听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览BMC Medicine期刊下所有文献
  • Model-based comorbidity clusters in patients with heart failure: association with clinical outcomes and healthcare utilization.

    abstract:BACKGROUND:Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. METHODS:Lat...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01881-7

    authors: Gulea C,Zakeri R,Quint JK

    更新日期:2021-01-18 00:00:00

  • Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study.

    abstract:BACKGROUND:Alcohol consumption is a leading contributor to death and disability worldwide, but previous research has not examined the effects of different patterns of alcohol consumption. The study objective was to understand the relationship between different alcohol consumption patterns and adverse health outcomes ri...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01878-2

    authors: Jani BD,McQueenie R,Nicholl BI,Field R,Hanlon P,Gallacher KI,Mair FS,Lewsey J

    更新日期:2021-01-12 00:00:00

  • Associations of six adiposity-related markers with incidence and mortality from 24 cancers-findings from the UK Biobank prospective cohort study.

    abstract:BACKGROUND:Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01848-8

    authors: Parra-Soto S,Cowley ES,Rezende LFM,Ferreccio C,Mathers JC,Pell JP,Ho FK,Celis-Morales C

    更新日期:2021-01-11 00:00:00

  • Cardiovascular implications of COVID-19 versus influenza infection: a review.

    abstract:BACKGROUND:Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are at a higher risk for severe manifestations of both illnesses. Considering the high transmission rate ...

    journal_title:BMC medicine

    pub_type: 杂志文章,评审

    doi:10.1186/s12916-020-01816-2

    authors: Khan MS,Shahid I,Anker SD,Solomon SD,Vardeny O,Michos ED,Fonarow GC,Butler J

    更新日期:2020-12-18 00:00:00

  • Comparing the effects of HIV self-testing to standard HIV testing for key populations: a systematic review and meta-analysis.

    abstract:BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01835-z

    authors: Witzel TC,Eshun-Wilson I,Jamil MS,Tilouche N,Figueroa C,Johnson CC,Reid D,Baggaley R,Siegfried N,Burns FM,Rodger AJ,Weatherburn P

    更新日期:2020-12-03 00:00:00

  • Development and validation of a 25-Gene Panel urine test for prostate cancer diagnosis and potential treatment follow-up.

    abstract:BACKGROUND:Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. METHODS:Using a machine learning program, we identified a 25-Gen...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01834-0

    authors: Johnson H,Guo J,Zhang X,Zhang H,Simoulis A,Wu AHB,Xia T,Li F,Tan W,Johnson A,Dizeyi N,Abrahamsson PA,Kenner L,Feng X,Zou C,Xiao K,Persson JL,Chen L

    更新日期:2020-12-01 00:00:00

  • Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies.

    abstract:BACKGROUND:Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lympho...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01817-1

    authors: Cupp MA,Cariolou M,Tzoulaki I,Aune D,Evangelou E,Berlanga-Taylor AJ

    更新日期:2020-11-20 00:00:00

  • Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis.

    abstract:BACKGROUND:Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise ev...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01801-9

    authors: Nkambule BB,Mxinwa V,Mkandla Z,Mutize T,Mokgalaboni K,Nyambuya TM,Dludla PV

    更新日期:2020-11-18 00:00:00

  • Chlamydia trachomatis transmission between the oropharynx, urethra and anorectum in men who have sex with men: a mathematical model.

    abstract:BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01796-3

    authors: Xu X,Chow EPF,Ong JJ,Hoebe CJPA,Zou Z,Hocking JS,Fairley CK,Zhang L

    更新日期:2020-11-17 00:00:00

  • Age, sex, disease severity, and disease duration difference in placebo response: implications from a meta-analysis of diabetes mellitus.

    abstract:BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01787-4

    authors: Lin C,Cai X,Yang W,Lv F,Nie L,Ji L

    更新日期:2020-11-16 00:00:00

  • Risk of invasive breast cancer in relatives of patients with breast carcinoma in situ: a prospective cohort study.

    abstract:BACKGROUND:Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in comparison to the risk in relatives of patients with invasive bre...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01772-x

    authors: Mukama T,Fallah M,Brenner H,Xu X,Sundquist K,Sundquist J,Kharazmi E

    更新日期:2020-11-05 00:00:00

  • Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

    abstract:BACKGROUND:Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined. METHODS:Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01743-2

    authors: Luo Q,Zhang L,Huang CC,Zheng Y,Kanen JW,Zhao Q,Yao Y,Quinlan EB,Jia T,Banaschewski T,Bokde ALW,Bromberg U,Büchel C,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,Martinot MP,Nees F,Orfanos

    更新日期:2020-10-15 00:00:00

  • Comorbidity between depression and anxiety: assessing the role of bridge mental states in dynamic psychological networks.

    abstract:BACKGROUND:Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01738-z

    authors: Groen RN,Ryan O,Wigman JTW,Riese H,Penninx BWJH,Giltay EJ,Wichers M,Hartman CA

    更新日期:2020-09-29 00:00:00

  • Estimating indirect mortality impacts of armed conflict in civilian populations: panel regression analyses of 193 countries, 1990-2017.

    abstract:BACKGROUND:Armed conflict can indirectly affect population health through detrimental impacts on political and social institutions and destruction of infrastructure. This study aimed to quantify indirect mortality impacts of armed conflict in civilian populations globally and explore differential effects by armed confl...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01708-5

    authors: Jawad M,Hone T,Vamos EP,Roderick P,Sullivan R,Millett C

    更新日期:2020-09-10 00:00:00

  • Spatial modes for transmission of chikungunya virus during a large chikungunya outbreak in Italy: a modeling analysis.

    abstract:BACKGROUND:The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial scales for transmission of chikungunya virus require definition to improve outbreak vector control re...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01674-y

    authors: Guzzetta G,Vairo F,Mammone A,Lanini S,Poletti P,Manica M,Rosa R,Caputo B,Solimini A,Torre AD,Scognamiglio P,Zumla A,Ippolito G,Merler S

    更新日期:2020-08-07 00:00:00

  • Processes of consent in research for adults with impaired mental capacity nearing the end of life: systematic review and transparent expert consultation (MORECare_Capacity statement).

    abstract:BACKGROUND:Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals with impaired capacity nearing the end of life in research, by identifying the challenges and solut...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01654-2

    authors: Evans CJ,Yorganci E,Lewis P,Koffman J,Stone K,Tunnard I,Wee B,Bernal W,Hotopf M,Higginson IJ,MORECare_Capacity.

    更新日期:2020-07-22 00:00:00

  • Mental health and smoking cessation-a population survey in England.

    abstract:BACKGROUND:To reduce inequalities between individuals with and without mental health problems, a better understanding is required of triggers and success of quit attempts among the third of smokers with mental health problems. The aim was to assess whether there are differences by mental health status in (i) triggers f...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01617-7

    authors: Brose LS,Brown J,McNeill A

    更新日期:2020-06-25 00:00:00

  • Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.

    abstract:BACKGROUND:Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outco...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01602-0

    authors: Snart CJP,Threapleton DE,Keeble C,Taylor E,Waiblinger D,Reid S,Alwan NA,Mason D,Azad R,Cade JE,Simpson NAB,Meadows S,McKillion A,Santorelli G,Waterman AH,Zimmermann M,Stewart PM,Wright J,Mon-Williams M,Greenwood DC

    更新日期:2020-06-11 00:00:00

  • Routine data for malaria morbidity estimation in Africa: challenges and prospects.

    abstract:BACKGROUND:The burden of malaria in sub-Saharan Africa remains challenging to measure relying on epidemiological modelling to evaluate the impact of investments and providing an in-depth analysis of progress and trends in malaria response globally. In malaria-endemic countries of Africa, there is increasing use of rout...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01593-y

    authors: Alegana VA,Okiro EA,Snow RW

    更新日期:2020-06-03 00:00:00

  • The challenges of colposcopy for cervical cancer screening in LMICs and solutions by artificial intelligence.

    abstract:BACKGROUND:The World Health Organization (WHO) called for global action towards the elimination of cervical cancer. One of the main strategies is to screen 70% of women at the age between 35 and 45 years and 90% of women managed appropriately by 2030. So far, approximately 85% of cervical cancers occur in low- and midd...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01613-x

    authors: Xue P,Ng MTA,Qiao Y

    更新日期:2020-06-03 00:00:00

  • Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study.

    abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS:A multicenter nested case-control study was conducted in four...

    journal_title:BMC medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12916-020-01633-7

    authors: Shi J,Li Y,Zhou X,Zhang Q,Ye X,Wu Z,Jiang X,Yu H,Shao L,Ai JW,Zhang H,Xu B,Sun F,Zhang W

    更新日期:2020-06-03 00:00:00

  • Statistical analyses and quality of individual participant data network meta-analyses were suboptimal: a cross-sectional study.

    abstract:BACKGROUND:Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for IPD-NMAs, it is unclear whether there are statistical defects in published IPD-NMAs and whether the...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01591-0

    authors: Gao Y,Shi S,Li M,Luo X,Liu M,Yang K,Zhang J,Song F,Tian J

    更新日期:2020-06-01 00:00:00

  • Guidance for identification and treatment of individuals with attention deficit/hyperactivity disorder and autism spectrum disorder based upon expert consensus.

    abstract:BACKGROUND:Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent con...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01585-y

    authors: Young S,Hollingdale J,Absoud M,Bolton P,Branney P,Colley W,Craze E,Dave M,Deeley Q,Farrag E,Gudjonsson G,Hill P,Liang HL,Murphy C,Mackintosh P,Murin M,O'Regan F,Ougrin D,Rios P,Stover N,Taylor E,Woodhouse E

    更新日期:2020-05-25 00:00:00

  • Risk prediction models for dementia: role of age and cardiometabolic risk factors.

    abstract:BACKGROUND:Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC diabetes score as predictors of dementia and assessed the role of age in their associa...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01578-x

    authors: Fayosse A,Nguyen DP,Dugravot A,Dumurgier J,Tabak AG,Kivimäki M,Sabia S,Singh-Manoux A

    更新日期:2020-05-19 00:00:00

  • Second and third trimester fetal ultrasound population screening for risks of preterm birth and small-size and large-size for gestational age at birth: a population-based prospective cohort study

    abstract:BACKGROUND:Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or L...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01540-x

    authors: Erkamp JS,Voerman E,Steegers EAP,Mulders AGMGJ,Reiss IKM,Duijts L,Jaddoe VWV,Gaillard R

    更新日期:2020-04-07 00:00:00

  • Trends in life expectancy: did the gap between the healthy and the ill widen or close?

    abstract:BACKGROUND:During the past decades, life expectancy has continued to increase in most high-income countries. Previous research suggests that improvements in life expectancy have primarily been driven by advances at the upper end of the health distribution, while parts of the population have lagged behind. Using data fr...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01514-z

    authors: Meyer AC,Drefahl S,Ahlbom A,Lambe M,Modig K

    更新日期:2020-03-20 00:00:00

  • Safety of occasional ingestion of gluten in patients with celiac disease: a real-life study.

    abstract:BACKGROUND:Gluten-free diet (GFD) decreases the quality of life of celiac disease (CD) patients, who frequently ask to occasionally ingest gluten-containing food. We evaluated CD patients reporting voluntary and occasional transgressions to their GFD. METHODS:From October 2017 to September 2018, the patients reporting...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-1511-6

    authors: Elli L,Bascuñán K,di Lernia L,Bardella MT,Doneda L,Soldati L,Orlando S,Ferretti F,Lombardo V,Barigelletti G,Scricciolo A,Fabiano S,Vecchi M,Roncoroni L

    更新日期:2020-03-16 00:00:00

  • Improving medical certification of cause of death: effective strategies and approaches based on experiences from the Data for Health Initiative.

    abstract:BACKGROUND:Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration and vital statistics (CRVS) systems. Accurate completion of the med...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01519-8

    authors: Hart JD,Sorchik R,Bo KS,Chowdhury HR,Gamage S,Joshi R,Kwa V,Li H,Mahesh BPK,Mclaughlin D,Mikkelsen L,Miki J,Napulan R,Rampatige R,Reeve M,Sarmiento C,War NS,Richards N,Riley ID,Lopez AD

    更新日期:2020-03-09 00:00:00

  • Functional somatic disorders: discussion paper for a new common classification for research and clinical use.

    abstract:BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-1505-4

    authors: Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

    更新日期:2020-03-03 00:00:00

  • Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy.

    abstract:BACKGROUND:Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1478-3

    authors: Yatsenko AS,Kucherenko MM,Xie Y,Aweida D,Urlaub H,Scheibe RJ,Cohen S,Shcherbata HR

    更新日期:2020-01-21 00:00:00

  • The research burden of randomized controlled trial participation: a systematic thematic synthesis of qualitative evidence.

    abstract:BACKGROUND:Participation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, and financial burdens) experienced by patients through their participation in a RCT. METHODS:We condu...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1476-5

    authors: Naidoo N,Nguyen VT,Ravaud P,Young B,Amiel P,Schanté D,Clarke M,Boutron I

    更新日期:2020-01-20 00:00:00

  • Reductions in sugar sales from soft drinks in the UK from 2015 to 2018.

    abstract:BACKGROUND:The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was to assess how individual soft drink companies and consumers have responded to calls to reduce sugar ...

    journal_title:BMC medicine

    pub_type: 历史文章,杂志文章

    doi:10.1186/s12916-019-1477-4

    authors: Bandy LK,Scarborough P,Harrington RA,Rayner M,Jebb SA

    更新日期:2020-01-13 00:00:00

  • Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics.

    abstract:BACKGROUND:Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are causal remains largely unknown. METHODS:We employed a two-sample Mendelian randomization approach to...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1448-9

    authors: Zeng P,Wang T,Zheng J,Zhou X

    更新日期:2019-12-04 00:00:00

  • Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records.

    abstract:BACKGROUND:The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagnosis. METHODS:The study was set within 568 practices contributing to a UK primary care health recor...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1462-y

    authors: Chen Y,Farooq S,Edwards J,Chew-Graham CA,Shiers D,Frisher M,Hayward R,Sumathipala A,Jordan KP

    更新日期:2019-12-04 00:00:00

  • Growth faltering is associated with altered brain functional connectivity and cognitive outcomes in urban Bangladeshi children exposed to early adversity.

    abstract:BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1431-5

    authors: Xie W,Jensen SKG,Wade M,Kumar S,Westerlund A,Kakon SH,Haque R,Petri WA,Nelson CA

    更新日期:2019-11-25 00:00:00

  • Representation of people with comorbidity and multimorbidity in clinical trials of novel drug therapies: an individual-level participant data analysis.

    abstract:BACKGROUND:Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-based medicine) when people have co-existing diseases (comorbidit...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1427-1

    authors: Hanlon P,Hannigan L,Rodriguez-Perez J,Fischbacher C,Welton NJ,Dias S,Mair FS,Guthrie B,Wild S,McAllister DA

    更新日期:2019-11-12 00:00:00

  • Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann-Pick diseases.

    abstract:BACKGROUND:Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle, high-de...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1423-5

    authors: Schultz ML,Fawaz MV,Azaria RD,Hollon TC,Liu EA,Kunkel TJ,Halseth TA,Krus KL,Ming R,Morin EE,McLoughlin HS,Bushart DD,Paulson HL,Shakkottai VG,Orringer DA,Schwendeman AS,Lieberman AP

    更新日期:2019-11-11 00:00:00

  • Psychological primitives can make sense of biopsychosocial factor complexity in psychopathology.

    abstract:BACKGROUND:Many agree that the biopsychosocial contributions to psychopathology are complex, yet it is unclear how we can make sense of this complexity. One approach is to reduce this complexity to a few necessary and sufficient biopsychosocial factors; although this approach is easy to understand, it has little explan...

    journal_title:BMC medicine

    pub_type: 杂志文章,评审

    doi:10.1186/s12916-019-1435-1

    authors: Franklin JC

    更新日期:2019-10-18 00:00:00

  • Combining serological and contact data to derive target immunity levels for achieving and maintaining measles elimination.

    abstract:BACKGROUND:Vaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can be challenging to achieve and maintain. The herd immunity threshold for measles is typically stipula...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1413-7

    authors: Funk S,Knapp JK,Lebo E,Reef SE,Dabbagh AJ,Kretsinger K,Jit M,Edmunds WJ,Strebel PM

    更新日期:2019-09-25 00:00:00

  • A dynamic neural network model for predicting risk of Zika in real time.

    abstract:BACKGROUND:In 2015, the Zika virus spread from Brazil throughout the Americas, posing an unprecedented challenge to the public health community. During the epidemic, international public health officials lacked reliable predictions of the outbreak's expected geographic scale and prevalence of cases, and were therefore ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1389-3

    authors: Akhtar M,Kraemer MUG,Gardner LM

    更新日期:2019-09-02 00:00:00

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