Abstract:
BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. A third question, called the 'help' question, improves the specificity without apparently decreasing the sensitivity of this screening procedure. We validated the abbreviated screening procedure for major depression with and without the 'help' question in primary care patients managed for a physical complaint. METHODS:This diagnostic accuracy study used data from the SODA (for 'SOmatisation Depression Anxiety') cohort study conducted by 24 general practitioners (GPs) in western Switzerland that included patients over 18 years of age with at least a single physical complaint at index consultation. Major depression was identified with the full Patient Health Questionnaire. GPs were asked to screen patients for major depression with the three screening questions 1 year after inclusion. RESULTS:Of 937 patients with at least a single physical complaint, 751 were eligible 1 year after index consultation. Major depression was diagnosed in 69/724 (9.5%) patients. The sensitivity and specificity of the two-question method alone were 91.3% (95% CI 81.4 to 96.4) and 65.0% (95% CI 61.2 to 68.6), respectively. Adding the 'help' question decreased the sensitivity (59.4%; 95% CI 47.0 to 70.9) but improved the specificity (88.2%; 95% CI 85.4 to 90.5) of the three-question method. CONCLUSIONS:The use of two screening questions for major depression was associated with high sensitivity and low specificity in primary care patients presenting a physical complaint. Adding the 'help' question improved the specificity but clearly decreased the sensitivity; when using the 'help' question, four out of ten patients with depression will be missed, compared to only one out of ten with the two-question method. Therefore, the 'help' question is not useful as a screening question, but may help discussing management strategies.
journal_name
BMC Medjournal_title
BMC medicineauthors
Lombardo P,Vaucher P,Haftgoli N,Burnand B,Favrat B,Verdon F,Bischoff T,Herzig Ldoi
10.1186/1741-7015-9-114subject
Has Abstractpub_date
2011-10-18 00:00:00pages
114issn
1741-7015pii
1741-7015-9-114journal_volume
9pub_type
杂志文章相关文献
BMC Medicine文献大全abstract:BACKGROUND:Many agree that the biopsychosocial contributions to psychopathology are complex, yet it is unclear how we can make sense of this complexity. One approach is to reduce this complexity to a few necessary and sufficient biopsychosocial factors; although this approach is easy to understand, it has little explan...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-019-1435-1
更新日期:2019-10-18 00:00:00
abstract::There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide ...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-016-0641-3
更新日期:2016-06-18 00:00:00
abstract:BACKGROUND:Mathematical and computational models for infectious diseases are increasingly used to support public-health decisions; however, their reliability is currently under debate. Real-time forecasts of epidemic spread using data-driven models have been hindered by the technical challenges posed by parameter estim...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-165
更新日期:2012-12-13 00:00:00
abstract::Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-5
更新日期:2012-01-13 00:00:00
abstract:BACKGROUND:Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only mixed effects on childhood diarrhea. Arriving at the inception of the United Nations' Sustainable De...
journal_title:BMC medicine
pub_type: 共识发展会议,杂志文章
doi:10.1186/s12916-019-1410-x
更新日期:2019-08-28 00:00:00
abstract:BACKGROUND:Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-a...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-4-28
更新日期:2006-12-01 00:00:00
abstract::Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial....
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0522-1
更新日期:2015-11-10 00:00:00
abstract::Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0296-5
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:Intimate partner violence is common among women having abortions, with between 6% and 22% reporting recent violence from an intimate partner. Concern about violence is a reason some pregnant women decide to terminate their pregnancies. Whether risk of violence decreases after having an abortion, remains unkn...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0144-z
更新日期:2014-09-29 00:00:00
abstract:BACKGROUND:Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant r...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0740-1
更新日期:2016-11-30 00:00:00
abstract:BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1431-5
更新日期:2019-11-25 00:00:00
abstract:BACKGROUND:The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective forces; thus, we analyze...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-140
更新日期:2012-11-15 00:00:00
abstract:BACKGROUND:Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS:We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-97
更新日期:2013-04-04 00:00:00
abstract::The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-017-0802-z
更新日期:2017-02-13 00:00:00
abstract:BACKGROUND:There has been concern that the incidence of autism and other pervasive developmental disorders (PDDs) is increasing. Previous studies have been smaller, restricted to autism (excluding other pervasive developmental disorders such as Asperger's syndrome), included boys only, or have not been based on a natio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-2-39
更新日期:2004-11-09 00:00:00
abstract:BACKGROUND:Studies addressing the effects of aerobic exercise and a prudent diet on lipid and lipoprotein concentrations in adults have reached conflicting conclusions. The purpose of this study was to determine the effects of aerobic exercise combined with a prudent diet on lipid and lipoprotein concentrations in adul...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析
doi:10.1186/1741-7015-9-74
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagnosis. METHODS:The study was set within 568 practices contributing to a UK primary care health recor...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1462-y
更新日期:2019-12-04 00:00:00
abstract::Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine...
journal_title:BMC medicine
pub_type: 面试
doi:10.1186/s12916-015-0508-z
更新日期:2015-10-16 00:00:00
abstract::The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-7
更新日期:2012-01-20 00:00:00
abstract:BACKGROUND:Tumor necrosis factor (TNF)-α inhibitors are increasingly being used in inflammatory bowel disease (IBD). Because this chronic intestinal disorder often affects women of fertile age, it is essential to assess the effect of biologics on pregnancy outcome. METHODS:We performed a systematic review of the Engli...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-174
更新日期:2013-07-31 00:00:00
abstract::The Ebola virus disease (EVD) outbreak in the three West Africa countries of Guinea, Liberia, and Sierra Leone, was declared by the World Health Organization (WHO) as a public health event of international concern in August 2014. The disease, which has caused more than 10,000 deaths from over 25,000 cases, has thrived...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0359-7
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pendrin expression and deafness using mice that have (Slc26a4+/+ or Slc26a4+/-) or lack (Slc26a4-/-...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-4-37
更新日期:2006-12-22 00:00:00
abstract::In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of these variants lie outside of the charted regions of the human genome whose function we understand; that is, the sequences that encode proteins. Consequently, t...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-12-97
更新日期:2014-06-12 00:00:00
abstract::In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...
journal_title:BMC medicine
pub_type: 面试,杂志文章
doi:10.1186/1741-7015-11-150
更新日期:2013-06-18 00:00:00
abstract::In a climate of economic uncertainty, cost effectiveness analysis is a potentially important tool for making choices about health care interventions. Methods for such analyses are well established, but the results need to be interpreted carefully and are subject to bias. Making decisions based on results of cost-effec...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-10
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or L...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01540-x
更新日期:2020-04-07 00:00:00
abstract::The complexity of tissue and the alterations that distinguish normal from cancer remain a challenge for translating results from tumor biological studies into clinical medicine. This has generated an unmet need to exploit the findings from studies based on cell lines and model organisms to develop, validate and clinic...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-103
更新日期:2012-09-12 00:00:00
abstract:BACKGROUND:Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) among pediatric inpatients, we aimed to test the hypothesis that OLUL status is a risk factor for ADRs. METHODS:A nested case?control study was co...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-238
更新日期:2013-11-07 00:00:00
abstract:BACKGROUND:The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with treatment outcome. A nov...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0539-5
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-117
更新日期:2011-10-27 00:00:00