解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. METHODS:Lat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01881-7
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Alcohol consumption is a leading contributor to death and disability worldwide, but previous research has not examined the effects of different patterns of alcohol consumption. The study objective was to understand the relationship between different alcohol consumption patterns and adverse health outcomes ri...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01878-2
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01848-8
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are at a higher risk for severe manifestations of both illnesses. Considering the high transmission rate ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-020-01816-2
更新日期:2020-12-18 00:00:00
abstract:BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01835-z
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND:Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. METHODS:Using a machine learning program, we identified a 25-Gen...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01834-0
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lympho...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01817-1
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise ev...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01801-9
更新日期:2020-11-18 00:00:00
abstract:BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01796-3
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01787-4
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in comparison to the risk in relatives of patients with invasive bre...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01772-x
更新日期:2020-11-05 00:00:00
abstract:BACKGROUND:Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined. METHODS:Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01743-2
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01738-z
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Armed conflict can indirectly affect population health through detrimental impacts on political and social institutions and destruction of infrastructure. This study aimed to quantify indirect mortality impacts of armed conflict in civilian populations globally and explore differential effects by armed confl...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01708-5
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial scales for transmission of chikungunya virus require definition to improve outbreak vector control re...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01674-y
更新日期:2020-08-07 00:00:00
abstract:BACKGROUND:Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals with impaired capacity nearing the end of life in research, by identifying the challenges and solut...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01654-2
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:To reduce inequalities between individuals with and without mental health problems, a better understanding is required of triggers and success of quit attempts among the third of smokers with mental health problems. The aim was to assess whether there are differences by mental health status in (i) triggers f...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01617-7
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outco...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01602-0
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:The burden of malaria in sub-Saharan Africa remains challenging to measure relying on epidemiological modelling to evaluate the impact of investments and providing an in-depth analysis of progress and trends in malaria response globally. In malaria-endemic countries of Africa, there is increasing use of rout...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01593-y
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:The World Health Organization (WHO) called for global action towards the elimination of cervical cancer. One of the main strategies is to screen 70% of women at the age between 35 and 45 years and 90% of women managed appropriately by 2030. So far, approximately 85% of cervical cancers occur in low- and midd...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01613-x
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS:A multicenter nested case-control study was conducted in four...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12916-020-01633-7
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for IPD-NMAs, it is unclear whether there are statistical defects in published IPD-NMAs and whether the...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01591-0
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent con...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01585-y
更新日期:2020-05-25 00:00:00
abstract:BACKGROUND:Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC diabetes score as predictors of dementia and assessed the role of age in their associa...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01578-x
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or L...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01540-x
更新日期:2020-04-07 00:00:00
abstract:BACKGROUND:During the past decades, life expectancy has continued to increase in most high-income countries. Previous research suggests that improvements in life expectancy have primarily been driven by advances at the upper end of the health distribution, while parts of the population have lagged behind. Using data fr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01514-z
更新日期:2020-03-20 00:00:00
abstract:BACKGROUND:Gluten-free diet (GFD) decreases the quality of life of celiac disease (CD) patients, who frequently ask to occasionally ingest gluten-containing food. We evaluated CD patients reporting voluntary and occasional transgressions to their GFD. METHODS:From October 2017 to September 2018, the patients reporting...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-1511-6
更新日期:2020-03-16 00:00:00
abstract:BACKGROUND:Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration and vital statistics (CRVS) systems. Accurate completion of the med...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01519-8
更新日期:2020-03-09 00:00:00
abstract:BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-1505-4
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1478-3
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Participation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, and financial burdens) experienced by patients through their participation in a RCT. METHODS:We condu...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1476-5
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was to assess how individual soft drink companies and consumers have responded to calls to reduce sugar ...
journal_title:BMC medicine
pub_type: 历史文章,杂志文章
doi:10.1186/s12916-019-1477-4
更新日期:2020-01-13 00:00:00
abstract:BACKGROUND:Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are causal remains largely unknown. METHODS:We employed a two-sample Mendelian randomization approach to...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1448-9
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagnosis. METHODS:The study was set within 568 practices contributing to a UK primary care health recor...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1462-y
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1431-5
更新日期:2019-11-25 00:00:00
abstract:BACKGROUND:Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-based medicine) when people have co-existing diseases (comorbidit...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1427-1
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle, high-de...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1423-5
更新日期:2019-11-11 00:00:00
abstract:BACKGROUND:Many agree that the biopsychosocial contributions to psychopathology are complex, yet it is unclear how we can make sense of this complexity. One approach is to reduce this complexity to a few necessary and sufficient biopsychosocial factors; although this approach is easy to understand, it has little explan...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-019-1435-1
更新日期:2019-10-18 00:00:00
abstract:BACKGROUND:Vaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can be challenging to achieve and maintain. The herd immunity threshold for measles is typically stipula...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1413-7
更新日期:2019-09-25 00:00:00
abstract:BACKGROUND:In 2015, the Zika virus spread from Brazil throughout the Americas, posing an unprecedented challenge to the public health community. During the epidemic, international public health officials lacked reliable predictions of the outbreak's expected geographic scale and prevalence of cases, and were therefore ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1389-3
更新日期:2019-09-02 00:00:00