Abstract:
:Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, particularly those well connected by travellers. In this respect, it was felt inevitable that Singapore would eventually realise its third endemic flavivirus. In late August 2016, a primary care practitioner observed a cluster of geographically linked patients attending with fever and rash. This resulted in the first identification of locally transmitted Zika in Singapore on August 27, 2016. This prompted a robust response in an attempt to stop further spread, which continued for approximately 10 days until a large number of laboratory-confirmed cases were found as a result of active case finding. Surprisingly, the strain was later identified to be of Asian lineage and distinct from that originating in the Americas, prompting speculation over the epidemiology of this under recognised virus in Asia.
journal_name
BMC Medjournal_title
BMC medicineauthors
Fisher D,Cutter Jdoi
10.1186/s12916-016-0737-9subject
Has Abstractpub_date
2016-11-21 00:00:00pages
188issue
1issn
1741-7015pii
10.1186/s12916-016-0737-9journal_volume
14pub_type
社论相关文献
BMC Medicine文献大全abstract::Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted effort...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-34
更新日期:2012-04-12 00:00:00
abstract:BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1304-y
更新日期:2019-03-25 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it ha...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-85
更新日期:2012-08-07 00:00:00
abstract::In this video Q&A, we talk to Associate Professor Felice Jacka about population health approaches to the primary prevention of mental disorders across the lifespan. These include addressing lifestyle factors, such as diet, smoking and physical activity. Latest strategies are being developed through epidemiological stu...
journal_title:BMC medicine
pub_type: 面试
doi:10.1186/s12916-015-0490-5
更新日期:2015-10-14 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) elimination is being seriously considered globally. Current elimination models require a combination of highly effective HCV treatment and harm reduction, but high treatment costs make such strategies prohibitively expensive. Vaccines should play a key role in elimination but their be...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0440-2
更新日期:2015-08-20 00:00:00
abstract:BACKGROUND:The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. Signal transducer and activator of transcription 3 protein (STAT3), a transcription factor that is persistently tyrosine-705 phosp...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0416-2
更新日期:2015-08-03 00:00:00
abstract:BACKGROUND:A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of a...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1741-7015-11-216
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS:We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database of...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12916-016-0631-5
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children....
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-018-1020-z
更新日期:2018-03-12 00:00:00
abstract:BACKGROUND:Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1478-3
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the im...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0183-5
更新日期:2014-10-16 00:00:00
abstract:BACKGROUND:Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upo...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-2-5
更新日期:2004-03-24 00:00:00
abstract::Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial....
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0522-1
更新日期:2015-11-10 00:00:00
abstract:BACKGROUND:Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-a...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-4-28
更新日期:2006-12-01 00:00:00
abstract::The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly. ...
journal_title:BMC medicine
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12916-018-1232-2
更新日期:2018-12-28 00:00:00
abstract::The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castra...
journal_title:BMC medicine
pub_type: 评论,杂志文章
doi:10.1186/s12916-015-0344-1
更新日期:2015-05-09 00:00:00
abstract:BACKGROUND:Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in comparison to the risk in relatives of patients with invasive bre...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01772-x
更新日期:2020-11-05 00:00:00
abstract::Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria mig...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0384-6
更新日期:2015-07-25 00:00:00
abstract:BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-018-1078-7
更新日期:2018-06-13 00:00:00
abstract::The diagnosis of multidrug resistant tuberculosis (MDR-TB) in any individual is the beginning of a prolonged and difficult therapeutic journey. It also marks the moment from which to begin consideration of how to manage close contacts. Preventive therapy for drug-susceptible latent tuberculosis infection has been demo...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-016-0610-x
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenic...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-8-27
更新日期:2010-05-21 00:00:00
abstract::This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way. ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-12-24
更新日期:2014-02-05 00:00:00
abstract:BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-87
更新日期:2011-07-19 00:00:00
abstract:BACKGROUND:Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1181-9
更新日期:2018-10-18 00:00:00
abstract:BACKGROUND:Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent con...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01585-y
更新日期:2020-05-25 00:00:00
abstract:BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-117
更新日期:2011-10-27 00:00:00
abstract::The Ebola virus disease (EVD) outbreak in the three West Africa countries of Guinea, Liberia, and Sierra Leone, was declared by the World Health Organization (WHO) as a public health event of international concern in August 2014. The disease, which has caused more than 10,000 deaths from over 25,000 cases, has thrived...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0359-7
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1363-0
更新日期:2019-07-11 00:00:00
abstract:BACKGROUND:Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objective was to test whether thymic size in infancy could be increased by maternal and/or infant nutriti...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-019-1264-2
更新日期:2019-02-18 00:00:00
abstract::There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-251
更新日期:2013-11-27 00:00:00