The 'help' question doesn't help when screening for major depression: external validation of the three-question screening test for primary care patients managed for physical complaints.

Abstract:

BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. A third question, called the 'help' question, improves the specificity without apparently decreasing the sensitivity of this screening procedure. We validated the abbreviated screening procedure for major depression with and without the 'help' question in primary care patients managed for a physical complaint. METHODS:This diagnostic accuracy study used data from the SODA (for 'SOmatisation Depression Anxiety') cohort study conducted by 24 general practitioners (GPs) in western Switzerland that included patients over 18 years of age with at least a single physical complaint at index consultation. Major depression was identified with the full Patient Health Questionnaire. GPs were asked to screen patients for major depression with the three screening questions 1 year after inclusion. RESULTS:Of 937 patients with at least a single physical complaint, 751 were eligible 1 year after index consultation. Major depression was diagnosed in 69/724 (9.5%) patients. The sensitivity and specificity of the two-question method alone were 91.3% (95% CI 81.4 to 96.4) and 65.0% (95% CI 61.2 to 68.6), respectively. Adding the 'help' question decreased the sensitivity (59.4%; 95% CI 47.0 to 70.9) but improved the specificity (88.2%; 95% CI 85.4 to 90.5) of the three-question method. CONCLUSIONS:The use of two screening questions for major depression was associated with high sensitivity and low specificity in primary care patients presenting a physical complaint. Adding the 'help' question improved the specificity but clearly decreased the sensitivity; when using the 'help' question, four out of ten patients with depression will be missed, compared to only one out of ten with the two-question method. Therefore, the 'help' question is not useful as a screening question, but may help discussing management strategies.

journal_name

BMC Med

journal_title

BMC medicine

authors

Lombardo P,Vaucher P,Haftgoli N,Burnand B,Favrat B,Verdon F,Bischoff T,Herzig L

doi

10.1186/1741-7015-9-114

subject

Has Abstract

pub_date

2011-10-18 00:00:00

pages

114

issn

1741-7015

pii

1741-7015-9-114

journal_volume

9

pub_type

杂志文章
  • EEG complexity as a biomarker for autism spectrum disorder risk.

    abstract:BACKGROUND:Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed t...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/1741-7015-9-18

    authors: Bosl W,Tierney A,Tager-Flusberg H,Nelson C

    更新日期:2011-02-22 00:00:00

  • Impact of interventions to improve the quality of peer review of biomedical journals: a systematic review and meta-analysis.

    abstract:BACKGROUND:The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS:We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database of...

    journal_title:BMC medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12916-016-0631-5

    authors: Bruce R,Chauvin A,Trinquart L,Ravaud P,Boutron I

    更新日期:2016-06-10 00:00:00

  • Age, sex, disease severity, and disease duration difference in placebo response: implications from a meta-analysis of diabetes mellitus.

    abstract:BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01787-4

    authors: Lin C,Cai X,Yang W,Lv F,Nie L,Ji L

    更新日期:2020-11-16 00:00:00

  • Tobacco smoking and risk of 36 cardiovascular disease subtypes: fatal and non-fatal outcomes in a large prospective Australian study.

    abstract:BACKGROUND:Tobacco smoking is a leading cause of cardiovascular disease (CVD) morbidity and mortality. Evidence on the relation of smoking to different subtypes of CVD, across fatal and non-fatal outcomes, is limited. METHODS:A prospective study of 188,167 CVD- and cancer-free individuals aged ≥ 45 years from the Aust...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1351-4

    authors: Banks E,Joshy G,Korda RJ,Stavreski B,Soga K,Egger S,Day C,Clarke NE,Lewington S,Lopez AD

    更新日期:2019-07-03 00:00:00

  • Reductions in sugar sales from soft drinks in the UK from 2015 to 2018.

    abstract:BACKGROUND:The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was to assess how individual soft drink companies and consumers have responded to calls to reduce sugar ...

    journal_title:BMC medicine

    pub_type: 历史文章,杂志文章

    doi:10.1186/s12916-019-1477-4

    authors: Bandy LK,Scarborough P,Harrington RA,Rayner M,Jebb SA

    更新日期:2020-01-13 00:00:00

  • Better management of multimorbidity: a critical look at the 'Ariadne principles'.

    abstract::Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...

    journal_title:BMC medicine

    pub_type: 社论

    doi:10.1186/s12916-014-0222-2

    authors: Bower P

    更新日期:2014-12-08 00:00:00

  • Evaluation of a multiple ecological level child obesity prevention program: Switch what you Do, View, and Chew.

    abstract:BACKGROUND:Schools are the most frequent target for intervention programs aimed at preventing child obesity; however, the overall effectiveness of these programs has been limited. It has therefore been recommended that interventions target multiple ecological levels (community, family, school and individual) to have gr...

    journal_title:BMC medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1741-7015-7-49

    authors: Gentile DA,Welk G,Eisenmann JC,Reimer RA,Walsh DA,Russell DW,Callahan R,Walsh M,Strickland S,Fritz K

    更新日期:2009-09-18 00:00:00

  • Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease.

    abstract:BACKGROUND:The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely available, safe and relatively low cost tools and analyses recent work highlighting their potential utili...

    journal_title:BMC medicine

    pub_type: 杂志文章,评审

    doi:10.1186/s12916-017-0799-3

    authors: Malojcic B,Giannakopoulos P,Sorond FA,Azevedo E,Diomedi M,Oblak JP,Carraro N,Boban M,Olah L,Schreiber SJ,Pavlovic A,Garami Z,Bornstein NM,Rosengarten B

    更新日期:2017-02-09 00:00:00

  • Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women.

    abstract:BACKGROUND:In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. METHODS:A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of reg...

    journal_title:BMC medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12916-017-0835-3

    authors: van Nieuwkoop C,van der Starre WE,Stalenhoef JE,van Aartrijk AM,van der Reijden TJ,Vollaard AM,Delfos NM,van 't Wout JW,Blom JW,Spelt IC,Leyten EM,Koster T,Ablij HC,van der Beek MT,Knol MJ,van Dissel JT

    更新日期:2017-04-03 00:00:00

  • Prostate-specific antigen-based screening: controversy and guidelines.

    abstract::Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-015-0296-5

    authors: Kim EH,Andriole GL

    更新日期:2015-03-24 00:00:00

  • Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies.

    abstract:BACKGROUND:Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lympho...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01817-1

    authors: Cupp MA,Cariolou M,Tzoulaki I,Aune D,Evangelou E,Berlanga-Taylor AJ

    更新日期:2020-11-20 00:00:00

  • Developing a measure of polypharmacy appropriateness in primary care: systematic review and expert consensus study.

    abstract:BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...

    journal_title:BMC medicine

    pub_type: 杂志文章,评审

    doi:10.1186/s12916-018-1078-7

    authors: Burt J,Elmore N,Campbell SM,Rodgers S,Avery AJ,Payne RA

    更新日期:2018-06-13 00:00:00

  • Proteinuria as a predictor of complications of pre-eclampsia.

    abstract::Proteinuria is a defining criterion for the diagnosis of pre-eclampsia. The amount of protein lost per day has been thought by some to predict both maternal and fetal outcome. The systematic review of 16 primary papers including over 6700 patients by Thangaratinam and colleagues published this month in BMC Medicine su...

    journal_title:BMC medicine

    pub_type: 杂志文章,评审

    doi:10.1186/1741-7015-7-11

    authors: Hofmeyr GJ,Belfort M

    更新日期:2009-03-24 00:00:00

  • Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice.

    abstract:BACKGROUND:We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. METHODS:eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunizat...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/1741-7015-11-92

    authors: Katzav A,Grigoriadis NC,Ebert T,Touloumi O,Blank M,Pick CG,Shoenfeld Y,Chapman J

    更新日期:2013-04-04 00:00:00

  • The ethics and editorial challenges of internet-based research.

    abstract::The internet has opened up vast possibilities for research. An increasing number of studies are being conducted using the internet as both a source of data and a venue for research. Use of the internet in research has created many challenges, not just for those conducting and reviewing the studies, but also for editor...

    journal_title:BMC medicine

    pub_type: 社论

    doi:10.1186/s12916-014-0124-3

    authors: Harriman S,Patel J

    更新日期:2014-07-15 00:00:00

  • Combining serological and contact data to derive target immunity levels for achieving and maintaining measles elimination.

    abstract:BACKGROUND:Vaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can be challenging to achieve and maintain. The herd immunity threshold for measles is typically stipula...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1413-7

    authors: Funk S,Knapp JK,Lebo E,Reef SE,Dabbagh AJ,Kretsinger K,Jit M,Edmunds WJ,Strebel PM

    更新日期:2019-09-25 00:00:00

  • Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity.

    abstract:BACKGROUND:Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on o...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/1741-7015-11-228

    authors: Skinner MK,Manikkam M,Tracey R,Guerrero-Bosagna C,Haque M,Nilsson EE

    更新日期:2013-10-23 00:00:00

  • Data management and sharing policy: the first step towards promoting data sharing.

    abstract:BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-019-1315-8

    authors: Waithira N,Mutinda B,Cheah PY

    更新日期:2019-04-17 00:00:00

  • Lifestyle factors in preventing mental health disorders: an interview with Felice Jacka.

    abstract::In this video Q&A, we talk to Associate Professor Felice Jacka about population health approaches to the primary prevention of mental disorders across the lifespan. These include addressing lifestyle factors, such as diet, smoking and physical activity. Latest strategies are being developed through epidemiological stu...

    journal_title:BMC medicine

    pub_type: 面试

    doi:10.1186/s12916-015-0490-5

    authors: Jacka FN

    更新日期:2015-10-14 00:00:00

  • Advances in the treatment of chronic myeloid leukemia.

    abstract::Although imatinib is firmly established as an effective therapy for newly diagnosed patients with chronic myeloid leukemia (CML), the field continues to advance on several fronts. In this minireview we cover recent results of second generation tyrosine kinase inhibitors in newly diagnosed patients, investigate the sta...

    journal_title:BMC medicine

    pub_type: 杂志文章,评审

    doi:10.1186/1741-7015-9-99

    authors: Eiring AM,Khorashad JS,Morley K,Deininger MW

    更新日期:2011-08-26 00:00:00

  • Towards a genuinely medical model for psychiatric nosology.

    abstract::Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/1741-7015-10-5

    authors: Nesse RM,Stein DJ

    更新日期:2012-01-13 00:00:00

  • Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis.

    abstract:BACKGROUND:Prescription of non-steroidal anti-inflammatory drugs (NSAIDs) should be based on the assessment of both gastrointestinal (GI) and cardiovascular (CV) risk for the individual patient. We aimed to assess the GI/CV risk profile and the pharmacological management of patients with osteoarthritis (OA) in clinical...

    journal_title:BMC medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1741-7015-9-38

    authors: Lanas A,Garcia-Tell G,Armada B,Oteo-Alvaro A

    更新日期:2011-04-14 00:00:00

  • Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since N...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-014-0137-y

    authors: Jiménez-Agüero R,Emparanza JI,Beguiristain A,Bujanda L,Alustiza JM,García E,Hijona E,Gallego L,Sánchez-González J,Perugorria MJ,Asensio JI,Larburu S,Garmendia M,Larzabal M,Portillo MP,Aguirre L,Banales JM

    更新日期:2014-08-26 00:00:00

  • Spatial modes for transmission of chikungunya virus during a large chikungunya outbreak in Italy: a modeling analysis.

    abstract:BACKGROUND:The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial scales for transmission of chikungunya virus require definition to improve outbreak vector control re...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-020-01674-y

    authors: Guzzetta G,Vairo F,Mammone A,Lanini S,Poletti P,Manica M,Rosa R,Caputo B,Solimini A,Torre AD,Scognamiglio P,Zumla A,Ippolito G,Merler S

    更新日期:2020-08-07 00:00:00

  • How to optimise the coverage rate of infant and adult immunisations in Europe.

    abstract:BACKGROUND:Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preventable diseases. DISCUSSION:The Summit of Independent European Vaccination Experts focused on the p...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/1741-7015-5-11

    authors: Schmitt HJ,Booy R,Aston R,Van Damme P,Schumacher RF,Campins M,Rodrigo C,Heikkinen T,Weil-Olivier C,Finn A,Olcén P,Fedson D,Peltola H

    更新日期:2007-05-29 00:00:00

  • Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities.

    abstract:BACKGROUND:Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malaria tr...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/s12916-017-0893-6

    authors: Ndam NT,Mbuba E,González R,Cisteró P,Kariuki S,Sevene E,Rupérez M,Fonseca AM,Vala A,Maculuve S,Jiménez A,Quintó L,Ouma P,Ramharter M,Aponte JJ,Nhacolo A,Massougbodji A,Briand V,Kremsner PG,Mombo-Ngoma G,Desai M,

    更新日期:2017-07-17 00:00:00

  • The effects of tea extracts on proinflammatory signaling.

    abstract:BACKGROUND:Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-a...

    journal_title:BMC medicine

    pub_type: 杂志文章

    doi:10.1186/1741-7015-4-28

    authors: Pajonk F,Riedisser A,Henke M,McBride WH,Fiebich B

    更新日期:2006-12-01 00:00:00

  • Step counter use in type 2 diabetes: a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:While step counter use has become popular among type 2 diabetes (T2D) patients, its effectiveness in increasing physical activity (PA) and improving glycemic control has been poorly defined. The aim of this meta-analysis of randomized controlled trials (RCTs) was to evaluate the association of step counter u...

    journal_title:BMC medicine

    pub_type: 杂志文章,meta分析

    doi:10.1186/1741-7015-12-36

    authors: Qiu S,Cai X,Chen X,Yang B,Sun Z

    更新日期:2014-02-27 00:00:00

  • The need for a personalized approach for prostate cancer management.

    abstract::The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castra...

    journal_title:BMC medicine

    pub_type: 评论,杂志文章

    doi:10.1186/s12916-015-0344-1

    authors: Sedelaar JP,Schalken JA

    更新日期:2015-05-09 00:00:00

  • Chemical and environmental vector control as a contribution to the elimination of visceral leishmaniasis on the Indian subcontinent: cluster randomized controlled trials in Bangladesh, India and Nepal.

    abstract:BACKGROUND:Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research programme to support integrated vector management for the elimination of VL from Bangladesh, India an...

    journal_title:BMC medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1741-7015-7-54

    authors: Joshi AB,Das ML,Akhter S,Chowdhury R,Mondal D,Kumar V,Das P,Kroeger A,Boelaert M,Petzold M

    更新日期:2009-10-05 00:00:00