Abstract:
Background:The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition of the S6 kinase 1 (S6K1) signaling pathway. Methods:The inhibitory effects of BST204 on S6K1 signaling were investigated by immunoblot, nuclear fractionation, immunoprecipitation analyses. The antiadipogenic effect of BST204 was evaluated by measuring mRNA levels of adipogenic genes and by chromatin immunoprecipitation and quantitative real-time polymerase chain reaction analysis. Results:Treatment with BST204 inhibited activation and nuclear translocation of S6K1, further decreasing the interaction between S6K1 and histone H2B in 10T1/2 mesenchymal stem cells. Subsequently, phosphorylation of H2B at serine 36 (H2BS36p) by S6K1 was reduced by BST204, inducing an increase in the mRNA expression of Wnt6, Wnt10a, and Wnt10b, which disturbed adipogenic differentiation and promoted myogenic and early osteogenic gene expression. Consistently, BST204 treatment during adipogenic commitment suppressed the expression of adipogenic marker genes and lipid drop formation. Conclusion:Our results indicate that BST204 blocks adipogenesis of mesenchymal stem cells through the inhibition of S6K1-mediated histone phosphorylation. This study suggests the potential therapeutic strategy using BST204 to combat obesity and musculoskeletal diseases.
journal_name
J Ginseng Resjournal_title
Journal of ginseng researchauthors
Yi SA,Lee J,Park SK,Kim JY,Park JW,Lee MG,Nam KH,Park JH,Oh H,Kim S,Han J,Kim BK,Jo DG,Han JWdoi
10.1016/j.jgr.2018.08.002subject
Has Abstractpub_date
2020-01-01 00:00:00pages
58-66issue
1eissn
1226-8453issn
2093-4947pii
S1226-8453(18)30173-8journal_volume
44pub_type
杂志文章abstract::This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.1.102
更新日期:2012-01-01 00:00:00
abstract::Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemo...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.4.383
更新日期:2012-10-01 00:00:00
abstract:Background:Ginsenoside Rg3, a derivative of steroidal saponins abundant in ginseng, has a range of effects on cancer cells, including anti-cell proliferation and anti-inflammation activity. Here, we investigate two long noncoding RNAs (lncRNAs), STXBP5-AS1 and RFX3-AS1, which are hypomethylated and hypermethylated in t...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.02.004
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:To investigate the effect of pectinase-treated Panax ginseng (GINST) in cellular and male subfertility animal models. METHODS:Hydrogen peroxide (H2O2)-induced mouse spermatocyte GC-2spd cells were used as an in vitro model. Cell viability was measured using MTT assay. For the in vivo study, GINST (200 mg/kg...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.08.005
更新日期:2016-04-01 00:00:00
abstract:Background:Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarifi...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.06.002
更新日期:2020-09-01 00:00:00
abstract:Background:Despite the large number of studies on ginseng, pharmacological activities of ginseng seed oil (GSO) have not been established. GSO is rich in unsaturated fatty acids, mostly oleic and linoleic acids. Unsaturated fatty acids are known to exert a therapeutic effect in nonalcoholic fatty liver disease (NAFLD)....
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.04.010
更新日期:2018-10-01 00:00:00
abstract::Jilin Province is one of the principal production bases of traditional Chinese medicine (TCM) in China with its typical preponderance in TCM resources, research and development power, and industrialization capacity. The province has 2,790 species of TCM materials in total. Over 20% of the TCM materials in common use a...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2014.05.007
更新日期:2014-10-15 00:00:00
abstract:Background:The root and rhizome are historically and officially utilized medicinal parts of Panax notoginseng (PN) (Burk.) F. H. Chen, which in raw and steamed forms are used differently in practice. Methods:To investigate the differences in chemical composition and bioactivities of PN root and rhizome between raw and...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.11.004
更新日期:2019-07-01 00:00:00
abstract:Background:The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used "Qi-invigorating" herbs, which provides tonic and preventive effects by resisting oxidative...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.02.002
更新日期:2019-10-01 00:00:00
abstract::Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpigmentation, darkening skin color by excessive pigmentation, is a major concern for Asian people with yellow-brown skin. A...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2014.10.006
更新日期:2015-01-01 00:00:00
abstract:Background:Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.07.004
更新日期:2019-01-01 00:00:00
abstract::An light-emitting diode (LED)-based light source was used as a monochromatic light source to determine the responses of raw ginseng roots (Panax ginseng Meyer) to specific emission spectra with respect to the production of ginsenosides. The ginsenoside content in the ginseng roots changed in response to the LED light ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.2.198
更新日期:2012-04-01 00:00:00
abstract::The ginseng plant (Panax ginseng Meyer) has a large number of active ingredients including steroidal saponins with a dammarane skeleton as well as protopanaxadiol and protopanaxatriol, commonly known as ginsenosides, which have antioxidant, anticancer, antidiabetic, anti-adipocyte, and sexual enhancing effects. Though...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.5142/jgr.2013.37.261
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.12.008
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. In this work, enzymatic hydrolysis of ginsenoside Rb1 was studied using enzyme preparations from cultured ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.05.007
更新日期:2016-04-01 00:00:00
abstract:Background:Ginsenoside Rf is a ginseng saponin found only in Panax ginseng that affects lipid metabolism. It also has neuroprotective and antiinflammatory properties. We previously showed that Korean Red Ginseng (KRG) inhibited the expression of cyclooxygenase-2 (COX-2) by hypoxia via peroxisome proliferator-activated ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.11.007
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Panax ginseng is a traditional herb used for medicinal purposes in eastern Asia. P. ginseng contains various ginsenosides with pharmacological effects. In this study, floralginsenoside A (FGA), ginsenoside Rd (GRD), and ginsenoside Re (GRE) were purified from P. ginseng berry. METHODS:Chemical structures of...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.03.005
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. METHODS:A dammarane-type triterpene saponin was isolated from P. ginseng root throug...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2016.10.002
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Radiotherapy is one of the most important modalities in cancer treatment; however, normal tissue damage is a serious concern. Drug development for the protection or reduction of normal tissue damage is therefore a clinical issue. Herein, we evaluated the protective properties of Panax ginseng Meyer and its c...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2016.02.006
更新日期:2017-04-01 00:00:00
abstract::Korean red ginseng (KRG) is used worldwide as a popular traditional herbal medicine. KRG has shown beneficial effects on cardiovascular diseases, such as atherosclerosis, diabetes, and hypertension. Up-regulation of a cytoprotective protein, heme oxygenase (HO)-1, is considered to augment the cellular defense against ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2011.35.3.352
更新日期:2011-09-01 00:00:00
abstract:Background:Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phos...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.11.002
更新日期:2021-01-01 00:00:00
abstract::Ginseng is one of the most widely used herbal medicines and is reported to have a wide range of therapeutic and pharmacological applications. Ginseng may also be potentially valuable in treating cardiovascular diseases. Research concerning cardiovascular disease is focusing on purified individual ginsenoside constitue...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.1.16
更新日期:2012-01-01 00:00:00
abstract::There seems to be some controversy about the effect of total ginseng saponin (TGS) on the secretion of catecholamines (CA) from the adrenal gland. Therefore, the present study aimed to determine whether TGS can affect the CA release in the perfused model of the adrenal medulla isolated from spontaneously hypertensive ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2011.35.2.176
更新日期:2011-06-01 00:00:00
abstract::Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effect...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2016.11.004
更新日期:2017-10-01 00:00:00
abstract:Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.03.008
更新日期:2018-07-01 00:00:00
abstract::In this study, we have investigated the effects of total saponin from Korean red ginseng (TSKRG) on thrombin-induced platelet aggregation. TSKRG dose-dependently inhibited thrombin-induced platelet aggregation with IC50 value of about 81.1 μg/mL. In addition, TSKRG dose-dependently decreased thrombin-elevated the leve...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2013.37.176
更新日期:2013-04-01 00:00:00
abstract:Background:Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regul...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.12.010
更新日期:2020-03-01 00:00:00
abstract:Background:Korean ginseng (Panax ginseng) plays an anti-inflammatory role in a variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. g...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.06.003
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). METHODS:We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2014.04.002
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Identifying suitable site for growing mountain-cultivated ginseng is a concern for ginseng producers. This study was conducted to evaluate the soil properties of cultivation sites for mountain-cultivated ginseng in Hamyang-gun, which is one of the most well-known areas for mountain-cultivated ginseng in Kore...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2014.06.004
更新日期:2015-01-01 00:00:00