Abstract:
BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts between social groups. Moreover, their space and time resolutions are limited, so that data are not explicit at the person-to-person level, and the dynamic nature of the contacts is disregarded. In this study, we aimed to assess the role of data-driven dynamic contact patterns between individuals, and in particular of their temporal aspects, in shaping the spread of a simulated epidemic in the population. METHODS:We considered high-resolution data about face-to-face interactions between the attendees at a conference, obtained from the deployment of an infrastructure based on radiofrequency identification (RFID) devices that assessed mutual face-to-face proximity. The spread of epidemics along these interactions was simulated using an SEIR (Susceptible, Exposed, Infectious, Recovered) model, using both the dynamic network of contacts defined by the collected data, and two aggregated versions of such networks, to assess the role of the data temporal aspects. RESULTS:We show that, on the timescales considered, an aggregated network taking into account the daily duration of contacts is a good approximation to the full resolution network, whereas a homogeneous representation that retains only the topology of the contact network fails to reproduce the size of the epidemic. CONCLUSIONS:These results have important implications for understanding the level of detail needed to correctly inform computational models for the study and management of real epidemics. Please see related article BMC Medicine, 2011, 9:88.
journal_name
BMC Medjournal_title
BMC medicineauthors
Stehlé J,Voirin N,Barrat A,Cattuto C,Colizza V,Isella L,Régis C,Pinton JF,Khanafer N,Van den Broeck W,Vanhems Pdoi
10.1186/1741-7015-9-87subject
Has Abstractpub_date
2011-07-19 00:00:00pages
87issn
1741-7015pii
1741-7015-9-87journal_volume
9pub_type
杂志文章相关文献
BMC Medicine文献大全abstract:BACKGROUND:The UK Clinical Aptitude Test (UKCAT) has been shown to have a modest but statistically significant ability to predict aspects of academic performance throughout medical school. Previously, this ability has been shown to be incremental to conventional measures of educational performance for the first year of...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0682-7
更新日期:2016-09-26 00:00:00
abstract::Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-5
更新日期:2012-01-13 00:00:00
abstract::This is an Erratum to BMC Medicine 2015, 13:59, highlighting previously undeclared competing interests and including more information in the acknowledgements section.Please see related article: http://www.biomedcentral.com/1741-7015/13/59. The statement in the competing interests should read as follows: This study is ...
journal_title:BMC medicine
pub_type: 已发布勘误
doi:10.1186/s12916-015-0338-z
更新日期:2015-04-16 00:00:00
abstract:BACKGROUND:Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or L...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01540-x
更新日期:2020-04-07 00:00:00
abstract::Intra-tumour heterogeneity is a common molecular phenomenon in metastatic clear cell renal carcinoma (mRCC), representing the genetic complexity of a tumour with multiple metastatic sites. The present commentary discusses the observed phenomena of phenotypic intra-tumour heterogeneity in mRCC patients treated with the...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-016-0754-8
更新日期:2016-12-07 00:00:00
abstract:BACKGROUND:Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed t...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-18
更新日期:2011-02-22 00:00:00
abstract:BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1431-5
更新日期:2019-11-25 00:00:00
abstract:BACKGROUND:Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for IPD-NMAs, it is unclear whether there are statistical defects in published IPD-NMAs and whether the...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01591-0
更新日期:2020-06-01 00:00:00
abstract::The damage to health caused by intimate partner violence demands effective responses from healthcare providers and healthcare systems worldwide. To date, most evidence for the few existing, effective interventions in use comes from high-income countries. Gupta et al. provide rare evidence of a nurse-delivered intimate...
journal_title:BMC medicine
pub_type: 评论,信件
doi:10.1186/s12916-017-0886-5
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Many agree that the biopsychosocial contributions to psychopathology are complex, yet it is unclear how we can make sense of this complexity. One approach is to reduce this complexity to a few necessary and sufficient biopsychosocial factors; although this approach is easy to understand, it has little explan...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-019-1435-1
更新日期:2019-10-18 00:00:00
abstract:BACKGROUND:The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagnosis. METHODS:The study was set within 568 practices contributing to a UK primary care health recor...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1462-y
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS:A multicenter nested case-control study was conducted in four...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12916-020-01633-7
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Iron deficiency without anemia is related to adverse symptoms that can be relieved by supplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact of iron treatment after a blood donation. METHODS:One week after donation, we randomly assigned 154 female don...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1741-7015-10-8
更新日期:2012-01-24 00:00:00
abstract:BACKGROUND:It is a common practice to use a singleton fetal growth standard to assess twin growth. We aim to create a twin fetal weight standard which is also adjustable for race/ethnicity and other factors. METHODS:Over half a million twin births of low risk pregnancies in the US, from 1995 to 2004, were used to cons...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0401-9
更新日期:2015-07-03 00:00:00
abstract:BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1252-6
更新日期:2019-01-31 00:00:00
abstract::Although clinical nutrition is a frequently used intervention in inpatient care, high quality trials proving its effectiveness and safety when used in the acutely-ill polymorbid medical inpatient population are largely lacking. From an evolutionary perspective, illness-related low appetite is protective and part of th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0812-x
更新日期:2017-02-24 00:00:00
abstract:BACKGROUND:Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS:We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-97
更新日期:2013-04-04 00:00:00
abstract:BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-194
更新日期:2013-09-02 00:00:00
abstract:BACKGROUND:The aim of the current study was to assess the antidepressant efficacy and safety of Hypericum perforatum (St. John's wort) extract WS 5570 at doses of 600 mg/day in a single dose and 1200 mg/day in two doses. METHODS:The participants in this double-blind, randomized, placebo-controlled, multi-center clinic...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1741-7015-4-14
更新日期:2006-06-23 00:00:00
abstract::Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0296-5
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statis...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-114
更新日期:2011-10-18 00:00:00
abstract:BACKGROUND:Dietary assessment is complex, and strategies to select the most appropriate dietary assessment tool (DAT) in epidemiological research are needed. The DIETary Assessment Tool NETwork (DIET@NET) aimed to establish expert consensus on Best Practice Guidelines (BPGs) for dietary assessment using self-report. M...
journal_title:BMC medicine
pub_type: 杂志文章,实务指引
doi:10.1186/s12916-017-0962-x
更新日期:2017-11-15 00:00:00
abstract:BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-1505-4
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1181-9
更新日期:2018-10-18 00:00:00
abstract:BACKGROUND:The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0833-5
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Over the last 100 years, several persistent misconceptions or 'false beliefs' have built up around allergen immunotherapy and its use in allergic rhinitis. This is perhaps because enthusiastic physicians administered complex allergen extracts to a diverse population of patients suffering from heterogeneous a...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-255
更新日期:2013-12-05 00:00:00
abstract:BACKGROUND:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated...
journal_title:BMC medicine
pub_type: 临床试验,杂志文章
doi:10.1186/1741-7015-11-182
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. METHODS...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0331-6
更新日期:2015-04-20 00:00:00
abstract:BACKGROUND:In childhood, attention deficit/hyperactivity disorder (ADHD) is characterized by age-inappropriate levels of inattentiveness/disorganization, hyperactivity/impulsiveness, or a combination thereof. Although the criteria for ADHD are well defined, the long-term consequences in adults and children need to be m...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1741-7015-10-99
更新日期:2012-09-04 00:00:00
abstract:BACKGROUND:Castration-resistant prostate cancer (CRPC) is associated with wide variations in survival. Recent studies of whole blood mRNA expression-based biomarkers strongly predicted survival but the genes used in these biomarker models were non-overlapping and their relationship was unknown. We developed a biomarker...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0442-0
更新日期:2015-08-21 00:00:00