,Kwon SW,Nguyen NK,Park JH,Nguyen MD

    更新日期:2014-04-01 00:00:00

  • Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-κB and ERK1/2 pathways in colon cancer.

    abstract:Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2017.03.008

    authors: Kim EJ,Kwon KA,Lee YE,Kim JH,Kim SH,Kim JH

    更新日期:2018-07-01 00:00:00

  • Gintonin absorption in intestinal model systems.

    abstract:Background:Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin e...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2016.12.007

    authors: Lee BH,Choi SH,Kim HJ,Park SD,Rhim H,Kim HC,Hwang SH,Nah SY

    更新日期:2018-01-01 00:00:00

  • Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3.

    abstract::The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. Th...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2013.11.008

    authors: Chang KH,Jo MN,Kim KT,Paik HD

    更新日期:2014-01-01 00:00:00

  • Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway.

    abstract:Background:Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarifi...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2019.06.002

    authors: Xu X,Jin L,Jiang T,Lu Y,Aosai F,Piao HN,Xu GH,Jin CH,Jin XJ,Ma J,Piao LX

    更新日期:2020-09-01 00:00:00

  • Biosynthesis of rare 20(R)-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes.

    abstract:Background:Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The presen...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2017.09.005

    authors: Yu L,Chen Y,Shi J,Wang R,Yang Y,Yang L,Zhao S,Wang Z

    更新日期:2019-01-01 00:00:00

  • Changes in the Contents of Prosapogenin in the Red Ginseng (Panax ginseng) Depending on Steaming Batches.

    abstract::This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.5142/jgr.2012.36.1.102

    authors: Lee SA,Jo HK,Im BO,Kim S,Whang WK,Ko SK

    更新日期:2012-01-01 00:00:00

  • Complete (1)H-NMR and (13)C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng.

    abstract:BACKGROUND:Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. METHODS:Medium-pressure liquid chromatography and semiprep...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2015.08.003

    authors: Wang YS,Jin YP,Gao W,Xiao SY,Zhang YW,Zheng PH,Wang J,Liu JX,Sun CH,Wang YP

    更新日期:2016-07-01 00:00:00

  • Chemical and bioactive comparison of Panax notoginseng root and rhizome in raw and steamed forms.

    abstract:Background:The root and rhizome are historically and officially utilized medicinal parts of Panax notoginseng (PN) (Burk.) F. H. Chen, which in raw and steamed forms are used differently in practice. Methods:To investigate the differences in chemical composition and bioactivities of PN root and rhizome between raw and...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2017.11.004

    authors: Xiong Y,Chen L,Man J,Hu Y,Cui X

    更新日期:2019-07-01 00:00:00

  • Antimelanogenesis and skin-protective activities of Panax ginseng calyx ethanol extract.

    abstract:Background:The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-E...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2018.02.007

    authors: Lee JO,Kim E,Kim JH,Hong YH,Kim HG,Jeong D,Kim J,Kim SH,Park C,Seo DB,Son YJ,Han SY,Cho JY

    更新日期:2018-07-01 00:00:00

  • Effect of Korean Red Ginseng in chronic liver disease.

    abstract::Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effect...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章,评审

    doi:10.1016/j.jgr.2016.11.004

    authors: Park TY,Hong M,Sung H,Kim S,Suk KT

    更新日期:2017-10-01 00:00:00

  • Glycosyl glycerides from hydroponic Panax ginseng inhibited NO production in lipopolysaccharide-stimulated RAW264.7 cells.

    abstract:BACKGROUND:Although the aerial parts of hydroponic Panax ginseng are reported to contain higher contents of total ginsenosides than those of roots, the isolation and identification of active metabolites from the aerial parts of hydroponic P. ginseng have not been carried out so far. METHODS:The aerial parts of hydropo...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2014.10.005

    authors: Cha BJ,Park JH,Shrestha S,Baek NI,Lee SM,Lee TH,Kim J,Kim GS,Kim SY,Lee DY

    更新日期:2015-04-01 00:00:00

  • Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms.

    abstract:Background:Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phos...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2019.11.002

    authors: Xu J,Liu H,Su G,Ding M,Wang W,Lu J,Bi X,Zhao Y

    更新日期:2021-01-01 00:00:00

  • Anti-aging effects of Korean Red Ginseng (KRG) in differentiated embryo chondrocyte (DEC) knockout mice.

    abstract:Background:The circadian rhythm is the internal clock that controls sleep-wake cycles, metabolism, cognition, and several processes in the body, and its disruption has been associated with aging. The differentiated embryo chondrocyte (Dec) gene is related to circadian rhythm. To our knowledge, there are no reports of t...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2020.09.003

    authors: Nam YH,Jeong SY,Kim YH,Rodriguez I,Nuankaew W,Bhawal UK,Hong BN,Kang TH

    更新日期:2021-01-01 00:00:00

  • Soil properties of cultivation sites for mountain-cultivated ginseng at local level.

    abstract:BACKGROUND:Identifying suitable site for growing mountain-cultivated ginseng is a concern for ginseng producers. This study was conducted to evaluate the soil properties of cultivation sites for mountain-cultivated ginseng in Hamyang-gun, which is one of the most well-known areas for mountain-cultivated ginseng in Kore...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2014.06.004

    authors: Kim C,Choo GC,Cho HS,Lim JT

    更新日期:2015-01-01 00:00:00

  • Ginsenoside Rb1 ameliorates liver fat accumulation by upregulating perilipin expression in adipose tissue of db/db obese mice.

    abstract:BACKGROUND:Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts antidiabetic effects. We tested whether the insulin-sensitizing and antidiabetic effects of G-Rb1 results from a reduction in ectopic fat accumulation, mediated by inhibition of lipolysis in adipocytes. ...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2014.11.004

    authors: Yu X,Ye L,Zhang H,Zhao J,Wang G,Guo C,Shang W

    更新日期:2015-07-01 00:00:00

  • Molecular discrimination of Panax ginseng cultivar K-1 using pathogenesis-related protein 5 gene.

    abstract:Background:The mixed-cultivation of different Panax ginseng cultivars can cause adverse effects on stability of yield and quality. K-1 is a superior cultivar with good root shape and stronger disease resistance. DNA markers mined from functional genes are clearly desirable for K-1, as they may associate with major trai...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2018.07.001

    authors: Wang H,Xu F,Wang X,Kwon WS,Yang DC

    更新日期:2019-07-01 00:00:00

  • Ginsenosides: potential therapeutic source for fibrosis-associated human diseases.

    abstract::Tissue fibrosis is an eventual pathologic change of numerous chronic illnesses, which is characterized by resident fibroblasts differentiation into myofibroblasts during inflammation, coupled with excessive extracellular matrix deposition in tissues, ultimately leading to failure of normal organ function. Now, there a...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章,评审

    doi:10.1016/j.jgr.2019.12.003

    authors: Li X,Mo N,Li Z

    更新日期:2020-05-01 00:00:00

  • Pectinase-treated Panax ginseng ameliorates hydrogen peroxide-induced oxidative stress in GC-2 sperm cells and modulates testicular gene expression in aged rats.

    abstract:BACKGROUND:To investigate the effect of pectinase-treated Panax ginseng (GINST) in cellular and male subfertility animal models. METHODS:Hydrogen peroxide (H2O2)-induced mouse spermatocyte GC-2spd cells were used as an in vitro model. Cell viability was measured using MTT assay. For the in vivo study, GINST (200 mg/kg...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2015.08.005

    authors: Kopalli SR,Cha KM,Jeong MS,Lee SH,Sung JH,Seo SK,Kim SK

    更新日期:2016-04-01 00:00:00

  • Chemical and pharmacological studies of saponins with a focus on American ginseng.

    abstract::Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L.) are the two most recognized ginseng botanicals. It is believed that the ginseng saponins called ginsenosides are the major active constituents in both ginsengs. Although American ginseng is not as extensively studied as Asian ginseng, it is on...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.5142/jgr.2010.34.3.160

    authors: Yuan CS,Wang CZ,Wicks SM,Qi LW

    更新日期:2010-09-01 00:00:00

  • Optimal fertilizer application for Panax notoginseng and effect of soil water on root rot disease and saponin contents.

    abstract:BACKGROUND:Blind and excessive application of fertilizers was found during the cultivation of Panax notoginseng in fields, as well as increase in root rot disease incidence. METHODS:Both "3414" application and orthogonal test designs were performed at Shilin county, Yunnan province, China, for NPK (nitrogen, phosphoru...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2015.04.003

    authors: Xia P,Guo H,Zhao H,Jiao J,Deyholos MK,Yan X,Liu Y,Liang Z

    更新日期:2016-01-01 00:00:00

  • Biotransformation of major ginsenosides in ginsenoside model culture by lactic acid bacteria.

    abstract:BACKGROUND:Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2015.12.008

    authors: Park SE,Na CS,Yoo SA,Seo SH,Son HS

    更新日期:2017-01-01 00:00:00

  • Inhibitory Effects of Total Ginseng Saponin on Catecholamine Secretion from the Perfused Adrenal Medulla of SHRs.

    abstract::There seems to be some controversy about the effect of total ginseng saponin (TGS) on the secretion of catecholamines (CA) from the adrenal gland. Therefore, the present study aimed to determine whether TGS can affect the CA release in the perfused model of the adrenal medulla isolated from spontaneously hypertensive ...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.5142/jgr.2011.35.2.176

    authors: Jang SJ,Lim HJ,Lim DY

    更新日期:2011-06-01 00:00:00

  • Korean Red Ginseng exhibits no significant adverse effect on disease activity in patients with rheumatoid arthritis: a randomized, double-blind, crossover study.

    abstract:Background:Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2017.01.006

    authors: Cho SK,Kim D,Yoo D,Jang EJ,Jun JB,Sung YK

    更新日期:2018-04-01 00:00:00

  • Ethyl acetate extract from tissue-cultured mountain ginseng adventitious roots inhibits in vitro platelet aggregation in whole human blood and augments peripheral blood flow in mice.

    abstract::We previously reported that in vitro anti-platelet activity of tissue-cultured mountain ginseng (TCMG) ethanol extracts show improved efficacy when compared with commercial ginseng products such as Korean red ginseng and Panax ginseng. However, information on the anti-platelet activity of the ethyl acetate fraction fr...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.5142/jgr.2011.35.4.442

    authors: Lee IS,Kim SK,Jeon MH,Jeon WK

    更新日期:2011-11-01 00:00:00

  • Ginseng saponins and the treatment of osteoporosis: mini literature review.

    abstract::The ginseng plant (Panax ginseng Meyer) has a large number of active ingredients including steroidal saponins with a dammarane skeleton as well as protopanaxadiol and protopanaxatriol, commonly known as ginsenosides, which have antioxidant, anticancer, antidiabetic, anti-adipocyte, and sexual enhancing effects. Though...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章,评审

    doi:10.5142/jgr.2013.37.261

    authors: Siddiqi MH,Siddiqi MZ,Ahn S,Kang S,Kim YJ,Sathishkumar N,Yang DU,Yang DC

    更新日期:2013-07-01 00:00:00

  • Up-regulation of Heme Oxygenase-1 by Korean Red Ginseng Water Extract as a Cytoprotective Effect in Human Endothelial Cells.

    abstract::Korean red ginseng (KRG) is used worldwide as a popular traditional herbal medicine. KRG has shown beneficial effects on cardiovascular diseases, such as atherosclerosis, diabetes, and hypertension. Up-regulation of a cytoprotective protein, heme oxygenase (HO)-1, is considered to augment the cellular defense against ...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.5142/jgr.2011.35.3.352

    authors: Yang H,Lee SE,Jeong SI,Park CS,Jin YH,Park YS

    更新日期:2011-09-01 00:00:00

  • Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.

    abstract::Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported....

    journal_title:Journal of ginseng research

    pub_type: 杂志文章,评审

    doi:10.1016/j.jgr.2017.01.001

    authors: Liu J,Xu Y,Yang J,Wang W,Zhang J,Zhang R,Meng Q

    更新日期:2017-07-01 00:00:00

  • Overexpression of ginseng cytochrome P450 CYP736A12 alters plant growth and confers phenylurea herbicide tolerance in Arabidopsis.

    abstract:Background:Cytochrome P450 enzymes catalyze a wide range of reactions in plant metabolism. Besides their physiological functions on primary and secondary metabolites, P450s are also involved in herbicide detoxification via hydroxylation or dealkylation. Ginseng as a perennial plant offers more sustainable solutions to ...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.1016/j.jgr.2019.04.005

    authors: Khanom S,Jang J,Lee OR

    更新日期:2019-10-01 00:00:00

  • Enzymatic Transformation of Ginsenoside Rb1 by Lactobacillus pentosus Strain 6105 from Kimchi.

    abstract::Ginsenoside (ginseng saponin), the principal component of ginseng, is responsible for the pharmacological and biological activities of ginseng. We isolated lactic acid bacteria from Kimchi using esculin agar, to produce β-glucosidase. We focused on the bio-transformation of ginsenoside. Phylogenetic analysis was perfo...

    journal_title:Journal of ginseng research

    pub_type: 杂志文章

    doi:10.5142/jgr.2012.36.3.291

    authors: Kim SH,Min JW,Quan LH,Lee S,Yang DU,Yang DC

    更新日期:2012-07-01 00:00:00