Abstract：
:The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. The conversion of ginsenoside Rb1 generated Rd, Rg3, Rh2, and compound K although the reaction rates were low due to the low concentration. In enzymatic conversion, all of the ginsenoside Rb1 was converted to ginsenoside Rd and ginsenoside Rg3 after 24 h of incubation. The crude enzyme (β-glucosidase) from A. niger KCCM 11239 hydrolyzed the β-(1→6)-glucosidic linkage at the C-20 of ginsenoside Rb1 to generate ginsenoside Rd and ginsenoside Rg3. Our experimental demonstration showing that A. niger KCCM 11239 produces the ginsenoside-hydrolyzing β-glucosidase reflects the feasibility of developing a specific bioconversion process to obtain active minor ginsenosides.
journal_name
J Ginseng Resjournal_title
Journal of ginseng researchauthors
Chang KH,Jo MN,Kim KT,Paik HDdoi
10.1016/j.jgr.2013.11.008subject
Has Abstractpub_date
2014-01-01 00:00:00pages
47-51issue
1eissn
1226-8453issn
2093-4947pii
S1226-8453(13)00009-2journal_volume
38pub_type
杂志文章abstract：:Identification of the origins of Panax ginseng has been issued in Korea scientifically and economically. We describe a metabolomics approach used for discrimination and prediction of ginseng roots from different origins in Korea. The fresh ginseng roots from six ginseng cooperative associations (Gangwon, Gaeseong, Pun...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2013.37.341
更新日期：2013-07-01 00:00:00
abstract：:Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported....
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2017.01.001
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.12.008
更新日期：2017-01-01 00:00:00
abstract：Background:Depression is a common neuropsychiatric disease that shows astrocyte pathology. Ginsenoside Rf (G-Rf) is a saponin found in Panax ginseng which has been used to treat neuropsychiatric diseases. We aimed to investigate antidepressant properties of G-Rf when introduced into the L-alpha-aminoadipic acid (L-AAA)...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.08.005
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Steaming of ginseng is known to change its chemical composition and biological activity. This study was carried out to investigate the effect of different steaming time-scales on chemical constituents and antiproliferative activity of Vietnamese ginseng (VG). METHODS:VG was steamed at 105°C for 2-20 h. Its ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.01.006
更新日期：2015-07-01 00:00:00
abstract：Background:Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regul...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.12.010
更新日期：2020-03-01 00:00:00
abstract：Background:Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The presen...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.09.005
更新日期：2019-01-01 00:00:00
abstract：Background:Korean ginseng (Panax ginseng) plays an anti-inflammatory role in a variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. g...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.06.003
更新日期：2018-10-01 00:00:00
abstract：:Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effect...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2016.11.004
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Identifying suitable site for growing mountain-cultivated ginseng is a concern for ginseng producers. This study was conducted to evaluate the soil properties of cultivation sites for mountain-cultivated ginseng in Hamyang-gun, which is one of the most well-known areas for mountain-cultivated ginseng in Kore...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.06.004
更新日期：2015-01-01 00:00:00
abstract：:There seems to be some controversy about the effect of total ginseng saponin (TGS) on the secretion of catecholamines (CA) from the adrenal gland. Therefore, the present study aimed to determine whether TGS can affect the CA release in the perfused model of the adrenal medulla isolated from spontaneously hypertensive ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2011.35.2.176
更新日期：2011-06-01 00:00:00
abstract：:This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.1.102
更新日期：2012-01-01 00:00:00
abstract：Background:Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Me...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.03.010
更新日期：2018-07-01 00:00:00
abstract：:Ginsenoside (ginseng saponin), the principal component of ginseng, is responsible for the pharmacological and biological activities of ginseng. We isolated lactic acid bacteria from Kimchi using esculin agar, to produce β-glucosidase. We focused on the bio-transformation of ginsenoside. Phylogenetic analysis was perfo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.3.291
更新日期：2012-07-01 00:00:00
abstract：:Korean red ginseng has been shown to possess a variety of biological activities. However, little is known about antiviral activity of ginsenosides of Korean red ginseng. Here, we investigated the protective effect by oral administration of various ginsenosides on the lethal infection of haemagglutinating virus of Japa...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2013.37.80
更新日期：2013-03-01 00:00:00
abstract：Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.03.008
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Although the aerial parts of hydroponic Panax ginseng are reported to contain higher contents of total ginsenosides than those of roots, the isolation and identification of active metabolites from the aerial parts of hydroponic P. ginseng have not been carried out so far. METHODS:The aerial parts of hydropo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.10.005
更新日期：2015-04-01 00:00:00
abstract：:A quick and simple method for simultaneous determination of the 30 ginsenosides (ginsenoside Ro, Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, 20(S)-Rg2, 20(R)-Rg2, 20(S)-Rg3, 20(R)-Rg3, 20(S)-Rh1, 20(S)-Rh2, 20(R)-Rh2, F1, F2, F4, Ra1, Rg6, Rh4, Rk3, Rg5, Rk1, Rb3, Rk2, Rh3, compound Y, compound K, and notoginsenoside R1) in Panax ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2013.37.457
更新日期：2013-10-01 00:00:00
abstract：Background:Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin e...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2016.12.007
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. METHODS:Samples of powdered Vietnamese ginseng were steamed at 120°C for various times and their extracts were subjecte...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2013.11.015
更新日期：2014-04-01 00:00:00
abstract：Background:Ginsenoside Rg3, a derivative of steroidal saponins abundant in ginseng, has a range of effects on cancer cells, including anti-cell proliferation and anti-inflammation activity. Here, we investigate two long noncoding RNAs (lncRNAs), STXBP5-AS1 and RFX3-AS1, which are hypomethylated and hypermethylated in t...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.02.004
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. In this work, enzymatic hydrolysis of ginsenoside Rb1 was studied using enzyme preparations from cultured ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.05.007
更新日期：2016-04-01 00:00:00
abstract：Background:The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition o...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.08.002
更新日期：2020-01-01 00:00:00
abstract：Background:The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-E...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.02.007
更新日期：2018-07-01 00:00:00
abstract：Background:Cytochrome P450 enzymes catalyze a wide range of reactions in plant metabolism. Besides their physiological functions on primary and secondary metabolites, P450s are also involved in herbicide detoxification via hydroxylation or dealkylation. Ginseng as a perennial plant offers more sustainable solutions to ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.04.005
更新日期：2019-10-01 00:00:00
abstract：:Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.4.383
更新日期：2012-10-01 00:00:00
abstract：:Ginseng (Panax ginseng Meyer) has been shown to have anti-aging effects in animal and clinical studies. However, the molecular mechanisms by which ginseng exerts these effects remain unknown. Here, the anti-aging effect of Korean red ginseng (KRG) in rat testes was examined by system biology analysis. KRG water extrac...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2011.35.3.272
更新日期：2011-09-01 00:00:00
abstract：Background:Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.07.004
更新日期：2019-01-01 00:00:00
abstract：:Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L.) are the two most recognized ginseng botanicals. It is believed that the ginseng saponins called ginsenosides are the major active constituents in both ginsengs. Although American ginseng is not as extensively studied as Asian ginseng, it is on...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2010.34.3.160
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:We evaluated the drug interaction profile of Red Ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers. METHODS:This article describes an open-label, crossover study. CYP probe cocktail drugs, caffeine, ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.11.005
更新日期：2016-10-01 00:00:00
