Abstract：
Background:Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion of ginsenosides in fermented red ginseng extract (FRGE). Methods:Red ginseng extract (RGE) was fermented using Lactobacillus plantarum KCCM 11613P. This study investigated the ginsenosides and their antioxidant capacity in FRGE using diverse methods. Results:Properties of RGE were changed upon fermentation. Fermentation reduced the pH value, but increased the titratable acidity and viable cell counts of lactic acid bacteria. L. plantarum KCCM 11613P converted ginsenosides Rb2 and Rb3 to ginsenoside Rd in RGE. Fermentation also enhanced the antioxidant effects of RGE. FRGE reduced 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and reducing power; however, it improved the inhibition of β-carotene and linoleic acid oxidation and the lipid peroxidation. This suggested that the fermentation of RGE is effective for producing ginsenoside Rd as precursor of ginsenoside compound K and inhibition of lipid oxidation. Conclusion:This study showed that RGE fermented by L. plantarum KCCM 11613P may contribute to the development of functional food materials.
journal_name
J Ginseng Resjournal_title
Journal of ginseng researchauthors
Jung J,Jang HJ,Eom SJ,Choi NS,Lee NK,Paik HDdoi
10.1016/j.jgr.2017.07.004subject
Has Abstractpub_date
2019-01-01 00:00:00pages
20-26issue
1eissn
1226-8453issn
2093-4947pii
S1226-8453(17)30050-7journal_volume
43pub_type
杂志文章abstract：Background:The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used "Qi-invigorating" herbs, which provides tonic and preventive effects by resisting oxidative...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.02.002
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Blind and excessive application of fertilizers was found during the cultivation of Panax notoginseng in fields, as well as increase in root rot disease incidence. METHODS:Both "3414" application and orthogonal test designs were performed at Shilin county, Yunnan province, China, for NPK (nitrogen, phosphoru...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.04.003
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Steaming of ginseng is known to change its chemical composition and biological activity. This study was carried out to investigate the effect of different steaming time-scales on chemical constituents and antiproliferative activity of Vietnamese ginseng (VG). METHODS:VG was steamed at 105°C for 2-20 h. Its ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.01.006
更新日期：2015-07-01 00:00:00
abstract：Background:Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.01.006
更新日期：2018-04-01 00:00:00
abstract：:Ginseng, a perennial plant belonging to the genus Panax of the Araliaceae family, is well known for its medicinal properties that help alleviate pathological symptoms, promote health, and prevent potential diseases. Among the active ingredients of ginseng are saponins, most of which are glycosides of triterpenoid agly...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2014.12.005
更新日期：2015-10-01 00:00:00
abstract：Background:Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phos...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.11.002
更新日期：2021-01-01 00:00:00
abstract：Background:The reports about valuable oligosaccharides in ginseng are quite limited. There is an urgent need to develop a practical procedure to detect and analyze ginseng oligosaccharides. Methods:The oligosaccharide extracts from ginseng were permethylated by solid-phase methylation method and then were analyzed by ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.08.001
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:The current typical drying methods for red ginseng are sun drying and hot-air drying. The purpose of this study was to investigate drying characteristics of red ginseng by using far-infrared drying. METHODS:The far-infrared drying tests on red ginseng were conducted at two drying stages: (1) high temperatur...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.04.001
更新日期：2015-10-01 00:00:00
abstract：Background:The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-E...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.02.007
更新日期：2018-07-01 00:00:00
abstract：:Ginseng is one of the most widely used herbal medicines and is reported to have a wide range of therapeutic and pharmacological applications. Ginseng may also be potentially valuable in treating cardiovascular diseases. Research concerning cardiovascular disease is focusing on purified individual ginsenoside constitue...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.1.16
更新日期：2012-01-01 00:00:00
abstract：:Korean red ginseng (KRG) is used worldwide as a popular traditional herbal medicine. KRG has shown beneficial effects on cardiovascular diseases, such as atherosclerosis, diabetes, and hypertension. Up-regulation of a cytoprotective protein, heme oxygenase (HO)-1, is considered to augment the cellular defense against ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2011.35.3.352
更新日期：2011-09-01 00:00:00
abstract：Background:The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition o...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.08.002
更新日期：2020-01-01 00:00:00
abstract：:This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.1.102
更新日期：2012-01-01 00:00:00
abstract：Background:Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The presen...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.09.005
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. METHODS:Samples of powdered Vietnamese ginseng were steamed at 120°C for various times and their extracts were subjecte...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2013.11.015
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Identifying suitable site for growing mountain-cultivated ginseng is a concern for ginseng producers. This study was conducted to evaluate the soil properties of cultivation sites for mountain-cultivated ginseng in Hamyang-gun, which is one of the most well-known areas for mountain-cultivated ginseng in Kore...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.06.004
更新日期：2015-01-01 00:00:00
abstract：:Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpigmentation, darkening skin color by excessive pigmentation, is a major concern for Asian people with yellow-brown skin. A...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2014.10.006
更新日期：2015-01-01 00:00:00
abstract：Background:Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin e...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2016.12.007
更新日期：2018-01-01 00:00:00
abstract：:Ginsenoside (ginseng saponin), the principal component of ginseng, is responsible for the pharmacological and biological activities of ginseng. We isolated lactic acid bacteria from Kimchi using esculin agar, to produce β-glucosidase. We focused on the bio-transformation of ginsenoside. Phylogenetic analysis was perfo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.3.291
更新日期：2012-07-01 00:00:00
abstract：:Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiati...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.02.002
更新日期：2018-04-01 00:00:00
abstract：Background:Korean Red Ginseng (KRG) has been known to possess many ginsenosides. These ginsenosides are used for curing cardiovascular problems. The present study show the protective potential of KRG against doxorubicin (DOX)-induced myocardial dysfunction, by assessing electrocardiographic, hemodynamic, and biochemica...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.03.002
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:We evaluated the drug interaction profile of Red Ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers. METHODS:This article describes an open-label, crossover study. CYP probe cocktail drugs, caffeine, ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.11.005
更新日期：2016-10-01 00:00:00
abstract：:Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer's disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression. Recent studies demonstrated that Panax ginseng extract improves AD symptoms in pat...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2017.12.008
更新日期：2018-10-01 00:00:00
abstract：:Jilin Province is one of the principal production bases of traditional Chinese medicine (TCM) in China with its typical preponderance in TCM resources, research and development power, and industrialization capacity. The province has 2,790 species of TCM materials in total. Over 20% of the TCM materials in common use a...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2014.05.007
更新日期：2014-10-15 00:00:00
abstract：:In this study, photosynthetic parameters such as the net photosynthesis rate, stomatal conductance, intercellular CO2 concentration, and transpiration rate were examined in selected ginseng varieties and/or lines that are resistant (Yunpoong, HTIR 1, HTIR 2, and HTIR 3) and susceptible (Chunpoong) to high temperature ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.4.461
更新日期：2012-10-01 00:00:00
abstract：Background:Depression is a common neuropsychiatric disease that shows astrocyte pathology. Ginsenoside Rf (G-Rf) is a saponin found in Panax ginseng which has been used to treat neuropsychiatric diseases. We aimed to investigate antidepressant properties of G-Rf when introduced into the L-alpha-aminoadipic acid (L-AAA)...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.08.005
更新日期：2020-07-01 00:00:00
abstract：:Tissue fibrosis is an eventual pathologic change of numerous chronic illnesses, which is characterized by resident fibroblasts differentiation into myofibroblasts during inflammation, coupled with excessive extracellular matrix deposition in tissues, ultimately leading to failure of normal organ function. Now, there a...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2019.12.003
更新日期：2020-05-01 00:00:00
abstract：Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.03.008
更新日期：2018-07-01 00:00:00
abstract：:The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. Th...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2013.11.008
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Although the aerial parts of hydroponic Panax ginseng are reported to contain higher contents of total ginsenosides than those of roots, the isolation and identification of active metabolites from the aerial parts of hydroponic P. ginseng have not been carried out so far. METHODS:The aerial parts of hydropo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.10.005
更新日期：2015-04-01 00:00:00
