Abstract:
BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. A third question, called the 'help' question, improves the specificity without apparently decreasing the sensitivity of this screening procedure. We validated the abbreviated screening procedure for major depression with and without the 'help' question in primary care patients managed for a physical complaint. METHODS:This diagnostic accuracy study used data from the SODA (for 'SOmatisation Depression Anxiety') cohort study conducted by 24 general practitioners (GPs) in western Switzerland that included patients over 18 years of age with at least a single physical complaint at index consultation. Major depression was identified with the full Patient Health Questionnaire. GPs were asked to screen patients for major depression with the three screening questions 1 year after inclusion. RESULTS:Of 937 patients with at least a single physical complaint, 751 were eligible 1 year after index consultation. Major depression was diagnosed in 69/724 (9.5%) patients. The sensitivity and specificity of the two-question method alone were 91.3% (95% CI 81.4 to 96.4) and 65.0% (95% CI 61.2 to 68.6), respectively. Adding the 'help' question decreased the sensitivity (59.4%; 95% CI 47.0 to 70.9) but improved the specificity (88.2%; 95% CI 85.4 to 90.5) of the three-question method. CONCLUSIONS:The use of two screening questions for major depression was associated with high sensitivity and low specificity in primary care patients presenting a physical complaint. Adding the 'help' question improved the specificity but clearly decreased the sensitivity; when using the 'help' question, four out of ten patients with depression will be missed, compared to only one out of ten with the two-question method. Therefore, the 'help' question is not useful as a screening question, but may help discussing management strategies.
journal_name
BMC Medjournal_title
BMC medicineauthors
Lombardo P,Vaucher P,Haftgoli N,Burnand B,Favrat B,Verdon F,Bischoff T,Herzig Ldoi
10.1186/1741-7015-9-114subject
Has Abstractpub_date
2011-10-18 00:00:00pages
114issn
1741-7015pii
1741-7015-9-114journal_volume
9pub_type
杂志文章相关文献
BMC Medicine文献大全abstract::In this video Q&A, we talk to Associate Professor Felice Jacka about population health approaches to the primary prevention of mental disorders across the lifespan. These include addressing lifestyle factors, such as diet, smoking and physical activity. Latest strategies are being developed through epidemiological stu...
journal_title:BMC medicine
pub_type: 面试
doi:10.1186/s12916-015-0490-5
更新日期:2015-10-14 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it ha...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-85
更新日期:2012-08-07 00:00:00
abstract:BACKGROUND:Electronic mail (email) has the potential to improve communication between physicians and patients. METHODS:We conducted two research studies in a family practice setting: 1) a brief, anonymous patient survey of a convenience sample to determine the number of clinic patients receptive to communicating with ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-4-18
更新日期:2006-08-15 00:00:00
abstract::The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-7
更新日期:2012-01-20 00:00:00
abstract:BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0313-8
更新日期:2015-03-30 00:00:00
abstract:BACKGROUND:The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complica...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0302-y
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:The possible relationship between chronic inflammatory diseases and their co-morbidities has become an increasing focus of research. Both chronic periodontitis and chronic obstructive pulmonary disease are neutrophilic, inflammatory conditions characterized by the loss of local connective tissue. Evidence su...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-241
更新日期:2013-11-13 00:00:00
abstract:BACKGROUND:Multiple-arm randomized trials can be more complex in their design, data analysis, and result reporting than two-arm trials. We conducted a systematic review to assess the reporting of analyses in reports of randomized controlled trials (RCTs) with multiple arms. METHODS:The literature in the MEDLINE databa...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验,评审
doi:10.1186/1741-7015-11-84
更新日期:2013-03-27 00:00:00
abstract:BACKGROUND:Cognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias. We developed the Brief Memory and Executive Test (BMET); a rapid screening measure sensitive to the impaired...
journal_title:BMC medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12916-015-0290-y
更新日期:2015-03-11 00:00:00
abstract:BACKGROUND:Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0975-5
更新日期:2017-11-28 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. METHODS...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0331-6
更新日期:2015-04-20 00:00:00
abstract:BACKGROUND:Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nuclear mag...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1240-2
更新日期:2019-01-07 00:00:00
abstract::Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0296-5
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-016-0731-2
更新日期:2016-11-10 00:00:00
abstract::Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without overt diarrhea that occurs in individuals exposed over time to poor sanitation and hygiene. It is implicated as a cause of stunting and malnutrition, oral vaccine failure and impaired development in children from low-income cou...
journal_title:BMC medicine
pub_type: 评论,杂志文章
doi:10.1186/s12916-014-0187-1
更新日期:2014-10-14 00:00:00
abstract::Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine...
journal_title:BMC medicine
pub_type: 面试
doi:10.1186/s12916-015-0508-z
更新日期:2015-10-16 00:00:00
abstract:BACKGROUND:Managing hearing communication for residents living with hearing loss and dementia in long-term care settings is challenging. This paper explores how care can be effective in optimising hearing communication for residents living with dementia. We argue that the underlying notion of permission or authorisatio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1286-9
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:This study was conducted to assess whether patient-reported outcomes (PROs) differ by the underlying diagnosis (rheumatoid arthritis (RA)/inflammatory arthritis, osteoarthritis (OA), avascular necrosis of bone (AVN), other) in patients undergoing primary total hip arthroplasty (THA). METHODS:We used prospec...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-210
更新日期:2013-09-24 00:00:00
abstract:BACKGROUND:A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of a...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1741-7015-11-216
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:Although a number of risk factors are known to predict mortality within the first years after myocardial infarction, little is known about interactions between risk factors, whereas these could contribute to accurate differentiation of patients with higher and lower risk for mortality. This study explored th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0242-y
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1363-0
更新日期:2019-07-11 00:00:00
abstract:BACKGROUND:Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01738-z
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary art...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1065-z
更新日期:2018-05-17 00:00:00
abstract:BACKGROUND:The 'Older People's Exercise intervention in Residential and nursing Accommodation' (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We rep...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1741-7015-12-1
更新日期:2014-01-03 00:00:00
abstract:BACKGROUND:In animal models, lack of thyroid hormone is associated with cone photoreceptor preservation, while administration of high doses of active thyroid hormone leads to deterioration. The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general popul...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0329-0
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-87
更新日期:2011-07-19 00:00:00
abstract:BACKGROUND:A sizeable fraction of tuberculosis (TB) cases go undiagnosed. By analysing data from enhanced demographic, microbiological and geospatial surveillance of TB registrations, we aimed to identify modifiable predictors of inequitable access to diagnosis and care. METHODS:Governmental community health workers (...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1260-6
更新日期:2019-01-29 00:00:00
abstract::Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-014-0222-2
更新日期:2014-12-08 00:00:00
abstract:BACKGROUND:Clinical pathways (CPs) are used to improve the outcomes of acute stroke, but their use in stroke care is questionable, because the evidence on their effectiveness is still inconclusive. The objective of this study was to evaluate whether CPs improve the outcomes and the quality of care provided to patients ...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1741-7015-10-71
更新日期:2012-07-10 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer deaths globally. However, there is overwhelming evidence that a large proportion of CRC cases and deaths could be prevented by screening. Nevertheless, CRC screening programmes are offered in a minority of coun...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0498-x
更新日期:2015-10-13 00:00:00