Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy?

abstract：BACKGROUND:Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed t...

journal_title：BMC medicine

authors： Bosl W,Tierney A,Tager-Flusberg H,Nelson C

更新日期：2011-02-22 00:00:00

abstract：BACKGROUND:Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nuclear mag...

journal_title：BMC medicine

authors： Vignoli A,Tenori L,Giusti B,Takis PG,Valente S,Carrabba N,Balzi D,Barchielli A,Marchionni N,Gensini GF,Marcucci R,Luchinat C,Gori AM

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...

journal_title：BMC medicine

authors： Donath X,Saint-Martin C,Dubois-Laforgue D,Rajasingham R,Mifsud F,Ciangura C,Timsit J,Bellanné-Chantelot C,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0-2, 3-7, and 8-27 days) and assess the change in mortality rate with previous assessments to inform programmatic decision-making in...

journal_title：BMC medicine

authors： Dandona R,Kumar GA,Bhattacharya D,Akbar M,Atmavilas Y,Nanda P,Dandona L

更新日期：2019-07-19 00:00:00

abstract：BACKGROUND:The treatment of patients with haematological malignancies by means of haematopoietic stem cell transplantation (HSCT) is often accompanied by life threatening infections. With emerging antimicrobial resistance there is an increased need for new agents, with a beneficial safety profile. Therefore we evaluate...

journal_title：BMC medicine

authors： Velden WJ,van Iersel TM,Blijlevens NM,Donnelly JP

更新日期：2009-09-08 00:00:00

abstract：BACKGROUND:We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. METHODS:eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunizat...

journal_title：BMC medicine

authors： Katzav A,Grigoriadis NC,Ebert T,Touloumi O,Blank M,Pick CG,Shoenfeld Y,Chapman J

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials c...

journal_title：BMC medicine

authors： Bagshaw SM,Ghali WA

更新日期：2004-10-22 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker ...

journal_title：BMC medicine

authors： Nickel CH,Bingisser R,Morgenthaler NG

更新日期：2012-01-20 00:00:00

abstract：:Several factors contribute to the high mortality attributed to severe infections in resource-limited settings. While improvements in survival and processes of care have been made in high-income settings among patients with severe conditions, such as sepsis, guidelines necessary for achieving these improvements may lac...

journal_title：BMC medicine

authors： Jacob ST,Lim M,Banura P,Bhagwanjee S,Bion J,Cheng AC,Cohen H,Farrar J,Gove S,Hopewell P,Moore CC,Roth C,West TE

更新日期：2013-04-18 00:00:00

abstract：BACKGROUND:Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity...

journal_title：BMC medicine

authors： Koyanagi A,Vancampfort D,Carvalho AF,DeVylder JE,Haro JM,Pizzol D,Veronese N,Stubbs B

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...

journal_title：BMC medicine

authors： Gottlieb A,Stein GY,Ruppin E,Altman RB,Sharan R

更新日期：2013-09-02 00:00:00

abstract：:A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that i...

journal_title：BMC medicine

authors： Sapone A,Bai JC,Ciacci C,Dolinsek J,Green PH,Hadjivassiliou M,Kaukinen K,Rostami K,Sanders DS,Schumann M,Ullrich R,Villalta D,Volta U,Catassi C,Fasano A

更新日期：2012-02-07 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it ha...

journal_title：BMC medicine

authors： Zhang SS,Han ZP,Jing YY,Tao SF,Li TJ,Wang H,Wang Y,Li R,Yang Y,Zhao X,Xu XD,Yu ED,Rui YC,Liu HJ,Zhang L,Wei LX

更新日期：2012-08-07 00:00:00

abstract：:The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some settings, and scores are increasingly being employed to define Mediterranean diet adherence in epidemiological st...

journal_title：BMC medicine

authors： Trichopoulou A,Martínez-González MA,Tong TY,Forouhi NG,Khandelwal S,Prabhakaran D,Mozaffarian D,de Lorgeril M

更新日期：2014-07-24 00:00:00

abstract：:Although imatinib is firmly established as an effective therapy for newly diagnosed patients with chronic myeloid leukemia (CML), the field continues to advance on several fronts. In this minireview we cover recent results of second generation tyrosine kinase inhibitors in newly diagnosed patients, investigate the sta...

journal_title：BMC medicine

authors： Eiring AM,Khorashad JS,Morley K,Deininger MW

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:The UK Clinical Aptitude Test (UKCAT) has been shown to have a modest but statistically significant ability to predict aspects of academic performance throughout medical school. Previously, this ability has been shown to be incremental to conventional measures of educational performance for the first year of...

journal_title：BMC medicine

authors： Tiffin PA,Mwandigha LM,Paton LW,Hesselgreaves H,McLachlan JC,Finn GM,Kasim AS

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preventable diseases. DISCUSSION:The Summit of Independent European Vaccination Experts focused on the p...

journal_title：BMC medicine

authors： Schmitt HJ,Booy R,Aston R,Van Damme P,Schumacher RF,Campins M,Rodrigo C,Heikkinen T,Weil-Olivier C,Finn A,Olcén P,Fedson D,Peltola H

更新日期：2007-05-29 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...

journal_title：BMC medicine

authors： Pouillon L,Vermeire S,Bossuyt P

更新日期：2019-05-08 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF)-α inhibitors are increasingly being used in inflammatory bowel disease (IBD). Because this chronic intestinal disorder often affects women of fertile age, it is essential to assess the effect of biologics on pregnancy outcome. METHODS:We performed a systematic review of the Engli...

journal_title：BMC medicine

authors： Nielsen OH,Loftus EV Jr,Jess T

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Clinical pathways are tools used to guide evidence-based healthcare that have been implemented internationally since the 1980s. However, there is widespread lack of agreement on the impact of clinical pathways on hospital resources and patient outcomes. This can be partially attributed to the confusion for b...

journal_title：BMC medicine

authors： Kinsman L,Rotter T,James E,Snow P,Willis J

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. METHODS...

journal_title：BMC medicine

authors： Li Y,Yan B,Wang H,Li H,Li Q,Zhao D,Chen Y,Zhang Y,Li W,Zhang J,Wang S,Shen J,Li Y,Guindi E,Zhao Y

更新日期：2015-04-20 00:00:00

abstract：BACKGROUND:Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or L...

journal_title：BMC medicine

authors： Erkamp JS,Voerman E,Steegers EAP,Mulders AGMGJ,Reiss IKM,Duijts L,Jaddoe VWV,Gaillard R

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of weight discrimination are more prevalent even than discrimination based on race or ethnicity. DISCUSSI...

journal_title：BMC medicine

authors： Tomiyama AJ,Carr D,Granberg EM,Major B,Robinson E,Sutin AR,Brewis A

更新日期：2018-08-15 00:00:00

abstract：:Clinical pathologies draw us to envisage disease as either an independent entity or a diverse set of traits governed by common physiopathological mechanisms, prompted by environmental assaults throughout life. Autoimmune diseases are not an exception, given they represent a diverse collection of diseases in terms of t...

journal_title：BMC medicine

authors： Castiblanco J,Arcos-Burgos M,Anaya JM

更新日期：2013-09-04 00:00:00

abstract：BACKGROUND:Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. METHODS:Using a machine learning program, we identified a 25-Gen...

journal_title：BMC medicine

authors： Johnson H,Guo J,Zhang X,Zhang H,Simoulis A,Wu AHB,Xia T,Li F,Tan W,Johnson A,Dizeyi N,Abrahamsson PA,Kenner L,Feng X,Zou C,Xiao K,Persson JL,Chen L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associated with dying in hospital in two common progressive respiratory diseases, and the impact of a natio...

journal_title：BMC medicine

authors： Higginson IJ,Reilly CC,Bajwah S,Maddocks M,Costantini M,Gao W,GUIDE_Care project.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...

journal_title：BMC medicine

authors： Lin C,Cai X,Yang W,Lv F,Nie L,Ji L

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis. OPV2 is also transmissible and can establish circulating lineages, calle...

journal_title：BMC medicine

authors： McCarthy KA,Chabot-Couture G,Famulare M,Lyons HM,Mercer LD

更新日期：2017-10-04 00:00:00

abstract：:Although clinical nutrition is a frequently used intervention in inpatient care, high quality trials proving its effectiveness and safety when used in the acutely-ill polymorbid medical inpatient population are largely lacking. From an evolutionary perspective, illness-related low appetite is protective and part of th...

journal_title：BMC medicine

authors： Schuetz P

更新日期：2017-02-24 00:00:00

abstract：BACKGROUND:Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-a...

journal_title：BMC medicine

authors： Pajonk F,Riedisser A,Henke M,McBride WH,Fiebich B

更新日期：2006-12-01 00:00:00