Abstract：
BACKGROUND:This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. METHODS:Samples of powdered Vietnamese ginseng were steamed at 120°C for various times and their extracts were subjected to chemical and biological studies. RESULTS:Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. CONCLUSION:It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.
journal_name
J Ginseng Resjournal_title
Journal of ginseng researchauthors
Le TH,Lee SY,Kim TR,Kim JY,Kwon SW,Nguyen NK,Park JH,Nguyen MDdoi
10.1016/j.jgr.2013.11.015subject
Has Abstractpub_date
2014-04-01 00:00:00pages
154-9issue
2eissn
1226-8453issn
2093-4947pii
S1226-8453(13)00019-5journal_volume
38pub_type
杂志文章abstract：Background:Korean ginseng (Panax ginseng) plays an anti-inflammatory role in a variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. g...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.06.003
更新日期：2018-10-01 00:00:00
abstract：:Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effect...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2016.11.004
更新日期：2017-10-01 00:00:00
abstract：:In this study, we have investigated the effects of total saponin from Korean red ginseng (TSKRG) on thrombin-induced platelet aggregation. TSKRG dose-dependently inhibited thrombin-induced platelet aggregation with IC50 value of about 81.1 μg/mL. In addition, TSKRG dose-dependently decreased thrombin-elevated the leve...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2013.37.176
更新日期：2013-04-01 00:00:00
abstract：:Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpigmentation, darkening skin color by excessive pigmentation, is a major concern for Asian people with yellow-brown skin. A...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2014.10.006
更新日期：2015-01-01 00:00:00
abstract：Background:The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.03.008
更新日期：2018-07-01 00:00:00
abstract：Background:The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-E...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.02.007
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts antidiabetic effects. We tested whether the insulin-sensitizing and antidiabetic effects of G-Rb1 results from a reduction in ectopic fat accumulation, mediated by inhibition of lipolysis in adipocytes. ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2014.11.004
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:The current typical drying methods for red ginseng are sun drying and hot-air drying. The purpose of this study was to investigate drying characteristics of red ginseng by using far-infrared drying. METHODS:The far-infrared drying tests on red ginseng were conducted at two drying stages: (1) high temperatur...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.04.001
更新日期：2015-10-01 00:00:00
abstract：Background:Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Method...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.08.009
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc. In this work, enzymatic hydrolysis of ginsenoside Rb1 was studied using enzyme preparations from cultured ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.05.007
更新日期：2016-04-01 00:00:00
abstract：Background:Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The presen...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.09.005
更新日期：2019-01-01 00:00:00
abstract：:Ginseng, a perennial plant belonging to the genus Panax of the Araliaceae family, is well known for its medicinal properties that help alleviate pathological symptoms, promote health, and prevent potential diseases. Among the active ingredients of ginseng are saponins, most of which are glycosides of triterpenoid agly...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2014.12.005
更新日期：2015-10-01 00:00:00
abstract：:Jilin Province is one of the principal production bases of traditional Chinese medicine (TCM) in China with its typical preponderance in TCM resources, research and development power, and industrialization capacity. The province has 2,790 species of TCM materials in total. Over 20% of the TCM materials in common use a...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2014.05.007
更新日期：2014-10-15 00:00:00
abstract：Background:Despite the large number of studies on ginseng, pharmacological activities of ginseng seed oil (GSO) have not been established. GSO is rich in unsaturated fatty acids, mostly oleic and linoleic acids. Unsaturated fatty acids are known to exert a therapeutic effect in nonalcoholic fatty liver disease (NAFLD)....
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.04.010
更新日期：2018-10-01 00:00:00
abstract：Background:The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used "Qi-invigorating" herbs, which provides tonic and preventive effects by resisting oxidative...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.02.002
更新日期：2019-10-01 00:00:00
abstract：Background:Cytochrome P450 enzymes catalyze a wide range of reactions in plant metabolism. Besides their physiological functions on primary and secondary metabolites, P450s are also involved in herbicide detoxification via hydroxylation or dealkylation. Ginseng as a perennial plant offers more sustainable solutions to ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.04.005
更新日期：2019-10-01 00:00:00
abstract：Background:Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Me...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2017.03.010
更新日期：2018-07-01 00:00:00
abstract：:Tissue fibrosis is an eventual pathologic change of numerous chronic illnesses, which is characterized by resident fibroblasts differentiation into myofibroblasts during inflammation, coupled with excessive extracellular matrix deposition in tissues, ultimately leading to failure of normal organ function. Now, there a...
journal_title：Journal of ginseng research
pub_type： 杂志文章,评审
doi：10.1016/j.jgr.2019.12.003
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Ginsenosides are the major effective ingredients responsible for the pharmacological effects of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a glucose unit of the corresponding neutral ginsenosides. METHODS:Medium-pressure liquid chromatography and semiprep...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.08.003
更新日期：2016-07-01 00:00:00
abstract：Background:Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarifi...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.06.002
更新日期：2020-09-01 00:00:00
abstract：Background:Korean Red Ginseng (KRG) has been known to possess many ginsenosides. These ginsenosides are used for curing cardiovascular problems. The present study show the protective potential of KRG against doxorubicin (DOX)-induced myocardial dysfunction, by assessing electrocardiographic, hemodynamic, and biochemica...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2019.03.002
更新日期：2020-05-01 00:00:00
abstract：:This study compared the contents of ginsenosides depending on steaming conditions of red ginsengs to provide basic information for developing functional foods using red ginsengs. The red ginseng steamed eight times at 98℃ ranked atop the amounts of prosapogenins ever detected in red ginsengs (ginsenoside Rg2, Rg3, Rg5...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.1.102
更新日期：2012-01-01 00:00:00
abstract：:Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.4.383
更新日期：2012-10-01 00:00:00
abstract：Background:The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its molecular action in metabolic disease remains poorly understood. In this study, we identified the antiadipogenic activity of BST204 resulting from its inhibition o...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.08.002
更新日期：2020-01-01 00:00:00
abstract：:Ginsenoside (ginseng saponin), the principal component of ginseng, is responsible for the pharmacological and biological activities of ginseng. We isolated lactic acid bacteria from Kimchi using esculin agar, to produce β-glucosidase. We focused on the bio-transformation of ginsenoside. Phylogenetic analysis was perfo...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.3.291
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:We evaluated the drug interaction profile of Red Ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers. METHODS:This article describes an open-label, crossover study. CYP probe cocktail drugs, caffeine, ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.11.005
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:To investigate the effect of pectinase-treated Panax ginseng (GINST) in cellular and male subfertility animal models. METHODS:Hydrogen peroxide (H2O2)-induced mouse spermatocyte GC-2spd cells were used as an in vitro model. Cell viability was measured using MTT assay. For the in vivo study, GINST (200 mg/kg...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2015.08.005
更新日期：2016-04-01 00:00:00
abstract：:Ginseng is one of the most widely used herbal medicines and is reported to have a wide range of therapeutic and pharmacological applications. Ginseng may also be potentially valuable in treating cardiovascular diseases. Research concerning cardiovascular disease is focusing on purified individual ginsenoside constitue...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.5142/jgr.2012.36.1.16
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Compound K (CK) is a bioactive derivative of ginsenoside Rb1 in Panax ginseng (Korean ginseng). Its biological and pharmacological activities have been studied in various disease conditions, although its immunomodulatory role in innate immunity mediated by monocytes/macrophages has been poorly understood. In...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2016.06.004
更新日期：2017-07-01 00:00:00
abstract：Background:Ginsenoside Rf is a ginseng saponin found only in Panax ginseng that affects lipid metabolism. It also has neuroprotective and antiinflammatory properties. We previously showed that Korean Red Ginseng (KRG) inhibited the expression of cyclooxygenase-2 (COX-2) by hypoxia via peroxisome proliferator-activated ...
journal_title：Journal of ginseng research
pub_type： 杂志文章
doi：10.1016/j.jgr.2018.11.007
更新日期：2019-04-01 00:00:00
