Abstract:
:In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment.
journal_name
BMC Medjournal_title
BMC medicineauthors
Caldas Cdoi
10.1186/1741-7015-11-150subject
Has Abstractpub_date
2013-06-18 00:00:00pages
150issn
1741-7015pii
1741-7015-11-150journal_volume
11pub_type
面试,杂志文章相关文献
BMC Medicine文献大全abstract:BACKGROUND:A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of a...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1741-7015-11-216
更新日期:2013-10-08 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer deaths globally. However, there is overwhelming evidence that a large proportion of CRC cases and deaths could be prevented by screening. Nevertheless, CRC screening programmes are offered in a minority of coun...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0498-x
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth the adrenals are essential for neonate salt retention through secretion of aldosterone, while adequate glucocorticoids are required to prevent adrenal in...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1009-7
更新日期:2018-02-12 00:00:00
abstract:BACKGROUND:Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed t...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-18
更新日期:2011-02-22 00:00:00
abstract:BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0313-8
更新日期:2015-03-30 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) elimination is being seriously considered globally. Current elimination models require a combination of highly effective HCV treatment and harm reduction, but high treatment costs make such strategies prohibitively expensive. Vaccines should play a key role in elimination but their be...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0440-2
更新日期:2015-08-20 00:00:00
abstract:BACKGROUND:To reduce inequalities between individuals with and without mental health problems, a better understanding is required of triggers and success of quit attempts among the third of smokers with mental health problems. The aim was to assess whether there are differences by mental health status in (i) triggers f...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01617-7
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals with impaired capacity nearing the end of life in research, by identifying the challenges and solut...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01654-2
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:Schools are the most frequent target for intervention programs aimed at preventing child obesity; however, the overall effectiveness of these programs has been limited. It has therefore been recommended that interventions target multiple ecological levels (community, family, school and individual) to have gr...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1741-7015-7-49
更新日期:2009-09-18 00:00:00
abstract::Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted effort...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-34
更新日期:2012-04-12 00:00:00
abstract:BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1431-5
更新日期:2019-11-25 00:00:00
abstract:BACKGROUND:Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objective was to test whether thymic size in infancy could be increased by maternal and/or infant nutriti...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-019-1264-2
更新日期:2019-02-18 00:00:00
abstract::The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly. ...
journal_title:BMC medicine
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12916-018-1232-2
更新日期:2018-12-28 00:00:00
abstract:BACKGROUND:Little is known about the impact of growing migration on the pattern of tuberculosis (TB) transmission in middle-income countries. We estimated TB recent transmission and its associated factors and investigated the presence of cross-transmission between South American migrants and Brazilians. METHODS:We stu...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1055-1
更新日期:2018-04-30 00:00:00
abstract:BACKGROUND:The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial scales for transmission of chikungunya virus require definition to improve outbreak vector control re...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01674-y
更新日期:2020-08-07 00:00:00
abstract:BACKGROUND:The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagnosis. METHODS:The study was set within 568 practices contributing to a UK primary care health recor...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1462-y
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:Interventions to alleviate stigma are demonstrating effectiveness across a range of conditions, though few move beyond the pilot phase, especially in low- and middle-income countries (LMICs). Implementation science offers tools to study complex interventions, understand barriers to implementation, and genera...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1237-x
更新日期:2019-02-15 00:00:00
abstract::Although clinical nutrition is a frequently used intervention in inpatient care, high quality trials proving its effectiveness and safety when used in the acutely-ill polymorbid medical inpatient population are largely lacking. From an evolutionary perspective, illness-related low appetite is protective and part of th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0812-x
更新日期:2017-02-24 00:00:00
abstract:BACKGROUND:Tobacco smoking is a leading cause of cardiovascular disease (CVD) morbidity and mortality. Evidence on the relation of smoking to different subtypes of CVD, across fatal and non-fatal outcomes, is limited. METHODS:A prospective study of 188,167 CVD- and cancer-free individuals aged ≥ 45 years from the Aust...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1351-4
更新日期:2019-07-03 00:00:00
abstract:BACKGROUND:Guidelines recommend that clinicians should make brief opportunistic behavioural interventions to patients who are obese to increase the uptake of effective weight loss programmes. The objective was to assess the effect of this policy on socioeconomic equity. METHODS:One thousand eight hundred eighty-two co...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-019-1284-y
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:In 2015, the Zika virus spread from Brazil throughout the Americas, posing an unprecedented challenge to the public health community. During the epidemic, international public health officials lacked reliable predictions of the outbreak's expected geographic scale and prevalence of cases, and were therefore ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1389-3
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1252-6
更新日期:2019-01-31 00:00:00
abstract:BACKGROUND:In recent years, medical practice has followed two different paradigms: evidence-based medicine (EBM) and values-based medicine (VBM). There is an urgent need to promote medical education that strengthens the relationship between these two paradigms. This work is designed to establish the foundations for a c...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-39
更新日期:2013-02-15 00:00:00
abstract::How should we approach trial design when we can get some, but not all, of the way to the numbers required for a randomised phase III trial?We present an ordered framework for designing randomised trials to address the problem when the ideal sample size is considered larger than the number of participants that can be r...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0722-3
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS:We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database of...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12916-016-0631-5
更新日期:2016-06-10 00:00:00
abstract::Cocaine is a stimulant that leads to the rapid accumulation of catecholamines and serotonin in the brain due to prevention of their re-uptake into the neuron that released the neurotransmitter. Cocaine dependence is a public health concern and cause of significant morbidity and mortality worldwide. At present, there a...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-9-119
更新日期:2011-11-03 00:00:00
abstract:BACKGROUND:In patients with stage II colorectal cancer (CRC) the number of surgically retrieved lymph nodes (LNs) is associated with prognosis, resulting in a minimum of 10-12 retrieved LNs being recommended for this stage. Current guidelines do not provide a recommendation regarding LN yield in T1 CRC. Studies evaluat...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12916-017-0892-7
更新日期:2017-07-14 00:00:00
abstract:BACKGROUND:The 'Older People's Exercise intervention in Residential and nursing Accommodation' (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We rep...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1741-7015-12-1
更新日期:2014-01-03 00:00:00
abstract:BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-1505-4
更新日期:2020-03-03 00:00:00
abstract::A series of primarily laboratory-based studies found attention bias modification in socially anxious participants to lead to reduced anxiety. It is argued that the failure to replicate the positive results of attention bias modification in the study of Carlbring et al. may be due to reasons other than the application ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-63
更新日期:2012-06-25 00:00:00