abstract：:Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventional antibiotics to be lowered and reduce the insurgence of antibiotic resistance. Herein, we report that an O-acetylserine sulfhydrylase (OASS) inhibitor can be used as a colistin adjuvant to treat infections caused by...

journal_title：ACS infectious diseases

authors： Annunziato G,Spadini C,Franko N,Storici P,Demitri N,Pieroni M,Flisi S,Rosati L,Iannarelli M,Marchetti M,Magalhaes J,Bettati S,Mozzarelli A,Cabassi CS,Campanini B,Costantino G

更新日期：2021-01-29 00:00:00

abstract：:Bacterial coinfection in COVID-19 patients has the potential to complicate treatments and accelerate the development of antibiotic resistance in the clinic due to the widespread use of broad-spectrum antibiotics, including in Indonesia. The surge of COVID-19 patients may worsen antibiotic overuse; therefore, informati...

journal_title：ACS infectious diseases

authors： Prasetyoputri A

更新日期：2021-01-27 00:00:00

abstract：:We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS...

journal_title：ACS infectious diseases

authors： Bajic G,Harrison SC

更新日期：2021-01-08 00:00:00

abstract：:MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targets and inhibit bacterial growth by more than one mechanism. Here, we ...

journal_title：ACS infectious diseases

authors： Grover S,Engelhart CA,Pérez-Herrán E,Li W,Abrahams KA,Papavinasasundaram K,Bean JM,Sassetti CM,Mendoza-Losana A,Besra GS,Jackson M,Schnappinger D

更新日期：2021-01-08 00:00:00

abstract：:Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated analogues and demonstrate that these compounds potently inhibit Plasm...

journal_title：ACS infectious diseases

authors： Cheuka PM,Centani L,Arendse LB,Fienberg S,Wambua L,Renga SS,Dziwornu GA,Kumar M,Lawrence N,Taylor D,Wittlin S,Coertzen D,Reader J,van der Watt M,Birkholtz LM,Chibale K

更新日期：2021-01-08 00:00:00

abstract：:The maintenance of deoxyribonucleotide triphosphate (dNTP) homeostasis through synthesis and degradation is critical for accurate genomic and mitochondrial DNA replication fidelity. Trypanosoma brucei makes use of both the salvage and de novo pathways for the provision of pyrimidine dNTPs. In this respect, the sterile...

journal_title：ACS infectious diseases

authors： Yagüe-Capilla M,Castillo-Acosta VM,Bosch-Navarrete C,Ruiz-Pérez LM,González-Pacanowska D

更新日期：2021-01-08 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is the causative agent of severe diarrheal disease in humans. Cattle are the natural reservoir of EHEC, and approximately 75% of EHEC infections in humans stem from bovine products. Many common bacterial pathogens, including EHEC, rely on chemical communication systems, such a...

journal_title：ACS infectious diseases

authors： Styles MJ,Early SA,Tucholski T,West KHJ,Ge Y,Blackwell HE

更新日期：2020-12-11 00:00:00

abstract：:Bacterial quorum sensing (QS) is being contemplated as a promising target for developing innovative diagnostic and therapeutic strategies. Here we report for the first time the development of antibodies against 2-heptyl-4-quinolone (HHQ), a signaling molecule from the pqs QS system of Pseudomonas aeruginosa, involved ...

journal_title：ACS infectious diseases

authors： Montagut EJ,Vilaplana L,Martin-Gomez MT,Marco MP

更新日期：2020-12-11 00:00:00

abstract：:Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and because its inhibition or dysregulation leads to bacterial cell death. ClpP...

journal_title：ACS infectious diseases

authors： Binepal G,Mabanglo MF,Goodreid JD,Leung E,Barghash MM,Wong KS,Lin F,Cossette M,Bansagi J,Song B,Balasco Serrão VH,Pai EF,Batey RA,Gray-Owen SD,Houry WA

更新日期：2020-12-11 00:00:00

abstract：:By the emergence and worldwide spread of multi-drug-resistant Gram-negative bacteria, there have been growing demands for efficacious drugs to cure these resistant infections. The key mechanism for resistance to β-lactam antibiotics is the production of β-lactamases, which hydrolyze and deactivate β-lactams. Diazabicy...

journal_title：ACS infectious diseases

authors： Fujiu M,Yokoo K,Sato J,Shibuya S,Komano K,Kusano H,Sato S,Aoki T,Kohira N,Miyagawa S,Kawachi T,Yamawaki K

更新日期：2020-11-13 00:00:00

abstract：:A method for the fast isolation, propagation, and characterization of very low count bacteriophages active against pathogenic bacterial strains is described in this study. Bacteriophages with a count of 102 phage particles were dynamically adhered from the maximum 10 mL blood plasma sample onto the nanostructured part...

journal_title：ACS infectious diseases

authors： Horká M,Šalplachta J,Karásek P,Růžička F,Štveráková D,Pantůček R,Roth M

更新日期：2020-10-09 00:00:00

abstract：:Flaviviruses causes significant human disease. Recent outbreaks of the Zika virus highlight the need to develop effective therapies for this class of viruses. Previously we identified niclosamide as a broad-spectrum inhibitor for flaviviruses by targeting the interface between viral protease NS3 and its cofactor NS2B....

journal_title：ACS infectious diseases

authors： Li Z,Xu J,Lang Y,Fan X,Kuo L,D'Brant L,Hu S,Samrat SK,Trudeau N,Tharappel AM,Rugenstein N,Koetzner CA,Zhang J,Chen H,Kramer LD,Butler D,Zhang QY,Zhou J,Li H

更新日期：2020-10-09 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRPs) from nonsegmented negative strand (NNS) RNA viruses perform both mRNA transcription and genome replication, and these activities are regulated by their interactions with RNA and other accessory proteins within the ribonucleoprotein (RNP) complex. Detailed biochemical characterizat...

journal_title：ACS infectious diseases

authors： Balakrishnan A,Price E,Luu C,Shaul J,Wartchow C,Cantwell J,Vo T,DiDonato M,Spraggon G,Hekmat-Nejad M

更新日期：2020-10-09 00:00:00

abstract：:Coronaviruses first garnered widespread attention in 2002 when the severe acute respiratory syndrome coronavirus (SARS-CoV) emerged from bats in China and rapidly spread in human populations. Since then, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged and still actively infects humans. The recent SARS-...

journal_title：ACS infectious diseases

authors： Firpo MR,Mastrodomenico V,Hawkins GM,Prot M,Levillayer L,Gallagher T,Simon-Loriere E,Mounce BC

更新日期：2020-10-06 00:00:00

abstract：:Intravenous artesunate is effective against cerebral malaria (CM), but high mortality and neurological sequelae in survivors are inevitable. We investigated the effect of combined artesunate and tetramethylpyrazine using mouse models of experimental cerebral malaria (ECM). Artesunate + tetramethylpyrazine reduced micr...

journal_title：ACS infectious diseases

authors： Jiang X,Chen L,Zheng Z,Chen Y,Weng X,Guo Y,Li K,Yang T,Qu S,Liu H,Li Y,Zhu X

更新日期：2020-09-11 00:00:00

abstract：:In December 2019, a novel beta (β) coronavirus eventually named SARS-CoV-2 emerged in Wuhan, Hubei province, China, causing an outbreak of severe and even fatal pneumonia in humans. The virus has spread very rapidly to many countries across the world, resulting in the World Health Organization (WHO) to declare a pande...

journal_title：ACS infectious diseases

authors： da Silva SJR,Silva CTAD,Guarines KM,Mendes RPG,Pardee K,Kohl A,Pena L

更新日期：2020-09-11 00:00:00

abstract：:Photodynamic inactivation (PDI) protocols using photoactive metallated porphyrin-doped conjugated polymer nanoparticles (CPNs) and blue light were developed to eliminate multidrug-resistant pathogens. CPNs-PDI protocols using varying particle concentrations and irradiation doses were tested against nine pathogenic bac...

journal_title：ACS infectious diseases

authors： Martínez SR,Ibarra LE,Ponzio RA,Forcone MV,Wendel AB,Chesta CA,Spesia MB,Palacios RE

更新日期：2020-08-14 00:00:00

abstract：:The envelope glycoprotein (Env) enables HIV-1 cell entry through fusion of host-cell and viral membranes induced by the transmembrane subunit gp41. Antibodies targeting the C-terminal sequence of the membrane-proximal external region (C-MPER) block the fusogenic activity of gp41 and achieve neutralization of divergent...

journal_title：ACS infectious diseases

authors： Torralba J,de la Arada I,Carravilla P,Insausti S,Rujas E,Largo E,Eggeling C,Arrondo JLR,Apellániz B,Nieva JL

更新日期：2020-08-14 00:00:00

abstract：:Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in children. In severe cases, it can lead to neurological complications such as acute flaccid myelitis (AFM). EV-D68 belongs to the enterovirus genera of the Picornaviridae family, which also includes many other significant human pathoge...

journal_title：ACS infectious diseases

authors： Hu Y,Musharrafieh R,Zheng M,Wang J

更新日期：2020-07-10 00:00:00

abstract：:Poor patient adherence to antiretroviral medication represents a major obstacle for managing disease and reducing rates of new HIV infections. The measurement of patient drug levels is the most objective method of determining adherence. Tenofovir and tenofovir diphosphate are metabolites of some of the most common HIV...

journal_title：ACS infectious diseases

authors： Sevenler D,Bardon A,Fernandez Suarez M,Marshall L,Toner M,Drain PK,Sandlin RD

更新日期：2020-07-10 00:00:00

abstract：:Subunit vaccines composed of protein antigens covalently attached to Toll-like receptor (TLR) agonists elicit superior immune responses compared to mixtures of antigens and TLR agonists. Among different conjugation approaches, enzyme-mediated ligation is one of the few that provides an opportunity for the generation o...

journal_title：ACS infectious diseases

authors： Xu Z,Rivera-Hernandez T,Moyle PM

更新日期：2020-07-10 00:00:00

abstract：:Viridicatumtoxins are a rare class of tetracycline-like antibiotics that strongly inhibit drug-resistant Gram-positive bacteria. Although reported to exhibit in vitro inhibition activity to undecaprenyl pyrophosphate synthase (UPPS), an essential enzyme in bacterial cell wall synthesis, the biological targets and mech...

journal_title：ACS infectious diseases

authors： Li W,Li L,Zhang C,Cai Y,Gao Q,Wang F,Cao Y,Lin J,Li J,Shang Z,Lin W

更新日期：2020-07-10 00:00:00

abstract：:Pandemics such as influenza, smallpox, and plague have caused the loss of hundreds of millions of lives and have occurred for many centuries. Fortunately, they have been largely eliminated by the use of vaccinations and drugs. More recently, Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (M...

journal_title：ACS infectious diseases

authors： Oldfield E,Malwal SR

更新日期：2020-07-10 00:00:00

abstract：:Boronic acid transition state inhibitors (BATSIs) are known reversible covalent inhibitors of serine β-lactamases. The selectivity and high potency of specific BATSIs bearing an amide side chain mimicking the β-lactam's amide side chain are an established and recognized synthetic strategy. Herein, we describe a new cl...

journal_title：ACS infectious diseases

authors： Caselli E,Fini F,Introvigne ML,Stucchi M,Taracila MA,Fish ER,Smolen KA,Rather PN,Powers RA,Wallar BJ,Bonomo RA,Prati F

更新日期：2020-07-10 00:00:00

abstract：:MurG (uridine diphosphate-N-acetylglucosamine/N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase) is an essential bacterial glycosyltransferase that catalyzes the N-acetylglucosamine (GlcNAc) transformation of lipid I to lipid II during peptidoglycan biosynthesis. Park's nucleot...

journal_title：ACS infectious diseases

authors： Mitachi K,Yun HG,Gillman CD,Skorupinska-Tudek K,Swiezewska E,Clemons WM Jr,Kurosu M

更新日期：2020-06-12 00:00:00

abstract：:Neurotoxicity is an unwanted side effect for patients when receiving parenteral colistin therapy. The development of effective neuroprotective agents that can be coadministered during colistin therapy remains a priority area in antimicrobial chemotherapy. The present study aimed to investigate the protective effect of...

journal_title：ACS infectious diseases

authors： Dai C,Xiong J,Wang Y,Shen J,Velkov T,Xiao X

更新日期：2020-06-12 00:00:00

abstract：:Decreasing the therapeutic pipeline for vancomycin-resistant Enterococci (VRE) calls for novel strategies to enhance our antibacterial arsenal. Herein, we investigated the potential applications of surface localized antimicrobial display (SLAY)-derived cationic peptides in the fight against VanA operon mediated vancom...

journal_title：ACS infectious diseases

authors： Liu Y,Jia Y,Yang K,Li R,Xiao X,Wang Z

更新日期：2020-05-08 00:00:00

abstract：:The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-...

journal_title：ACS infectious diseases

authors： Xu J,Shi PY,Li H,Zhou J

更新日期：2020-05-08 00:00:00

abstract：:Clostridioides difficile (C. difficile) infection (CDI) is the primary cause of nosocomial antibiotic-associated diarrhea, with high recurrence rates following initial antibiotic treatment regimens. Restoration of the host gut microbiome through probiotic therapy is under investigation to reduce recurrence. Current in...

journal_title：ACS infectious diseases

authors： Moore JH,Honrado C,Stagnaro V,Kolling G,Warren CA,Swami NS

更新日期：2020-05-08 00:00:00

abstract：:Natural product antibiotics have played an essential role in the treatment of bacterial infection in addition to serving as useful tools to explore the intricate biology of bacteria. Our current arsenal of antibiotics operate through the inhibition of well-defined bacterial targets critical for replication and growth....

journal_title：ACS infectious diseases

authors： Liu K,Huigens RW 3rd

更新日期：2020-04-10 00:00:00

abstract：:The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of Mycobacterium tuberculosis, which causes tuberculosis. By employing a lead repurposing strategy, the malarial cytochrome bc1 inhibitor SCR0911 was tested against mycobacteria. Docking stu...

journal_title：ACS infectious diseases

authors： Chong SMS,Manimekalai MSS,Sarathy JP,Williams ZC,Harold LK,Cook GM,Dick T,Pethe K,Bates RW,Grüber G

更新日期：2020-04-10 00:00:00

abstract：:Although iron is essential for bacteria, the nutrient presents problems of toxicity and solubility. Bacteria circumvent these problems with the aid of iron storage proteins where Fe3+ is deposited and, when necessary, mobilized as Fe2+ for metabolic requirements. In Pseudomonas aeruginosa, Fe3+ is compartmentalized in...

journal_title：ACS infectious diseases

authors： Soldano A,Yao H,Chandler JR,Rivera M

更新日期：2020-03-13 00:00:00

abstract：:Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation is regulated by concerted activit...

journal_title：ACS infectious diseases

authors： Siddiqui MA,Singh S,Malhotra P,Chitnis CE

更新日期：2020-03-13 00:00:00

abstract：:Because of its essential role as a bacterial virulence factor, enzyme sortase A (SrtA) has become an attractive target for the development of new antivirulence drugs against Gram-positive infections. Here we describe 27 compounds identified as covalent inhibitors of Staphylococcus aureus SrtA by screening a library of...

journal_title：ACS infectious diseases

authors： Jaudzems K,Kurbatska V,Je Kabsons A,Bobrovs R,Rudevica Z,Leonchiks A

更新日期：2020-02-14 00:00:00

abstract：:In this study, we describe a simple and rapid antibacterial susceptibility testing (AST) method for Staphylococcus aureus called S. aureus specific fluorescence resonance energy transfer (FRET) probe-based AST (SF-AST), which is based on an S. aureus specific FRET probe (SF probe) that detects micrococcal nuclease (MN...

journal_title：ACS infectious diseases

authors： Yi SY,Jeong J,Kim KE,Park K,Shin YB

更新日期：2020-02-14 00:00:00

abstract：:Across zoonotic pathogens, RNA viruses are responsible for disproportionate levels of human disease, suffering, and death. Neurotropic RNA viruses (e.g., rabies, Japanese and Eastern Equine Encephalitis, Ebola, West Nile, Powassan) infect the brain and spinal cord, causing meningitis, encephalitis, microcephaly, and G...

journal_title：ACS infectious diseases

authors： Antonucci J,Gehrke L

更新日期：2019-12-13 00:00:00

abstract：:The genomes of diverse mycobacterial species encode multiple proteins with the canonical l,d-transpeptidase (Ldt) sequence motif. The reason for this apparent redundancy is not well understood, but evidence suggests paralogous Ldts may serve niche roles in maintaining and/or remodeling mycobacterial peptidoglycan. We ...

journal_title：ACS infectious diseases

authors： Zandi TA,Marshburn RL,Stateler PK,Brammer Basta LA

更新日期：2019-12-13 00:00:00

abstract：:Brain-eating amoebae cause devastating infections in the central nervous system of humans, resulting in a mortality rate of 95%. There are limited effective therapeutic options available clinically for treating granulomatous amoebic encephalitis and primary amoebic meningoencephalitis caused by Acanthamoeba castellani...

journal_title：ACS infectious diseases

authors： Anwar A,Mungroo MR,Anwar A,Sullivan WJ Jr,Khan NA,Siddiqui R

更新日期：2019-12-13 00:00:00

abstract：:Dysentery is a major health threat that dramatically impacts childhood morbidity and mortality in developing countries. Various pathogenic agents cause dysentery, such as Shigella spp. and Escherichia coli, which are very closely related if not identical species. Sensitive and precise detection and identification of t...

journal_title：ACS infectious diseases

authors： Rautureau GJP,Palama TL,Canard I,Mirande C,Chatellier S,van Belkum A,Elena-Herrmann B

更新日期：2019-11-08 00:00:00

abstract：:Amonabactins are a group of four related catecholate siderophores produced by several species of the genus Aeromonas, including A. hydrophila and the fish pathogen A. salmonicida subsp. salmonicida. Although the gene cluster encoding amonabactin biosynthesis also contains a gene that could encode the ferri-siderophore...

journal_title：ACS infectious diseases

authors： Rey-Varela D,Cisneros-Sureda J,Balado M,Rodríguez J,Lemos ML,Jiménez C

更新日期：2019-11-08 00:00:00