Abstract:
Background:Depression is a common neuropsychiatric disease that shows astrocyte pathology. Ginsenoside Rf (G-Rf) is a saponin found in Panax ginseng which has been used to treat neuropsychiatric diseases. We aimed to investigate antidepressant properties of G-Rf when introduced into the L-alpha-aminoadipic acid (L-AAA)-infused mice model which is representative of a major depressive disorder that features diminished astrocytes in the brain. Methods:L-AAA was infused into the prefrontal cortex (PFC) of mice to induce decrease of astrocytes. Mice were orally administered G-Rf (20 mg/kg) as well as vehicle only or imipramine (20 mg/kg) as controls. Depression-like behavior of mice was evaluated using forced swimming test (FST) and tail suspension test (TST). We observed recovery of astroglial impairment and increased proliferative cells in the PFC and its accompanied change in the hippocampus by Western blot and immunohistochemistry to assess the effect of G-Rf. Results:After injection of L-AAA into the PFC, mice showed increased immobility time in FST and TST and loss of astrocytes without significant neuronal change in the PFC. G-Rf-treated mice displayed significantly more decreased immobility time in FST and TST than did vehicle-treated mice, and their immobility time almost recovered to those of the sham mice and imipramine-treated mice. G-Rf upregulated glial fibrillary acidic protein (GFAP) expression and Ki-67 expression in the PFC reduced by L-AAA and also alleviated astroglial change in the hippocampus. Conclusion:G-Rf markedly reversed depression-like behavioral changes and exhibited protective effect against the astrocyte ablation in the PFC induced by L-AAA. These protective properties suggest that G-Rf might be a therapeutic agent for major depressive disorders.
journal_name
J Ginseng Resjournal_title
Journal of ginseng researchauthors
Kim Y,Lee HY,Choi YJ,Cho SHdoi
10.1016/j.jgr.2019.08.005subject
Has Abstractpub_date
2020-07-01 00:00:00pages
603-610issue
4eissn
1226-8453issn
2093-4947pii
S1226-8453(18)30294-Xjournal_volume
44pub_type
杂志文章abstract::Korean red ginseng has been shown to possess a variety of biological activities. However, little is known about antiviral activity of ginsenosides of Korean red ginseng. Here, we investigated the protective effect by oral administration of various ginsenosides on the lethal infection of haemagglutinating virus of Japa...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2013.37.80
更新日期:2013-03-01 00:00:00
abstract::Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer's disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression. Recent studies demonstrated that Panax ginseng extract improves AD symptoms in pat...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2017.12.008
更新日期:2018-10-01 00:00:00
abstract:Background:Korean Red Ginseng (KRG) has been known to possess many ginsenosides. These ginsenosides are used for curing cardiovascular problems. The present study show the protective potential of KRG against doxorubicin (DOX)-induced myocardial dysfunction, by assessing electrocardiographic, hemodynamic, and biochemica...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.03.002
更新日期:2020-05-01 00:00:00
abstract::This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.1.102
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Although the aerial parts of hydroponic Panax ginseng are reported to contain higher contents of total ginsenosides than those of roots, the isolation and identification of active metabolites from the aerial parts of hydroponic P. ginseng have not been carried out so far. METHODS:The aerial parts of hydropo...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2014.10.005
更新日期:2015-04-01 00:00:00
abstract::The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. Th...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2013.11.008
更新日期:2014-01-01 00:00:00
abstract:Background:Ginsenosides, which are bioactive components in ginseng, can be converted to smaller compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.07.004
更新日期:2019-01-01 00:00:00
abstract::Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpigmentation, darkening skin color by excessive pigmentation, is a major concern for Asian people with yellow-brown skin. A...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2014.10.006
更新日期:2015-01-01 00:00:00
abstract:Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.03.008
更新日期:2018-07-01 00:00:00
abstract::Ginseng is one of the most widely used herbal medicines and is reported to have a wide range of therapeutic and pharmacological applications. Ginseng may also be potentially valuable in treating cardiovascular diseases. Research concerning cardiovascular disease is focusing on purified individual ginsenoside constitue...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.1.16
更新日期:2012-01-01 00:00:00
abstract::The ginseng plant (Panax ginseng Meyer) has a large number of active ingredients including steroidal saponins with a dammarane skeleton as well as protopanaxadiol and protopanaxatriol, commonly known as ginsenosides, which have antioxidant, anticancer, antidiabetic, anti-adipocyte, and sexual enhancing effects. Though...
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.5142/jgr.2013.37.261
更新日期:2013-07-01 00:00:00
abstract:Background:Korean ginseng (Panax ginseng) plays an anti-inflammatory role in a variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. g...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.06.003
更新日期:2018-10-01 00:00:00
abstract::In this study, photosynthetic parameters such as the net photosynthesis rate, stomatal conductance, intercellular CO2 concentration, and transpiration rate were examined in selected ginseng varieties and/or lines that are resistant (Yunpoong, HTIR 1, HTIR 2, and HTIR 3) and susceptible (Chunpoong) to high temperature ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.4.461
更新日期:2012-10-01 00:00:00
abstract::There seems to be some controversy about the effect of total ginseng saponin (TGS) on the secretion of catecholamines (CA) from the adrenal gland. Therefore, the present study aimed to determine whether TGS can affect the CA release in the perfused model of the adrenal medulla isolated from spontaneously hypertensive ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2011.35.2.176
更新日期:2011-06-01 00:00:00
abstract:Background:Ginsenoside Rf is a ginseng saponin found only in Panax ginseng that affects lipid metabolism. It also has neuroprotective and antiinflammatory properties. We previously showed that Korean Red Ginseng (KRG) inhibited the expression of cyclooxygenase-2 (COX-2) by hypoxia via peroxisome proliferator-activated ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.11.007
更新日期:2019-04-01 00:00:00
abstract:Background:The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used "Qi-invigorating" herbs, which provides tonic and preventive effects by resisting oxidative...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.02.002
更新日期:2019-10-01 00:00:00
abstract:Background:The root and rhizome are historically and officially utilized medicinal parts of Panax notoginseng (PN) (Burk.) F. H. Chen, which in raw and steamed forms are used differently in practice. Methods:To investigate the differences in chemical composition and bioactivities of PN root and rhizome between raw and...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.11.004
更新日期:2019-07-01 00:00:00
abstract:Background:Panax ginseng is regarded as one of the best compounds for promoting health, and it has been used traditionally as a medicinal herb. Recently, Korean Red Ginseng (RG) has been shown to protect skin from aging and wrinkling; it can also relieve atopic dermatitis and allergy symptoms. This study aimed to evalu...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2017.12.006
更新日期:2019-04-01 00:00:00
abstract:Background:The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-E...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.02.007
更新日期:2018-07-01 00:00:00
abstract::Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported....
journal_title:Journal of ginseng research
pub_type: 杂志文章,评审
doi:10.1016/j.jgr.2017.01.001
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Steaming of ginseng is known to change its chemical composition and biological activity. This study was carried out to investigate the effect of different steaming time-scales on chemical constituents and antiproliferative activity of Vietnamese ginseng (VG). METHODS:VG was steamed at 105°C for 2-20 h. Its ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.01.006
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Identifying suitable site for growing mountain-cultivated ginseng is a concern for ginseng producers. This study was conducted to evaluate the soil properties of cultivation sites for mountain-cultivated ginseng in Hamyang-gun, which is one of the most well-known areas for mountain-cultivated ginseng in Kore...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2014.06.004
更新日期:2015-01-01 00:00:00
abstract:Background:Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regul...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2018.12.010
更新日期:2020-03-01 00:00:00
abstract:Background:Cytochrome P450 enzymes catalyze a wide range of reactions in plant metabolism. Besides their physiological functions on primary and secondary metabolites, P450s are also involved in herbicide detoxification via hydroxylation or dealkylation. Ginseng as a perennial plant offers more sustainable solutions to ...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.04.005
更新日期:2019-10-01 00:00:00
abstract::Ginseng (Panax ginseng Meyer) has been shown to have anti-aging effects in animal and clinical studies. However, the molecular mechanisms by which ginseng exerts these effects remain unknown. Here, the anti-aging effect of Korean red ginseng (KRG) in rat testes was examined by system biology analysis. KRG water extrac...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2011.35.3.272
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. METHODS:A dammarane-type triterpene saponin was isolated from P. ginseng root throug...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2016.10.002
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:To investigate the effect of pectinase-treated Panax ginseng (GINST) in cellular and male subfertility animal models. METHODS:Hydrogen peroxide (H2O2)-induced mouse spermatocyte GC-2spd cells were used as an in vitro model. Cell viability was measured using MTT assay. For the in vivo study, GINST (200 mg/kg...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2015.08.005
更新日期:2016-04-01 00:00:00
abstract::Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemo...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.5142/jgr.2012.36.4.383
更新日期:2012-10-01 00:00:00
abstract:Background:Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing lysophosphatidic acid receptors and that oral administration of gintonin e...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2016.12.007
更新日期:2018-01-01 00:00:00
abstract:Background:Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarifi...
journal_title:Journal of ginseng research
pub_type: 杂志文章
doi:10.1016/j.jgr.2019.06.002
更新日期:2020-09-01 00:00:00