解剖学和形态学

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听力与言语-语言病理学

行为科学

细胞和组织工程学

牙科,口腔外科和医学

皮肤病学

肠胃学和肝脏学

医学伦理学

医学实验室技术

医学,法律

神经影像学

护理

产科医学和妇科医学

周围血管疾病

基本医疗保健

放射学,核医学和医学成像

康复学

兽医学

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老年医学

心理学,精神分析

你正在浏览ACS Infectious Diseases期刊下所有文献
  • Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant.

    abstract::Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventional antibiotics to be lowered and reduce the insurgence of antibiotic resistance. Herein, we report that an O-acetylserine sulfhydrylase (OASS) inhibitor can be used as a colistin adjuvant to treat infections caused by...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00378

    authors: Annunziato G,Spadini C,Franko N,Storici P,Demitri N,Pieroni M,Flisi S,Rosati L,Iannarelli M,Marchetti M,Magalhaes J,Bettati S,Mozzarelli A,Cabassi CS,Campanini B,Costantino G

    更新日期:2021-01-29 00:00:00

  • Detection of Bacterial Coinfection in COVID-19 Patients Is a Missing Piece of the Puzzle in the COVID-19 Management in Indonesia.

    abstract::Bacterial coinfection in COVID-19 patients has the potential to complicate treatments and accelerate the development of antibiotic resistance in the clinic due to the widespread use of broad-spectrum antibiotics, including in Indonesia. The surge of COVID-19 patients may worsen antibiotic overuse; therefore, informati...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.1c00006

    authors: Prasetyoputri A

    更新日期:2021-01-27 00:00:00

  • Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.

    abstract::We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00726

    authors: Bajic G,Harrison SC

    更新日期:2021-01-08 00:00:00

  • Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis.

    abstract::MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targets and inhibit bacterial growth by more than one mechanism. Here, we ...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00675

    authors: Grover S,Engelhart CA,Pérez-Herrán E,Li W,Abrahams KA,Papavinasasundaram K,Bean JM,Sassetti CM,Mendoza-Losana A,Besra GS,Jackson M,Schnappinger D

    更新日期:2021-01-08 00:00:00

  • New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase.

    abstract::Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated analogues and demonstrate that these compounds potently inhibit Plasm...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00481

    authors: Cheuka PM,Centani L,Arendse LB,Fienberg S,Wambua L,Renga SS,Dziwornu GA,Kumar M,Lawrence N,Taylor D,Wittlin S,Coertzen D,Reader J,van der Watt M,Birkholtz LM,Chibale K

    更新日期:2021-01-08 00:00:00

  • A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in Trypanosoma brucei.

    abstract::The maintenance of deoxyribonucleotide triphosphate (dNTP) homeostasis through synthesis and degradation is critical for accurate genomic and mitochondrial DNA replication fidelity. Trypanosoma brucei makes use of both the salvage and de novo pathways for the provision of pyrimidine dNTPs. In this respect, the sterile...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00551

    authors: Yagüe-Capilla M,Castillo-Acosta VM,Bosch-Navarrete C,Ruiz-Pérez LM,González-Pacanowska D

    更新日期:2021-01-08 00:00:00

  • Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) is the causative agent of severe diarrheal disease in humans. Cattle are the natural reservoir of EHEC, and approximately 75% of EHEC infections in humans stem from bovine products. Many common bacterial pathogens, including EHEC, rely on chemical communication systems, such a...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00654

    authors: Styles MJ,Early SA,Tucholski T,West KHJ,Ge Y,Blackwell HE

    更新日期:2020-12-11 00:00:00

  • High-Throughput Immunochemical Method to Assess the 2-Heptyl-4-quinolone Quorum Sensing Molecule as a Potential Biomarker of Pseudomonas aeruginosa Infections.

    abstract::Bacterial quorum sensing (QS) is being contemplated as a promising target for developing innovative diagnostic and therapeutic strategies. Here we report for the first time the development of antibodies against 2-heptyl-4-quinolone (HHQ), a signaling molecule from the pqs QS system of Pseudomonas aeruginosa, involved ...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00604

    authors: Montagut EJ,Vilaplana L,Martin-Gomez MT,Marco MP

    更新日期:2020-12-11 00:00:00

  • Development of Antibiotics That Dysregulate the Neisserial ClpP Protease.

    abstract::Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and because its inhibition or dysregulation leads to bacterial cell death. ClpP...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00599

    authors: Binepal G,Mabanglo MF,Goodreid JD,Leung E,Barghash MM,Wong KS,Lin F,Cossette M,Bansagi J,Song B,Balasco Serrão VH,Pai EF,Batey RA,Gray-Owen SD,Houry WA

    更新日期:2020-12-11 00:00:00

  • Introduction of a Thio Functional Group to Diazabicyclooctane: An Effective Modification to Potentiate the Activity of β-Lactams against Gram-Negative Bacteria Producing Class A, C, and D Serine β-Lactamases.

    abstract::By the emergence and worldwide spread of multi-drug-resistant Gram-negative bacteria, there have been growing demands for efficacious drugs to cure these resistant infections. The key mechanism for resistance to β-lactam antibiotics is the production of β-lactamases, which hydrolyze and deactivate β-lactams. Diazabicy...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00560

    authors: Fujiu M,Yokoo K,Sato J,Shibuya S,Komano K,Kusano H,Sato S,Aoki T,Kohira N,Miyagawa S,Kawachi T,Yamawaki K

    更新日期:2020-11-13 00:00:00

  • Rapid Isolation, Propagation, and Online Analysis of a Small Number of Therapeutic Staphylococcal Bacteriophages from a Complex Matrix.

    abstract::A method for the fast isolation, propagation, and characterization of very low count bacteriophages active against pathogenic bacterial strains is described in this study. Bacteriophages with a count of 102 phage particles were dynamically adhered from the maximum 10 mL blood plasma sample onto the nanostructured part...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00358

    authors: Horká M,Šalplachta J,Karásek P,Růžička F,Štveráková D,Pantůček R,Roth M

    更新日期:2020-10-09 00:00:00

  • JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo.

    abstract::Flaviviruses causes significant human disease. Recent outbreaks of the Zika virus highlight the need to develop effective therapies for this class of viruses. Previously we identified niclosamide as a broad-spectrum inhibitor for flaviviruses by targeting the interface between viral protease NS3 and its cofactor NS2B....

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00217

    authors: Li Z,Xu J,Lang Y,Fan X,Kuo L,D'Brant L,Hu S,Samrat SK,Trudeau N,Tharappel AM,Rugenstein N,Koetzner CA,Zhang J,Chen H,Kramer LD,Butler D,Zhang QY,Zhou J,Li H

    更新日期:2020-10-09 00:00:00

  • Biochemical Characterization of Respiratory Syncytial Virus RNA-Dependent RNA Polymerase Complex.

    abstract::RNA-dependent RNA polymerases (RdRPs) from nonsegmented negative strand (NNS) RNA viruses perform both mRNA transcription and genome replication, and these activities are regulated by their interactions with RNA and other accessory proteins within the ribonucleoprotein (RNP) complex. Detailed biochemical characterizat...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00554

    authors: Balakrishnan A,Price E,Luu C,Shaul J,Wartchow C,Cantwell J,Vo T,DiDonato M,Spraggon G,Hekmat-Nejad M

    更新日期:2020-10-09 00:00:00

  • Targeting Polyamines Inhibits Coronavirus Infection by Reducing Cellular Attachment and Entry.

    abstract::Coronaviruses first garnered widespread attention in 2002 when the severe acute respiratory syndrome coronavirus (SARS-CoV) emerged from bats in China and rapidly spread in human populations. Since then, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged and still actively infects humans. The recent SARS-...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00491

    authors: Firpo MR,Mastrodomenico V,Hawkins GM,Prot M,Levillayer L,Gallagher T,Simon-Loriere E,Mounce BC

    更新日期:2020-10-06 00:00:00

  • Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria.

    abstract::Intravenous artesunate is effective against cerebral malaria (CM), but high mortality and neurological sequelae in survivors are inevitable. We investigated the effect of combined artesunate and tetramethylpyrazine using mouse models of experimental cerebral malaria (ECM). Artesunate + tetramethylpyrazine reduced micr...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00124

    authors: Jiang X,Chen L,Zheng Z,Chen Y,Weng X,Guo Y,Li K,Yang T,Qu S,Liu H,Li Y,Zhu X

    更新日期:2020-09-11 00:00:00

  • Clinical and Laboratory Diagnosis of SARS-CoV-2, the Virus Causing COVID-19.

    abstract::In December 2019, a novel beta (β) coronavirus eventually named SARS-CoV-2 emerged in Wuhan, Hubei province, China, causing an outbreak of severe and even fatal pneumonia in humans. The virus has spread very rapidly to many countries across the world, resulting in the World Health Organization (WHO) to declare a pande...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1021/acsinfecdis.0c00274

    authors: da Silva SJR,Silva CTAD,Guarines KM,Mendes RPG,Pardee K,Kohl A,Pena L

    更新日期:2020-09-11 00:00:00

  • Photodynamic Inactivation of ESKAPE Group Bacterial Pathogens in Planktonic and Biofilm Cultures Using Metallated Porphyrin-Doped Conjugated Polymer Nanoparticles.

    abstract::Photodynamic inactivation (PDI) protocols using photoactive metallated porphyrin-doped conjugated polymer nanoparticles (CPNs) and blue light were developed to eliminate multidrug-resistant pathogens. CPNs-PDI protocols using varying particle concentrations and irradiation doses were tested against nine pathogenic bac...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00268

    authors: Martínez SR,Ibarra LE,Ponzio RA,Forcone MV,Wendel AB,Chesta CA,Spesia MB,Palacios RE

    更新日期:2020-08-14 00:00:00

  • Cholesterol Constrains the Antigenic Configuration of the Membrane-Proximal Neutralizing HIV-1 Epitope.

    abstract::The envelope glycoprotein (Env) enables HIV-1 cell entry through fusion of host-cell and viral membranes induced by the transmembrane subunit gp41. Antibodies targeting the C-terminal sequence of the membrane-proximal external region (C-MPER) block the fusogenic activity of gp41 and achieve neutralization of divergent...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00243

    authors: Torralba J,de la Arada I,Carravilla P,Insausti S,Rujas E,Largo E,Eggeling C,Arrondo JLR,Apellániz B,Nieva JL

    更新日期:2020-08-14 00:00:00

  • Enterovirus D68 Antivirals: Past, Present, and Future.

    abstract::Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in children. In severe cases, it can lead to neurological complications such as acute flaccid myelitis (AFM). EV-D68 belongs to the enterovirus genera of the Picornaviridae family, which also includes many other significant human pathoge...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00120

    authors: Hu Y,Musharrafieh R,Zheng M,Wang J

    更新日期:2020-07-10 00:00:00

  • Immunoassay for HIV Drug Metabolites Tenofovir and Tenofovir Diphosphate.

    abstract::Poor patient adherence to antiretroviral medication represents a major obstacle for managing disease and reducing rates of new HIV infections. The measurement of patient drug levels is the most objective method of determining adherence. Tenofovir and tenofovir diphosphate are metabolites of some of the most common HIV...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00010

    authors: Sevenler D,Bardon A,Fernandez Suarez M,Marshall L,Toner M,Drain PK,Sandlin RD

    更新日期:2020-07-10 00:00:00

  • Development of an Enzyme-Mediated, Site-Specific Method to Conjugate Toll-Like Receptor 2 Agonists onto Protein Antigens: Toward a Broadly Protective, Four Component, Group A Streptococcal Self-Adjuvanting Lipoprotein-Fusion Combination Vaccine.

    abstract::Subunit vaccines composed of protein antigens covalently attached to Toll-like receptor (TLR) agonists elicit superior immune responses compared to mixtures of antigens and TLR agonists. Among different conjugation approaches, enzyme-mediated ligation is one of the few that provides an opportunity for the generation o...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00047

    authors: Xu Z,Rivera-Hernandez T,Moyle PM

    更新日期:2020-07-10 00:00:00

  • Investigations into the Antibacterial Mechanism of Action of Viridicatumtoxins.

    abstract::Viridicatumtoxins are a rare class of tetracycline-like antibiotics that strongly inhibit drug-resistant Gram-positive bacteria. Although reported to exhibit in vitro inhibition activity to undecaprenyl pyrophosphate synthase (UPPS), an essential enzyme in bacterial cell wall synthesis, the biological targets and mech...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00031

    authors: Li W,Li L,Zhang C,Cai Y,Gao Q,Wang F,Cao Y,Lin J,Li J,Shang Z,Lin W

    更新日期:2020-07-10 00:00:00

  • COVID-19 and Other Pandemics: How Might They Be Prevented?

    abstract::Pandemics such as influenza, smallpox, and plague have caused the loss of hundreds of millions of lives and have occurred for many centuries. Fortunately, they have been largely eliminated by the use of vaccinations and drugs. More recently, Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (M...

    journal_title:ACS infectious diseases

    pub_type: 历史文章,杂志文章,评审

    doi:10.1021/acsinfecdis.0c00291

    authors: Oldfield E,Malwal SR

    更新日期:2020-07-10 00:00:00

  • 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase.

    abstract::Boronic acid transition state inhibitors (BATSIs) are known reversible covalent inhibitors of serine β-lactamases. The selectivity and high potency of specific BATSIs bearing an amide side chain mimicking the β-lactam's amide side chain are an established and recognized synthetic strategy. Herein, we describe a new cl...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00254

    authors: Caselli E,Fini F,Introvigne ML,Stucchi M,Taracila MA,Fish ER,Smolen KA,Rather PN,Powers RA,Wallar BJ,Bonomo RA,Prati F

    更新日期:2020-07-10 00:00:00

  • Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-Based Assays.

    abstract::MurG (uridine diphosphate-N-acetylglucosamine/N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase) is an essential bacterial glycosyltransferase that catalyzes the N-acetylglucosamine (GlcNAc) transformation of lipid I to lipid II during peptidoglycan biosynthesis. Park's nucleot...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00242

    authors: Mitachi K,Yun HG,Gillman CD,Skorupinska-Tudek K,Swiezewska E,Clemons WM Jr,Kurosu M

    更新日期:2020-06-12 00:00:00

  • Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity.

    abstract::Neurotoxicity is an unwanted side effect for patients when receiving parenteral colistin therapy. The development of effective neuroprotective agents that can be coadministered during colistin therapy remains a priority area in antimicrobial chemotherapy. The present study aimed to investigate the protective effect of...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.0c00107

    authors: Dai C,Xiong J,Wang Y,Shen J,Velkov T,Xiao X

    更新日期:2020-06-12 00:00:00

  • Antagonizing Vancomycin Resistance in Enterococcus by Surface Localized Antimicrobial Display-Derived Peptides.

    abstract::Decreasing the therapeutic pipeline for vancomycin-resistant Enterococci (VRE) calls for novel strategies to enhance our antibacterial arsenal. Herein, we investigated the potential applications of surface localized antimicrobial display (SLAY)-derived cationic peptides in the fight against VanA operon mediated vancom...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00164

    authors: Liu Y,Jia Y,Yang K,Li R,Xiao X,Wang Z

    更新日期:2020-05-08 00:00:00

  • Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

    abstract::The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1021/acsinfecdis.0c00052

    authors: Xu J,Shi PY,Li H,Zhou J

    更新日期:2020-05-08 00:00:00

  • Rapid in Vitro Assessment of Clostridioides difficile Inhibition by Probiotics Using Dielectrophoresis to Quantify Cell Structure Alterations.

    abstract::Clostridioides difficile (C. difficile) infection (CDI) is the primary cause of nosocomial antibiotic-associated diarrhea, with high recurrence rates following initial antibiotic treatment regimens. Restoration of the host gut microbiome through probiotic therapy is under investigation to reduce recurrence. Current in...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00415

    authors: Moore JH,Honrado C,Stagnaro V,Kolling G,Warren CA,Swami NS

    更新日期:2020-05-08 00:00:00

  • Instructive Advances in Chemical Microbiology Inspired by Nature's Diverse Inventory of Molecules.

    abstract::Natural product antibiotics have played an essential role in the treatment of bacterial infection in addition to serving as useful tools to explore the intricate biology of bacteria. Our current arsenal of antibiotics operate through the inhibition of well-defined bacterial targets critical for replication and growth....

    journal_title:ACS infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1021/acsinfecdis.9b00413

    authors: Liu K,Huigens RW 3rd

    更新日期:2020-04-10 00:00:00

  • Antituberculosis Activity of the Antimalaria Cytochrome bcc Oxidase Inhibitor SCR0911.

    abstract::The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of Mycobacterium tuberculosis, which causes tuberculosis. By employing a lead repurposing strategy, the malarial cytochrome bc1 inhibitor SCR0911 was tested against mycobacteria. Docking stu...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00408

    authors: Chong SMS,Manimekalai MSS,Sarathy JP,Williams ZC,Harold LK,Cook GM,Dick T,Pethe K,Bates RW,Grüber G

    更新日期:2020-04-10 00:00:00

  • Inhibiting Iron Mobilization from Bacterioferritin in Pseudomonas aeruginosa Impairs Biofilm Formation Irrespective of Environmental Iron Availability.

    abstract::Although iron is essential for bacteria, the nutrient presents problems of toxicity and solubility. Bacteria circumvent these problems with the aid of iron storage proteins where Fe3+ is deposited and, when necessary, mobilized as Fe2+ for metabolic requirements. In Pseudomonas aeruginosa, Fe3+ is compartmentalized in...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00398

    authors: Soldano A,Yao H,Chandler JR,Rivera M

    更新日期:2020-03-13 00:00:00

  • Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Plasmodium falciparum Merozoites.

    abstract::Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. In vivo, palmitoylation is regulated by concerted activit...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00321

    authors: Siddiqui MA,Singh S,Malhotra P,Chitnis CE

    更新日期:2020-03-13 00:00:00

  • Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization.

    abstract::Because of its essential role as a bacterial virulence factor, enzyme sortase A (SrtA) has become an attractive target for the development of new antivirulence drugs against Gram-positive infections. Here we describe 27 compounds identified as covalent inhibitors of Staphylococcus aureus SrtA by screening a library of...

    journal_title:ACS infectious diseases

    pub_type: 信件

    doi:10.1021/acsinfecdis.9b00265

    authors: Jaudzems K,Kurbatska V,Je Kabsons A,Bobrovs R,Rudevica Z,Leonchiks A

    更新日期:2020-02-14 00:00:00

  • Staphylococcus aureus Specific FRET Probe-Based Antibacterial Susceptibility Testing (SF-AST) by Detection of Micrococcal Nuclease Activity.

    abstract::In this study, we describe a simple and rapid antibacterial susceptibility testing (AST) method for Staphylococcus aureus called S. aureus specific fluorescence resonance energy transfer (FRET) probe-based AST (SF-AST), which is based on an S. aureus specific FRET probe (SF probe) that detects micrococcal nuclease (MN...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00260

    authors: Yi SY,Jeong J,Kim KE,Park K,Shin YB

    更新日期:2020-02-14 00:00:00

  • Cerebral Organoid Models for Neurotropic Viruses.

    abstract::Across zoonotic pathogens, RNA viruses are responsible for disproportionate levels of human disease, suffering, and death. Neurotropic RNA viruses (e.g., rabies, Japanese and Eastern Equine Encephalitis, Ebola, West Nile, Powassan) infect the brain and spinal cord, causing meningitis, encephalitis, microcephaly, and G...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00339

    authors: Antonucci J,Gehrke L

    更新日期:2019-12-13 00:00:00

  • Phylogenetic and Biochemical Analyses of Mycobacterial l,d-Transpeptidases Reveal a Distinct Enzyme Class That Is Preferentially Acylated by Meropenem.

    abstract::The genomes of diverse mycobacterial species encode multiple proteins with the canonical l,d-transpeptidase (Ldt) sequence motif. The reason for this apparent redundancy is not well understood, but evidence suggests paralogous Ldts may serve niche roles in maintaining and/or remodeling mycobacterial peptidoglycan. We ...

    journal_title:ACS infectious diseases

    pub_type: 信件

    doi:10.1021/acsinfecdis.9b00234

    authors: Zandi TA,Marshburn RL,Stateler PK,Brammer Basta LA

    更新日期:2019-12-13 00:00:00

  • Repositioning of Guanabenz in Conjugation with Gold and Silver Nanoparticles against Pathogenic Amoebae Acanthamoeba castellanii and Naegleria fowleri.

    abstract::Brain-eating amoebae cause devastating infections in the central nervous system of humans, resulting in a mortality rate of 95%. There are limited effective therapeutic options available clinically for treating granulomatous amoebic encephalitis and primary amoebic meningoencephalitis caused by Acanthamoeba castellani...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00263

    authors: Anwar A,Mungroo MR,Anwar A,Sullivan WJ Jr,Khan NA,Siddiqui R

    更新日期:2019-12-13 00:00:00

  • Discrimination of Escherichia coli and Shigella spp. by Nuclear Magnetic Resonance Based Metabolomic Characterization of Culture Media.

    abstract::Dysentery is a major health threat that dramatically impacts childhood morbidity and mortality in developing countries. Various pathogenic agents cause dysentery, such as Shigella spp. and Escherichia coli, which are very closely related if not identical species. Sensitive and precise detection and identification of t...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00199

    authors: Rautureau GJP,Palama TL,Canard I,Mirande C,Chatellier S,van Belkum A,Elena-Herrmann B

    更新日期:2019-11-08 00:00:00

  • The Outer Membrane Protein FstC of Aeromonas salmonicida subsp. salmonicida Acts as Receptor for Amonabactin Siderophores and Displays a Wide Ligand Plasticity. Structure-Activity Relationships of Synthetic Amonabactin Analogues.

    abstract::Amonabactins are a group of four related catecholate siderophores produced by several species of the genus Aeromonas, including A. hydrophila and the fish pathogen A. salmonicida subsp. salmonicida. Although the gene cluster encoding amonabactin biosynthesis also contains a gene that could encode the ferri-siderophore...

    journal_title:ACS infectious diseases

    pub_type: 杂志文章

    doi:10.1021/acsinfecdis.9b00274

    authors: Rey-Varela D,Cisneros-Sureda J,Balado M,Rodríguez J,Lemos ML,Jiménez C

    更新日期:2019-11-08 00:00:00

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