Mapping malaria by combining parasite genomic and epidemiologic data.

abstract：:Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...

journal_title：BMC medicine

authors： Nesse RM,Stein DJ

更新日期：2012-01-13 00:00:00

abstract：BACKGROUND:Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are causal remains largely unknown. METHODS:We employed a two-sample Mendelian randomization approach to...

journal_title：BMC medicine

authors： Zeng P,Wang T,Zheng J,Zhou X

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:During the past decades, life expectancy has continued to increase in most high-income countries. Previous research suggests that improvements in life expectancy have primarily been driven by advances at the upper end of the health distribution, while parts of the population have lagged behind. Using data fr...

journal_title：BMC medicine

authors： Meyer AC,Drefahl S,Ahlbom A,Lambe M,Modig K

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only mixed effects on childhood diarrhea. Arriving at the inception of the United Nations' Sustainable De...

journal_title：BMC medicine

authors： Cumming O,Arnold BF,Ban R,Clasen T,Esteves Mills J,Freeman MC,Gordon B,Guiteras R,Howard G,Hunter PR,Johnston RB,Pickering AJ,Prendergast AJ,Prüss-Ustün A,Rosenboom JW,Spears D,Sundberg S,Wolf J,Null C,Luby SP,Hum

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evi...

journal_title：BMC medicine

authors： Créquit P,Trinquart L,Yavchitz A,Ravaud P

更新日期：2016-01-20 00:00:00

abstract：:Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...

journal_title：BMC medicine

authors： Weir GA,Cader MZ

更新日期：2011-10-25 00:00:00

abstract：BACKGROUND:Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic...

journal_title：BMC medicine

authors： Aramburo A,Todd J,George EC,Kiguli S,Olupot-Olupot P,Opoka RO,Engoru C,Akech SO,Nyeko R,Mtove G,Gibb DM,Babiker AG,Maitland K

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenic...

journal_title：BMC medicine

authors： Fleming JM,Miller TC,Quinones M,Xiao Z,Xu X,Meyer MJ,Ginsburg E,Veenstra TD,Vonderhaar BK

更新日期：2010-05-21 00:00:00

abstract：:Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the control-to-elimination pathway. Herein, we present a case study on malaria, and its control, at the border be...

journal_title：BMC medicine

authors： Al Zahrani MH,Omar AI,Abdoon AMO,Ibrahim AA,Alhogail A,Elmubarak M,Elamin YE,AlHelal MA,Alshahrani AM,Abdelgader TM,Saeed I,El Gamri TB,Alattas MS,Dahlan AA,Assiri AM,Maina J,Li XH,Snow RW

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:To help design population-based pediatric palliative care services, we sought to describe the hospital care received in the last year of life by children and young adults who died. We also determined the proportion with complex chronic conditions (CCCs) and tested whether the use of hospital services increas...

journal_title：BMC medicine

authors： Feudtner C,DiGiuseppe DL,Neff JM

更新日期：2003-12-23 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF)-α inhibitors are increasingly being used in inflammatory bowel disease (IBD). Because this chronic intestinal disorder often affects women of fertile age, it is essential to assess the effect of biologics on pregnancy outcome. METHODS:We performed a systematic review of the Engli...

journal_title：BMC medicine

authors： Nielsen OH,Loftus EV Jr,Jess T

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:The United States Preventive Services Task Force (USPSTF) recommends screening adults for depression in primary care settings when staff-assisted depression management programs are available. This recommendation, however, is based on evidence from depression management programs conducted with patients alread...

journal_title：BMC medicine

authors： Thombs BD,Ziegelstein RC,Roseman M,Kloda LA,Ioannidis JP

更新日期：2014-01-28 00:00:00

abstract：:Several factors contribute to the high mortality attributed to severe infections in resource-limited settings. While improvements in survival and processes of care have been made in high-income settings among patients with severe conditions, such as sepsis, guidelines necessary for achieving these improvements may lac...

journal_title：BMC medicine

authors： Jacob ST,Lim M,Banura P,Bhagwanjee S,Bion J,Cheng AC,Cohen H,Farrar J,Gove S,Hopewell P,Moore CC,Roth C,West TE

更新日期：2013-04-18 00:00:00

abstract：BACKGROUND:Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods surrounding a prison in Lima, Peru, where inmates experience a high risk of M...

journal_title：BMC medicine

authors： Warren JL,Grandjean L,Moore DAJ,Lithgow A,Coronel J,Sheen P,Zelner JL,Andrews JR,Cohen T

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:While step counter use has become popular among type 2 diabetes (T2D) patients, its effectiveness in increasing physical activity (PA) and improving glycemic control has been poorly defined. The aim of this meta-analysis of randomized controlled trials (RCTs) was to evaluate the association of step counter u...

journal_title：BMC medicine

authors： Qiu S,Cai X,Chen X,Yang B,Sun Z

更新日期：2014-02-27 00:00:00

abstract：BACKGROUND:Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of cancer, the procedure is very basic: nuclear morphology is used as a common assessment of the degre...

journal_title：BMC medicine

authors： Capo-chichi CD,Cai KQ,Simpkins F,Ganjei-Azar P,Godwin AK,Xu XX

更新日期：2011-03-26 00:00:00

abstract：BACKGROUND:Predicting treatment benefit and/or outcome before any therapeutic intervention has taken place would be clinically very useful. Herein, we evaluate the ability of the intrinsic subtypes and the risk of relapse score at diagnosis to predict survival and response following neoadjuvant chemotherapy. In additio...

journal_title：BMC medicine

authors： Prat A,Fan C,Fernández A,Hoadley KA,Martinello R,Vidal M,Viladot M,Pineda E,Arance A,Muñoz M,Paré L,Cheang MC,Adamo B,Perou CM

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:The major psychoactive cannabinoid compound of marijuana, delta-9 tetrahydrocannabinol (THC), has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in lymphoid cell nuclei in a latent episomal circular form. In respon...

journal_title：BMC medicine

authors： Medveczky MM,Sherwood TA,Klein TW,Friedman H,Medveczky PG

更新日期：2004-09-15 00:00:00

abstract：:In this podcast, we talk to Dr Sunil Verma about the evolution of HER2 as a therapeutic target in breast cancer, and about how targeted therapy has revolutionized breast cancer treatment. We also discuss new agents in clinical development and the ways in which advances in treating HER2-positive breast cancer can be us...

journal_title：BMC medicine

authors： Verma S

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme ...

journal_title：BMC medicine

authors： Kandadi MR,Yu X,Frankel AE,Ren J

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Current policies encourage healthcare institutions to acquire clinical information systems (CIS) so that captured data can be used for secondary purposes, including clinical process improvement. Such policies do not account for the extra work required to repurpose data for uses other than direct clinical car...

journal_title：BMC medicine

authors： Morrison C,Jones M,Jones R,Vuylsteke A

更新日期：2013-04-10 00:00:00

abstract：BACKGROUND:The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical Manual fourth edition (DSM-IV) in a large dataset of patients assessed for delirium and related presen...

journal_title：BMC medicine

authors： Meagher DJ,Morandi A,Inouye SK,Ely W,Adamis D,Maclullich AJ,Rudolph JL,Neufeld K,Leonard M,Bellelli G,Davis D,Teodorczuk A,Kreisel S,Thomas C,Hasemann W,Timmons S,O'Regan N,Grover S,Jabbar F,Cullen W,Dunne C,Kam

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) among pediatric inpatients, we aimed to test the hypothesis that OLUL status is a risk factor for ADRs. METHODS:A nested case?control study was co...

journal_title：BMC medicine

authors： Bellis JR,Kirkham JJ,Thiesen S,Conroy EJ,Bracken LE,Mannix HL,Bird KA,Duncan JC,Peak M,Turner MA,Smyth RL,Nunn AJ,Pirmohamed M

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are at a higher risk for severe manifestations of both illnesses. Considering the high transmission rate ...

journal_title：BMC medicine

authors： Khan MS,Shahid I,Anker SD,Solomon SD,Vardeny O,Michos ED,Fonarow GC,Butler J

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop and evaluate an interventional tool to improve communication and palliative care, usi...

journal_title：BMC medicine

authors： Higginson IJ,Koffman J,Hopkins P,Prentice W,Burman R,Leonard S,Rumble C,Noble J,Dampier O,Bernal W,Hall S,Morgan M,Shipman C

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...

journal_title：BMC medicine

authors： Burt J,Elmore N,Campbell SM,Rodgers S,Avery AJ,Payne RA

更新日期：2018-06-13 00:00:00

abstract：:The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for...

journal_title：BMC medicine

authors： Ward TL,Knights D,Gale CA

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. METHODS:eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunizat...

journal_title：BMC medicine

authors： Katzav A,Grigoriadis NC,Ebert T,Touloumi O,Blank M,Pick CG,Shoenfeld Y,Chapman J

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Despite the worldwide increasing burden of diabetes, there has been no corresponding scale-up of treatment in developing countries and limited evidence of program effectiveness. In 2002, in collaboration with the Ministry of Health of Cambodia, Médecins Sans Frontières initiated an outpatient program of subs...

journal_title：BMC medicine

authors： Raguenaud ME,Isaakidis P,Reid T,Chy S,Keuky L,Arellano G,Van Damme W

更新日期：2009-07-14 00:00:00

abstract：:Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria mig...

journal_title：BMC medicine

authors： Tanner M,Greenwood B,Whitty CJ,Ansah EK,Price RN,Dondorp AM,von Seidlein L,Baird JK,Beeson JG,Fowkes FJ,Hemingway J,Marsh K,Osier F

更新日期：2015-07-25 00:00:00