Abstract:
BACKGROUND:Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lymphocyte ratio (NLR) or tumour-associated neutrophils (TAN) and cancer prognosis. METHODS:We searched MEDLINE, Embase and Cochrane Database of Systematic Reviews from inception to 29 May 2020 for systematic reviews and meta-analyses of observational studies on neutrophil counts (here NLR or TAN) and specific cancer outcomes related to disease progression or survival. The available evidence was graded as strong, highly suggestive, suggestive, weak or uncertain through the application of pre-set GRADE criteria. RESULTS:A total of 204 meta-analyses from 86 studies investigating the association between either NLR or TAN and cancer outcomes met the criteria for inclusion. All but one meta-analyses found a hazard ratio (HR) which increased risk (HR > 1). We did not find sufficient meta-analyses to evaluate TAN and cancer outcomes (N = 9). When assessed for magnitude of effect, significance and bias related to heterogeneity and small study effects, 18 (9%) associations between NLR and outcomes in composite cancer endpoints (combined analysis), cancers treated with immunotherapy and some site specific cancers (urinary, nasopharyngeal, gastric, breast, endometrial, soft tissue sarcoma and hepatocellular cancers) were supported by strong evidence. CONCLUSION:In total, 60 (29%) meta-analyses presented strong or highly suggestive evidence. Although the NLR and TAN hold clinical promise in their association with poor cancer prognosis, further research is required to provide robust evidence, assess causality and test clinical utility. TRIAL REGISTRATION:PROSPERO CRD42017069131 .
journal_name
BMC Medjournal_title
BMC medicineauthors
Cupp MA,Cariolou M,Tzoulaki I,Aune D,Evangelou E,Berlanga-Taylor AJdoi
10.1186/s12916-020-01817-1subject
Has Abstractpub_date
2020-11-20 00:00:00pages
360issue
1issn
1741-7015pii
10.1186/s12916-020-01817-1journal_volume
18pub_type
杂志文章相关文献
BMC Medicine文献大全abstract::Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, pa...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-016-0737-9
更新日期:2016-11-21 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-w...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1364-z
更新日期:2019-07-17 00:00:00
abstract::The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-7
更新日期:2012-01-20 00:00:00
abstract::Although clinical nutrition is a frequently used intervention in inpatient care, high quality trials proving its effectiveness and safety when used in the acutely-ill polymorbid medical inpatient population are largely lacking. From an evolutionary perspective, illness-related low appetite is protective and part of th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0812-x
更新日期:2017-02-24 00:00:00
abstract::This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way. ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-12-24
更新日期:2014-02-05 00:00:00
abstract:BACKGROUND:Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent con...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01585-y
更新日期:2020-05-25 00:00:00
abstract:BACKGROUND:Populations exposed to humanitarian emergencies are particularly vulnerable to mental health problems, including new onset, relapse and deterioration of psychotic disorders. Inadequate care for this group may lead to human rights abuses and even premature death. The WHO Mental Health Gap Action Programme Int...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0960-z
更新日期:2017-12-11 00:00:00
abstract:BACKGROUND:The term 'lower value services' concerns healthcare that is of little or no value to the patient and consequently should not be provided routinely, or not be provided at all. De-adoption of lower value care may occur through explicit recommendations in clinical guidelines. The present study aimed to generate...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0747-7
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory genes and the development of CAD, using a large discordant sibship collection (2699 individuals in 89...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-8-5
更新日期:2010-01-13 00:00:00
abstract:BACKGROUND:The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses. METHODS:The participants in this double-blind, randomized, placebo-controlled, multi-center clinic...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1741-7015-4-14
更新日期:2006-06-23 00:00:00
abstract::Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of complex protein C termi...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-20
更新日期:2012-02-23 00:00:00
abstract:BACKGROUND:The World Health Organization (WHO) called for global action towards the elimination of cervical cancer. One of the main strategies is to screen 70% of women at the age between 35 and 45 years and 90% of women managed appropriately by 2030. So far, approximately 85% of cervical cancers occur in low- and midd...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01613-x
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1013-y
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:Participation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, and financial burdens) experienced by patients through their participation in a RCT. METHODS:We condu...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1476-5
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Israeli citizens have been exposed to intense and ongoing terrorism since September 2000. We previously studied the mental health impact of terrorism on the Israeli population (Bleich et al., 2002), however the long-term impact of ongoing terrorism has not yet been examined. The present study evaluated the p...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-4-21
更新日期:2006-08-27 00:00:00
abstract::The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some settings, and scores are increasingly being employed to define Mediterranean diet adherence in epidemiological st...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-12-112
更新日期:2014-07-24 00:00:00
abstract:BACKGROUND:We conducted this analysis to determine i) which journals publish high-quality, clinically relevant studies in internal medicine, general/family practice, general practice nursing, and mental health; and ii) the proportion of clinically relevant articles in each journal. METHODS:We performed an analytic sur...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-2-33
更新日期:2004-09-06 00:00:00
abstract:BACKGROUND:Clinical pathways (CPs) are used to improve the outcomes of acute stroke, but their use in stroke care is questionable, because the evidence on their effectiveness is still inconclusive. The objective of this study was to evaluate whether CPs improve the outcomes and the quality of care provided to patients ...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1741-7015-10-71
更新日期:2012-07-10 00:00:00
abstract::A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that i...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-13
更新日期:2012-02-07 00:00:00
abstract:BACKGROUND:Interventions to promote positive parenting are often reported to offer good outcomes for children but they can consume substantial resources and they require rigorous appraisal. METHODS:Evaluations of the Triple P parenting program were subjected to systematic review and meta-analysis with analysis of bias...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1741-7015-10-130
更新日期:2012-11-02 00:00:00
abstract:BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-018-1078-7
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1363-0
更新日期:2019-07-11 00:00:00
abstract:BACKGROUND:Despite the worldwide increasing burden of diabetes, there has been no corresponding scale-up of treatment in developing countries and limited evidence of program effectiveness. In 2002, in collaboration with the Ministry of Health of Cambodia, Médecins Sans Frontières initiated an outpatient program of subs...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-7-33
更新日期:2009-07-14 00:00:00
abstract:BACKGROUND:Intimate partner violence is common among women having abortions, with between 6% and 22% reporting recent violence from an intimate partner. Concern about violence is a reason some pregnant women decide to terminate their pregnancies. Whether risk of violence decreases after having an abortion, remains unkn...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0144-z
更新日期:2014-09-29 00:00:00
abstract:BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01787-4
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous fumarate in Kenyan children aged 12-36 months. In addition, we updated a recent meta-analysi...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-017-0839-z
更新日期:2017-04-28 00:00:00
abstract::How should we approach trial design when we can get some, but not all, of the way to the numbers required for a randomised phase III trial?We present an ordered framework for designing randomised trials to address the problem when the ideal sample size is considered larger than the number of participants that can be r...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0722-3
更新日期:2016-11-25 00:00:00
abstract::In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has l...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-016-0571-0
更新日期:2016-02-06 00:00:00
abstract::Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-12
更新日期:2012-02-02 00:00:00
abstract:BACKGROUND:Gluten-free diet (GFD) decreases the quality of life of celiac disease (CD) patients, who frequently ask to occasionally ingest gluten-containing food. We evaluated CD patients reporting voluntary and occasional transgressions to their GFD. METHODS:From October 2017 to September 2018, the patients reporting...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-1511-6
更新日期:2020-03-16 00:00:00